Compounds > buthionine sulfoximine
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buthionine sulfoximine and Neuroblastoma

buthionine sulfoximine has been researched along with Neuroblastoma in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (12.50)18.2507
2000's21 (52.50)29.6817
2010's13 (32.50)24.3611
2020's1 (2.50)2.80

Authors

AuthorsStudies
Ishimaru, Y; Kadoi, H; Maeda, S; Motegi, T; Negoro, R; Shibagaki, F; Yamamuro, A; Yoshioka, Y1
Bothwell, AL; Dukhande, VV; Kawikova, I; Lai, JC1
Gunjima, K; Hashida, K; Hori, O; Konishi, T; Matsugo, S; Nakamura, Y; Takakura, K; Tomiyama, R; Yamada, T1
Cichon, AC; Clark, O; Di Florio, A; Jugov, R; Maeshima, R; Park, I; Rustin, S; Stoker, AW1
Anderson, CP; Bailey, HH; Groshen, S; Hasenauer, B; Maris, JM; Matthay, KK; Neglia, JP; Perentesis, JP; Reynolds, CP; Seeger, RC; Villablanca, JG1
Jamal, R; Mazlan, M; Ngah, WZ; Tan, JK; Then, SM1
Anderson, CP; Cho, H; Cohn, SL; Czarnecki, S; Goodarzian, F; Groshen, S; Hasenauer, CE; Kang, MH; Lai, H; Marachelian, A; Maris, JM; Matthay, KK; Reynolds, CP; Shimada, H; Tsao-Wei, D; Villablanca, JG; Volchenboum, SL1
Du, M; Scorsone, KA; Woodfield, SE; Zage, PE; Zhang, L1
Colla, R; De Ciucis, C; Domenicotti, C; Fenoglio, D; Furfaro, AL; Izzotti, A; Marengo, B; Passalacqua, M; Pronzato, MA; Pulliero, A; Ravera, S; Ricciarelli, R; Speciale, A; Traverso, N1
Becker, A; Soliman, KF1
Igisu, H; Sumizawa, T1
Lee, HG; Perry, G; Smith, MA; Su, B; Tabaton, M; Wang, X; Zhu, X1
Agrawal, K; George, W; Mondal, D; Petroni, D; Tsai, J1
De Ciucis, C; Domenicotti, C; Marengo, B; Marinari, UM; Nitti, M; Passalacqua, M; Pronzato, MA; Ricciarelli, R; Zingg, JM1
Bras, J; Caron, HN; Cuperus, R; Leen, R; Tytgat, GA; van Kuilenburg, AB1
Domenicotti, C; Fenoglio, D; Furfaro, AL; Macay, JR; Marengo, B; Marinari, UM; Nitti, M; Parodi, A; Pronzato, MA; Traverso, N1
Anderson, CP; Reynolds, CP1
Hashimoto, K; Iyo, M; Komatsu, N; Shimizu, E1
Cristòfol, R; Martín, M; Rodríguez-Farré, E; Sanfeliu, C; Sebastià, J1
Anderson, CP; Keshelava, N; Reynolds, CP; Yang, B1
Cottalasso, D; Domenicotti, C; Garibotto, G; Maloberti, G; Marengo, B; Marinari, UM; Melloni, E; Passalacqua, M; Patriarca, S; Poli, G; Pronzato, MA; Traverso, N; Verzola, D1
Alfaro, PA; Goto, H; Kohn, DB; Pepper, KA; Petersen, D; Reynolds, CP; Yang, B1
Esparza, A; Gallardo, V; Muñoz, P; Núñez, MT; Salazar, J; Speisky, H; Tapia, V1
Maezawa, I; Milatovic, D; Montine, KS; Montine, TJ; Nghiem, W; Vaisar, T; Woltjer, RL1
Akaike, A; Izumi, Y; Katsuki, H; Kume, T; Sawada, H; Shimohama, S; Yamamoto, N1
Daniels, CK; Dukhande, VV; Hugus, JJ; Lai, JC; Malthankar-Phatak, GH1
Frgala, T; Kalous, O; Proffitt, RT; Reynolds, CP1
Boyle, JP; Hettiarachchi, NT; Peers, C; Wilkinson, JA1
Balbis, E; Cottalasso, D; De Ciucis, C; Domenicotti, C; Marengo, B; Marinari, UM; Patriarca, S; Pistoia, V; Pronzato, MA; Raffaghello, L; Traverso, N; Verzola, D1
Balbis, E; De Ciucis, C; Domenicotti, C; Furfaro, A; Marengo, B; Marinari, UM; Nitti, M; Patriarca, S; Pronzato, MA; Traverso, N1
Jope, RS; Li, X; Song, L1
Anderson, CP; Chan, W; Forman, HJ; Lui, RM; Park, CK; Reynolds, CP; Tian, L; Tsai, J1
Anderson, CP; Forman, HJ; Liu, RM; Meek, WE; Reynolds, CP; Tang, Y; Tsai, JM1
Aschner, M; Grant, KW; Jerome, WG; Lash, LH; Lewis, DY; Stokes, AH; Vrana, KE1
Anderson, CP; Keshelava, N; Meek, WH; Reynolds, CP; Satake, N1
Anderson, CP; Bleyer, WA; Cairncross, JG; Cloughesy, T; Doolittle, ND; Eck, SL; Guastadisegni, P; Hall, WA; Muldoon, LL; Neuwelt, EA; Patel, SJ; Peereboom, D; Siegal, T1
Canals, S; Casarejos, MJ; de Bernardo, S; Handler, A; Mena, MA; Rodríguez-Martín, E1
Anderson, CP; Bailey, HH; Keshelava, N; Monforte-Munoz, HL; Reynolds, CP; Satake, N; Seeger, RC1
Busse, E; Kornhuber, B; Zimmer, G1
Bartsch, O; Busse, E; Kornhuber, B1

