butyric acid has been researched along with Disease Models, Animal in 107 studies
Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is the first report where intranasal curcumin inhibited asthma severity via affecting HDAC 1 (H3acK9) leading to NF-kB suppression in mouse model of allergic asthma." | 8.12 | Intranasal curcumin and sodium butyrate modulates airway inflammation and fibrosis via HDAC inhibition in allergic asthma. ( Dash, D; Islam, R; Singh, R, 2022) |
| "The present study screened the effect of Myricitrin on cognitive deficits post-cerebral ischemic stroke and the involved mechanism." | 8.02 | Myricitrin ameliorates cognitive deficits in MCAO cerebral stroke rats via histone acetylation-induced alterations of brain-derived neurotrophic factor. ( Gao, Y; Guo, Y; Li, X; Ya, B; Yin, H, 2021) |
| "Phenylalanine-butyramide protects against experimental doxorubicin cardiotoxicity." | 7.91 | The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity. ( Abete, P; Aitoro, R; Avagliano, C; Berni Canani, R; Bianco, R; Bonaduce, D; Calignano, A; Ciccarelli, M; Fiordelisi, A; Ghigo, A; Guida, F; Hirsch, E; Iaccarino, G; Li, M; Mercurio, V; Napolitano, F; Paparo, L; Russo, M; Sala, V; Sorriento, D; Tocchetti, CG; Trinchese, G, 2019) |
| "To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model." | 7.80 | Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis. ( Abdolghaffari, AH; Abdollahi, M; Baeeri, M; Ghasemi-Niri, SF; Moeinian, M; Mozaffari, S; Navaea-Nigjeh, M, 2014) |
| "We recently showed that prenatal exposure to valproic acid (VPA) in mice causes autism-like behavioral abnormalities, including social interaction deficits, anxiety-like behavior and spatial learning disability, in male offspring." | 7.80 | Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism. ( Ago, Y; Hara, Y; Hashimoto, H; Hayata-Takano, A; Kataoka, S; Kawanai, T; Maeda, Y; Matsuda, T; Takano, E; Takuma, K; Watanabe, R, 2014) |
| "The efficacy of target-released butyric acid, medium-chain fatty acids (C(6) to C(12) but mainly lauric acid) and essential oils (thymol, cinnamaldehyde, essential oil of eucalyptus) micro-encapsulated in a poly-sugar matrix to control necrotic enteritis was investigated." | 7.76 | Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils. ( Dewulf, J; Ducatelle, R; Haesebrouck, F; Lanckriet, A; Nollet, N; Schwarzer, K; Timbermont, L; Van Immerseel, F, 2010) |
| "This is the first report where intranasal curcumin inhibited asthma severity via affecting HDAC 1 (H3acK9) leading to NF-kB suppression in mouse model of allergic asthma." | 4.12 | Intranasal curcumin and sodium butyrate modulates airway inflammation and fibrosis via HDAC inhibition in allergic asthma. ( Dash, D; Islam, R; Singh, R, 2022) |
| "The present study screened the effect of Myricitrin on cognitive deficits post-cerebral ischemic stroke and the involved mechanism." | 4.02 | Myricitrin ameliorates cognitive deficits in MCAO cerebral stroke rats via histone acetylation-induced alterations of brain-derived neurotrophic factor. ( Gao, Y; Guo, Y; Li, X; Ya, B; Yin, H, 2021) |
| " For the first time, we assessed the synthesis of 5-hydroxytryptamine (5HT) and the metabolic capacity of the 5HT system in the peripheral and central nervous systems (PNS and CNS, respectively) based on tryptophan metabolism based on VPA-induced autism model." | 4.02 | Daily intake of Lactobacillus alleviates autistic-like behaviors by ameliorating the 5-hydroxytryptamine metabolic disorder in VPA-treated rats during weaning and sexual maturation. ( Chen, W; Kong, Q; Li, X; Tian, P; Wang, B; Wang, G; Zhang, H; Zhao, J, 2021) |
| " Liver damage, markers of glucose metabolism, inflammation, intestinal barrier function and melatonin metabolism were determined." | 3.96 | Oral Supplementation of Sodium Butyrate Attenuates the Progression of Non-Alcoholic Steatohepatitis. ( Baumann, A; Bergheim, I; Brandt, A; Burkard, M; Jin, CJ; Nier, A; Sellmann, C; Venturelli, S, 2020) |
| " The present study is aimed at testing the hypothesis that resistant maltodextrin (RM), a soluble dietary fiber produced by starch debranching, alleviated dextran sulfate sodium- (DSS-) induced colitis in mice." | 3.96 | Resistant Maltodextrin Alleviates Dextran Sulfate Sodium-Induced Intestinal Inflammatory Injury by Increasing Butyric Acid to Inhibit Proinflammatory Cytokine Levels. ( Han, D; Huang, S; Pang, J; Wang, J; Wang, S; Wu, Y; Wu, Z; Zhang, S, 2020) |
| "Phenylalanine-butyramide protects against experimental doxorubicin cardiotoxicity." | 3.91 | The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity. ( Abete, P; Aitoro, R; Avagliano, C; Berni Canani, R; Bianco, R; Bonaduce, D; Calignano, A; Ciccarelli, M; Fiordelisi, A; Ghigo, A; Guida, F; Hirsch, E; Iaccarino, G; Li, M; Mercurio, V; Napolitano, F; Paparo, L; Russo, M; Sala, V; Sorriento, D; Tocchetti, CG; Trinchese, G, 2019) |
