Compounds > buthionine sulfoximine
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buthionine sulfoximine and Breast Cancer

buthionine sulfoximine has been researched along with Breast Cancer in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.13)18.7374
1990's15 (46.88)18.2507
2000's7 (21.88)29.6817
2010's9 (28.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Falls, KC; Fath, MA; Klinger, AR; Rodman, SN; Ross, NL; Schoenfeld, JD; Sciegienka, SJ; Solst, SR; Spitz, DR1
Berger, T; Cappello, P; Cescon, DW; Chu, MF; Duncan, G; Garcia-Valero, M; Gorrini, C; Hodgson, K; Jafari, SM; Mak, TW; McGaha, TL; Palomero, L; Pujana, MA; Roux, C; Shinde, R; Silvester, J; Wakeham, A1
Barozzi, I; Botrugno, OA; Bucci, G; Chiaradonna, F; Chiocca, S; Di Fiore, PP; Draetta, G; Fantin, VR; Fornasari, L; Galimberti, VE; Masullo, M; Miccolo, C; Minucci, S; Palorini, R; Passafaro, A; Pece, S; Pelicci, PG; Pruneri, G; Richon, VM; Viale, G1
Abdalla, MY; Ahmad, IM; Al-Hudhud, MY; Elkarmi, AZ; Mahmoud, HT; Mustafa, EH; Tahtamouni, LH; Yasin, SR1
Asara, JM; Cantley, LC; Hu, H; Juvekar, A; Lien, EC; Lyssiotis, CA; Toker, A1
Berg, K; Hothersall, JS; Jonsson, M; Kubin, A; Olsen, CE; Theodossiou, TA1
Jordan, VC; Kim, HR; Klein-Szanto, AJ; Lewis-Wambi, JS; Patel, R; Pyle, JR; Wambi, C1
Jordan, VC; Kim, H; Lewis-Wambi, JS; Swaby, R1
Aykin-Burns, N; Coleman, MC; Hadzic, T; Jacobson, GM; Leick, K; Spitz, DR; Zhu, Y1
Bahar, M; Khaghani, S; Khorramizadeh, MR; Mirmiranpour, H; Nejad, SG; Paknejad, M; Pasalar, P1
Bohl, LP; Liaudat, AC; Marchionatti, AM; Narvaez, CJ; Picotto, G; Rodriguez, VA; Tolosa de Talamoni, NG; Welsh, J1
Manna, SK; Ramesh, GT; Sarkar, A; Sreenivasan, Y1
Andringa, KK; Aykin-Burns, N; Coleman, MC; Domann, FE; Hitchler, MJ; Spitz, DR; Walsh, SA1
Brooks, SE; Dupuis, NP; Holden, SA; Korbut, TT; Teicher, BA1
Cowan, KH; Schneider, E; Sinha, BK; Yamazaki, H1
Chen, G; Waxman, DJ2
Chow, S; Hedley, DW1
Blask, DE; Wilson, ST; Zalatan, F1
al-Bassam, M; Buzaid, AC; Dasgupta, C; Fruehauf, JP; Kyshtoobayeva, A; Milovanovic, T; Parker, RJ; Zonis, S2
Aakvaag, A; Abdi-Dezfuli, F; Berge, RK; Frøyland, L; Thorsen, T1
Dimitriadis, KA; Geromichalos, GD; Kortsaris, AH; Kouretas, D; Papazisis, KT; Sivridis, E; Tsekreli, OK1
Benderra, Z; Doglia, SM; Manfait, M; Morjani, H; Trussardi, A; Villa, AM1
Hadari-Naor, I; Koren, R; Liberman, UA; Ravid, A; Rotem, C; Zuck, E1
Andrieu-Abadie, N; Carpentier, S; Gouazé, V; Levade, T; Mirault, ME; Salvayre, R1
Lafleur, MV; Lankelma, J; Mans, DR; Pinedo, HM; Retèl, J; Schuurhuis, GJ; Treskes, M1
Armstrong, DK; Colvin, OM; Davidson, NE; Gordon, GB; Hilton, J; Streeper, RT1
Boylan, LM; Spallholz, JE; Yan, L; Yee, JA1
Batist, G; Greene, D; Lehnert, S; Schecter, R; Woo, A1
Benz, CC; Ford, JM; Hait, WN; Matlin, SA1
Dusre, L; Mimnaugh, EG; Myers, CE; Sinha, BK1

Other Studies

32 other study(ies) available for buthionine sulfoximine and Breast Cancer

ArticleYear
D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H
    Free radical biology & medicine, 2017, Volume: 108

