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butyric acid and Glioma

butyric acid has been researched along with Glioma in 22 studies

Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
" In this study, we investigated the function of anti-proliferative effects of HDAC inhibitors, N-butyric acid and trichostatin A, on human malignant glioma cell lines, U251-MG and D54."7.73Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells. ( Aoki, H; Endo, S; Kanzawa, T; Komata, T; Kon, T; Kondo, S; Nashimoto, T; Takahashi, H; Tanaka, R, 2005)
" Resveratrol (Rsv) and quercetin (Quer), two natural polyphenols, are able to induce senescence in different cancer models, including gliomas, the most common and aggressive primary brain tumor."3.80Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells. ( Bonatto, D; Filippi-Chiela, EC; Kipper, FC; Lenz, G; Suhre, T; Vargas, JE, 2014)
" In this study, we investigated the function of anti-proliferative effects of HDAC inhibitors, N-butyric acid and trichostatin A, on human malignant glioma cell lines, U251-MG and D54."3.73Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells. ( Aoki, H; Endo, S; Kanzawa, T; Komata, T; Kon, T; Kondo, S; Nashimoto, T; Takahashi, H; Tanaka, R, 2005)
" There was a striking similarity in the dose-response of butyrate for increasing receptor levels and inhibiting histone deacetylation."1.27Modulation of thyroid hormone nuclear receptors by short-chain fatty acids in glial C6 cells. Role of histone acetylation. ( Aranda, A; Montiel, F; Ortiz-Caro, J; Pascual, A, 1986)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19909 (40.91)18.7374
1990's7 (31.82)18.2507
2000's3 (13.64)29.6817
2010's1 (4.55)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Wagner, W1
Sobierajska, K1
Kania, KD1
Paradowska, E1
Ciszewski, WM1
Qin, X1
Xu, Y1
Peng, S1
Qian, S1
Zhang, X1
Shen, S1
Yang, J1
Ye, J1
Vargas, JE1
Filippi-Chiela, EC1
Suhre, T1
Kipper, FC1
Bonatto, D1
Lenz, G1
Komata, T1
Kanzawa, T1
Nashimoto, T1
Aoki, H1
Endo, S1
Kon, T1
Takahashi, H1
Kondo, S1
Tanaka, R1
Kim, EH1
Kim, HS1
Kim, SU1
Noh, EJ1
Lee, JS1
Choi, KS1
Entin-Meer, M1
Rephaeli, A1
Yang, X1
Nudelman, A1
VandenBerg, SR1
Haas-Kogan, DA1
Tang, SJ1
Huang, YM1
Wang, FF1
Ebert, PS1
Salcman, M1
Haag, MM1
Krystosek, A1
Arenson, E1
Puck, TT1
Sun, SH2
Ou, HC2
Jang, TH1
Lin, LB1
Huang, HM1
Jea-Chien, E1
Hurst, RD1
Clark, JB1
Yusta, B3
Ortiz-Caro, J3
Bedo, G1
Pascual, A4
Aranda, A4
Iavarone, A1
Eboli, ML1
Osti, M1
Redler, A1
Pocchiari, M1
Russo, MA1
Hargreaves, AJ1
Avila, J1
Hesketh, JE1
Hirschfeld, A1
Bressler, J1
Pennypacker, KR1
Kyritsis, A1
Chader, GJ1
Billingsley, ML1
Gross, JL1
Behrens, DL1
Mullins, DE1
Kornblith, PL1
Dexter, DL1
Hong, SJ1
Ko, LW1
Montiel, F2
Villa, A1
Lin, LI1
Lin, JK1

Other Studies

22 other studies available for butyric acid and Glioma

ArticleYear
Lactate Suppresses Retroviral Transduction in Cervical Epithelial Cells through DNA-PKcs Modulation.
    International journal of molecular sciences, 2021, Dec-07, Volume: 22, Issue:24

    Topics: Benzoates; Butyric Acid; Cell Line, Tumor; Cell Nucleus; Chromones; DNA-Activated Protein Kinase; Fe

2021
Sodium butyrate opens mitochondrial permeability transition pore (MPTP) to induce a proton leak in induction of cell apoptosis.
    Biochemical and biophysical research communications, 2020, 06-30, Volume: 527, Issue:3

    Topics: Apoptosis; Butyric Acid; Cell Line, Tumor; Glioma; Humans; Membrane Potential, Mitochondrial; Mitoch

2020
Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2014, Volume: 92, Issue:4

    Topics: Animals; Antineoplastic Agents; Butyric Acid; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependen

2014
Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells.
    International journal of oncology, 2005, Volume: 26, Issue:5

    Topics: Apoptosis; Brain Neoplasms; Butyric Acid; Caspase 8; Caspase 9; Caspases; Cell Cycle; Cell Cycle Pro

2005
Sodium butyrate sensitizes human glioma cells to TRAIL-mediated apoptosis through inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP.
    Oncogene, 2005, Oct-20, Volume: 24, Issue:46

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Astrocytes; Base Sequence; Butyric Acid; CDC2 Protein Kina

2005
Butyric acid prodrugs are histone deacetylase inhibitors that show antineoplastic activity and radiosensitizing capacity in the treatment of malignant gliomas.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:12

