Page last updated: 2024-08-22

buthionine sulfoximine and Neoplasms

buthionine sulfoximine has been researched along with Neoplasms in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19908 (18.60)18.7374
1990's10 (23.26)18.2507
2000's9 (20.93)29.6817
2010's10 (23.26)24.3611
2020's6 (13.95)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Jia, Q; Li, J; Qiao, C; Wang, X; Wang, Z; Xiao, H; Yang, Y; Yang, Z; Yu, J; Zhang, R; Zhou, B1
Chen, Z; Jia, Q; Liu, X; Pu, K; Qiao, C; Wang, X; Wang, Z; Yang, Z; Zhang, R1
Anraku, Y; Ikoma, T; Nakagawa, Y; Quindoza, GM1
Jia, Q; Liu, G; Liu, X; Ning, P; Qiao, C; Rao, Z; Wang, L; Wang, Z; Xia, Y; Yang, P; Zhang, R; Zhang, X; Zhu, Y1
Barros Ibiapina, A; Carneiro da Silva, FC; de Castro E Sousa, JM; Dos Reis Oliveira, C; Ferreira, PMP; Pereira, JC; Roseno Martins, IR1
Gong, S; Hu, Y; Lu, M; Luo, Y; Ma, XN; Tian, J; Wu, Y; Xu, Z; Yu, BY; Yu, XA; Zhang, Y1
De Ridder, M; Jiang, H; Wang, H1
Floberg, JM; Schwarz, JK1
Jung, CL; Kim, HJ; Kim, JS; Kong, AN; Lee, CH; Park, JH1
Aldrich-Wright, JR; Garbutcheon-Singh, KB; Harper, BW; Myers, S1
Boix, J; Mattiolo, P; Ribas, J1
Dvořák, Z; Kašpárková, J; Prachařová, J; Radošová-Muchová, T; Štarha, P; Trávníček, Z; Vančo, J1
Kuppusamy, P; Rivera, BK; Vikram, DS1
Akitaya, T; Kamiie, K; Kidachi, Y; Noshita, T; Ryoyama, K; Umetsu, H; Yamaguchi, H; Yoshida, K; Yu, T1
Aykin-Burns, N; Coleman, MC; Dayal, D; Domann, FE; Owens, KM; Spitz, DR1
Ardail, D; Beuve, M; Boivin, A; Colliaux, A; Douki, T; Foray, N; Hanot, M; Malésys, C; Rodriguez-Lafrasse, C1
Batist, G; Fotouhi-Ardakani, N; Hamilton, D1
Hori, S; Kakehi, Y; Kakizuka, A; Maeda, H; Ogawa, O; Ohizumi, H; Segawa, T1
Renschler, MF1
Barbacioru, C; Dai, Z; Huang, Y; Sadée, W1
Engel, RH; Evens, AM1
Estrela, JM; Obrador, E; Ortega, A1
Giovannini, C; Grande, S; Guidoni, L; Luciani, AM; Palma, A; Rosi, A; Sapora, O; Viti, V1
Adams, GE1
Brennan, J; Gallo, JM; Halbherr, T; Hamilton, TC; Laub, PB; O'Dwyer, PJ; Ozols, RF1
Eady, JJ; Orta, T; Peacock, JH; Steel, GG1
Godwin, AK; Hamilton, TC; O'Dwyer, PJ; Ozols, RF; Yao, K1
Alberti, D; Arzoomanian, RZ; Bailey, HH; Mulcahy, RT; Pomplun, M; Spriggs, DR; Tombes, MB; Tutsch, KD; Wilding, G1
Bookman, MA; Brennan, J; Comis, RL; Gallo, JM; Halbherr, T; Hamilton, TC; Hoffman, J; Kilpatrick, D; LaCreta, FP; O'Dwyer, PJ; Ozols, RF; Young, RC1
Alberti, D; Arzoomanian, RZ; Bailey, HH; Feierabend, C; Mahvi, D; Mulcahy, RT; Pomplun, M; Ripple, G; Schink, J; Tutsch, KD; Wilding, G1
Calvert, P; Hamilton, TC; O'Dwyer, PJ; Yao, KS1
Bailey, HH1
Batist, G; Carystinos, GD; Chen, X1
Carp, N; Comis, RL; Hamilton, TC; LaCreta, FP; O'Dwyer, PJ; Ozols, RF; Padavic, K; Tew, KD; Young, RC1
DeGraff, W; Friedman, N; Mitchell, JB; Russo, A1
Cook, JA; DeGraff, W; Glatstein, E; Mitchell, JB; Russo, A1
Evans, WK; Stewart, DJ1
Glatstein, E; Kinsella, TJ; Mitchell, JB; Russo, A1
Dorr, RT; Liddil, JD; Soble, MJ1
Guichard, M; Lespinasse, F; Malaise, EP1
Astromoff, A; Harris, JW; Li, GC; Shrieve, DC1
Chew, EH; Holmgren, A; Lu, J1

