Page last updated: 2024-10-16

butyric acid and Bowel Diseases, Inflammatory

butyric acid has been researched along with Bowel Diseases, Inflammatory in 13 studies

Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.

Research Excerpts

ExcerptRelevanceReference
"Patients aged 6-18 years with colonic Crohn's disease or ulcerative colitis, who received standard therapy depending on the disease's severity, were randomized to receive 150 mg sodium butyrate twice a day (group A) or placebo (group B)."3.11Sodium Butyrate Effectiveness in Children and Adolescents with Newly Diagnosed Inflammatory Bowel Diseases-Randomized Placebo-Controlled Multicenter Trial. ( Banasiuk, M; Banaszkiewicz, A; Borys-Iwanicka, A; Pietrzak, A; Pytrus, T; Szczepanik, M; Walkowiak, J, 2022)
"We induced ulcerative colitis (UC) in mice utilizing dextran sodium sulfate (DSS) in the drinking water for 7 days."1.91Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model. ( De Oliveira, J; do Nascimento, ND; Fröhlich, NT; Gelain, DP; Gomes, HM; Kessler, F; Martins, A; Moreira, JCF; Paz, AH; Possa, L; Rodrigues, MS; Santos, L; Silveira, AK; Sirena, D, 2023)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's1 (7.69)29.6817
2010's3 (23.08)24.3611
2020's8 (61.54)2.80

Authors

AuthorsStudies
Pietrzak, A1
Banasiuk, M1
Szczepanik, M1
Borys-Iwanicka, A1
Pytrus, T1
Walkowiak, J2
Banaszkiewicz, A1
Xia, X2
Lin, H2
Luo, F2
Wu, X2
Zhu, L2
Chen, S2
Luo, H2
Ye, F2
Peng, X2
Zhang, Y2
Yang, G2
Lin, Q2
Ikeda, Y1
Matsuda, S1
Silveira, AK1
Gomes, HM1
Fröhlich, NT1
Possa, L1
Santos, L1
Kessler, F1
Martins, A1
Rodrigues, MS1
De Oliveira, J1
do Nascimento, ND1
Sirena, D1
Paz, AH1
Gelain, DP1
Moreira, JCF1
Kaden-Volynets, V1
Günther, C1
Zimmermann, J1
Beisner, J1
Becker, C1
Bischoff, SC1
Facchin, S2
Vitulo, N1
Calgaro, M1
Buda, A2
Romualdi, C1
Pohl, D1
Perini, B1
Lorenzon, G1
Marinelli, C1
D'Incà, R1
Sturniolo, GC1
Savarino, EV1
Sitkin, S1
Vakhitov, T1
Pokrotnieks, J1
Savarino, E1
Jamka, M1
Kokot, M1
Kaczmarek, N1
Bermagambetova, S1
Nowak, JK1
Van Immerseel, F1
Ducatelle, R1
De Vos, M1
Boon, N1
Van De Wiele, T1
Verbeke, K1
Rutgeerts, P1
Sas, B1
Louis, P1
Flint, HJ1
Sossai, P1
Takaishi, H1
Matsuki, T1
Nakazawa, A1
Takada, T1
Kado, S1
Asahara, T1
Kamada, N1
Sakuraba, A1
Yajima, T1
Higuchi, H1
Inoue, N1
Ogata, H1
Iwao, Y1
Nomoto, K1
Tanaka, R1
Hibi, T1
D'Argenio, G1
Mazzacca, G1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Inflammation and Intestinal Microbiota Modulation in Inflammatory Bowel Diseases[NCT04879914]160 participants (Actual)Interventional2020-06-01Completed
A Randomized Controlled Trial to Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain in Overweight But Generally Healthy Adults Over the Winter Holiday Period[NCT03372109]23 participants (Actual)Interventional2017-11-14Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for butyric acid and Bowel Diseases, Inflammatory

ArticleYear
The Effect of Sodium Butyrate Enemas Compared with Placebo on Disease Activity, Endoscopic Scores, and Histological and Inflammatory Parameters in Inflammatory Bowel Diseases: A Systematic Review of Randomised Controlled Trials.
    Complementary medicine research, 2021, Volume: 28, Issue:4

    Topics: Butyric Acid; Colitis, Ulcerative; Enema; Humans; Inflammatory Bowel Diseases; Randomized Controlled