    Topics: Antineoplastic Agents; Astrocytes; Blotting, Western; Butyric Acid; Caspases; Cell Line, Tumor; Cycl

2005
Analysis of c-fos expression in the butyrate-induced F-98 glioma cell differentiation.
    The Biochemical journal, 1995, Feb-15, Volume: 306 ( Pt 1)

    Topics: Animals; Base Sequence; Butyrates; Butyric Acid; Cell Differentiation; Cell Division; Gene Expressio

1995
Differentiation therapy is potentiated by chemotherapy and hyperthermia in human and canine brain tumor cells in vitro.
    Neurosurgery, 1994, Volume: 34, Issue:4

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Bucladesine; Butyrates; Butyric Acid; Carmustine; C

1994
Reverse transformation and genome exposure in the C6 glial tumor cell line.
    Cancer investigation, 1994, Volume: 12, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Brain; Bucladesine; Butyrates; Bu

1994
Altered phospholipid metabolism in sodium butyrate-induced differentiation of C6 glioma cells.
    Lipids, 1997, Volume: 32, Issue:3

    Topics: Acylation; Animals; Arachidonic Acid; Butyrates; Butyric Acid; Calcium; Chloroform; Glioma; Glutamat

1997
Sodium butyrate decreases histamine-stimulated calcium mobilization in C6 glioma cells.
    Neuroreport, 1997, Apr-14, Volume: 8, Issue:6

    Topics: Animals; Butyrates; Butyric Acid; Calcium; Cell Differentiation; Chlorpheniramine; Fluorescent Dyes;

1997
Butyric acid mediated induction of enhanced transendothelial resistance in an in vitro model blood-brain barrier system.
    Neurochemistry international, 1999, Volume: 35, Issue:3

    Topics: Blood-Brain Barrier; Butyric Acid; Cell Differentiation; Coculture Techniques; Dexamethasone; Dose-R

1999
Regulation of thyroid hormone receptor and c-erbA mRNA levels by butyrate in neuroblastoma (N2A) and glioma (C6) cells.
    Journal of neuroscience research, 1990, Volume: 27, Issue:1

    Topics: Animals; Butyrates; Butyric Acid; Cell Division; Down-Regulation; Gene Expression Regulation, Neopla

1990
3-D changes in neuroblastoma x glioma hybrid (NG 108-15) cell differentiation as studied by SEM and TEM.
    Progress in clinical and biological research, 1989, Volume: 295

    Topics: Animals; Bucladesine; Butyrates; Butyric Acid; Cell Differentiation; Cell Line; Glioma; Hybrid Cells

1989
Sodium butyrate induces major morphological changes in C6 glioma cells that are correlated with increased synthesis of a spectrin-like protein.
    Brain research. Developmental brain research, 1989, Feb-01, Volume: 45, Issue:2

    Topics: Autoradiography; Blotting, Western; Butyrates; Butyric Acid; Carrier Proteins; Electrophoresis, Poly

1989
Effect of sodium butyrate on S-100 protein levels and the cAMP response.
    Journal of cellular physiology, 1987, Volume: 133, Issue:1

    Topics: Animals; Butyrates; Butyric Acid; Colforsin; Cyclic AMP; Glial Fibrillary Acidic Protein; Glioma; Hu

1987
Calmodulin-binding proteins in human Y-79 retinoblastoma and HTB-14 glioma cell lines.
    Journal of neurochemistry, 1988, Volume: 50, Issue:5

    Topics: Biotin; Bucladesine; Butyrates; Butyric Acid; Calmodulin-Binding Proteins; Cell Differentiation; Cel

1988
Plasminogen activator and inhibitor activity in human glioma cells and modulation by sodium butyrate.
    Cancer research, 1988, Jan-15, Volume: 48, Issue:2

    Topics: Animals; Butyrates; Butyric Acid; Dose-Response Relationship, Drug; Glioma; Glycoproteins; Humans; M

1988
Activation of protein expression in clonal glioma cells by sodium butyrate.
    Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences, 1987, Volume: 3, Issue:11

    Topics: Butyrates; Butyric Acid; Cell Differentiation; Cell Division; DNA, Neoplasm; Glioma; Neoplasm Protei

1987
Identification and characterization of L-triiodothyronine receptors in cells of glial and neuronal origin.
    Endocrinology, 1986, Volume: 119, Issue:5

    Topics: Animals; Butyrates; Butyric Acid; Cell Line; Cell Nucleus; Glioma; Kinetics; Mice; Neuroblastoma; Ne

1986
Modulation of thyroid hormone nuclear receptors by short-chain fatty acids in glial C6 cells. Role of histone acetylation.
    The Journal of biological chemistry, 1986, Oct-25, Volume: 261, Issue:30

    Topics: Acetates; Acetic Acid; Acetylation; Animals; Butyrates; Butyric Acid; Cell Compartmentation; Cell Nu

1986
[Induction of morphological changes and polyamine alterations in glioma cells by butyrate].
    Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1985, Volume: 84, Issue:5

    Topics: Animals; Butyrates; Butyric Acid; Chromatography, High Pressure Liquid; Ethylnitrosourea; Female; Gl

1985