Reviews

12 review(s) available for buthionine sulfoximine and Neoplasms

ArticleYear
Buthionine sulfoximine and chemoresistance in cancer treatments: a systematic review with meta-analysis of preclinical studies.
    Journal of toxicology and environmental health. Part B, Critical reviews, 2023, 11-17, Volume: 26, Issue:8

    Topics: Antineoplastic Agents; Buthionine Sulfoximine; Drug Resistance, Neoplasm; Humans; Methionine Sulfoximine; Neoplasms

2023
Targeting antioxidant enzymes as a radiosensitizing strategy.
    Cancer letters, 2018, 12-01, Volume: 438

    Topics: Antioxidants; Buthionine Sulfoximine; Glutathione; Homeostasis; Humans; Models, Biological; Neoplasms; Radiation-Sensitizing Agents; Reactive Oxygen Species; Superoxide Dismutase

2018
Manipulation of Glucose and Hydroperoxide Metabolism to Improve Radiation Response.
    Seminars in radiation oncology, 2019, Volume: 29, Issue:1

    Topics: Animals; Auranofin; Buthionine Sulfoximine; Deoxyglucose; Glucose; Glycolysis; Humans; Hydrogen Peroxide; Neoplasms; Oxidation-Reduction; Oxidative Stress; Radiation-Sensitizing Agents

2019
The glutathione system in alkylator resistance.
    Cancer treatment and research, 2002, Volume: 112

    Topics: Alkylating Agents; Anticarcinogenic Agents; Buthionine Sulfoximine; Enzyme Inhibitors; Ethacrynic Acid; Glutamate-Cysteine Ligase; Glutathione; Glutathione Synthase; Humans; Neoplasms; Pyrazines; Thiones; Thiophenes

2002
The emerging role of reactive oxygen species in cancer therapy.
    European journal of cancer (Oxford, England : 1990), 2004, Volume: 40, Issue:13

    Topics: Antineoplastic Agents; Buthionine Sulfoximine; Combined Modality Therapy; DNA; Humans; Metalloporphyrins; Neoplasms; Oxidation-Reduction; Procarbazine; Reactive Oxygen Species

2004
Oxidative stress and apoptosis: a new treatment paradigm in cancer.
    Frontiers in bioscience : a journal and virtual library, 2006, Jan-01, Volume: 11

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Buthionine Sulfoximine; Cell Death; Dose-Response Relationship, Drug; Glutathione; Hexanones; Humans; Metalloporphyrins; Models, Biological; Models, Chemical; Neoplasms; Oxidation-Reduction; Oxidative Stress; Oxides; Reactive Oxygen Species

2006
Glutathione in cancer biology and therapy.
    Critical reviews in clinical laboratory sciences, 2006, Volume: 43, Issue:2

    Topics: Animals; Apoptosis; Buthionine Sulfoximine; Genes, bcl-2; Glutathione; Humans; Neoplasm Metastasis; Neoplasms

2006
Clinical studies of reversal of drug resistance based on glutathione.
    Chemico-biological interactions, 1998, Apr-24, Volume: 111-112

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Clinical Trials as Topic; Drug Resistance; Female; Glutathione; Humans; Male; Melphalan; Neoplasms

1998
Potential for selective modulation of glutathione in cancer chemotherapy.
    Chemico-biological interactions, 1998, Apr-24, Volume: 111-112

    Topics: Animals; Buthionine Sulfoximine; Cell Communication; Drug Resistance; Enzyme Inhibitors; Female; Gap Junctions; Glutamate-Cysteine Ligase; Glutathione; Humans; Mammary Neoplasms, Experimental; Neoplasms; Prodrugs; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines

1998
Glutathione modulation in cancer treatment: will it work?
    International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:5

    Topics: Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Glutathione; Humans; Methionine Sulfoximine; Neoplasms; Radiation-Sensitizing Agents

1989
Non-chemotherapeutic agents that potentiate chemotherapy efficacy.
    Cancer treatment reviews, 1989, Volume: 16, Issue:1

    Topics: Adult; Amphotericin B; Animals; Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Calcium Channel Blockers; Calmodulin; Cardiotonic Agents; Child; Clinical Trials as Topic; Dipyridamole; Drug Evaluation; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Methionine Sulfoximine; Mice; Neoplasms; Nitroimidazoles; Xanthines

1989
The use of non-hypoxic cell sensitizers in radiobiology and radiotherapy.
    International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:8

    Topics: Animals; Bromodeoxyuridine; Buthionine Sulfoximine; Cell Survival; Cricetinae; Diamide; DNA Repair; Glutathione; Humans; Idoxuridine; In Vitro Techniques; Methionine Sulfoximine; Neoplasms; Radiation-Sensitizing Agents

1986

Trials

6 trial(s) available for buthionine sulfoximine and Neoplasms

ArticleYear
Time-dependent pharmacodynamic models in cancer chemotherapy: population pharmacodynamic model for glutathione depletion following modulation by buthionine sulfoximine (BSO) in a Phase I trial of melphalan and BSO.
    Cancer research, 1995, Oct-15, Volume: 55, Issue:20

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Enzyme Inhibitors; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Neoplasms; Neutrophils

1995
Variable baseline gamma-glutamylcysteine synthetase messenger RNA expression in peripheral mononuclear cells of cancer patients, and its induction by buthionine sulfoximine treatment.
    Cancer research, 1993, Aug-15, Volume: 53, Issue:16

    Topics: Adult; Antimetabolites, Antineoplastic; Base Sequence; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutamate-Cysteine Ligase; Humans; Male; Methionine Sulfoximine; Molecular Sequence Data; Neoplasms; Polymerase Chain Reaction; RNA, Messenger

1993
Phase I clinical trial of intravenous L-buthionine sulfoximine and melphalan: an attempt at modulation of glutathione.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Female; Glutathione; Humans; Infusions, Intravenous; Male; Melphalan; Methionine Sulfoximine; Middle Aged; Neoplasms

1994
Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Glutathione; Humans; Linear Models; Male; Melphalan; Methionine Sulfoximine; Middle Aged; Nausea; Neoplasm Recurrence, Local; Neoplasms; Neutropenia; Neutrophils; Radiography; Vomiting

1996
Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan.
    Journal of the National Cancer Institute, 1997, Dec-03, Volume: 89, Issue:23

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Drug Administration Schedule; Female; Glutathione; Humans; Infusions, Intravenous; Lymphocytes; Male; Melphalan; Middle Aged; Neoplasms; Treatment Outcome

1997
Non-chemotherapeutic agents that potentiate chemotherapy efficacy.
    Cancer treatment reviews, 1989, Volume: 16, Issue:1

    Topics: Adult; Amphotericin B; Animals; Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Calcium Channel Blockers; Calmodulin; Cardiotonic Agents; Child; Clinical Trials as Topic; Dipyridamole; Drug Evaluation; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Methionine Sulfoximine; Mice; Neoplasms; Nitroimidazoles; Xanthines

1989

Other Studies

26 other study(ies) available for buthionine sulfoximine and Neoplasms

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
A Potent Strategy of Combinational Blow Toward Enhanced Cancer Chemo-Photodynamic Therapy via Sustainable GSH Elimination.
    Small (Weinheim an der Bergstrasse, Germany), 2022, Volume: 18, Issue:9

    Topics: Buthionine Sulfoximine; Glutathione; Humans; Neoplasms; Photochemotherapy; Reactive Oxygen Species

2022
Redox dyshomeostasis modulation of the tumor intracellular environment through a metabolic intervention strategy for enhanced photodynamic therapy.
    Theranostics, 2022, Volume: 12, Issue:14

    Topics: Buthionine Sulfoximine; Cell Line, Tumor; Glutathione; Humans; Hypoxia; Lipids; Metal-Organic Frameworks; Metformin; Neoplasms; Oxidation-Reduction; Photochemotherapy; Photosensitizing Agents; Singlet Oxygen

