butyric acid has been researched along with Alzheimer Disease in 8 studies
Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Current strategies for the treatment of Alzheimer's disease (AD) focus on the pathology in the later stages of disease progression." | 1.62 | Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice. ( Jiang, Y; Li, K; Li, X; Xu, L; Yang, Z, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 6 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, C | 1 |
| Zheng, D | 1 |
| Weng, F | 1 |
| Jin, Y | 2 |
| He, L | 1 |
| Yuan, B | 1 |
| Liu, M | 1 |
| Gong, Y | 1 |
| Wang, Z | 1 |
| Jin, X | 1 |
| Xie, G | 1 |
| Zhu, M | 1 |
| Zhang, X | 1 |
| Luo, S | 1 |
| Qu, Q | 1 |
| Zhu, Y | 1 |
| Wang, M | 1 |
| Li, B | 2 |
| Wang, W | 1 |
| Gao, C | 1 |
| He, Y | 1 |
| Huang, P | 1 |
| Du, J | 1 |
| He, G | 1 |
| Zhang, P | 1 |
| Tang, H | 1 |
| Chen, S | 1 |
| Fernando, WMADB | 1 |
| Martins, IJ | 1 |
| Morici, M | 1 |
| Bharadwaj, P | 1 |
| Rainey-Smith, SR | 1 |
| Lim, WLF | 1 |
| Martins, RN | 1 |
| Kim, SY | 1 |
| Chae, CW | 1 |
| Lee, HJ | 1 |
| Jung, YH | 1 |
| Choi, GE | 1 |
| Kim, JS | 1 |
| Lim, JR | 1 |
| Lee, JE | 1 |
| Cho, JH | 1 |
| Park, H | 1 |
| Park, C | 1 |
| Han, HJ | 1 |
| Jiang, Y | 1 |
| Li, K | 1 |
| Li, X | 1 |
| Xu, L | 1 |
| Yang, Z | 1 |
| Tran, TTT | 1 |
| Corsini, S | 1 |
| Kellingray, L | 1 |
| Hegarty, C | 1 |
| Le Gall, G | 1 |
| Narbad, A | 1 |
| Müller, M | 1 |
| Tejera, N | 1 |
| O'Toole, PW | 1 |
| Minihane, AM | 1 |
| Vauzour, D | 1 |
| Cuadrado-Tejedor, M | 1 |
| Ricobaraza, AL | 1 |
| Torrijo, R | 1 |
| Franco, R | 1 |
| Garcia-Osta, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| DIetary plAnt Extracts, Colonic MicrObes, and Apoe geNetics Interactions stuDy[NCT05905822] | 64 participants (Anticipated) | Observational | 2023-06-19 | Recruiting | |||
| A Pharmacokinetic and Pharmacodynamic Study of AMX0035 in Patients With ALS[NCT04987671] | Phase 1/Phase 2 | 14 participants (Anticipated) | Interventional | 2021-08-05 | Active, not recruiting | ||
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for butyric acid and Alzheimer Disease
7 other studies available for butyric acid and Alzheimer Disease
| Article | Year |
|---|---|
Sodium butyrate ameliorates the cognitive impairment of Alzheimer's disease by regulating the metabolism of astrocytes.
Topics: Alzheimer Disease; Animals; Astrocytes; Butyric Acid; Cognitive Dysfunction; Mice; Mice, Transgenic | 2022 |
Sodium butyrate exerts antioxidant stress effects and attenuates Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Butyric Acid; Cell Survi | 2022 |
Early changes of fecal short-chain fatty acid levels in patients with mild cognitive impairments.
Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Atrophy; Butyric Acid; Caproates; Cognitive Dysf | 2023 |
Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer's Disease Transgenic Mouse Model at an Early Disease Stage.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain Chemistry; Butyric Acid; Cues; Diet; Fear; | 2020 |
Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyric Acid; Humans; Mice; NADPH Oxidase 2; NF-E | 2020 |
Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Butyric Acid; Cognitive Dysfunction; Disea | 2021 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |