Page last updated: 2024-10-16

butyric acid and Insulin Sensitivity

butyric acid has been researched along with Insulin Sensitivity in 14 studies

Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.

Research Excerpts

ExcerptRelevanceReference
" The present study aimed to evaluate the comparative effects of sodium butyrate (NaB) and metformin on the glucose homeostasis, insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat."7.83Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin. ( Jena, G; Khan, S, 2016)
"Dietary administration of the histone deacetylase (HDAC) inhibitor butyric acid - a short chain fatty acid present in milk products and also bacterially produced in the intestine - has been shown to increase energy expenditure and favour insulin sensitivity in mice through induction of PGC1α (peroxisome proliferator-activated receptor gamma co-activator 1α) and AMPK (AMP-activated protein kinase) in skeletal muscle, and a consequential increase of mitochondrial fatty acid oxidation."3.85The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1. ( Chriett, S; Pirola, L; Vidal, H; Zerzaihi, O, 2017)
" The present study aimed to evaluate the comparative effects of sodium butyrate (NaB) and metformin on the glucose homeostasis, insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat."3.83Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin. ( Jena, G; Khan, S, 2016)
"Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease."1.39Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet. ( Calignano, A; Canani, RB; Ferrante, MC; Iacono, A; Mattace Raso, G; Meli, R; Paciello, O; Russo, R; Santoro, A; Simeoli, R, 2013)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (78.57)24.3611
2020's3 (21.43)2.80