| "To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model." | 3.80 | Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis. ( Abdolghaffari, AH; Abdollahi, M; Baeeri, M; Ghasemi-Niri, SF; Moeinian, M; Mozaffari, S; Navaea-Nigjeh, M, 2014) |
| "We recently showed that prenatal exposure to valproic acid (VPA) in mice causes autism-like behavioral abnormalities, including social interaction deficits, anxiety-like behavior and spatial learning disability, in male offspring." | 3.80 | Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism. ( Ago, Y; Hara, Y; Hashimoto, H; Hayata-Takano, A; Kataoka, S; Kawanai, T; Maeda, Y; Matsuda, T; Takano, E; Takuma, K; Watanabe, R, 2014) |
| "The efficacy of target-released butyric acid, medium-chain fatty acids (C(6) to C(12) but mainly lauric acid) and essential oils (thymol, cinnamaldehyde, essential oil of eucalyptus) micro-encapsulated in a poly-sugar matrix to control necrotic enteritis was investigated." | 3.76 | Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils. ( Dewulf, J; Ducatelle, R; Haesebrouck, F; Lanckriet, A; Nollet, N; Schwarzer, K; Timbermont, L; Van Immerseel, F, 2010) |
| "We induced ulcerative colitis (UC) in mice utilizing dextran sodium sulfate (DSS) in the drinking water for 7 days." | 1.91 | Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model. ( De Oliveira, J; do Nascimento, ND; Fröhlich, NT; Gelain, DP; Gomes, HM; Kessler, F; Martins, A; Moreira, JCF; Paz, AH; Possa, L; Rodrigues, MS; Santos, L; Silveira, AK; Sirena, D, 2023) |
| "Two models were used to induce cancer cachexia: B16F1 induced metastatic cancer cachexia and Lewis lung carcinoma cell - induced cancer cachexia." | 1.72 | Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia. ( Bora, V; Goyal, RK; Johar, K; Patel, BM; Patel, D, 2022) |
| "Migraine is a common brain-disorder that affects 15% of the population." | 1.72 | Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine. ( Campolo, M; Casili, G; Cuzzocrea, S; Esposito, E; Filippone, A; Giuffrè, L; Lanza, M; Paterniti, I; Scuderi, SA, 2022) |
| "Research has connected Parkinson's disease (PD) with impaired intestinal barrier." | 1.72 | Neuroprotective Effects of Sodium Butyrate and Monomethyl Fumarate Treatment through GPR109A Modulation and Intestinal Barrier Restoration on PD Mice. ( Ding, ST; Jian, YX; Lei, YH; Liu, HD; Liu, MR; Miao, WT; Xu, JY; Xu, RC; Xu, WX; Yan, N, 2022) |
| "Colitis was induced by drinking 2% DSS for 7 days." | 1.72 | Intermittent Fasting Alleviates Risk Markers in a Murine Model of Ulcerative Colitis by Modulating the Gut Microbiome and Metabolome. ( Bian, X; Li, L; Li, Y; Man, D; Shi, D; Wang, K; Wang, Q; Wang, S; Wu, J; Wu, W; Yang, L, 2022) |
| "Current strategies for the treatment of Alzheimer's disease (AD) focus on the pathology in the later stages of disease progression." | 1.62 | Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice. ( Jiang, Y; Li, K; Li, X; Xu, L; Yang, Z, 2021) |
| "Butyric acid is an intestinal microbiota-produced short-chain fatty acid, which exerts salutary effects on alleviating nonalcoholic fatty liver disease (NAFLD)." | 1.62 | Sodium Butyrate Supplementation Inhibits Hepatic Steatosis by Stimulating Liver Kinase B1 and Insulin-Induced Gene. ( Bai, J; Cai, G; Cui, A; Dai, X; Fan, JG; Han, Y; Hu, Z; Li, Y; Liu, XL; Liu, Y; Liu, Z; Ma, F; Pan, Q; Ren, TY; Shen, F; Su, W; Wang, ZX; Xin, FZ; Xue, Y; Zhang, F; Zhao, ZH; Zhou, D, 2021) |
| "Therapeutic options for Parkinson's disease (PD) are limited to a symptomatic approach, making it a global threat." | 1.62 | Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson's Disease. ( Dubey, SK; K C, S; Kakoty, V; Taliyan, R; Yang, CH, 2021) |
| "Rats were subjected to repeated mild traumatic brain injury (rMTBI) using the closed head weight-drop model." | 1.62 | Role for Histone Deacetylation in Traumatic Brain Injury-Induced Deficits in Neuropeptide Y in Arcuate Nucleus: Possible Implications in Feeding Behavior. ( Balasubramanian, N; Jadhav, M; Sagarkar, S; Sakharkar, AJ; Shahi, N; Sirmaur, R, 2021) |
| "Sodium butyrate attenuated NAFLD progression by regulating miR-150." | 1.62 | Sodium butyrate ameliorates non-alcoholic fatty liver disease by upregulating miR-150 to suppress CXCR4 expression. ( Qin, B; Qu, Y; Zhang, N, 2021) |
| "Depression is a common disease that afflicts one in 6 people." | 1.56 | Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress. ( Chen, J; Chen, Z; He, H; Huang, C; Li, Y; Liu, R; Ma, Y; Qiu, J; Tong, L; You, Q, 2020) |
| " To help choose the best dose of d-gal for the induction of the aging model, we performed a dose-response curve (100, 200 or 300 mg/kg)." | 1.48 | Sodium butyrate improves memory and modulates the activity of histone deacetylases in aged rats after the administration of d-galactose. ( Bellettini-Santos, T; Budni, J; Campos, ACBF; da Silva, S; Damiani, AP; de Andrade, VM; de Carvalho, CA; Garcez, ML; Longaretti, LM; Mina, F; Schiavo, GL; Valvassori, SS; Varela, RB, 2018) |
| "Similarly, in the NAFLD mouse model, mice fed with a high-fat diet showed reduced hepatic GLP-1R expression, which was reversed by NaB treatment and accompanied by markedly alleviated liver steatosis." | 1.48 | Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression. ( Chen, YW; Fan, JG; Liu, XL; Pan, Q; Xin, FZ; Yang, RX; Zhao, ZH; Zhou, D; Zhou, H, 2018) |
| "Atopic dermatitis is a chronic and recurrent inflammatory skin disease." | 1.48 | Anti-Inflammatory Effects of a Mixture of Lactic Acid Bacteria and Sodium Butyrate in Atopic Dermatitis Murine Model. ( Cho, KK; Choi, IS; Kim, IS; Kim, JA; Kim, SC; Kim, SH; Lee, SH; Lee, SS; Yu, DY; Yun, CH, 2018) |
| "The core behavioral symptoms of Autism Spectrum Disorders (ASD) include dysregulation of social communication and the presence of repetitive behaviors." | 1.43 | Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory/excitatory genes in the frontal cortex of an autism model. ( Elliott, E; Getselter, D; Kratsman, N, 2016) |
| "Using in vivo and in vitro models of liver cancer, we demonstrate that an increase in the level of p53 protein in nuclei, a decrease in the level of cytoplasmic p53, and, consequently, an increase in the ratio of nuclear/cytoplasmic p53 in rat preneoplastic livers and in rat and human HCC cell lines caused by tributyrin or sodium butyrate treatments was associated with a marked increase in the level of nuclear chromosome region maintenance 1 (CRM1) protein." | 1.43 | Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein. ( Beland, FA; de Conti, A; Fernandes, LH; Furtado, KS; Heidor, R; Horst, MA; Moreno, FS; Ortega, JF; Pogribna, M; Pogribny, IP; Shpyleva, S; Tavares, PE; Tryndyak, V, 2016) |
| "Repeated treatment with electroconvulsive seizure (ECS) induces changes in histone acetylation, expression of various genes, and intrabrain cellular changes, including neurogenesis." | 1.40 | Repeated treatment with electroconvulsive seizures induces HDAC2 expression and down-regulation of NMDA receptor-related genes through histone deacetylation in the rat frontal cortex. ( Ahn, YM; Kim, SH; Kim, YS; Park, HG; Park, S; Yu, HS, 2014) |
| "Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease." | 1.39 | Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet. ( Calignano, A; Canani, RB; Ferrante, MC; Iacono, A; Mattace Raso, G; Meli, R; Paciello, O; Russo, R; Santoro, A; Simeoli, R, 2013) |
| "Juvenile visceral steatosis (JVS) mice have been reported to have systemic carnitine deficiency, and the carnitine concentration in the liver of JVS mice was markedly lower than that of controls (11." | 1.30 | The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency. ( Horiuchi, M; Inoue, F; Kinugasa, A; Kizaki, Z; Kodo, N; Nakajima, T; Saheki, T; Sawada, T; Yamanaka, H, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.93) | 18.7374 |
| 1990's | 4 (3.74) | 18.2507 |
| 2000's | 2 (1.87) | 29.6817 |
| 2010's | 52 (48.60) | 24.3611 |
| 2020's | 48 (44.86) | 2.80 |
| Authors | Studies |
|---|---|
| Leo, A | 1 |
| De Caro, C | 1 |
| Mainardi, P | 1 |
| Tallarico, M | 1 |
| Nesci, V | 1 |
| Marascio, N | 1 |
| Striano, P | 1 |
| Russo, E | 1 |
| Constanti, A | 1 |
| De Sarro, G | 1 |
| Citraro, R | 1 |
| Bora, V | 1 |
| Patel, D | 1 |
| Johar, K | 1 |
| Goyal, RK | 1 |
| Patel, BM | 2 |
| Islam, R | 1 |
| Dash, D | 1 |
| Singh, R | 1 |
| Sun, Q | 1 |
| Ji, YC | 1 |
| Wang, ZL | 1 |
| She, X | 1 |
| He, Y | 2 |
| Ai, Q | 1 |
| Li, LQ | 1 |
| Chen, H | 1 |
| Li, G | 2 |
| Zhang, J | 1 |
| Zheng, T | 1 |
| Chen, Q | 1 |
| Zhang, Y | 3 |
| Yang, F | 2 |
| Wang, C | 3 |
| Nie, H | 2 |
| Zheng, B | 1 |
| Gong, Q | 2 |
| Liyanage, GSG | 1 |
| Inoue, R | 1 |
| Fujitani, M | 1 |
| Ishijima, T | 1 |
| Shibutani, T | 1 |
| Abe, K | 1 |
| Kishida, T | 1 |
| Okada, S | 1 |
| Mu, Y | 1 |
| Kinashi, Y | 1 |
| Li, J | 2 |
| Yoshikawa, T | 1 |
| Kishimura, A | 1 |
| Tanaka, M | 1 |
| Matsui, T | 1 |
| Mori, T | 1 |
| Hase, K | 1 |
| Katayama, Y | 1 |
| Dou, X | 1 |
| Ma, Z | 1 |
| Yan, D | 1 |
| Gao, N | 1 |
| Li, Z | 1 |
| Li, Y | 5 |
| Feng, X | 1 |
| Meng, L | 1 |
| Shan, A | 1 |
| Chen, MJ | 2 |
| Feng, Y | 1 |
| Gao, L | 2 |
| Lin, MX | 1 |
| Wang, SD | 1 |
| Tong, ZQ | 1 |
| Lanza, M | 1 |
| Filippone, A | 1 |
| Casili, G | 1 |
| Giuffrè, L | 1 |
| Scuderi, SA | 1 |
| Paterniti, I | 1 |
| Campolo, M | 1 |
| Cuzzocrea, S | 1 |
| Esposito, E | 1 |
| Kaya-Sezginer, E | 1 |
| Yilmaz-Oral, D | 1 |
| Kırlangıç, OF | 1 |
| Yilmaz, S | 1 |
| Özen, FZ | 1 |
| Aşan, M | 1 |
| Gur, S | 1 |
| Xu, RC | 1 |
| Miao, WT | 1 |
| Xu, JY | 1 |
| Xu, WX | 1 |
| Liu, MR | 1 |
| Ding, ST | 1 |
| Jian, YX | 1 |
