Compounds > bz-423
Page last updated: 2024-09-04

bz-423 and Lupus Erythematosus, Systemic

bz-423 has been researched along with Lupus Erythematosus, Systemic in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bednarski, JJ; Blatt, NB; Boitano, A; Ellman, JA; Glick, GD; Johnson, KJ; Johnson, KM; Leonetti, F; Opipari, AW; Richardson, BC; Warner, RE; Yung, R1
Habeck, M1
Bednarski, JJ; Boitano, AE; Glick, GD; Lyssiotis, CA; Opipari, AW; Roush, R1
Gestwicki, JE1
Boitano, A; Chen, X; Glick, GD; Johnson, KM; Opipari, AW; Swenson, L1

Other Studies

5 other study(ies) available for bz-423 and Lupus Erythematosus, Systemic

ArticleYear
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility.
    The Journal of clinical investigation, 2002, Volume: 110, Issue:8

    Topics: Animals; Antibodies, Antinuclear; Apoptosis; B-Lymphocytes; Benzodiazepines; Cell Line, Transformed; Female; Humans; In Vitro Techniques; Lupus Erythematosus, Systemic; Mice; Mice, Inbred NZB; Models, Biological; Reactive Oxygen Species; Signal Transduction; Superoxides

2002
Benzodiazepine library yields lupus target.
    Drug discovery today, 2002, Dec-15, Volume: 7, Issue:24

    Topics: Animals; Benzodiazepines; Combinatorial Chemistry Techniques; Drug Delivery Systems; Humans; Lupus Erythematosus, Systemic

2002
A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis.
    The Journal of biological chemistry, 2004, Jul-09, Volume: 279, Issue:28

    Topics: Animals; Apoptosis; B-Lymphocytes; Benzodiazepines; Calcium; Calcium Signaling; Cells, Cultured; Chelating Agents; Disease Models, Animal; Egtazic Acid; Female; Fluorescent Dyes; Germinal Center; Humans; Lupus Erythematosus, Systemic; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Molecular Structure; Receptors, Antigen, B-Cell; Superoxides

2004
Target identification for a promising anti-lupus drug.
    Chemistry & biology, 2005, Volume: 12, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Benzodiazepines; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Immunologic Factors; Lupus Erythematosus, Systemic; Mitochondrial Proton-Translocating ATPases; Peptide Library

2005
Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423.
    Chemistry & biology, 2005, Volume: 12, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Benzodiazepines; Carrier Proteins; Cattle; Cell Death; Cell Line; Cloning, Molecular; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Immunologic Factors; Indicators and Reagents; Lupus Erythematosus, Systemic; Membrane Proteins; Mitochondria; Mitochondria, Heart; Mitochondrial Proton-Translocating ATPases; Oxygen Consumption; RNA, Small Interfering; Transfection

2005