butyric acid has been researched along with Leukemia, Promyelocytic, Acute in 21 studies
Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
Leukemia, Promyelocytic, Acute: An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To use NB4, an authentic human acute promyelocytic leukemia cell line, as well as the marrow cells from patients with acute promyelocytic leukemia (APL), containing the PML/RAR alpha fusion gene and fused protein to examine the growth inhibition and cytodifferentiation induced by all-trans retinoic acid (ATRA), butyric acid (BA) and its prodrug tributyrin (TB) either as a single agent or in combinations." | 7.70 | Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells. ( Chen, L; Chen, Z; Pan, J; Wang, W; Xue, Y, 1999) |
| "To use NB4, an authentic human acute promyelocytic leukemia cell line, as well as the marrow cells from patients with acute promyelocytic leukemia (APL), containing the PML/RAR alpha fusion gene and fused protein to examine the growth inhibition and cytodifferentiation induced by all-trans retinoic acid (ATRA), butyric acid (BA) and its prodrug tributyrin (TB) either as a single agent or in combinations." | 3.70 | Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells. ( Chen, L; Chen, Z; Pan, J; Wang, W; Xue, Y, 1999) |
| "Butyric acid is a potent cell growth inhibitor and differentiation inducer (1-4)." | 1.29 | Butyric acid and its monosaccharide ester induce apoptosis in the HL-60 cell line. ( Belpomme, D; Calabresse, C; Chomienne, C; Ronco, G; Venturini, L; Villa, P, 1993) |
| "Dimethyl sulfoxide was used to induce these promyelocytic leukemia cells to undergo terminal differentiation into mature myeloid cells." | 1.28 | Inducers of leukemic cell differentiation cause down-regulation of RB gene expression. ( Chandler, S; Yen, A, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 18 (85.71) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nudelman, A | 2 |
| Ruse, M | 1 |
| Aviram, A | 2 |
| Rabizadeh, E | 1 |
| Shaklai, M | 2 |
| Zimrah, Y | 2 |
| Rephaeli, A | 2 |
| Coradini, D | 1 |
| Pellizzaro, C | 1 |
| Scarlata, I | 1 |
| Zorzet, S | 1 |
| Garrovo, C | 1 |
| Abolafio, G | 1 |
| Speranza, A | 1 |
| Fedeli, M | 1 |
| Cantoni, S | 1 |
| Sava, G | 1 |
| Daidone, MG | 1 |
| Perbellini, A | 1 |
| García-Bermejo, L | 1 |
| Vilaboa, NE | 1 |
| Pérez, C | 1 |
| de Blas, E | 1 |
| Calle, C | 1 |
| Aller, P | 1 |
| Grässel, S | 1 |
| Cohen, IR | 1 |
| Murdoch, AD | 1 |
| Eichstetter, I | 1 |
| Iozzo, RV | 1 |
| Atkins, KB | 1 |
| Troen, BR | 1 |
| Fraser, DJ | 1 |
| Brandt, TL | 1 |
| Kroll, DJ | 1 |
| Yen, A | 3 |
| Varvayanis, S | 2 |
| Breitman, TR | 2 |
| Chen, ZX | 2 |
| Takahashi, N | 1 |
| Calabresse, C | 1 |
| Venturini, L | 1 |
| Ronco, G | 1 |
| Villa, P | 1 |
| Chomienne, C | 1 |
| Belpomme, D | 1 |
| Heruth, DP | 1 |
| Zirnstein, GW | 1 |
| Bradley, JF | 1 |
| Rothberg, PG | 1 |
| Taimi, M | 1 |
| Chen, Z | 1 |
| Wang, W | 1 |
| Pan, J | 1 |
| Chen, L | 1 |
| Xue, Y | 1 |
| Richard, D | 1 |
| Hollender, P | 1 |
| Chénais, B | 1 |
| Chandler, S | 1 |
| Ahmed, N | 1 |
| Williams, JF | 1 |
| Weidemann, MJ | 1 |
| Munks, RJ | 1 |
| Moore, J | 1 |
| O'Neill, LP | 1 |
| Turner, BM | 1 |
| Fischkoff, SA | 2 |
| Rossi, RM | 1 |
| Plaetinck, G | 1 |
| Van der Heyden, J | 1 |
| Tavernier, J | 1 |
| Faché, I | 1 |
| Tuypens, T | 1 |
| Fischkoff, S | 1 |
| Fiers, W | 1 |
| Devos, R | 1 |
1 review available for butyric acid and Leukemia, Promyelocytic, Acute
| Article | Year |
|---|---|
Potential applications of cytodifferentiation therapy in hematologic malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Butyrates; Butyric Acid; Cell Differentiation; Child | 1994 |
20 other studies available for butyric acid and Leukemia, Promyelocytic, Acute
| Article | Year |
|---|---|
Novel anticancer prodrugs of butyric acid. 2.
