butyric acid has been researched along with Diabetes Mellitus, Type 1 in 6 studies
Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pathophysiology of type 1 diabetes has been linked to altered gut microbiota and more specifically to a shortage of intestinal production of the short-chain fatty acid (SCFA) butyrate, which may play key roles in maintaining intestinal epithelial integrity and in human and gut microbial metabolism." | 2.94 | Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: a randomised controlled trial. ( Bekkering, S; Berkvens, A; Bindraban, R; Dallinga-Thie, GM; Davids, M; de Groot, PF; Duinkerken, G; Herrema, H; Hoekstra, JBL; Holleman, F; Hutten, B; Imangaliyev, S; Keij, FM; Kemper, EM; Kroon, J; Levels, JHM; Levin, E; Netea, M; Nieuwdorp, M; Nikolic, T; Roep, BO; Simsek, S; Stroes, ESG; van Hoorn, FA; van Raalte, DH; Winkelmeijer, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 4 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Elgamal, DA | 1 |
| Abou-Elghait, AT | 1 |
| Ali, AY | 1 |
| Ali, M | 1 |
| Bakr, MH | 1 |
| de Groot, PF | 1 |
| Nikolic, T | 1 |
| Imangaliyev, S | 1 |
| Bekkering, S | 1 |
| Duinkerken, G | 1 |
| Keij, FM | 1 |
| Herrema, H | 1 |
| Winkelmeijer, M | 1 |
| Kroon, J | 1 |
| Levin, E | 1 |
| Hutten, B | 1 |
| Kemper, EM | 1 |
| Simsek, S | 1 |
| Levels, JHM | 1 |
| van Hoorn, FA | 1 |
| Bindraban, R | 1 |
| Berkvens, A | 1 |
| Dallinga-Thie, GM | 1 |
| Davids, M | 1 |
| Holleman, F | 1 |
| Hoekstra, JBL | 1 |
| Stroes, ESG | 1 |
| Netea, M | 1 |
| van Raalte, DH | 1 |
| Roep, BO | 1 |
| Nieuwdorp, M | 1 |
| Traisaeng, S | 1 |
| Batsukh, A | 1 |
| Chuang, TH | 1 |
| Herr, DR | 1 |
| Huang, YF | 1 |
| Chimeddorj, B | 1 |
| Huang, CM | 1 |
| Jacob, N | 1 |
| Jaiswal, S | 1 |
| Maheshwari, D | 1 |
| Nallabelli, N | 1 |
| Khatri, N | 1 |
| Bhatia, A | 1 |
| Bal, A | 1 |
| Malik, V | 1 |
| Verma, S | 1 |
| Kumar, R | 1 |
| Sachdeva, N | 1 |
| Endesfelder, D | 1 |
| Engel, M | 1 |
| Davis-Richardson, AG | 1 |
| Ardissone, AN | 1 |
| Achenbach, P | 1 |
| Hummel, S | 1 |
| Winkler, C | 1 |
| Atkinson, M | 1 |
| Schatz, D | 1 |
| Triplett, E | 1 |
| Ziegler, AG | 1 |
| zu Castell, W | 1 |
| Deinhofer, M | 1 |
| Weissenböck, H | 1 |
1 trial available for butyric acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: a randomised controlled trial.
Topics: Adaptive Immunity; Administration, Oral; Adult; Autoimmunity; Butyric Acid; Diabetes Mellitus, Type | 2020 |
5 other studies available for butyric acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Ultrastructure characterization of pancreatic β-cells is accompanied by modulatory effects of the HDAC inhibitor sodium butyrate on the PI3/AKT insulin signaling pathway in juvenile diabetic rats.
Topics: Animals; Butyric Acid; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucose; Histone | 2020 |
Leuconostoc mesenteroides fermentation produces butyric acid and mediates Ffar2 to regulate blood glucose and insulin in type 1 diabetic mice.
Topics: Animals; Blood Glucose; Butyric Acid; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2020 |
Butyrate induced Tregs are capable of migration from the GALT to the pancreas to restore immunological tolerance during type-1 diabetes.
Topics: Animals; Butyric Acid; Cell Movement; Diabetes Mellitus, Type 1; Disease Progression; Female; Immune | 2020 |
Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production.
Topics: Acetic Acid; Adult; Autoantibodies; Autoimmunity; Bacteroides; Breast Feeding; Butyric Acid; Child; | 2016 |
Diagnosis of diabetes mellitus in a bull by means of butyrate infusion.
Topics: Animals; Blood Glucose; Butyrates; Butyric Acid; Cattle; Cattle Diseases; Diabetes Mellitus, Type 1; | 1998 |