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butyric acid and Leukemia, Promyelocytic, Acute

butyric acid has been researched along with Leukemia, Promyelocytic, Acute in 21 studies

Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.

Leukemia, Promyelocytic, Acute: An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.

Research Excerpts

ExcerptRelevanceReference
"To use NB4, an authentic human acute promyelocytic leukemia cell line, as well as the marrow cells from patients with acute promyelocytic leukemia (APL), containing the PML/RAR alpha fusion gene and fused protein to examine the growth inhibition and cytodifferentiation induced by all-trans retinoic acid (ATRA), butyric acid (BA) and its prodrug tributyrin (TB) either as a single agent or in combinations."7.70Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells. ( Chen, L; Chen, Z; Pan, J; Wang, W; Xue, Y, 1999)
"To use NB4, an authentic human acute promyelocytic leukemia cell line, as well as the marrow cells from patients with acute promyelocytic leukemia (APL), containing the PML/RAR alpha fusion gene and fused protein to examine the growth inhibition and cytodifferentiation induced by all-trans retinoic acid (ATRA), butyric acid (BA) and its prodrug tributyrin (TB) either as a single agent or in combinations."3.70Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells. ( Chen, L; Chen, Z; Pan, J; Wang, W; Xue, Y, 1999)
"Butyric acid is a potent cell growth inhibitor and differentiation inducer (1-4)."1.29Butyric acid and its monosaccharide ester induce apoptosis in the HL-60 cell line. ( Belpomme, D; Calabresse, C; Chomienne, C; Ronco, G; Venturini, L; Villa, P, 1993)
"Dimethyl sulfoxide was used to induce these promyelocytic leukemia cells to undergo terminal differentiation into mature myeloid cells."1.28Inducers of leukemic cell differentiation cause down-regulation of RB gene expression. ( Chandler, S; Yen, A, 1992)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's18 (85.71)18.2507
2000's2 (9.52)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nudelman, A2
Ruse, M1
Aviram, A2
Rabizadeh, E1
Shaklai, M2
Zimrah, Y2
Rephaeli, A2
Coradini, D1
Pellizzaro, C1
Scarlata, I1
Zorzet, S1
Garrovo, C1
Abolafio, G1
Speranza, A1
Fedeli, M1
Cantoni, S1
Sava, G1
Daidone, MG1
Perbellini, A1
García-Bermejo, L1
Vilaboa, NE1
Pérez, C1
de Blas, E1
Calle, C1
Aller, P1
Grässel, S1
Cohen, IR1
Murdoch, AD1
Eichstetter, I1
Iozzo, RV1
Atkins, KB1
Troen, BR1
Fraser, DJ1
Brandt, TL1
Kroll, DJ1
Yen, A3
Varvayanis, S2
Breitman, TR2
Chen, ZX2
Takahashi, N1
Calabresse, C1
Venturini, L1
Ronco, G1
Villa, P1
Chomienne, C1
Belpomme, D1
Heruth, DP1
Zirnstein, GW1
Bradley, JF1
Rothberg, PG1
Taimi, M1
Chen, Z1
Wang, W1
Pan, J1
Chen, L1
Xue, Y1
Richard, D1
Hollender, P1
Chénais, B1
Chandler, S1
Ahmed, N1
Williams, JF1
Weidemann, MJ1
Munks, RJ1
Moore, J1
O'Neill, LP1
Turner, BM1
Fischkoff, SA2
Rossi, RM1
Plaetinck, G1
Van der Heyden, J1
Tavernier, J1
Faché, I1
Tuypens, T1
Fischkoff, S1
Fiers, W1
Devos, R1

Reviews

1 review available for butyric acid and Leukemia, Promyelocytic, Acute

ArticleYear
Potential applications of cytodifferentiation therapy in hematologic malignancies.
    Seminars in hematology, 1994, Volume: 31, Issue:4 Suppl 5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Butyrates; Butyric Acid; Cell Differentiation; Child

1994

Other Studies

20 other studies available for butyric acid and Leukemia, Promyelocytic, Acute

ArticleYear
Novel anticancer prodrugs of butyric acid. 2.
    Journal of medicinal chemistry, 1992, Feb-21, Volume: 35, Issue:4

    Topics: Animals; Antineoplastic Agents; Butyrates; Cell Differentiation; Cell Division; Female; Humans; Leuk

1992
A novel retinoic/butyric hyaluronan ester for the treatment of acute promyelocytic leukemia: preliminary preclinical results.
    Leukemia, 2006, Volume: 20, Issue:5

    Topics: Apoptosis; Butyric Acid; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta;

2006
Modulation of HSP70 and HSP27 gene expression by the differentiation inducer sodium butyrate in U-937 human promonocytic leukemia cells.
    Leukemia research, 1995, Volume: 19, Issue:10

    Topics: Base Sequence; Butyrates; Butyric Acid; Cell Differentiation; DNA-Binding Proteins; Gene Expression

1995
The proteoglycan perlecan is expressed in the erythroleukemia cell line K562 and is upregulated by sodium butyrate and phorbol ester.
    Molecular and cellular biochemistry, 1995, Apr-12, Volume: 145, Issue:1