Topics: Animals; Antineoplastic Agents; Butyrates; Cell Differentiation; Cell Division; Female; Humans; Leuk | 1992 |
A novel retinoic/butyric hyaluronan ester for the treatment of acute promyelocytic leukemia: preliminary preclinical results.
Topics: Apoptosis; Butyric Acid; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; | 2006 |
Modulation of HSP70 and HSP27 gene expression by the differentiation inducer sodium butyrate in U-937 human promonocytic leukemia cells.
Topics: Base Sequence; Butyrates; Butyric Acid; Cell Differentiation; DNA-Binding Proteins; Gene Expression | 1995 |
The proteoglycan perlecan is expressed in the erythroleukemia cell line K562 and is upregulated by sodium butyrate and phorbol ester.
Topics: Base Sequence; Butyrates; Butyric Acid; Cell Differentiation; Chondroitinases and Chondroitin Lyases | 1995 |
Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to retinoic acid, calcitriol, 9 cis-retinoic acid, and sodium butyrate.
Topics: Butyrates; Butyric Acid; Calcitriol; Cathepsin D; Cathepsin L; Cathepsins; Cell Differentiation; Cys | 1995 |
Topoisomerase II alpha promoter trans-activation early in monocytic differentiation of HL-60 human leukemia cells.
Topics: Base Sequence; Butyrates; Butyric Acid; Cell Differentiation; DNA Topoisomerases, Type II; Genes, Re | 1995 |
DMSO, sodium butyrate, and TPA induce hypophosphorylation of RB with HL-60 cell differentiation.
Topics: Blotting, Western; Butyrates; Butyric Acid; Cell Differentiation; Dimethyl Sulfoxide; Humans; Leukem | 1995 |
RB phosphorylation in sodium butyrate-resistant HL-60 cells: cross-resistance to retinoic acid but not vitamin D3.
Topics: Butyrates; Butyric Acid; Cell Differentiation; Cholecalciferol; Drug Resistance; Humans; Leukemia, P | 1995 |
Comparison between the effect of butyric acid and its prodrug pivaloyloxymethylbutyrate on histones hyperacetylation in an HL-60 leukemic cell line.
Topics: Acetylation; Aniline Compounds; Butyrates; Butyric Acid; Histones; Leukemia, Promyelocytic, Acute; O | 1994 |
Butyric acid and its monosaccharide ester induce apoptosis in the HL-60 cell line.
Topics: Antineoplastic Agents; Apoptosis; Butyrates; Butyric Acid; Cell Line; Cell Survival; DNA, Neoplasm; | 1993 |
Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells.
Topics: Antisense Elements (Genetics); Blotting, Northern; Butyrates; Butyric Acid; Cell Differentiation; Ce | 1993 |
Potentiation of retinoic acid-induced differentiation of human acute promyelocytic leukemia NB4 cells by butyric acid, tributyrin, and hexamethylene bisacetamide.
Topics: Acetamides; Antineoplastic Agents; Butyrates; Butyric Acid; Cell Differentiation; Drug Synergism; Hu | 1998 |
Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells.
Topics: Butyric Acid; Cell Transformation, Neoplastic; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; | 1999 |
Butyric acid increases invasiveness of HL-60 leukemia cells: role of reactive oxygen species.
Topics: Antioxidants; Butyric Acid; Cell Differentiation; Cell Movement; HL-60 Cells; Humans; Leukemia, Prom | 2002 |
Inducers of leukemic cell differentiation cause down-regulation of RB gene expression.
Topics: Butyrates; Butyric Acid; Cell Differentiation; Dimethyl Sulfoxide; DNA; Down-Regulation; Gene Expres | 1992 |
The human promyelocytic HL60 cell line: a model of myeloid cell differentiation using dimethylsulphoxide, phorbol ester and butyrate.
Topics: Butyrates; Butyric Acid; Cell Differentiation; Cytochrome c Group; Dimethyl Sulfoxide; Hematopoietic | 1991 |
Histone H4 acetylation in Drosophila. Frequency of acetylation at different sites defined by immunolabelling with site-specific antibodies.
Topics: Acetylation; Animals; Autoradiography; Blotting, Western; Butyrates; Butyric Acid; Drosophila; Histo | 1991 |
Lineage directed HL-60 cell sublines as a model system for the study of early events in lineage determination of myeloid cells.
Topics: Butyrates; Butyric Acid; Cell Differentiation; Cholecalciferol; Dimethyl Sulfoxide; Eosinophils; Hem | 1990 |
Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells.
Topics: Butyrates; Butyric Acid; Cell Line; Clone Cells; Eosinophils; Humans; Interleukin-5; Kinetics; Leuke | 1990 |
Graded increase in probability of eosinophilic differentiation of HL-60 promyelocytic leukemia cells induced by culture under alkaline conditions.
Topics: Agar; Butyrates; Butyric Acid; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cul | 1988 |