2022
Adsorption of l-buthionine sulfoximine on Bi(III) and Eu(III) co-substituted hydroxyapatite nanocrystals for enhancing radiosensitization effects.
    Colloids and surfaces. B, Biointerfaces, 2023, Volume: 228

    Topics: Adsorption; Buthionine Sulfoximine; Durapatite; Glutathione; Humans; Ions; Methionine Sulfoximine; Nanoparticles; Neoplasms

2023
Iron-based metal-organic framework co-loaded with buthionine sulfoximine and oxaliplatin for enhanced cancer chemo-ferrotherapy via sustainable glutathione elimination.
    Journal of nanobiotechnology, 2023, Aug-10, Volume: 21, Issue:1

    Topics: Animals; Buthionine Sulfoximine; Glutathione; Humans; Metal-Organic Frameworks; Mice; Neoplasms; Oxaliplatin

2023
A cancer-specific activatable theranostic nanodrug for enhanced therapeutic efficacy via amplification of oxidative stress.
    Theranostics, 2020, Volume: 10, Issue:1

    Topics: Animals; Artemisinins; Buthionine Sulfoximine; Drug Carriers; Female; Glutathione; Hep G2 Cells; Humans; Liposomes; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms; Oxidation-Reduction; Oxidative Stress; Precision Medicine; Reactive Oxygen Species; Transferrin

2020
Synergistic activation of the Nrf2-signaling pathway by glyceollins under oxidative stress induced by glutathione depletion.
    Journal of agricultural and food chemistry, 2013, May-01, Volume: 61, Issue:17

    Topics: Animals; Anticarcinogenic Agents; Antioxidants; Buthionine Sulfoximine; Cell Line; Genes, Reporter; Glutamate-Cysteine Ligase; Glutathione; Glycine max; Hep G2 Cells; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Mice; Neoplasms; NF-E2-Related Factor 2; Oxidative Stress; Phytochemicals; Pterocarpans; Signal Transduction

2013
Combination studies of platinum(II)-based metallointercalators with buthionine-S,R-sulfoximine, 3-bromopyruvate, cisplatin or carboplatin.
    Metallomics : integrated biometal science, 2014, Volume: 6, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Carboplatin; Cell Line; Cell Line, Tumor; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Organoplatinum Compounds; Platinum; Pyruvates

2014
Pharmacological modulation of reactive oxygen species in cancer treatment.
    Current drug targets, 2015, Volume: 16, Issue:1

    Topics: Antineoplastic Agents; Buthionine Sulfoximine; Drug Discovery; Gene Expression Regulation, Neoplastic; Humans; Mitochondrial Dynamics; Neoplasms; Oxidative Stress; Reactive Oxygen Species; Sulfonamides; Tumor Suppressor Protein p53

2015
Potentiating effect of UVA irradiation on anticancer activity of Carboplatin derivatives involving 7-azaindoles.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Antineoplastic Agents; Buthionine Sulfoximine; Carboplatin; Cell Line, Tumor; Cell Survival; DNA Adducts; DNA Breaks, Double-Stranded; Drug Synergism; Humans; Indoles; Molecular Structure; Neoplasms; Nucleic Acid Conformation; Proton Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Ultraviolet Rays

2015
In vivo imaging of free radicals and oxygen.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 610

    Topics: Animals; Antimetabolites, Antineoplastic; Brain; Buthionine Sulfoximine; Carbon Dioxide; Electron Spin Resonance Spectroscopy; Female; Free Radicals; Humans; Hypoxia; Image Processing, Computer-Assisted; Molecular Structure; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Neoplasms; Nitric Oxide; Oxidation-Reduction; Oximetry; Oxygen; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Skin

2010
Selective toxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells is potentially attributed to downregulation of glutathione.
    Biochimie, 2011, Volume: 93, Issue:7

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Acetylcysteine; Animals; Anti-Inflammatory Agents; Buthionine Sulfoximine; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Free Radical Scavengers; Glutathione; Glycyrrhetinic Acid; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Neoplasms; Oxidation-Reduction; Protein Binding; Protein Conformation; Reactive Oxygen Species; Up-Regulation

2011
Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2.
    Free radical biology & medicine, 2012, Jan-01, Volume: 52, Issue:1