| Lei, YH | 1 |
| Yan, N | 1 |
| Liu, HD | 2 |
| Cristiano, C | 1 |
| Hoxha, E | 1 |
| Lippiello, P | 1 |
| Balbo, I | 1 |
| Russo, R | 2 |
| Tempia, F | 1 |
| Miniaci, MC | 1 |
| Xia, X | 2 |
| Lin, H | 2 |
| Luo, F | 2 |
| Wu, X | 2 |
| Zhu, L | 2 |
| Chen, S | 2 |
| Luo, H | 2 |
| Ye, F | 2 |
| Peng, X | 2 |
| Yang, G | 2 |
| Lin, Q | 2 |
| Davies, DL | 1 |
| Asatryan, L | 1 |
| Wu, J | 2 |
| Man, D | 1 |
| Shi, D | 1 |
| Wu, W | 1 |
| Wang, S | 2 |
| Wang, K | 1 |
| Yang, L | 1 |
| Bian, X | 1 |
| Wang, Q | 2 |
| Li, L | 1 |
| Chen, Z | 2 |
| Nong, Y | 1 |
| Feng, L | 1 |
| Guo, B | 1 |
| Qin, Y | 2 |
| Zhong, X | 1 |
| Qin, J | 1 |
| Wei, J | 1 |
| Dong, M | 1 |
| Pan, S | 1 |
| Su, Z | 1 |
| Guo, TT | 1 |
| Zhang, Z | 1 |
| Sun, Y | 1 |
| Zhu, RY | 1 |
| Wang, FX | 1 |
| Ma, LJ | 1 |
| Jiang, L | 1 |
| Shashni, B | 1 |
| Tajika, Y | 1 |
| Ikeda, Y | 2 |
| Nishikawa, Y | 1 |
| Nagasaki, Y | 1 |
| Bian, Z | 1 |
| Zhang, Q | 2 |
| Sun, X | 1 |
| Liu, L | 1 |
| Liu, H | 1 |
| Mao, L | 1 |
| Yan, Y | 1 |
| Liao, W | 1 |
| Zha, L | 1 |
| Sun, S | 1 |
| Li, H | 4 |
| Wang, R | 1 |
| Yu, Y | 1 |
| Liu, X | 1 |
| Tian, Z | 1 |
| Matsuda, S | 1 |
| Silveira, AK | 1 |
| Gomes, HM | 1 |
| Fröhlich, NT | 1 |
| Possa, L | 1 |
| Santos, L | 1 |
| Kessler, F | 1 |
| Martins, A | 1 |
| Rodrigues, MS | 1 |
| De Oliveira, J | 1 |
| do Nascimento, ND | 1 |
| Sirena, D | 1 |
| Paz, AH | 1 |
| Gelain, DP | 1 |
| Moreira, JCF | 1 |
| Eepho, OI | 1 |
| Bashir, AM | 1 |
| Oniyide, AA | 2 |
| Aturamu, A | 1 |
| Owolabi, OV | 1 |
| Ajadi, IO | 1 |
| Fafure, AA | 1 |
| Ajadi, MB | 1 |
| Areloegbe, SE | 1 |
| Olaniyi, KS | 2 |
| Topuz, RD | 1 |
| Gunduz, O | 1 |
| Tastekin, E | 1 |
| Karadag, CH | 1 |
| Du, Y | 1 |
| Tang, G | 1 |
| Yuan, W | 1 |
| Oh, TJ | 1 |
| Sul, WJ | 1 |
| Oh, HN | 1 |
| Lee, YK | 1 |
| Lim, HL | 1 |
| Choi, SH | 1 |
| Park, KS | 1 |
| Jang, HC | 1 |
| Busbee, PB | 2 |
| Menzel, L | 1 |
| Alrafas, HR | 1 |
| Dopkins, N | 1 |
| Becker, W | 1 |
| Miranda, K | 1 |
| Tang, C | 1 |
| Chatterjee, S | 1 |
| Singh, U | 1 |
| Nagarkatti, M | 2 |
| Nagarkatti, PS | 1 |
| Qiu, J | 1 |
| Liu, R | 1 |
| Ma, Y | 1 |
| He, H | 1 |
| Chen, J | 1 |
| Tong, L | 1 |
| Huang, C | 1 |
| You, Q | 1 |
| Varela, RB | 8 |
| Resende, WR | 4 |
| Dal-Pont, GC | 5 |
| Gava, FF | 1 |
| Tye, SJ | 1 |
| Quevedo, J | 8 |
| Valvassori, SS | 9 |
| Baumann, A | 1 |
| Jin, CJ | 1 |
| Brandt, A | 1 |
| Sellmann, C | 1 |
| Nier, A | 1 |
| Burkard, M | 1 |
| Venturelli, S | 1 |
| Bergheim, I | 1 |
| Traisaeng, S | 1 |
| Batsukh, A | 1 |
| Chuang, TH | 1 |
| Herr, DR | 1 |
| Huang, YF | 1 |
| Chimeddorj, B | 1 |
| Huang, CM | 1 |
| Nooromid, M | 1 |
| Chen, EB | 1 |
| Xiong, L | 1 |
| Shapiro, K | 1 |
| Jiang, Q | 1 |
| Demsas, F | 1 |
| Eskandari, M | 1 |
| Priyadarshini, M | 1 |
| Chang, EB | 1 |
| Layden, BT | 1 |
| Ho, KJ | 1 |
| Lyzogubov, V | 1 |
| Dasso, M | 1 |
| Bora, N | 1 |
| Bora, PS | 1 |
| Zhang, S | 1 |
| Huang, S | 1 |
| Wu, Z | 1 |
| Pang, J | 1 |
| Wu, Y | 2 |
| Wang, J | 2 |
| Han, D | 1 |
| Gao, Y | 1 |
| Ya, B | 1 |
| Li, X | 6 |
| Guo, Y | 1 |
| Yin, H | 1 |
| Adeyanju, OA | 1 |
| Badejogbin, OC | 1 |
| Areola, DE | 1 |
| Dibia, C | 1 |
| Soetan, OA | 1 |
| Michael, OS | 1 |
| Olatunji, LA | 1 |
| Soladoye, AO | 1 |
| Balasubramanian, N | 1 |
| Sagarkar, S | 1 |
| Jadhav, M | 1 |
| Shahi, N | 1 |
| Sirmaur, R | 1 |
| Sakharkar, AJ | 1 |
| Castro, PR | 1 |
| Bittencourt, LFF | 1 |
| Larochelle, S | 1 |
| Andrade, SP | 1 |
| Mackay, CR | 1 |
| Slevin, M | 1 |
| Moulin, VJ | 1 |
| Barcelos, LS | 1 |
| Kong, Q | 1 |
| Wang, B | 1 |
| Tian, P | 1 |
| Zhao, J | 1 |
| Zhang, H | 1 |
| Chen, W | 1 |
| Wang, G | 1 |
| Zhang, N | 1 |
| Qu, Y | 1 |
| Qin, B | 1 |
| Makizaki, Y | 1 |
| Uemoto, T | 1 |
| Yokota, H | 1 |
| Yamamoto, M | 1 |
| Tanaka, Y | 1 |
| Ohno, H | 1 |
| Jiang, Y | 1 |
| Li, K | 1 |
| Xu, L | 1 |
| Yang, Z | 1 |
| Mohammadi-Farani, A | 1 |
| Limoee, M | 1 |
| Shirooie, S | 1 |
| Zhao, ZH | 2 |
| Wang, ZX | 1 |
| Zhou, D | 2 |
| Han, Y | 1 |
| Ma, F | 1 |
| Hu, Z | 1 |
| Xin, FZ | 2 |
| Liu, XL | 2 |
| Ren, TY | 1 |
| Zhang, F | 1 |
| Xue, Y | 1 |
| Cui, A | 1 |
| Liu, Z | 1 |
| Bai, J | 1 |
| Liu, Y | 1 |
| Cai, G | 1 |
| Su, W | 2 |
| Dai, X | 1 |
| Shen, F | 1 |
| Pan, Q | 2 |
| Fan, JG | 2 |
| Liu, FY | 1 |
| Wen, J | 1 |
| Hou, J | 1 |
| Zhang, SQ | 1 |
| Sun, CB | 1 |
| Zhou, LC | 1 |
| Yin, W | 1 |
| Pang, WL | 1 |
| Ying, Y | 1 |
| Han, SS | 1 |
| Yan, JY | 1 |
| Li, CX | 1 |
| Yuan, JL | 1 |
| Xing, HJ | 1 |
| Yang, ZS | 1 |
| Beisner, J | 1 |
| Filipe Rosa, L | 1 |
| Kaden-Volynets, V | 1 |
| Stolzer, I | 1 |
| Günther, C | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pharmacokinetic and Pharmacodynamic Study of AMX0035 in Patients With ALS[NCT04987671] | Phase 1/Phase 2 | 14 participants (Anticipated) | Interventional | 2021-08-05 | Active, not recruiting | ||
