bx795 has been researched along with Thrombosis* in 1 studies
1 other study(ies) available for bx795 and Thrombosis
| Article | Year |
|---|---|
PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway.
Essentials Phosphoinositide 3-kinase and MAPK pathways crosstalk via PDK1. PDK1 is required for adenosine diphosphate-induced platelet activation and thromboxane generation. PDK1 regulates RAF proto-oncogene Ser/Thr kinase (Raf1) activation in the MAPK pathway. Genetic ablation of PDK1 protects against platelet-dependent thrombosis in vivo. Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Blood Platelets; Disease Models, Animal; Humans; Mice, Knockout; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-raf; Pulmonary Embolism; Pyrimidines; Signal Transduction; Thiophenes; Thrombosis; Thromboxanes | 2018 |