c-peptide and Hydronephrosis

Retroperitoneal fibrosis is characterized by the presence of a retroperitoneal tissue, consisting of chronic inflammation and marked fibrosis, which entraps the retroperitoneal organs. In two-thirds of cases, the retroperitoneal fibrosis is idiopathic. The pathogenic mechanism is not clearly identified. We report a case of idiopathic retroperitoneal fibrosis associated with type 1 diabetes mellitus. A 61-year-old woman with C peptide negative insulindependent diabetes developed retroperitoneal fibrosis revealed by bilateral hydronephrosis. Anti-GAD 65 antibodies were positive. There were no signs of autoimmune pancreatitis: no steatorrhea, normal IgG4 isotype levels, and absence of pancreas morphological abnormalities.

Topics: Anti-Inflammatory Agents; C-Peptide; Diabetes Mellitus, Type 1; Female; Glutamate Decarboxylase; Humans; Hydronephrosis; Middle Aged; Retroperitoneal Fibrosis; Retroperitoneal Space; Steroids; Tomography, X-Ray Computed; Ureter