    Topics: Base Sequence; Butyrates; Butyric Acid; Cell Differentiation; Chondroitinases and Chondroitin Lyases

1995
Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to retinoic acid, calcitriol, 9 cis-retinoic acid, and sodium butyrate.
    Blood, 1995, Oct-01, Volume: 86, Issue:7

    Topics: Butyrates; Butyric Acid; Calcitriol; Cathepsin D; Cathepsin L; Cathepsins; Cell Differentiation; Cys

1995
Topoisomerase II alpha promoter trans-activation early in monocytic differentiation of HL-60 human leukemia cells.
    Molecular pharmacology, 1995, Volume: 47, Issue:4

    Topics: Base Sequence; Butyrates; Butyric Acid; Cell Differentiation; DNA Topoisomerases, Type II; Genes, Re

1995
DMSO, sodium butyrate, and TPA induce hypophosphorylation of RB with HL-60 cell differentiation.
    In vitro cellular & developmental biology. Animal, 1995, Volume: 31, Issue:3

    Topics: Blotting, Western; Butyrates; Butyric Acid; Cell Differentiation; Dimethyl Sulfoxide; Humans; Leukem

1995
RB phosphorylation in sodium butyrate-resistant HL-60 cells: cross-resistance to retinoic acid but not vitamin D3.
    Journal of cellular physiology, 1995, Volume: 163, Issue:3

    Topics: Butyrates; Butyric Acid; Cell Differentiation; Cholecalciferol; Drug Resistance; Humans; Leukemia, P

1995
Comparison between the effect of butyric acid and its prodrug pivaloyloxymethylbutyrate on histones hyperacetylation in an HL-60 leukemic cell line.
    International journal of cancer, 1994, Mar-15, Volume: 56, Issue:6

    Topics: Acetylation; Aniline Compounds; Butyrates; Butyric Acid; Histones; Leukemia, Promyelocytic, Acute; O

1994
Butyric acid and its monosaccharide ester induce apoptosis in the HL-60 cell line.
    Biochemical and biophysical research communications, 1993, Aug-31, Volume: 195, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Butyrates; Butyric Acid; Cell Line; Cell Survival; DNA, Neoplasm;

1993
Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells.
    The Journal of biological chemistry, 1993, Sep-25, Volume: 268, Issue:27

    Topics: Antisense Elements (Genetics); Blotting, Northern; Butyrates; Butyric Acid; Cell Differentiation; Ce

1993
Potentiation of retinoic acid-induced differentiation of human acute promyelocytic leukemia NB4 cells by butyric acid, tributyrin, and hexamethylene bisacetamide.
    Oncology research, 1998, Volume: 10, Issue:2

    Topics: Acetamides; Antineoplastic Agents; Butyrates; Butyric Acid; Cell Differentiation; Drug Synergism; Hu

1998
Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells.
    Chinese medical journal, 1999, Volume: 112, Issue:4

    Topics: Butyric Acid; Cell Transformation, Neoplastic; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute;

1999
Butyric acid increases invasiveness of HL-60 leukemia cells: role of reactive oxygen species.
    FEBS letters, 2002, May-08, Volume: 518, Issue:1-3

    Topics: Antioxidants; Butyric Acid; Cell Differentiation; Cell Movement; HL-60 Cells; Humans; Leukemia, Prom

2002
Inducers of leukemic cell differentiation cause down-regulation of RB gene expression.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 199, Issue:3

    Topics: Butyrates; Butyric Acid; Cell Differentiation; Dimethyl Sulfoxide; DNA; Down-Regulation; Gene Expres

1992
The human promyelocytic HL60 cell line: a model of myeloid cell differentiation using dimethylsulphoxide, phorbol ester and butyrate.
    Biochemistry international, 1991, Volume: 23, Issue:3

    Topics: Butyrates; Butyric Acid; Cell Differentiation; Cytochrome c Group; Dimethyl Sulfoxide; Hematopoietic

1991
Histone H4 acetylation in Drosophila. Frequency of acetylation at different sites defined by immunolabelling with site-specific antibodies.
    FEBS letters, 1991, Jun-24, Volume: 284, Issue:2

    Topics: Acetylation; Animals; Autoradiography; Blotting, Western; Butyrates; Butyric Acid; Drosophila; Histo

1991
Lineage directed HL-60 cell sublines as a model system for the study of early events in lineage determination of myeloid cells.
    Leukemia research, 1990, Volume: 14, Issue:11-12

    Topics: Butyrates; Butyric Acid; Cell Differentiation; Cholecalciferol; Dimethyl Sulfoxide; Eosinophils; Hem

1990
Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells.
    The Journal of experimental medicine, 1990, Sep-01, Volume: 172, Issue:3

    Topics: Butyrates; Butyric Acid; Cell Line; Clone Cells; Eosinophils; Humans; Interleukin-5; Kinetics; Leuke

1990
Graded increase in probability of eosinophilic differentiation of HL-60 promyelocytic leukemia cells induced by culture under alkaline conditions.
    Leukemia research, 1988, Volume: 12, Issue:8

    Topics: Agar; Butyrates; Butyric Acid; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cul

1988