Authors

AuthorsStudies
Tang, X1
Sun, Y1
Li, Y2
Ma, S1
Zhang, K1
Chen, A1
Lyu, Y1
Yu, R1
Elgamal, DA1
Abou-Elghait, AT1
Ali, AY1
Ali, M1
Bakr, MH1
Vitale, M1
Giacco, R1
Laiola, M1
Della Pepa, G1
Luongo, D1
Mangione, A1
Salamone, D1
Vitaglione, P1
Ercolini, D1
Rivellese, AA1
Zhou, D1
Pan, Q1
Shen, F1
Cao, HX1
Ding, WJ1
Chen, YW1
Fan, JG1
Gonzalez, A1
Krieg, R1
Massey, HD1
Carl, D1
Ghosh, S1
Gehr, TWB1
Ghosh, SS1
Winiczenko, R1
Górnicki, K1
Kaleta, A1
Janaszek-Mańkowska, M1
Khan, ZA1
Singh, C1
Khan, T1
Ganguly, M1
Bradsher, C1
Goodwin, P1
Petty, JT1
Sandau, C1
Bove, DG1
Marsaa, K1
Bekkelund, CS1
Lindholm, MG1
Salazar, J1
Bermúdez, V1
Olivar, LC1
Torres, W1
Palmar, J1
Añez, R1
Ordoñez, MG1
Rivas, JR1
Martínez, MS1
Hernández, JD1
Graterol, M1
Rojas, J1
Mubarak, Z1
Humaira, A1
Gani, BA1
Muchlisin, ZA1
Gremillet, C1
Jakobsson, JG1
Gomila, A1
Shaw, E1
Carratalà, J1
Leibovici, L1
Tebé, C1
Wiegand, I1
Vallejo-Torres, L1
Vigo, JM1
Morris, S1
Stoddart, M1
Grier, S1
Vank, C1
Cuperus, N1
Van den Heuvel, L1
Eliakim-Raz, N1
Vuong, C1
MacGowan, A1
Addy, I1
Pujol, M1
Cobb, A1
Rieger, E1
Bell, J1
Mallik, S1
Zhao, Z1
Szécsényi, Á1
Li, G1
Gascon, J1
Pidko, EA1
Zhang, GR1
Wolker, T1
Sandbeck, DJS1
Munoz, M1
Mayrhofer, KJJ1
Cherevko, S1
Etzold, BJM1
Lukashuk, L1
Yigit, N1
Rameshan, R1
Kolar, E1
Teschner, D1
Hävecker, M1
Knop-Gericke, A1
Schlögl, R1
Föttinger, K1
Rupprechter, G1
Franconieri, F1
Deshayes, S1
de Boysson, H1
Trad, S1
Martin Silva, N1
Terrier, B1
Bienvenu, B1
Galateau-Sallé, F1
Emile, JF1
Johnson, AC1
Aouba, A1
Vogt, TJ1
Gevensleben, H1
Dietrich, J1
Kristiansen, G1
Bootz, F1
Landsberg, J1
Goltz, D1
Dietrich, D1
Idorn, M1
Skadborg, SK1
Kellermann, L1
Halldórsdóttir, HR1
Holmen Olofsson, G1
Met, Ö1
Thor Straten, P1
Johnson, LE1
Brockstedt, D1
Leong, M1
Lauer, P1
Theisen, E1
Sauer, JD1
McNeel, DG1
Morandi, F1
Marimpietri, D1
Horenstein, AL1
Bolzoni, M1
Toscani, D1
Costa, F1
Castella, B1
Faini, AC1
Massaia, M1
Pistoia, V1
Giuliani, N1
Malavasi, F1
Qiu, J1
Peng, S1
Yang, A1
Ma, Y1
Han, L1
Cheng, MA1
Farmer, E1
Hung, CF1
Wu, TC1
Modak, S1
Le Luduec, JB1
Cheung, IY1
Goldman, DA1
Ostrovnaya, I1
Doubrovina, E1
Basu, E1
Kushner, BH1
Kramer, K1
Roberts, SS1
O'Reilly, RJ1
Cheung, NV1
Hsu, KC1
Salgarello, T1
Giudiceandrea, A1
Calandriello, L1
Marangoni, D1
Colotto, A1
Caporossi, A1
Falsini, B1
Lefrançois, P1
Xie, P1
Wang, L2
Tetzlaff, MT1
Moreau, L1
Watters, AK1
Netchiporouk, E1
Provost, N1
Gilbert, M1
Ni, X1
Sasseville, D1
Wheeler, DA1
Duvic, M1
Litvinov, IV1
O'Connor, BJ1
Fryda, NJ1
Ranglack, DH1
Yang, Y2
Yang, J1
Zhang, X2
Grün, AL1
Emmerling, C1
Aumeeruddy-Elalfi, Z1
Ismaël, IS1
Hosenally, M1
Zengin, G1
Mahomoodally, MF1
Dotsenko, A1
Gusakov, A1
Rozhkova, A1
Sinitsyna, O1
Shashkov, I1
Sinitsyn, A1
Hong, CE1
Kim, JU1
Lee, JW1
Lee, SW1
Jo, IH1
Pandiyarajan, S1
Premasudha, P1
Kadirvelu, K1
Wang, B1
Luo, L1
Wang, D1
Ding, R1
Hong, J1
Caviezel, D1
Maissen, S1
Niess, JH1
Kiss, C1
Hruz, P1
Pockes, S1
Wifling, D1
Keller, M1
Buschauer, A1
Elz, S1
Santos, AF1
Ferreira, IP1
Pinheiro, CB1
Santos, VG1
Lopes, MTP1
Teixeira, LR1
Rocha, WR1
Rodrigues, GLS1
Beraldo, H1
Lohar, S1
Dhara, K1
Roy, P1
Sinha Babu, SP1
Chattopadhyay, P1
Sukwong, P1
Sunwoo, IY1
Lee, MJ1
Ra, CH1
Jeong, GT1
Kim, SK2
Huvinen, E1
Eriksson, JG1
Stach-Lempinen, B1
Tiitinen, A1
Koivusalo, SB1
Malhotra, M1
Suresh, S1
Garg, A1
Wei, L1
Jiang, Y2
Zhou, W1
Liu, S1
Liu, Y1
Rausch-Fan, X1
Liu, Z1
Marques, WL1
van der Woude, LN1
Luttik, MAH1
van den Broek, M1
Nijenhuis, JM1