Trials

2 trial(s) available for buthionine sulfoximine and Neuroblastoma

ArticleYear
Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma.
    Pediatric blood & cancer, 2015, Volume: 62, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Child; Chromatography, High Pressure Liquid; Female; Glutathione; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Melphalan; Neoplasm Recurrence, Local; Neuroblastoma; Pilot Projects

2015
A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Child; Child, Preschool; Drug Synergism; Female; Glutamate-Cysteine Ligase; Glutathione; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Male; Melphalan; Myeloablative Agonists; Neoplasm Recurrence, Local; Neuroblastoma

2016

Other Studies

38 other study(ies) available for buthionine sulfoximine and Neuroblastoma

ArticleYear
Noradrenaline protects neurons against H
    Journal of neuroscience research, 2021, Volume: 99, Issue:2

    Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-3 Receptor Antagonists; Animals; Astrocytes; Astrocytoma; Brain; Buthionine Sulfoximine; Cell Line, Tumor; Coculture Techniques; Dioxoles; Glutathione; Humans; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Neuroblastoma; Neurons; Neuroprotective Agents; Norepinephrine; Oxidative Stress; Propanolamines; Propionates; Quinolines; Receptors, Adrenergic, beta-3

2021
Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione.
    Apoptosis : an international journal on programmed cell death, 2013, Volume: 18, Issue:6

    Topics: Apoptosis; Azoles; bcl-2-Associated X Protein; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Coculture Techniques; Cytochromes c; Cytosol; Ethacrynic Acid; Glioblastoma; Glutathione; Humans; Isoindoles; Mitochondria; Neuroblastoma; Neurons; Organoselenium Compounds; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species

2013
3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway.
    Journal of cellular biochemistry, 2014, Volume: 115, Issue:1

    Topics: Buthionine Sulfoximine; Caffeic Acids; Cell Line, Tumor; Dose-Response Relationship, Drug; Glutathione; Humans; Neuroblastoma; Neuroprotective Agents; Neurotoxins; NF-E2-Related Factor 2; Oxidative Stress; Oxidopamine; Parkinson Disease; Protein Transport; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species

2014
Oxovanadium-based inhibitors can drive redox-sensitive cytotoxicity in neuroblastoma cells and synergise strongly with buthionine sulfoximine.
    Cancer letters, 2015, Feb-01, Volume: 357, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Cell Line, Tumor; Drug Synergism; Fibroblasts; Humans; Mice; Neuroblastoma; Oxidation-Reduction; Pyrones; Signal Transduction; Transfection; Vanadates

2015
Vitamin E, γ-tocotrienol, Protects Against Buthionine Sulfoximine-Induced Cell Death by Scavenging Free Radicals in SH-SY5Y Neuroblastoma Cells.
    Nutrition and cancer, 2016, Volume: 68, Issue:3

    Topics: Antioxidants; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Chromans; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Humans; Imidazoles; MAP Kinase Signaling System; Neuroblastoma; Protective Agents; Protein Kinase C-delta; Pyridines; Reactive Oxygen Species; Vitamin E

2016
Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine.
    Scientific reports, 2016, 06-10, Volume: 6

    Topics: Apoptosis; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Drug Synergism; Humans; Neuroblastoma; Nifurtimox; Phosphorylation; Signal Transduction

2016
Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma.
    Oncotarget, 2016, Oct-25, Volume: 7, Issue:43

