butyric acid has been researched along with Anemia, Sickle Cell in 15 studies
Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The fact that valproic acid, a derivative of pentanoic acid, also induces gamma-globin expression suggests that short-chain fatty acid derivatives that are already approved for human use may possess the property of gamma-globin inducibility and may be of therapeutic relevance to the beta-chain hemoglobinopathies." | 3.69 | Stimulation of fetal hemoglobin production by short chain fatty acids. ( Blau, CA; Dover, G; Fournarakis, B; Josephson, B; Li, Q; Liakopoulou, E; Papayannopoulou, T; Raisys, V; Stamatoyannopoulos, G; Wolf, JA, 1995) |
| " Because butyrate and alpha-amino-n-butyric acid (ABA) augment gamma globin expression in normal neonatal and adult erythroid progenitors, we investigated the effects of sodium butyrate and ABA on erythroid progenitors of patients with beta thalassemia and sickle cell anemia who might benefit from such an effect." | 3.67 | Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia. ( Cohen, RA; Faller, DV; Hurst, D; Lubin, BH; Miller, BA; Papayannopoulou, T; Perrine, SP; Vichinsky, EP, 1989) |
| " However, application of these drugs at large is not yet justified because a series of questions concerning their long-term efficacy, the correct dosage and timing, their tolerance and toxicity, and the potential long-term dangers, including mutagenicity are still unresolved." | 2.40 | New therapies for the haemoglobinopathies. ( Loukopoulos, D, 1997) |
| "Only hydroxyurea has shown significant clinical effects in terms of reduction of pain-crises, chest syndrome and transfusions in sickle-cell patients." | 2.40 | Pharmacological induction of foetal haemoglobin synthesis in sickle-cell disease. ( Hillen, HF; Saleh, AW, 1997) |
| "Hydroxyurea (HU) has become the most widely used agent, although its effectiveness in increasing HbF levels and the number of F cells is highly variable." | 2.38 | Fetal hemoglobin reactivation in baboon and man: a short perspective. ( DeSimone, J; Heller, P; Lavelle, D, 1993) |
| "The pathophysiology of sickle cell anemia is primarily explained in terms of the oxygen-dependent polymerization of sickle hemoglobin (HbS) followed by sickling of erythrocytes." | 1.30 | Sickling of nucleated erythroid precursors from patients with sickle cell anemia. ( Blanchette-Mackie, EJ; Dwyer, N; Fibach, E; Hasegawa, S; Noguchi, CT; Rodgers, GP; Schechter, AN; Uyesaka, N, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Xie, W | 1 |
| Gore, ER | 1 |
| Montoute, MN | 1 |
| Bee, WT | 1 |
| Zappacosta, F | 1 |
| Zeng, X | 1 |
| Wu, Z | 1 |
| Kallal, L | 1 |
| Ames, RS | 1 |
| Pope, AJ | 1 |
| Benowitz, A | 1 |
| Erickson-Miller, CL | 1 |
| Ronzoni, L | 1 |
| Sonzogni, L | 1 |
| Fossati, G | 1 |
| Modena, D | 1 |
| Trombetta, E | 1 |
| Porretti, L | 1 |
| Cappellini, MD | 1 |
| Fard, AD | 1 |
| Kaviani, S | 1 |
| Noruzinia, M | 1 |
| Saki, N | 1 |
| Mortaz, E | 1 |
| Chou, YC | 1 |
| Chen, RL | 1 |
| Lai, ZS | 1 |
| Song, JS | 1 |
| Chao, YS | 1 |
| Shen, CK | 1 |
| Durlak, M | 1 |
| Fugazza, C | 1 |
| Elangovan, S | 1 |
| Marini, MG | 1 |
| Marongiu, MF | 1 |
| Moi, P | 1 |
| Fraietta, I | 1 |
| Cappella, P | 1 |
| Barbarani, G | 1 |
| Font-Monclus, I | 1 |
| Mauri, M | 1 |
| Ottolenghi, S | 1 |
| Gasparri, F | 1 |
| Ronchi, A | 1 |
| Liakopoulou, E | 1 |
| Blau, CA | 1 |
| Li, Q | 1 |
| Josephson, B | 1 |
| Wolf, JA | 1 |
| Fournarakis, B | 1 |
| Raisys, V | 1 |
| Dover, G | 1 |
| Papayannopoulou, T | 2 |
| Stamatoyannopoulos, G | 1 |
| Lavelle, D | 1 |
| DeSimone, J | 1 |
| Heller, P | 1 |
| Fibach, E | 2 |
| Prasanna, P | 1 |
| Rodgers, GP | 2 |
| Samid, D | 1 |
| Loukopoulos, D | 1 |
| Faller, DV | 4 |
| Perrine, SP | 4 |
| Saleh, AW | 1 |
| Hillen, HF | 1 |
| Hasegawa, S | 1 |
| Dwyer, N | 1 |
| Noguchi, CT | 1 |
| Blanchette-Mackie, EJ | 1 |
| Uyesaka, N | 1 |
| Schechter, AN | 1 |
| Swerdlow, P | 2 |
| Miller, BA | 2 |
| Bank, A | 1 |
| Sytkowski, AJ | 1 |
| Reczek, J | 2 |
| Rudolph, AM | 2 |
| Kan, YW | 2 |
| Cohen, RA | 1 |
| Vichinsky, EP | 1 |
| Hurst, D | 1 |
| Lubin, BH | 1 |
| Qin, G | 1 |
5 reviews available for butyric acid and Anemia, Sickle Cell
| Article | Year |
|---|---|
Induction of fetal hemoglobin as a novel therapeutic strategy for β-hemoglobinopathy.