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| The Infant MiND Study: An Examination of Infants' Microbiome, Nutrition, and Development Study.[NCT03229863] | 102 participants (Actual) | Interventional | 2017-04-18 | Active, not recruiting | |||
| Prebiotic GOS and Lactoferrin for Beneficial Gut Microbiota With Iron Supplements[NCT03866837] | 288 participants (Actual) | Interventional | 2020-01-15 | Active, not recruiting | |||
| Effects of 3-month Probiotic Mix Supplementation (L. Helveticus R-0052, B. Longum R-0175) on Gut Microbiota and Metabolome, Endocannabinoid and Immune Systems Activation, Along With Symptoms of Fatigue in Professional Dancers[NCT05567653] | 60 participants (Anticipated) | Interventional | 2022-09-21 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for butyric acid and Disease Models, Animal
| Article | Year |
|---|---|
Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents.
Topics: Animals; Butyric Acid; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Curcumin; Disease Mode | 2016 |
106 other studies available for butyric acid and Disease Models, Animal
| Article | Year |
|---|---|
Increased efficacy of combining prebiotic and postbiotic in mouse models relevant to autism and depression.
Topics: Animals; Anxiety; Autistic Disorder; Avoidance Learning; Behavior, Animal; Brain-Gut Axis; Butyric A | 2021 |
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia.
Topics: Animals; Benzamides; Butyric Acid; Cachexia; Cell Line, Tumor; Disease Models, Animal; Disease Progr | 2022 |
Intranasal curcumin and sodium butyrate modulates airway inflammation and fibrosis via HDAC inhibition in allergic asthma.
Topics: Administration, Intranasal; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; | 2022 |
Sodium Butyrate Alleviates Intestinal Inflammation in Mice with Necrotizing Enterocolitis.
Topics: Animals; Butyric Acid; Disease Models, Animal; Enterocolitis, Necrotizing; Female; HMGB1 Protein; In | 2021 |
Sodium butyrate ameliorates Schistosoma japonicum-induced liver fibrosis by inhibiting HMGB1 expression.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Butyric Acid; Cytokin | 2021 |
Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Butyric Acid; Disease Models, Animal; Equol; Female; Gas | 2021 |
Polyvinyl Butyrate Nanoparticles as Butyrate Donors for Colitis Treatment.
Topics: Animals; Biocompatible Materials; Butyric Acid; Cells, Cultured; Colitis; Dextran Sulfate; Disease M | 2021 |
Sodium butyrate alleviates intestinal injury and microbial flora disturbance induced by lipopolysaccharides in rats.
Topics: Animals; Anti-Inflammatory Agents; Butyric Acid; Dietary Supplements; Disease Models, Animal; Gastro | 2022 |
Composite Sophora Colon-Soluble Capsule Ameliorates DSS-Induced Ulcerative Colitis in Mice via Gut Microbiota-Derived Butyric Acid and NCR
Topics: Animals; Butyric Acid; Colitis; Colitis, Ulcerative; Colon; Disease Models, Animal; Gastrointestinal | 2023 |
Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine.
Topics: Animals; Butyric Acid; Dietary Supplements; Disease Models, Animal; Fatty Acids, Volatile; Gastroint | 2022 |
Sodium butyrate ameliorates erectile dysfunction through fibrosis in a rat model of partial bladder outlet obstruction.
Topics: Animals; Butyric Acid; Disease Models, Animal; Erectile Dysfunction; Fibrosis; Histone Deacetylases; | 2022 |
Neuroprotective Effects of Sodium Butyrate and Monomethyl Fumarate Treatment through GPR109A Modulation and Intestinal Barrier Restoration on PD Mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Butyric Acid; Claudin-1; Cytokines; Disease M | 2022 |
Maternal treatment with sodium butyrate reduces the development of autism-like traits in mice offspring.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Butyric Acid; Disease Models | 2022 |
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Topics: Animals; Butyric Acid; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Mic | 2022 |
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Topics: Animals; Butyric Acid; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Mic | 2022 |
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Topics: Animals; Butyric Acid; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Mic | 2022 |
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Topics: Animals; Butyric Acid; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Mic | 2022 |
Sodium Butyrate Supplementation Modulates Neuroinflammatory Response Aggravated by Antibiotic Treatment in a Mouse Model of Binge-like Ethanol Drinking.
Topics: Alcohol Drinking; Alcoholism; Animals; Anti-Bacterial Agents; Butyric Acid; Cytokines; Dietary Suppl | 2022 |
Intermittent Fasting Alleviates Risk Markers in a Murine Model of Ulcerative Colitis by Modulating the Gut Microbiome and Metabolome.