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Buthionine Sulfoximine; Catalase; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Glutathione; Humans; Hydrogen Peroxide; Lipid Peroxidation; Neuroblastoma; Topoisomerase II Inhibitors; Up-Regulation

2016
The role of intracellular glutathione in inorganic mercury-induced toxicity in neuroblastoma cells.
    Neurochemical research, 2009, Volume: 34, Issue:9

    Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Cytoprotection; Glutamate-Cysteine Ligase; Glutathione; Mercuric Chloride; Mercury Poisoning; Mice; Neuroblastoma; Sulfhydryl Compounds

2009
Suppression of acrylamide toxicity by carboxyfullerene in human neuroblastoma cells in vitro.
    Archives of toxicology, 2009, Volume: 83, Issue:9

    Topics: Acrylamide; Antineoplastic Agents; Buthionine Sulfoximine; Carboxylic Acids; Caspase 3; Cell Line, Tumor; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Fullerenes; G1 Phase; Glutathione; Humans; L-Lactate Dehydrogenase; Nanoparticles; Neuroblastoma; Neurons; Particle Size

2009
Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells.
    Neuroscience letters, 2010, Jan-14, Volume: 468, Issue:3

    Topics: Buthionine Sulfoximine; Cell Line, Tumor; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Neuroblastoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Phosphatase 2; tau Proteins

2010
Low-dose methylmercury-induced oxidative stress, cytotoxicity, and tau-hyperphosphorylation in human neuroblastoma (SH-SY5Y) cells.
    Environmental toxicology, 2012, Volume: 27, Issue:9

    Topics: Acetylcysteine; Antioxidants; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Dipeptides; Glutathione; Humans; Methylmercury Compounds; Mitochondria; Neuroblastoma; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; tau Proteins

2012
PKCδ sensitizes neuroblastoma cells to L-buthionine-sulfoximine and etoposide inducing reactive oxygen species overproduction and DNA damage.
    PloS one, 2011, Feb-07, Volume: 6, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Buthionine Sulfoximine; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Etoposide; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Neuroblastoma; Onium Compounds; Protein Kinase C-delta; Reactive Oxygen Species; RNA, Small Interfering; Transfection; Tumor Cells, Cultured

2011
Promising effects of the 4HPR-BSO combination in neuroblastoma monolayers and spheroids.
    Free radical biology & medicine, 2011, Sep-15, Volume: 51, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Buthionine Sulfoximine; Cell Line; Drug Synergism; Fenretinide; Glutathione; Growth Inhibitors; Humans; Neuroblastoma; Reactive Oxygen Species; Spheroids, Cellular

2011
Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1.
    Free radical biology & medicine, 2012, Jan-15, Volume: 52, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Etoposide; Gene Expression; Gene Knockdown Techniques; Glutamate-Cysteine Ligase; Glutathione; Heme Oxygenase-1; Humans; Neuroblastoma; NF-E2-Related Factor 2; Oxidative Stress; Protoporphyrins; Reactive Nitrogen Species; Reactive Oxygen Species

2012
Synergistic cytotoxicity of buthionine sulfoximine (BSO) and intensive melphalan (L-PAM) for neuroblastoma cell lines established at relapse after myeloablative therapy.
    Bone marrow transplantation, 2002, Volume: 30, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Glutathione; Humans; Melphalan; Myeloablative Agonists; Neuroblastoma; Recurrence; Tumor Cells, Cultured

2002
Roles of endogenous glutathione levels on 6-hydroxydopamine-induced apoptotic neuronal cell death in human neuroblastoma SK-N-SH cells.
    Neuropharmacology, 2002, Volume: 43, Issue:3

    Topics: Acetylcysteine; Apoptosis; Benzimidazoles; Brain Neoplasms; Buthionine Sulfoximine; Cystine; DNA Fragmentation; Fluorescent Dyes; Free Radical Scavengers; Glutathione; Humans; Neuroblastoma; Neurons; Oxidopamine; Sympatholytics; Tumor Cells, Cultured

2002
Evaluation of fluorescent dyes for measuring intracellular glutathione content in primary cultures of human neurons and neuroblastoma SH-SY5Y.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2003, Volume: 51, Issue:1

    Topics: Antioxidants; Biological Assay; Bridged Bicyclo Compounds; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Coumarins; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Glutathione; Humans; Neuroblastoma; Neurons; Oxidative Stress; Pyrazoles; Reproducibility of Results

