butyl-meta-cycloheptylprodiginine and Staphylococcal-Infections

Biofilm is one virulence factor of bacteria. It contributes not only to bacterial adherence to many kinds of infection-establishing surfaces, but also to bacterial resistance against antimicrobial agents and antiseptic agents. Thus, inhibitors of bacterial biofilm formation should be useful in the prevention of infections. We found that a culture of Streptomyces sp. strain MC11024 showed inhibitory activity on biofilm formation by Staphylococcus aureus and isolated streptorubin B as an inhibitor of this formation in S. aureus. The biofilm formation of methicillin resistant S. aureus (MRSA) N315 was reduced to less than 30% at 1 µg/mL of streptorubin B, and at this concentration cell growth was not affected. Our study suggests that streptorubin B has the potential to be a leading compound of anti-infectious agents of S. aureus.

Topics: Anti-Bacterial Agents; Biofilms; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Interactions; Microbial Sensitivity Tests; Prodigiosin; Staphylococcal Infections; Streptomyces