Topics: Akkermansia; Animals; Bile Acids and Salts; Butyric Acid; Chromatography, Liquid; Colitis; Colitis, | 2022 |
Preventive effect of tilapia skin collagen hydrolysates on ulcerative colitis mice based on metabonomic and 16 S rRNA gene sequencing.
Topics: Acetic Acid; Actinobacteria; Animals; Bacteroidetes; Butyric Acid; Colitis; Colitis, Ulcerative; Col | 2023 |
Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's Disease.
Topics: Animals; Butyric Acid; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Inflammation; | 2023 |
Self-assembling polymer-based short chain fatty acid prodrugs ameliorate non-alcoholic steatohepatitis and liver fibrosis.
Topics: Animals; Butyric Acid; Disease Models, Animal; Fatty Acids, Volatile; Liver; Liver Cirrhosis; Mice; | 2023 |
Sodium Butyrate Inhibits Oxidative Stress and NF-κB/NLRP3 Activation in Dextran Sulfate Sodium Salt-Induced Colitis in Mice with Involvement of the Nrf2 Signaling Pathway and Mitophagy.
Topics: Animals; Butyric Acid; Colitis; Colitis, Ulcerative; Cyclooxygenase 2; Dextran Sulfate; Disease Mode | 2023 |
Protective effect of sodium butyrate on intestinal barrier damage and uric acid reduction in hyperuricemia mice.
Topics: Animals; Butyric Acid; Caco-2 Cells; Disease Models, Animal; Fatty Acids, Volatile; Humans; Hyperuri | 2023 |
Gut Protective Effect from D-Methionine or Butyric Acid against DSS and Carrageenan-Induced Ulcerative Colitis.
Topics: Animals; Butyric Acid; Carrageenan; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, A | 2023 |
Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model.
Topics: Animals; Butyric Acid; Claudin-5; Colitis, Ulcerative; Disease Models, Animal; Inflammation; Inflamm | 2023 |
Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS.
Topics: Animals; Butyric Acid; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Humans; Letrozole; M | 2023 |
Effects of hippocampal histone acetylation and HDAC inhibition on spatial learning and memory in the Morris water maze in rats.
Topics: Acetylation; Animals; Butyric Acid; Disease Models, Animal; Hippocampus; Histone Deacetylase Inhibit | 2020 |
Suppression of HDAC2 by sodium butyrate alleviates apoptosis of kidney cells in db/db mice and HG‑induced NRK‑52E cells.
Topics: Animals; Apoptosis; Butyric Acid; Cell Line; Diabetic Nephropathies; Disease Models, Animal; Gene Ex | 2020 |
Butyrate attenuated fat gain through gut microbiota modulation in db/db mice following dapagliflozin treatment.
Topics: Adipose Tissue; Animals; Benzhydryl Compounds; Butyric Acid; Disease Models, Animal; Gastrointestina | 2019 |
Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22-dependent manner.
Topics: Animals; Butyric Acid; Colitis; Colon; Disease Models, Animal; Dysbiosis; Female; Gastrointestinal M | 2020 |
Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Butyric Acid; Cytokines; Depression; Disease Model | 2020 |
HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain.
Topics: Animals; Behavior, Animal; Bipolar Disorder; Butyric Acid; Corpus Striatum; Disease Models, Animal; | 2020 |
Oral Supplementation of Sodium Butyrate Attenuates the Progression of Non-Alcoholic Steatohepatitis.
Topics: Animals; Butyric Acid; Cholesterol, Dietary; Diet, High-Fat; Dietary Supplements; Disease Models, An | 2020 |
Leuconostoc mesenteroides fermentation produces butyric acid and mediates Ffar2 to regulate blood glucose and insulin in type 1 diabetic mice.
Topics: Animals; Blood Glucose; Butyric Acid; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2020 |
Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Butyric Acid; Cell Movement; Cell Proliferation; Disease M | 2020 |
Role of thalidomide, senicapoc, and sodium butyrate in choroidal neovascularization.
Topics: Acetamides; Angiogenesis Inhibitors; Animals; Butyric Acid; Cell Line; Cell Proliferation; Choroidal | 2020 |
Resistant Maltodextrin Alleviates Dextran Sulfate Sodium-Induced Intestinal Inflammatory Injury by Increasing Butyric Acid to Inhibit Proinflammatory Cytokine Levels.
Topics: Animals; Butyric Acid; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Feces; Fe | 2020 |
Myricitrin ameliorates cognitive deficits in MCAO cerebral stroke rats via histone acetylation-induced alterations of brain-derived neurotrophic factor.
Topics: Acetylation; Animals; Brain-Derived Neurotrophic Factor; Butyric Acid; Cerebral Cortex; Cognitive Dy | 2021 |
Sodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats.
Topics: Animals; Blood Glucose; Butyric Acid; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Female; | 2021 |
Role for Histone Deacetylation in Traumatic Brain Injury-Induced Deficits in Neuropeptide Y in Arcuate Nucleus: Possible Implications in Feeding Behavior.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Behavior, Animal; Brain Concussion; Butyric Acid; Disease | 2021 |
GPR43 regulates sodium butyrate-induced angiogenesis and matrix remodeling.
Topics: Angiogenesis Inducing Agents; Animals; Butyric Acid; Cell Line; Cell Movement; Cell Proliferation; C | 2021 |
Daily intake of Lactobacillus alleviates autistic-like behaviors by ameliorating the 5-hydroxytryptamine metabolic disorder in VPA-treated rats during weaning and sexual maturation.
Topics: Animals; Autistic Disorder; Behavior, Animal; Butyric Acid; Disease Models, Animal; Fatty Acids, Vol | 2021 |
Sodium butyrate ameliorates non-alcoholic fatty liver disease by upregulating miR-150 to suppress CXCR4 expression.
Topics: Alanine Transaminase; Animals; Butyric Acid; Diet, High-Fat; Disease Models, Animal; Non-alcoholic F | 2021 |
Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis.
Topics: Animals; Bifidobacterium bifidum; Butyrates; Butyric Acid; Constipation; Disease Models, Animal; Dop | 2021 |
Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Butyric Acid; Cognitive Dysfunction; Disea | 2021 |
Sodium butyrate enhances fear extinction and rescues hippocampal acetylcholinesterase activity in a rat model of posttraumatic stress disorder.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Butyric Acid; Cholinergic Neurons; Disease Models, Ani | 2021 |
Sodium Butyrate Supplementation Inhibits Hepatic Steatosis by Stimulating Liver Kinase B1 and Insulin-Induced Gene.
