Compounds > butyric acid
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butyric acid and Experimental Hepatoma

butyric acid has been researched along with Experimental Hepatoma in 26 studies

Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.

Research Excerpts

ExcerptRelevanceReference
" Thus, the objective of this study was to kinetically evaluate the antiangiogenic activity of tributyrin (TB), a butyric acid prodrug, in the promotion stage of hepatocarcinogenesis."7.91Antiangiogenic effects of the chemopreventive agent tributyrin, a butyric acid prodrug, during the promotion phase of hepatocarcinogenesis. ( Andrade, FO; Farsky, SHP; Fernandes, LHG; Furtado, KS; Hebeda, CB; Heidor, R; Horst, MA; Miranda, MLP; Moreno, FS; Sandri, S; Yamamoto, RC, 2019)
" Previously, it has been demonstrated that histone deacetylase (HDAC) inhibitor tributyrin, a butyric acid prodrug, to have chemopreventive effects on rat hepatocarcinogenesis."7.79The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway. ( Beland, FA; de Conti, A; Heidor, R; Koturbash, I; Kuroiwa-Trzmielina, J; Moreno, FS; Ong, TP; Pogribny, IP; Tryndyak, V, 2013)
" Thus, the objective of this study was to kinetically evaluate the antiangiogenic activity of tributyrin (TB), a butyric acid prodrug, in the promotion stage of hepatocarcinogenesis."3.91Antiangiogenic effects of the chemopreventive agent tributyrin, a butyric acid prodrug, during the promotion phase of hepatocarcinogenesis. ( Andrade, FO; Farsky, SHP; Fernandes, LHG; Furtado, KS; Hebeda, CB; Heidor, R; Horst, MA; Miranda, MLP; Moreno, FS; Sandri, S; Yamamoto, RC, 2019)
" Previously, it has been demonstrated that histone deacetylase (HDAC) inhibitor tributyrin, a butyric acid prodrug, to have chemopreventive effects on rat hepatocarcinogenesis."3.79The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway. ( Beland, FA; de Conti, A; Heidor, R; Koturbash, I; Kuroiwa-Trzmielina, J; Moreno, FS; Ong, TP; Pogribny, IP; Tryndyak, V, 2013)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199016 (61.54)18.7374
1990's7 (26.92)18.2507
2000's0 (0.00)29.6817
2010's3 (11.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrade, FO1
Furtado, KS2
Heidor, R3
Sandri, S1
Hebeda, CB1
Miranda, MLP1
Fernandes, LHG1
Yamamoto, RC1
Horst, MA1
Farsky, SHP1
Moreno, FS3
de Conti, A2
Tryndyak, V1
Koturbash, I1
Kuroiwa-Trzmielina, J1
Ong, TP1
Beland, FA1
Pogribny, IP2
Ortega, JF1
Silva, RC1
Tavares, PE1
Purgatto, E1
Ract, JN1
de Paiva, SA1
Gioielli, LA1
Tichonicky, L4
Santana-Calderon, MA1
Defer, N3
Giesen, EM1
Beck, G1
Kruh, J4
Plesko, MM1
Hargrove, JL1
Granner, DK1
Chalkley, R5
Covault, J2
Sealy, L1
Schnell, R1
Shires, A2
Perry, M1
Pack, R1
Heck, R1
Dienes, HP1
Oesch, F1
Steinberg, P1
Levavasseur, F1
Burbelo, PD1
Cariou, S1
Liétard, J1
Yamada, Y1
Clément, B1
Gupta, S1
Alpini, G1
Vemuru, RP1
Hurston, E1
Shafritz, DA1
Zvibel, I1
Fiorino, AS1
Brill, S1
Reid, LM1
Guo, Z1
Yuan, C1
Wei-Lavery, T1
Fang, Y1
Garvin, RA1
Nishida, HI1
Nishida, T1
Cook, JR2
Chiu, JF2
Schwartz, CE1
Fausel, ED1
Yeh, HJ1
Chu, TH1
Chen, RM1
Higgins, PJ2
Ryan, MP2
Birren, BW2
Herschman, HR2
Borenfreund, E1
Rhoads, DB1
Takano, M1
Gattoni-Celli, S1
Chen, CC1
Isselbacher, KJ1
Taplitz, SJ1
Mitsuhashi, T1
Uchimura, H1
Takaku, F1
Wright, PS1
Dudley, DT1
Corral, M1
Guguen-Guillouzo, C1
Corcos, D1
Raymondjean, M1
Paris, B1
Delpech, M1
Lévy-Favatier, F1