Pronk, JT1
van Maris, AJA1
Mans, R1
Gombert, AK1
Xu, A1
Sun, J1
Li, J1
Chen, W2
Zheng, R1
Han, Z1
Ji, L1
Shen, WQ1
Bao, LP1
Hu, SF1
Gao, XJ1
Xie, YP1
Gao, XF1
Huang, WH1
Lu, X1
Gostin, PF1
Addison, O1
Morrell, AP1
Zhang, Y2
Cook, AJMC1
Liens, A1
Stoica, M1
Ignatyev, K1
Street, SR1
Wu, J1
Chiu, YL1
Davenport, AJ1
Qiu, Z1
Shu, J1
Tang, D1
Gao, X1
Zhang, J3
Huang, K1
Wai, H1
Du, K1
Anesini, J1
Kim, WS1
Eastman, A1
Micalizio, GC1
Liang, JH1
Huo, XK1
Cheng, ZB1
Sun, CP1
Zhao, JC1
Kang, XH1
Zhang, TY1
Chen, ZJ1
Yang, TM1
Wu, YY1
Deng, XP1
Zhang, YX1
Salem, HF1
Kharshoum, RM1
Abou-Taleb, HA1
AbouTaleb, HA1
AbouElhassan, KM1
Ohata, C1
Ohyama, B1
Kuwahara, F1
Katayama, E1
Nakama, T1
Kobayashi, S1
Kashiwagi, T1
Kimura, J1
Lin, JD1
Liou, MJ1
Hsu, HL1
Leong, KK1
Chen, YT1
Wang, YR1
Hung, WS1
Lee, HY1
Tsai, HJ1
Tseng, CP1
Alten, B1
Yesiltepe, M1
Bayraktar, E1
Tas, ST1
Gocmen, AY1
Kursungoz, C1
Martinez, A1
Sara, Y1
Huang, S2
Adams, E1
Van Schepdael, A1
Wang, Q1
Chung, CY1
Yang, W1
Yang, G1
Chough, S1
Chen, Y1
Yin, B1
Bhattacharya, R1
Hu, Y1
Saeui, CT1
Yarema, KJ1
Betenbaugh, MJ1
Zhang, H1
Patik, JC1
Tucker, WJ1
Curtis, BM1
Nelson, MD1
Nasirian, A1
Park, S1
Brothers, RM1
Dohlmann, TL1
Hindsø, M1
Dela, F1
Helge, JW1
Larsen, S1
Gayani, B1
Dilhari, A1
Wijesinghe, GK1
Kumarage, S1
Abayaweera, G1
Samarakoon, SR1
Perera, IC1
Kottegoda, N1
Weerasekera, MM1
Nardi, MV1
Timpel, M1
Ligorio, G1
Zorn Morales, N1
Chiappini, A1
Toccoli, T1
Verucchi, R1
Ceccato, R1
Pasquali, L1
List-Kratochvil, EJW1
Quaranta, A1
Dirè, S1
Heo, K1
Jo, SH1
Shim, J1
Kang, DH1
Kim, JH1
Park, JH1
Akhtar, N1
Saha, A1
Kumar, V1
Pradhan, N1
Panda, S1
Morla, S1
Kumar, S1
Manna, D1
Wang, H2
Xu, E1
Yu, S1
Li, D1
Quan, J1
Xu, L1
Saslow, SA1
Um, W1
Pearce, CI1
Bowden, ME1
Engelhard, MH1
Lukens, WL1
Kim, DS1
Schweiger, MJ1
Kruger, AA1
Adair, LS1
Kuzawa, C1
McDade, T1
Carba, DB1
Borja, JB1
Liang, X2
Song, W1
Wang, K1
Zhang, B1
Peele, ME1
Luo, HR1
Chen, ZY1
Fei, JJ1
Du, ZJ1
Yi, KJ1
Im, WT1
Kim, DW1
Ji, X1
Zhang, C1
Xu, Z1
Ding, Y1
Song, Q1
Li, B2
Zhao, H1
Lee, DW1
Lee, H1
Kwon, BO1
Khim, JS1
Yim, UH1
Park, H1
Park, B1
Choi, IG1
Kim, BS1
Kim, JJ1
Wang, JJ1
Chen, Q1
Li, YZ1
Sakai, M1
Yamaguchi, M1
Nagao, Y1
Kawachi, N1
Kikuchi, M1
Torikai, K1
Kamiya, T1
Takeda, S1
Watanabe, S1
Takahashi, T1
Arakawa, K1
Nakano, T1
Rufo, S1
Continentino, MA1
Nikolaou, V1
Plass, F1
Planchat, A1
Charisiadis, A1
Charalambidis, G1
Angaridis, PA1
Kahnt, A1
Odobel, F1
Coutsolelos, AG1
Fuentes, I1
García-Mendiola, T1
Sato, S1
Pita, M1
Nakamura, H1
Lorenzo, E1
Teixidor, F1
Marques, F1
Viñas, C1
Liu, F1
Qi, P1
Zhang, L2
Badejogbin, C1
Areola, DE1
Olaniyi, KS1
Adeyanju, OA1
Adeosun, IO1
Mattace Raso, G1
Simeoli, R1
Russo, R1
Iacono, A1
Santoro, A1
Paciello, O1
Ferrante, MC1
Canani, RB1
Calignano, A1
Meli, R1
Henagan, TM1
Stefanska, B1
Fang, Z1
Navard, AM1
Ye, J1
Lenard, NR1
Devarshi, PP1
Li, H1
Zhou, B1
Liu, J1
Li, F1
Kang, X1
Sun, H1
Wu, S1
Yan, H1
Ajuwon, KM1
Khan, S1
Jena, G1
Chriett, S1
Zerzaihi, O1
Vidal, H1
Pirola, L1
Du, J1
Yano, N1
Zhao, YT1
Dubielecka, PM1
Zhuang, S1
Chin, YE1
Qin, G1
Zhao, TC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Role of Microbiome Reprogramming on Liver Fat Accumulation[NCT03914495]57 participants (Actual)Interventional2019-05-21Terminated (stopped due to PI carefully considered multiple factors and decided to close study to any further enrollment.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for butyric acid and Insulin Sensitivity

