bwa-4c has been researched along with Hypersensitivity* in 1 studies
1 other study(ies) available for bwa-4c and Hypersensitivity
| Article | Year |
|---|---|
Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.
A novel class of potent 5-lipoxygenase (5-LO) product synthesis inhibitors based on the structure of pirinixic acid (4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid, compound 1) is presented. Systematic profiling of 1, i.e., esterification of the carboxylic acid, alpha-substitution, and replacement of the o-dimethylaniline by 6-aminoquinoline, leads to potent suppressors of 5-LO product formation in activated polymorphonuclear leukocytes, exemplified by ethyl 2-[4-chloro-6-(quinoline-6-ylamino)-pyrimidin-2-ylsulfanyl]octane-1-carboxylate (6d, IC50 = 0.6 microM). These derivatives may possess potential for intervention with inflammatory and allergic diseases. Topics: Aminoquinolines; Cells, Cultured; Esterification; Humans; Hypersensitivity; Inflammation; Leukocytes; Lipoxygenase; Lipoxygenase Inhibitors; Pyrimidines; Structure-Activity Relationship | 2008 |