Other Studies

26 other studies available for butyric acid and Experimental Hepatoma

ArticleYear
Antiangiogenic effects of the chemopreventive agent tributyrin, a butyric acid prodrug, during the promotion phase of hepatocarcinogenesis.
    Carcinogenesis, 2019, 08-22, Volume: 40, Issue:8

    Topics: Actins; Angiogenesis Inhibitors; Animals; Apoptosis; Butyric Acid; Carcinogenesis; Carcinoma, Hepato

2019
The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway.
    Carcinogenesis, 2013, Volume: 34, Issue:8

    Topics: Acetylation; Animals; Apoptosis; Butyric Acid; Carcinogenesis; Hepatocytes; Histone Deacetylase Inhi

2013
The chemopreventive activity of butyrate-containing structured lipids in experimental rat hepatocarcinogenesis.
    Molecular nutrition & food research, 2016, Volume: 60, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Butyric Acid; Gene Expression Regulation; Histones; Linseed Oil; L

2016
Selective inhibition by sodium butyrate of glucocorticoid-induced tyrosine aminotransferase synthesis in hepatoma tissue-cultured cells.
    European journal of biochemistry, 1981, Volume: 120, Issue:3

    Topics: Animals; Butyrates; Butyric Acid; Cattle; Cells, Cultured; Enzyme Induction; Glucocorticoids; Liver

1981
Inhibition by sodium butyrate of enzyme induction by glucocorticoids and dibutyryl cyclic AMP. A role for the rapid form of histone acetylation.
    The Journal of biological chemistry, 1983, Nov-25, Volume: 258, Issue:22

    Topics: Acetylation; Animals; Bucladesine; Butyrates; Butyric Acid; Cell Line; Dexamethasone; Enzyme Inducti

1983
Histone hypoacetylation following release of HTC cells from butyrate.
    The Journal of biological chemistry, 1982, May-25, Volume: 257, Issue:10

    Topics: Acetylation; Acetyltransferases; Amidohydrolases; Animals; Butyrates; Butyric Acid; Cell Line; Chlor

1982
Effects of histone hyperacetylation and hypoacetylation on RNA synthesis in HTC cells.
    The Journal of biological chemistry, 1982, Nov-25, Volume: 257, Issue:22

    Topics: Acetylation; Animals; Butyrates; Butyric Acid; Cell Line; Cell Nucleus; DNA Replication; Histones; K

1982
Isolation, biochemical characterization, long-term culture, and phenotype modulation of oval cells from carcinogen-fed rats.
    Experimental cell research, 1993, Volume: 204, Issue:2

    Topics: Animals; Butyrates; Butyric Acid; Cell Line; Cell Separation; Dimethyl Sulfoxide; gamma-Glutamyltran

1993
Nuclear recruitment of A1p145 subunit of replication factor C in the early G1 phase of the cell cycle in Faza 567 hepatoma cell line and hepatocyte primary cultures.
    FEBS letters, 1995, Apr-17, Volume: 363, Issue:1-2

    Topics: Animals; Blotting, Western; Butyrates; Butyric Acid; Cell Nucleus; Cytoplasm; DNA-Binding Proteins;

1995
Butyrate synchronization of hepatocytes: modulation of cycling and cell cycle regulated gene expression.
    Growth factors (Chur, Switzerland), 1994, Volume: 10, Issue:3

    Topics: Animals; Butyrates; Butyric Acid; Cell Cycle; Cell Division; Cells, Cultured; Flow Cytometry; Gene E

1994
Phenotypic characterization of rat hepatoma cell lines and lineage-specific regulation of gene expression by differentiation agents.
    Differentiation; research in biological diversity, 1998, Volume: 63, Issue:4

    Topics: alpha-Fetoproteins; Animals; Antigens, CD; Butyrates; Butyric Acid; Cell Differentiation; Dimethyl S

1998
Secretion of phospholipid transfer protein by human hepatoma cell line, Hep G2, is enhanced by sodium butyrate.
    The Journal of nutrition, 1999, Volume: 129, Issue:11

    Topics: Animals; Blotting, Western; Butyric Acid; Carrier Proteins; Gene Expression Regulation, Neoplastic;

1999
Alpha-fetoprotein mRNA: variation of half-life in rat hepatoma cell lines and destabilization by sodium butyrate.
    Cell biology international reports, 1990, Volume: 14, Issue:7

    Topics: alpha-Fetoproteins; Animals; Butyrates; Butyric Acid; Dexamethasone; Glucocorticoids; Half-Life; Liv