2003
Antagonism of buthionine sulfoximine cytotoxicity for human neuroblastoma cell lines by hypoxia is reversed by the bioreductive agent tirapazamine.
    Cancer research, 2003, Apr-01, Volume: 63, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Buthionine Sulfoximine; Cell Hypoxia; Drug Synergism; Glutathione; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Neuroblastoma; Oxygen; Reactive Oxygen Species; Tirapazamine; Triazines; Tumor Cells, Cultured

2003
Role of PKC-delta activity in glutathione-depleted neuroblastoma cells.
    Free radical biology & medicine, 2003, Sep-01, Volume: 35, Issue:5

    Topics: Acetophenones; Antioxidants; Apoptosis; Ascorbic Acid; Benzopyrans; Buthionine Sulfoximine; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Glutathione; Humans; Malondialdehyde; Neuroblastoma; Oxidation-Reduction; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured

2003
Transduction of green fluorescent protein increased oxidative stress and enhanced sensitivity to cytotoxic drugs in neuroblastoma cell lines.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; B7-1 Antigen; Buthionine Sulfoximine; Carboplatin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Glutathione; Green Fluorescent Proteins; Humans; Lentivirus; Luminescent Proteins; Melphalan; Mutation; Neuroblastoma; Oxidative Stress; Transduction, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2003
Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells.
    Free radical biology & medicine, 2004, Oct-01, Volume: 37, Issue:7

    Topics: Buthionine Sulfoximine; Cell Line, Tumor; Glutathione; Humans; Iron; Neuroblastoma; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Substantia Nigra

2004
Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity.
    Journal of neurochemistry, 2005, Volume: 93, Issue:4

    Topics: alpha-Tocopherol; Amyloid beta-Protein Precursor; Analysis of Variance; Antioxidants; Blotting, Western; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; F2-Isoprostanes; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Neuroblastoma; Peptide Fragments; Protein Synthesis Inhibitors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetracycline; Tetrazolium Salts; Thiazoles; Time Factors; Tocopherols

2005
Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells.
    Journal of neuroscience research, 2005, Oct-01, Volume: 82, Issue:1

    Topics: Acetylcysteine; Analysis of Variance; Area Under Curve; Buthionine Sulfoximine; Catalase; Cell Death; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Cystine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Indolequinones; Iron; Melanins; Models, Biological; Neuroblastoma; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Time Factors

2005
Manganese-induced neurotoxicity is differentially enhanced by glutathione depletion in astrocytoma and neuroblastoma cells.
    Neurochemical research, 2006, Volume: 31, Issue:11

    Topics: Antimetabolites; Astrocytoma; Brain Neoplasms; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Glutathione; Humans; Manganese Poisoning; Nerve Degeneration; Neuroblastoma

2006
A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Cell Proliferation; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Eosine Yellowish-(YS); Fenretinide; Fluorescent Dyes; Humans; Leukemia; Melphalan; Microscopy, Fluorescence; Neuroblastoma; Protein Kinase C; Sphingosine; Tumor Cells, Cultured; Tumor Stem Cell Assay

2007
Hypoxic remodelling of Ca2+signalling in SH-SY5Y cells: influence of glutathione.
    Neuroreport, 2007, Jul-02, Volume: 18, Issue:10

    Topics: Bradykinin; Buthionine Sulfoximine; Calcium Signaling; Carmustine; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Humans; Hypoxia; Neuroblastoma

2007
Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma.
    Free radical biology & medicine, 2008, Feb-01, Volume: 44, Issue:3

    Topics: Acetophenones; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Ascorbic Acid; Benzopyrans; Biphenyl Compounds; Buthionine Sulfoximine; Calpain; Caspases; Catalase; Cell Line, Tumor; DNA Damage; Glutathione; Humans; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Onium Compounds; Protein Kinase C; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1

2008
GSH loss per se does not affect neuroblastoma survival and is not genotoxic.
    International journal of oncology, 2008, Volume: 32, Issue:1

    Topics: Buthionine Sulfoximine; Cell Line, Tumor; Glutathione; Glutathione Disulfide; Heme Oxygenase-1; Humans; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Reactive Oxygen Species

2008
Glutathione depletion exacerbates impairment by oxidative stress of phosphoinositide hydrolysis, AP-1, and NF-kappaB activation by cholinergic stimulation.
    Brain research. Molecular brain research, 1998, Volume: 53, Issue:1-2

    Topics: Analysis of Variance; Base Sequence; Binding Sites; Buthionine Sulfoximine; Carbachol; Consensus Sequence; Diamide; Glutathione; GTP-Binding Proteins; Humans; Hydrogen Peroxide; Ionomycin; Neuroblastoma; NF-kappa B; Oligodeoxyribonucleotides; Oxidative Stress; Phosphatidylinositols; Second Messenger Systems; Sodium Fluoride; Transcription Factor AP-1; Tumor Cells, Cultured; Vanadates