ArticleYear
Acute and chronic improvement in postprandial glucose metabolism by a diet resembling the traditional Mediterranean dietary pattern: Can SCFAs play a role?
    Clinical nutrition (Edinburgh, Scotland), 2021, Volume: 40, Issue:2

    Topics: Adult; Area Under Curve; Blood Glucose; Butyric Acid; Diet, Mediterranean; Diet, Western; Fasting; F

2021
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018

Other Studies

12 other studies available for butyric acid and Insulin Sensitivity

ArticleYear
Sodium butyrate protects against oxidative stress in high-fat-diet-induced obese rats by promoting GSK-3β/Nrf2 signaling pathway and mitochondrial function.
    Journal of food biochemistry, 2022, Volume: 46, Issue:10

    Topics: Animals; Antioxidants; Body Weight; Butyric Acid; Diet, High-Fat; Dietary Fiber; Glucose; Glutathion

2022
Ultrastructure characterization of pancreatic β-cells is accompanied by modulatory effects of the HDAC inhibitor sodium butyrate on the PI3/AKT insulin signaling pathway in juvenile diabetic rats.
    Molecular and cellular endocrinology, 2020, 03-01, Volume: 503

    Topics: Animals; Butyric Acid; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucose; Histone

2020
Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota.
    Scientific reports, 2017, 05-08, Volume: 7, Issue:1

    Topics: Adipose Tissue; Animals; Body Weight; Butyric Acid; Cecum; Diet, High-Fat; Endotoxemia; Epididymis;

2017
Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019, 05-01, Volume: 34, Issue:5

    Topics: Animals; Butyric Acid; Disease Models, Animal; Histamine Antagonists; Immunohistochemistry; Insulin

2019
Sodium butyrate recovers high-fat diet-fed female Wistar rats from glucose dysmetabolism and uric acid-associated cardiac tissue damage.
    Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:11

    Topics: Animals; Antioxidants; Body Weight; Butyric Acid; Diet, High-Fat; Female; Glucose; Glucose Tolerance

2019
Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Adipose Tissue; Amides; Animals; Butyric Acid; Diet, High-Fat; Disease Models, Animal; Enzyme Activa

2013
Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning.
    British journal of pharmacology, 2015, Volume: 172, Issue:11

    Topics: Adaptation, Physiological; Adiposity; Animals; Blood Glucose; Body Weight; Butyric Acid; Carnitine;

2015
Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner.
    Cell cycle (Georgetown, Tex.), 2015, Volume: 14, Issue:12

    Topics: 3T3 Cells; Adipocytes; Adipose Tissue; Animals; Butyric Acid; Endoplasmic Reticulum; Endoplasmic Ret

2015
Mechanism of Butyrate Stimulation of Triglyceride Storage and Adipokine Expression during Adipogenic Differentiation of Porcine Stromovascular Cells.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Adipocytes; Adipogenesis; Adipokines; AMP-Activated Protein Kinases; Animals; Butyric Acid; Cell Dif

2015
Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin.
    Chemico-biological interactions, 2016, Jul-25, Volume: 254

    Topics: Acetylation; Adipose Tissue; Animals; Blood Glucose; Butyric Acid; Diabetes Mellitus, Experimental;

2016
The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1.
    Molecular and cellular endocrinology, 2017, 01-05, Volume: 439

    Topics: Acetylation; Animals; Butyric Acid; Cell Differentiation; Epigenesis, Genetic; Glycogen Synthase Kin

2017
Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice.
    Journal of cellular biochemistry, 2017, Volume: 118, Issue:8

    Topics: Animals; Butyric Acid; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; E

2017