c-peptide and Cardiomyopathies

Serum C-peptide exhibits various biological activities. The relationship between C-peptide and atrial cardiomyopathy remains unknown. We aimed to investigate the association between C-peptide level and atrial cardiomyopathy in nondiabetic adults. Our study enrolled 4578 participants without diagnosed diabetes from the Third National Health and Nutrition Examination Survey (NHANES III). Atrial cardiomyopathy was defined as a deep terminal negative P wave in V1 below - 100 µV (more negative), according to the electrocardiogram. The participants were categorized into low C-peptide (≤ 1.46 nmol/L) and high C-peptide (> 1.46 nmol/L) groups, according to the receiver operating characteristic analysis. Odds ratio (OR) and 95% confidence interval (CI) for the association between C-peptide level and atrial cardiomyopathy were generated using multivariate logistic regression analysis. The prevalence of atrial cardiomyopathy was higher in the high C-peptide group than in the low C-peptide group (5.62% vs. 2.31%, P < 0.001, respectively). Multivariate logistic regression analysis showed that participants in the high C-peptide group had a 3.60-fold (95% CI 1.81-6.99) higher risk of atrial cardiomyopathy than those in the low C-peptide group. Per standard deviation increase in C-peptide was linked to a 1.20-fold (95% CI 1.00-1.41) higher risk in atrial cardiomyopathy. High C-peptide level might be an independent risk factor for atrial cardiomyopathy in nondiabetic adults.

Topics: Adult; Atrial Fibrillation; C-Peptide; Cardiomyopathies; Humans; Nutrition Surveys; Risk Factors

Pancreas tissue collected from 77 patients died of Keshan disease as well as pancreas specimens of experimental rats having been fed with grains collected from Keshan disease endemic area were studied with immunohistochemical stainings. There were lesions found morphologically in the pancreatic islets of the patients, including atrophy, reduction of number, abnormal arrangement and degeneration of the islet cells. The serum insulin and connective peptide levels as well as the connective peptide secretory reserve in the islets of rats fed with endemic area grains were all markedly decreased. These findings suggest that the islet lesions in Keshan disease may be an important factor in aggravating the development of necrosis in the myocardium.

Topics: Adolescent; Animals; Atrophy; C-Peptide; Cardiomyopathies; Child; Child, Preschool; Female; Humans; Immunohistochemistry; Infant; Insulin; Islets of Langerhans; Male; Pancreas; Rats; Rats, Wistar; Selenium; Sodium Selenite; Vitamin E