Topics: Anemia, Sickle Cell; Angiogenesis Inhibitors; Animals; beta-Thalassemia; Butyric Acid; Drug Synergis | 2014 |
Fetal hemoglobin reactivation in baboon and man: a short perspective.
Topics: Anemia, Sickle Cell; Animals; Azacitidine; Butyrates; Butyric Acid; Erythropoietin; Fetal Hemoglobin | 1993 |
New therapies for the haemoglobinopathies.
Topics: Anemia, Sickle Cell; Antisickling Agents; Butyrates; Butyric Acid; Drug Therapy, Combination; Erythr | 1997 |
Butyrate in the treatment of sickle cell disease and beta-thalassemia.
Topics: Anemia, Sickle Cell; beta-Thalassemia; Butyrates; Butyric Acid; Forecasting; Gene Expression Regulat | 1995 |
Pharmacological induction of foetal haemoglobin synthesis in sickle-cell disease.
Topics: Anemia, Sickle Cell; Animals; Butyrates; Butyric Acid; Erythropoietin; Fetal Hemoglobin; Humans; Hyd | 1997 |
10 other studies available for butyric acid and Anemia, Sickle Cell
| Article | Year |
|---|---|
Development of phenotypic screening assays for γ-globin induction using primary human bone marrow day 7 erythroid progenitor cells.
Topics: Anemia, Sickle Cell; Azacitidine; Bone Marrow Cells; Butyric Acid; Cell Survival; Decitabine; DNA Mo | 2013 |
Modulation of gamma globin genes expression by histone deacetylase inhibitors: an in vitro study.
Topics: Adult; Anemia, Sickle Cell; Antigens, CD34; Butyric Acid; Carbamates; Cell Differentiation; Cells, C | 2014 |
Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells.
Topics: Adult; Anemia, Sickle Cell; Animals; Antineoplastic Agents; beta-Thalassemia; Blotting, Western; But | 2015 |
A Novel High-Content Immunofluorescence Assay as a Tool to Identify at the Single Cell Level γ-Globin Inducing Compounds.
Topics: Anemia, Sickle Cell; beta-Globins; beta-Thalassemia; Butyric Acid; Fetal Hemoglobin; gamma-Globins; | 2015 |
Stimulation of fetal hemoglobin production by short chain fatty acids.
Topics: Adult; Anemia, Sickle Cell; Animals; Anticonvulsants; Butyrates; Butyric Acid; Cells, Cultured; Epil | 1995 |
Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia.
Topics: Anemia, Sickle Cell; Azacitidine; beta-Thalassemia; Blotting, Northern; Butyrates; Butyric Acid; Cel | 1993 |
Sickling of nucleated erythroid precursors from patients with sickle cell anemia.
Topics: Anemia, Sickle Cell; Bone Marrow Cells; Butyrates; Butyric Acid; Cell Hypoxia; Cell Nucleus; Cells, | 1998 |
Stopping the biologic clock for globin gene switching.
Topics: Anemia, Sickle Cell; Animals; Biological Clocks; Butyrates; Butyric Acid; Cell Line; Cells, Cultured | 1990 |
Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia.
Topics: Anemia, Sickle Cell; Butyrates; Butyric Acid; Cells, Cultured; Child; Child, Preschool; Erythropoies | 1989 |
Butyric acid modulates developmental globin gene switching in man and sheep.
Topics: Acetylation; Adult; Anemia, Sickle Cell; Animals; Butyrates; Butyric Acid; Fetal Hemoglobin; Gene Ex | 1989 |