bx-471 and Psoriasis

bx-471 has been researched along with Psoriasis* in 1 studies

Reviews

1 review(s) available for bx-471 and Psoriasis

Article	Year
BX471: a CCR1 antagonist with anti-inflammatory activity in man. Mini reviews in medicinal chemistry, 2005, Volume: 5, Issue:9 Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. The chemokine receptor CCR1 appears to be involved in a variety of proinflammatory and autoimmune diseases and this makes it a very attractive therapeutic target. This review discusses the identification, chemistry, biology and therapeutic potential of BX 471 a potent CCR1 antagonist that is currently in the clinic for a variety of indications. Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Multiple Sclerosis; Phenylurea Compounds; Piperidines; Protein Serine-Threonine Kinases; Psoriasis	2005

Article

Year

BX471: a CCR1 antagonist with anti-inflammatory activity in man.

Mini reviews in medicinal chemistry, 2005, Volume: 5, Issue:9

Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. The chemokine receptor CCR1 appears to be involved in a variety of proinflammatory and autoimmune diseases and this makes it a very attractive therapeutic target. This review discusses the identification, chemistry, biology and therapeutic potential of BX 471 a potent CCR1 antagonist that is currently in the clinic for a variety of indications.

Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Multiple Sclerosis; Phenylurea Compounds; Piperidines; Protein Serine-Threonine Kinases; Psoriasis

2005