1990
Sodium butyrate inhibits c-myc and stimulates c-fos expression in all the steps of the cell-cycle in hepatoma tissue cultured cells.
    Biology of the cell, 1990, Volume: 69, Issue:1

    Topics: Animals; Butyrates; Butyric Acid; Cell Cycle; Cycloheximide; Dactinomycin; Gene Expression Regulatio

1990
Effect of sodium butyrate on alpha-fetoprotein gene expression in rat hepatoma cells in vitro.
    Cancer research, 1985, Volume: 45, Issue:7

    Topics: alpha-Fetoproteins; Animals; Butyrates; Butyric Acid; Cell Division; Dexamethasone; Gene Expression

1985
[Effect of sodium butyrate on cell proliferation and alphafetoprotein synthesis of rat hepatoma cells (CBRH-7919) in vitro].
    Shi yan sheng wu xue bao, 1985, Volume: 18, Issue:1

    Topics: alpha-Fetoproteins; Animals; Butyrates; Butyric Acid; Cell Division; Cell Line; Liver Neoplasms, Exp

1985
Cytoarchitecture of ras oncogene-expressing tumor cells: butyrate modulation of substrate adhesion, cytoskeletal actin content and subcellular microfilament distribution.
    The International journal of biochemistry, 1989, Volume: 21, Issue:10

    Topics: Actin Cytoskeleton; Actins; Animals; Butyrates; Butyric Acid; Cell Adhesion; Cytoskeleton; Electroph

1989
The isolation of HTC variant cells which can replicate in butyrate. Changes in histone acetylation and tyrosine aminotransferase induction.
    The Journal of biological chemistry, 1985, Jun-25, Volume: 260, Issue:12

    Topics: Acetylation; Animals; Butyrates; Butyric Acid; Cell Line; Cell Nucleus; Dexamethasone; Drug Resistan

1985
Regulation of the rat metallothionein-I gene by sodium butyrate.
    Nucleic acids research, 1986, Jan-24, Volume: 14, Issue:2

    Topics: Animals; Butyrates; Butyric Acid; Cytoplasm; Dexamethasone; Enzyme Induction; Genes; Kinetics; Liver

1986
Butyrate-induced cytoarchitectural reorganization of Mallory body-containing rat hepatic tumor cells.
    Journal of the National Cancer Institute, 1987, Volume: 79, Issue:3

    Topics: Actins; Animals; Butyrates; Butyric Acid; Cell Division; Cells, Cultured; Cytoskeleton; Inclusion Bo

1987
Evidence for expression of the facilitated glucose transporter in rat hepatocytes.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:23

    Topics: Animals; Butyrates; Butyric Acid; Cells, Cultured; Dimethyl Sulfoxide; Female; Hormones; Liver; Live

1988
Butyrate-induced changes in nuclease sensitivity of chromatin cannot be correlated with transcriptional activation.
    Molecular and cellular biology, 1987, Volume: 7, Issue:11

    Topics: Animals; Butyrates; Butyric Acid; Cell Line; Chromatin; Deoxyribonuclease I; Genes; Liver Neoplasms,

1987
n-Butyrate increases the level of thyroid hormone nuclear receptor in non-pituitary cultured cells.
    The Journal of biological chemistry, 1987, Mar-25, Volume: 262, Issue:9

    Topics: Acetylation; Animals; Butyrates; Butyric Acid; Cell Line; Cell Nucleus; Dexamethasone; Dose-Response

1987
Butyrate effects on normal and adapted hepatoma cells: morphological response and implications for vectoral cholesterol transport.
    Archives of biochemistry and biophysics, 1986, Volume: 248, Issue:1

    Topics: Acetates; Animals; Biological Transport; Butyrates; Butyric Acid; Cholesterol; Cholesterol Esters; D

1986
Expression of c-fos oncogene during hepatocarcinogenesis, liver regeneration and in synchronized HTC cells.
    Experimental cell research, 1985, Volume: 160, Issue:2

    Topics: Animals; Butyrates; Butyric Acid; Cell Cycle; Cytological Techniques; Female; Gene Expression Regula

1985
The 25 kDa protein kinase inhibitor present in liver cell is absent in fast growing HTC cells and is induced in sodium butyrate treated cells.
    FEBS letters, 1985, Oct-07, Volume: 190, Issue:1

    Topics: Animals; Butyrates; Butyric Acid; Carrier Proteins; Cell Division; Cells, Cultured; Chromosomal Prot

1985