Topics: AMP-Activated Protein Kinases; Animals; Butyric Acid; Diet, High-Fat; Dietary Supplements; Disease M | 2021 |
Gastrodia remodels intestinal microflora to suppress inflammation in mice with early atherosclerosis.
Topics: Acetic Acid; Animals; Aorta; Atherosclerosis; Benzyl Alcohols; Butyric Acid; Disease Models, Animal; | 2021 |
Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides.
Topics: Animal Feed; Animals; Biomarkers; Butyric Acid; Dietary Supplements; Disease Models, Animal; Female; | 2021 |
Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Butyric Acid; Disease Models, Animal; Neuroprotective Agents; Parkinson Di | 2021 |
The Ability of AhR Ligands to Attenuate Delayed Type Hypersensitivity Reaction Is Associated With Alterations in the Gut Microbiota.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Butyric Acid; Carbazoles; Cytokines; Disease | 2021 |
Sodium Butyrate Controls Cardiac Hypertrophy in Experimental Models of Rats.
Topics: Animals; Aorta, Abdominal; Butyric Acid; Collagen; Constriction; Disease Models, Animal; DNA, Mitoch | 2018 |
Sodium butyrate regulates Th17/Treg cell balance to ameliorate uveitis via the Nrf2/HO-1 pathway.
Topics: Animals; Butyric Acid; Disease Models, Animal; Female; Flow Cytometry; Heme Oxygenase-1; Membrane Pr | 2017 |
Supplementation with Lactobacillus paracasei or Pediococcus pentosaceus does not prevent diarrhoea in neonatal pigs infected with Escherichia coli F18.
Topics: Acetic Acid; Animals; Animals, Newborn; Butyric Acid; Colon; Colony Count, Microbial; Diarrhea; Diet | 2017 |
Butyrate protects against disruption of the blood-milk barrier and moderates inflammatory responses in a model of mastitis induced by lipopolysaccharide.
Topics: Animals; Butyric Acid; Disease Models, Animal; Epithelial Cells; Female; Inflammation; Lipopolysacch | 2017 |
Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor 4 signaling pathway.
Topics: Animals; Butyric Acid; Cells, Cultured; Disease Models, Animal; Escherichia coli; Escherichia coli I | 2017 |
Butyrate promotes visceral hypersensitivity in an IBS-like model via enteric glial cell-derived nerve growth factor.
Topics: Animals; Butyric Acid; Cell Line; Disease Models, Animal; Enteric Nervous System; Gene Expression Pr | 2018 |
Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice.
Topics: Animals; Antidepressive Agents; Butyric Acid; Calcium-Binding Proteins; Cytokines; Depression; Disea | 2018 |
High fiber dietary and sodium butyrate attenuate experimental autoimmune hepatitis through regulation of immune regulatory cells and intestinal barrier.
Topics: Animals; Butyric Acid; Cytokines; Dietary Fiber; Disease Models, Animal; Hepatitis, Autoimmune; Inte | 2018 |
Anti-Inflammatory Effects of a Mixture of Lactic Acid Bacteria and Sodium Butyrate in Atopic Dermatitis Murine Model.
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Butyric Acid; Dermatitis, Atopic; Disease Models | 2018 |
Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression.
Topics: Animals; Butyric Acid; Disease Models, Animal; Histamine Antagonists; Immunohistochemistry; Insulin | 2019 |
Sodium butyrate improves memory and modulates the activity of histone deacetylases in aged rats after the administration of d-galactose.
Topics: Aging; Animals; Brain; Butyric Acid; Disease Models, Animal; DNA Damage; Galactose; Histone Deacetyl | 2018 |
Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression.
Topics: Adult; Animals; Butyric Acid; Diet, High-Fat; Disease Models, Animal; Disease Progression; Down-Regu | 2018 |
Effect of the HDAC Inhibitor, Sodium Butyrate, on Neurogenesis in a Rat Model of Neonatal Hypoxia-Ischemia: Potential Mechanism of Action.
Topics: Acetylation; Animals; Brain; Butyric Acid; Cell Proliferation; Cyclic AMP Response Element-Binding P | 2019 |
The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity.
Topics: Amides; Animals; Antibiotics, Antineoplastic; Apoptosis; Butyrates; Butyric Acid; Cardiotoxicity; Di | 2019 |
Sodium butyrate ameliorates Corynebacterium pseudotuberculosis infection in RAW264.7 macrophages and C57BL/6 mice.
Topics: Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Bacterial Load; Butyric Acid; Cathe | 2019 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson's disease.
Topics: Animals; Animals, Genetically Modified; Butyric Acid; Disease Models, Animal; Drosophila; Histone De | 2013 |
Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8.
Topics: Administration, Rectal; Animals; Antigens, Surface; Butyric Acid; Cell Line; Colitis; Dextran Sulfat | 2013 |
Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet.
Topics: Adipose Tissue; Amides; Animals; Butyric Acid; Diet, High-Fat; Disease Models, Animal; Enzyme Activa | 2013 |
Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer.
Topics: Affect; Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Butyric Acid; Disease Models, | 2013 |
Altered gut microbiota and activity in a murine model of autism spectrum disorders.
Topics: Acetic Acid; Animals; Butyric Acid; Child Development Disorders, Pervasive; Disease Models, Animal; | 2014 |
Hizikia fusiformis fractions successfully improve atopic dermatitis indices in anti-CD3-stimulated splenocytes and 2,4-dinitrochlorobenzene-treated BALB/c mice.
Topics: Animals; Antibodies; Butyric Acid; CD3 Complex; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; | 2014 |
Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat.
Topics: Animals; Apoptosis; Blotting, Western; Body Weight; Butyric Acid; Cell Proliferation; Diabetes Melli | 2014 |
Iron supplementation promotes gut microbiota metabolic activity but not colitis markers in human gut microbiota-associated rats.
Topics: Animals; Bacteroides; Biomarkers; Butyric Acid; Cecum; Child; Clostridium; Colitis; Colon; Dietary S | 2014 |
Repeated treatment with electroconvulsive seizures induces HDAC2 expression and down-regulation of NMDA receptor-related genes through histone deacetylation in the rat frontal cortex.