2021
Butyric acid: what is the future for this old substance?
    Swiss medical weekly, 2012, Volume: 142

    Topics: beta-Thalassemia; Butyric Acid; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines;

2012
Short-chain fatty acid in the human colon. Relation to inflammatory bowel diseases and colon cancer.
    Advances in experimental medicine and biology, 1999, Volume: 472

    Topics: Butyric Acid; Colon; Colonic Neoplasms; Dietary Fiber; Fatty Acids; Humans; Inflammatory Bowel Disea

1999

Trials

2 trials available for butyric acid and Bowel Diseases, Inflammatory

ArticleYear
Sodium Butyrate Effectiveness in Children and Adolescents with Newly Diagnosed Inflammatory Bowel Diseases-Randomized Placebo-Controlled Multicenter Trial.
    Nutrients, 2022, Aug-11, Volume: 14, Issue:16

    Topics: Adolescent; Butyric Acid; Child; Colitis, Ulcerative; Crohn Disease; Humans; Inflammatory Bowel Dise

2022
Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease.
    Neurogastroenterology and motility, 2020, Volume: 32, Issue:10

    Topics: Administration, Oral; Adult; Aged; Butyric Acid; Capsules; Double-Blind Method; Female; Gastrointest

2020

Other Studies

8 other studies available for butyric acid and Bowel Diseases, Inflammatory

ArticleYear
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
    Journal of agricultural and food chemistry, 2022, Dec-21, Volume: 70, Issue:50

    Topics: Animals; Butyric Acid; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Mic

2022
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
    Journal of agricultural and food chemistry, 2022, Dec-21, Volume: 70, Issue:50

    Topics: Animals; Butyric Acid; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Mic

2022
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
    Journal of agricultural and food chemistry, 2022, Dec-21, Volume: 70, Issue:50

    Topics: Animals; Butyric Acid; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Mic

2022
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
    Journal of agricultural and food chemistry, 2022, Dec-21, Volume: 70, Issue:50

    Topics: Animals; Butyric Acid; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Mic

2022
Gut Protective Effect from D-Methionine or Butyric Acid against DSS and Carrageenan-Induced Ulcerative Colitis.
    Molecules (Basel, Switzerland), 2023, May-28, Volume: 28, Issue:11

    Topics: Animals; Butyric Acid; Carrageenan; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, A

2023
Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model.
    Immunological investigations, 2023, Volume: 52, Issue:7

    Topics: Animals; Butyric Acid; Claudin-5; Colitis, Ulcerative; Disease Models, Animal; Inflammation; Inflamm

2023
Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction, and malassimilation, which can be partially attenuated by inulin or sodium butyrate.
    American journal of physiology. Gastrointestinal and liver physiology, 2019, 10-01, Volume: 317, Issue:4

    Topics: Animals; Body Weight; Butyric Acid; Caspase 8; Crohn Disease; Diet, Western; Dietary Supplements; Fe

2019
Oral butyrate modulates the gut microbiota in patients with inflammatory bowel disease, most likely by reversing proinflammatory metabolic reprogramming of colonocytes.
    Neurogastroenterology and motility, 2021, Volume: 33, Issue:1

    Topics: Butyrates; Butyric Acid; Colitis; Gastrointestinal Microbiome; Humans; Inflammatory Bowel Diseases;

2021
Reply Letter to "Oral butyrate modulates the gut microbiota in patients with inflammatory bowel disease, most likely by reversing proinflammatory metabolic reprogramming of colonocytes".
    Neurogastroenterology and motility, 2021, Volume: 33, Issue:1

    Topics: Butyric Acid; Colitis; Gastrointestinal Microbiome; Humans; Inflammatory Bowel Diseases; Microbiota

2021
Butyric acid-producing anaerobic bacteria as a novel probiotic treatment approach for inflammatory bowel disease.
    Journal of medical microbiology, 2010, Volume: 59, Issue:Pt 2

    Topics: Bacteria, Anaerobic; Butyric Acid; Fermentation; Humans; Inflammatory Bowel Diseases; Probiotics

2010
Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease.
    International journal of medical microbiology : IJMM, 2008, Volume: 298, Issue:5-6

    Topics: Actinobacteria; Bacteria; Bacteroides; Bifidobacterium; Biodiversity; Butyric Acid; Clostridium; Col

2008