    Topics: Animals; Buthionine Sulfoximine; Catalase; Cell Transformation, Neoplastic; Cricetinae; Fibroblasts; Gene Expression; Genomic Instability; Glutathione; Humans; Hydrogen Peroxide; Mutagenesis, Site-Directed; Mutation Rate; Neoplasms; Plasmids; Point Mutation; Polyethylene Glycols; Protein Subunits; Succinate Dehydrogenase; Superoxide Dismutase; Superoxides; Transfection

2012
Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Buthionine Sulfoximine; Carbon; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Chromosomes, Human; Clone Cells; Cluster Analysis; Dimethyl Fumarate; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Damage; Fumarates; Gene Rearrangement; Glutathione; Histones; Humans; Ions; Kinetics; Micronucleus Tests; Neoplasms; Radiation; X-Rays

2012
Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine.
    Cell death and differentiation, 2004, Volume: 11, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Buthionine Sulfoximine; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Glutathione; HeLa Cells; Humans; Hydrogen Peroxide; Male; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Oxides; Prostatic Neoplasms; Reactive Oxygen Species; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2004
Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance.
    Cancer research, 2005, Aug-15, Volume: 65, Issue:16

    Topics: Amino Acid Transport System y+; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Line, Tumor; Cystine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glutathione; Humans; Neoplasms; RNA, Small Interfering

2005
Metabolism of glutathione in tumour cells as evidenced by 1H MRS.
    FEBS letters, 2007, Feb-20, Volume: 581, Issue:4

    Topics: Buthionine Sulfoximine; Cell Line, Tumor; Cysteine; Glutamic Acid; Glutathione; Humans; Magnetic Resonance Spectroscopy; Neoplasms; Protons; Time Factors

2007
Radiosensitizers: a conference preview.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8

    Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1984
Glutathione manipulation and the radiosensitivity of human tumour and fibroblast cell lines.
    International journal of radiation biology, 1995, Volume: 68, Issue:4

    Topics: Buthionine Sulfoximine; Fibroblasts; Glutathione; Humans; Methionine Sulfoximine; Neoplasms; Radiation Tolerance; Tumor Cells, Cultured

1995
L-S,R-buthionine sulfoximine: historical development and clinical issues.
    Chemico-biological interactions, 1998, Apr-24, Volume: 111-112

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Drug Resistance; Enzyme Inhibitors; Female; Glutamate-Cysteine Ligase; History, 20th Century; Humans; Male; Melphalan; Neoplasms

1998
Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results.
    Journal of the National Cancer Institute, 1992, Feb-19, Volume: 84, Issue:4

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Middle Aged; Neoplasms

1992
Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs.
    Cancer research, 1986, Volume: 46, Issue:6

    Topics: Antineoplastic Agents; Bleomycin; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cisplatin; Glutathione; Humans; Lung; Lung Neoplasms; Melphalan; Methionine Sulfoximine; Neoplasms; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Zinostatin

1986
Cytotoxic effects of glutathione synthesis inhibition by L-buthionine-(SR)-sulfoximine on human and murine tumor cells.
    Investigational new drugs, 1986, Volume: 4, Issue:4

    Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Female; Glutathione; Humans; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasms; Sulfhydryl Compounds

1986
Influence of buthionine sulfoximine and misonidazole on glutathione level and radiosensitivity of human tumor xenografts.
    Radiation research, 1986, Volume: 105, Issue:1

    Topics: Adenocarcinoma; Animals; Buthionine Sulfoximine; Cell Line; Colonic Neoplasms; Female; Glutathione; Humans; Melanoma; Methionine Sulfoximine; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Radiation Tolerance; Transplantation, Heterologous

1986
Cellular glutathione, thermal sensitivity, and thermotolerance in Chinese hamster fibroblasts and their heat-resistant variants.
    Cancer research, 1986, Volume: 46, Issue:4 Pt 1

    Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Fibroblasts; Glutathione; Hot Temperature; Hyperthermia, Induced; Methionine Sulfoximine; Neoplasms; Time Factors

1986
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Jul-24, Volume: 104, Issue:30

    Topics: Amino Acid Sequence; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Glutathione; Humans; Molecular Sequence Data; Neoplasms; Oxidation-Reduction; Oxides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thioredoxin-Disulfide Reductase

2007