1998
Buthionine sulphoximine alone and in combination with melphalan (L-PAM) is highly cytotoxic for human neuroblastoma cell lines.
    European journal of cancer (Oxford, England : 1990), 1997, Volume: 33, Issue:12

    Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Buthionine Sulfoximine; Drug Screening Assays, Antitumor; Drug Synergism; Glutathione; Humans; Melphalan; Neuroblastoma; Tumor Cells, Cultured

1997
Depletion of glutathione by buthionine sulfoxine is cytotoxic for human neuroblastoma cell lines via apoptosis.
    Experimental cell research, 1999, Jan-10, Volume: 246, Issue:1

    Topics: Antioxidants; Apoptosis; Ascorbic Acid; Buthionine Sulfoximine; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Gene Amplification; Genes, myc; Glutathione; Humans; In Situ Nick-End Labeling; Inhibitory Concentration 50; Neuroblastoma; Reactive Oxygen Species; Time Factors; Tumor Cells, Cultured; Vitamin E

1999
Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis.
    Brain research, 2000, Mar-06, Volume: 858, Issue:1

    Topics: Apoptosis; Ascorbic Acid; Biological Assay; Buthionine Sulfoximine; Cell Membrane; Chromatography, High Pressure Liquid; DNA Fragmentation; Dopamine; Drug Synergism; Glutathione; Humans; Manganese; Microscopy, Electron, Scanning; Neuroblastoma; Oxidative Stress; Pyruvic Acid; Tumor Cells, Cultured

2000
Synergism of buthionine sulfoximine and melphalan against neuroblastoma cell lines derived after disease progression.
    Medical and pediatric oncology, 2000, Volume: 35, Issue:6

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Buthionine Sulfoximine; Child; Disease Progression; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Melphalan; Neuroblastoma; Tumor Cells, Cultured

2000
Importance of dose intensity in neuro-oncology clinical trials: summary report of the Sixth Annual Meeting of the Blood-Brain Barrier Disruption Consortium.
    Neuro-oncology, 2001, Volume: 3, Issue:1

    Topics: Adult; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Bone Marrow Diseases; Bone Marrow Transplantation; Brain Neoplasms; Buthionine Sulfoximine; Child; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Drug; Drug Synergism; Genetic Therapy; Genetic Vectors; Glioma; Glutathione; Guinea Pigs; Hearing Loss, Sensorineural; Hematopoietic Stem Cell Transplantation; Humans; Hypertonic Solutions; Lymphoma, Non-Hodgkin; Meningeal Neoplasms; Multicenter Studies as Topic; Neuroblastoma; Oligodendroglioma; Permeability; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome

2001
L-DOPA and glia-conditioned medium have additive effects on tyrosine hydroxylase expression in human catecholamine-rich neuroblastoma NB69 cells.
    Journal of neurochemistry, 2001, Volume: 78, Issue:3

    Topics: Antioxidants; Apoptosis; Ascorbic Acid; bcl-X Protein; Buthionine Sulfoximine; Carbidopa; Cell Differentiation; Culture Media, Conditioned; Culture Media, Serum-Free; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Humans; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Levodopa; Neuroblastoma; Neuroglia; Neurons; Proto-Oncogene Proteins c-bcl-2; Time Factors; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase

2001
Buthionine sulfoximine and myeloablative concentrations of melphalan overcome resistance in a melphalan-resistant neuroblastoma cell line.
    Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:8

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Buthionine Sulfoximine; Cell Survival; Child; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Glutathione; Humans; Melphalan; Neuroblastoma; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured

2001
[Plasma-membrane fluidity studies of murine neuroblastoma and malignant melanoma cells under irradiation].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1992, Volume: 168, Issue:7

    Topics: Animals; Buthionine Sulfoximine; Cell Cycle; Cell Survival; Dose-Response Relationship, Radiation; Glutathione; Melanoma, Experimental; Membrane Fluidity; Methionine Sulfoximine; Mice; Neuroblastoma; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Tamoxifen; Tumor Cells, Cultured

1992
Non-myelotoxic antitumour effects of L-dopa, buthionine sulphoximine and tamoxifen on neuroblastoma cells in vitro and in vivo.
    Journal of cancer research and clinical oncology, 1991, Volume: 117, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Survival; Cyclic AMP; Glutathione; Humans; Levodopa; Male; Methionine Sulfoximine; Mice; Mice, Nude; Monophenol Monooxygenase; Neuroblastoma; Tamoxifen; Tumor Cells, Cultured

1991