bx-471 and Aspergillosis

bx-471 has been researched along with Aspergillosis* in 1 studies

Other Studies

1 other study(ies) available for bx-471 and Aspergillosis

ArticleYear
Therapeutic targeting of CCR1 attenuates established chronic fungal asthma in mice.
    British journal of pharmacology, 2005, Volume: 145, Issue:8

    CC chemokine receptor 1 (CCR1) represents a promising target in chronic airway inflammation and remodeling due to fungus-associated allergic asthma. The present study addressed the therapeutic effect of a nonpeptide CCR1 antagonist, BX-471, in a model of chronic fungal asthma induced by Aspergillus fumigatus conidia. BX-471 treatment of isolated macrophages inhibited CCL22 and TNF-alpha and promoted IL-10 release. BX-471 also increased toll like receptor-9 (TLR9) and decreased TLR2 and TLR6 expression in these cells. When administered daily by intraperitoneal injection, from days 15 to 30 after the initiation of chronic fungal asthma, BX-471 (3, 10, or 30 mg kg(-1)) dose-dependently reduced airway inflammation, hyper-responsiveness, and remodeling at day 30 after conidia challenge. The maximal therapeutic effect was observed at the 10 mg kg(-1) dose. In summary, the therapeutic administration of BX-471 significantly attenuated experimental fungal asthma via its effects on both innate and adaptive immune processes.

    Topics: Animals; Aspergillosis; Aspergillus fumigatus; Asthma; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Immunity, Innate; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Phenylurea Compounds; Piperidines; Receptors, CCR1; Receptors, Chemokine

2005