Topics: Acetylation; Analysis of Variance; Animals; Butyric Acid; Chromatin Immunoprecipitation; Disease Mod | 2014 |
Possible additional antidepressant-like mechanism of sodium butyrate: targeting the hippocampus.
Topics: Adaptation, Ocular; Animals; Antidepressive Agents; Butyric Acid; CREB-Binding Protein; Depression; | 2014 |
Sodium butyrate protects against toxin-induced acute liver failure in rats.
Topics: Animals; Biomarkers; Butyric Acid; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease M | 2014 |
Polyglutamine-expanded ataxin-3 impairs long-term depression in Purkinje neurons of SCA3 transgenic mouse by inhibiting HAT and impairing histone acetylation.
Topics: Acetylation; Animals; Ataxin-3; Butyric Acid; Cerebellum; Disease Models, Animal; Histone Acetyltran | 2014 |
Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Butyric Acid; Carnitine; Colitis; Colon | 2014 |
Sodium butyrate functions as an antidepressant and improves cognition with enhanced neurotrophic expression in models of maternal deprivation and chronic mild stress.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Butyric Acid; Cognition Disorders; Depression; | 2014 |
Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism.
Topics: Acetylation; Animals; Autistic Disorder; Butyric Acid; CA1 Region, Hippocampal; Dendritic Spines; Di | 2014 |
[Sodium butyrate inhibits HMGB1 expression and release and attenuates concanavalin A-induced acute liver injury in mice].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Butyric Acid; Chemical and Drug Induced | 2014 |
Histone deacetylase inhibitors reverse manic-like behaviors and protect the rat brain from energetic metabolic alterations induced by ouabain.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Brain; Butyric Acid; Citric Acid Cycl | 2015 |
Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats.
Topics: Affect; Animals; Antimanic Agents; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Butyric Acid | 2015 |
Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Butyric Acid; Depressive Disorder | 2014 |
Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats.
Topics: Acetic Acid; Administration, Oral; Administration, Rectal; Animals; Butyric Acid; Colitis, Ulcerativ | 2015 |
Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes.
Topics: Animals; Butyric Acid; Cell Division; Cryptococcus neoformans; Disease Models, Animal; Fungal Capsul | 2015 |
Sodium Butyrate, a Histone Deacetylase Inhibitor, Reverses Behavioral and Mitochondrial Alterations in Animal Models of Depression Induced by Early- or Late-life Stress.
Topics: Animals; Animals, Newborn; Butyric Acid; Citric Acid Cycle; Corpus Striatum; Depression; Disease Mod | 2015 |
Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway.
Topics: Adipocytes; Animals; Anti-Inflammatory Agents; Butyric Acid; Carrier Proteins; Disease Models, Anima | 2015 |
Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection.
Topics: Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Biological Availability; Butyric Ac | 2015 |
Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory/excitatory genes in the frontal cortex of an autism model.
Topics: Animals; Autism Spectrum Disorder; Avoidance Learning; Behavior, Animal; Butyric Acid; Cyclic AMP Re | 2016 |
Sodium butyrate has an antimanic effect and protects the brain against oxidative stress in an animal model of mania induced by ouabain.
Topics: Animals; Antimanic Agents; Antioxidants; Bipolar Disorder; Brain; Butyric Acid; Catalase; Disease Mo | 2016 |
Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Butyric Acid; Depression; Disease | 2016 |
Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.
Topics: Animals; Apoptosis; Butyric Acid; Carcinoma, Hepatocellular; Cell Compartmentation; Cell Line, Tumor | 2016 |
Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction.
Topics: Animals; Avoidance Learning; Bombesin; Brain-Derived Neurotrophic Factor; Butyric Acid; Disease Mode | 2016 |
Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate-producing bacterium.
Topics: Adult; Animals; Butyric Acid; Clostridiales; Colitis; Colon; Dextran Sulfate; Disease Models, Animal | 2016 |
Dual influences of early-life maternal deprivation on histone deacetylase activity and recognition memory in rats.
Topics: Acetylation; Animals; Brain-Derived Neurotrophic Factor; Butyric Acid; Disease Models, Animal; Hippo | 2017 |
Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils.
Topics: Animals; Butyric Acid; Chickens; Clostridium Infections; Clostridium perfringens; Disease Models, An | 2010 |
Mesenchymal stem cells in renal function recovery after acute kidney injury: use of a differentiating agent in a rat model.
Topics: Acute Kidney Injury; Animals; Butyric Acid; Cell Differentiation; Cytokines; Disease Models, Animal; | 2011 |
Behavioral and neurochemical effects of sodium butyrate in an animal model of mania.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Brain; Butyric Acid; Central Nervous | 2011 |
Roles of mucosal bacteria and succinic acid in colitis caused by dextran sulfate sodium in mice.
Topics: Acetates; Animals; Bacteroidaceae; Bacteroides; Butyric Acid; Carboxylic Acids; Cecum; Colitis; Coli | 2000 |
Variable effects of short chain fatty acids and lactic acid in inducing intestinal mucosal injury in newborn rats.
Topics: Acetic Acid; Animals; Animals, Newborn; Butyric Acid; Colon; Disease Models, Animal; Dose-Response R | 2002 |
A comparative study of the influence of differing barley brans on DMH-induced intestinal tumours in male Sprague-Dawley rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Body Weight; Butyrates; Butyric Acid; Carcino | 1996 |
The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency.
Topics: Animals; Butyrates; Butyric Acid; Caprylates; Carnitine; Disease Models, Animal; Fatty Liver; In Vit | 1997 |
Clostridial pathogenicity in experimental necrotising enterocolitis in gnotobiotic quails and protective role of bifidobacteria.
Topics: Animals; Bifidobacterium; Butyric Acid; Cecum; Clostridioides difficile; Clostridium; Clostridium pe | 1998 |
Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate.
Topics: Administration, Oral; Anemia; Animals; Bloodletting; Butyrates; Butyric Acid; Cell Division; Chromat | 1992 |
Beige mouse mast cells generated in vitro: ultrastructural analysis of maturation induced by sodium butyrate and of IgE-mediated, antigen-dependent degranulation.
Topics: Animals; Bone Marrow; Butyrates; Butyric Acid; Cell Line; Chediak-Higashi Syndrome; Cytoplasmic Gran | 1987 |