    Topics: Antineoplastic Combined Chemotherapy Protocols; Auranofin; Breast Neoplasms; Buthionine Sulfoximine; Carboplatin; Catalase; Cell Line, Tumor; Chelating Agents; Copper; Epithelial Cells; Female; Humans; Hydrogen Peroxide; Lung Neoplasms; Oxidative Stress; Penicillamine; Radiation; Thioredoxin-Disulfide Reductase

2017
Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 03-05, Volume: 116, Issue:10

    Topics: Animals; B7-H1 Antigen; Breast Neoplasms; Buthionine Sulfoximine; Cell Line, Tumor; Chemokines; Drug Therapy; Female; Glutathione; Humans; Immunosuppressive Agents; Macrophages; Mice; Paclitaxel; Phenotype; Reactive Oxygen Species; RNA, Messenger; Triple Negative Breast Neoplasms; Tumor Microenvironment; Up-Regulation

2019
Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer.
    Antioxidants & redox signaling, 2015, Jul-01, Volume: 23, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Oxidation-Reduction; Primary Cell Culture; Vorinostat

2015
2-deoxy-D-Glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:8

    Topics: Actins; Antibiotics, Antineoplastic; Antimetabolites; Antioxidants; Apoptosis; Blotting, Western; Breast Neoplasms; Buthionine Sulfoximine; Cell Adhesion; Cell Movement; Cell Proliferation; Deoxyglucose; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Female; Flow Cytometry; Focal Adhesions; Glutathione; Humans; Lipid Peroxidation; Mitosis; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Tumor Cells, Cultured; Wound Healing

2015
Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.
    Nature cell biology, 2016, Volume: 18, Issue:5

    Topics: Biosynthetic Pathways; Breast Neoplasms; Buthionine Sulfoximine; Cell Line, Tumor; Cisplatin; Female; Glutathione; Humans; Mutation; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Spheroids, Cellular

2016
The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy.
    Redox biology, 2017, Volume: 12

    Topics: Anthracenes; Breast Neoplasms; Buthionine Sulfoximine; Carmustine; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Glutathione; Glutathione Peroxidase; Glutathione S-Transferase pi; Humans; MCF-7 Cells; Perylene; Phospholipid Hydroperoxide Glutathione Peroxidase; Photochemotherapy

2017
Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis.
    Breast cancer research : BCR, 2008, Volume: 10, Issue:6

    Topics: Animals; Annexin A5; Antimetabolites, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Buthionine Sulfoximine; Cell Proliferation; Cytochromes c; Drug Resistance, Neoplasm; Drug Synergism; Estradiol; Estrogens; Female; Forkhead Transcription Factors; Glutathione; Humans; Immunoenzyme Techniques; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Cells, Cultured

2008
Potential of l-buthionine sulfoximine to enhance the apoptotic action of estradiol to reverse acquired antihormonal resistance in metastatic breast cancer.
    The Journal of steroid biochemistry and molecular biology, 2009, Volume: 114, Issue:1-2

    Topics: Apoptosis; Breast Neoplasms; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estradiol; Female; Glutathione; Humans; Molecular Structure; Selective Estrogen Receptor Modulators

2009
Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress.
    Free radical biology & medicine, 2010, Apr-15, Volume: 48, Issue:8

    Topics: Breast Neoplasms; Buthionine Sulfoximine; Cell Survival; Deoxyglucose; Drug Synergism; Female; Fibroblasts; Glucose; Humans; Hydrogen Peroxide; Oxidative Stress; Paclitaxel; Reactive Oxygen Species; Tumor Cells, Cultured

2010
Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model.
    Nutrition journal, 2010, Nov-30, Volume: 9

    Topics: Acetylcysteine; Biomarkers; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Female; Free Radical Scavengers; Glutamate-Cysteine Ligase; Humans; Hydrogen Peroxide; Matrix Metalloproteinase 2; Osmolar Concentration; Oxidation-Reduction; Oxidative Stress; Time Factors; Ubiquinone

2010
Buthionine sulfoximine and 1,25-dihydroxyvitamin D induce apoptosis in breast cancer cells via induction of reactive oxygen species.
    Cancer investigation, 2012, Volume: 30, Issue:8

    Topics: Apoptosis; Breast Neoplasms; Buthionine Sulfoximine; Caspases; Cell Cycle; Cell Line, Tumor; Enzyme Activation; Female; Humans; Oxidation-Reduction; Reactive Oxygen Species; Vitamin D

2012
beta-D-Glucoside suppresses tumor necrosis factor-induced activation of nuclear transcription factor kappaB but potentiates apoptosis.
    The Journal of biological chemistry, 2004, Aug-06, Volume: 279, Issue:32

    Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Antioxidants; Apoptosis; Breast Neoplasms; Buthionine Sulfoximine; Calcium-Binding Proteins; Catalase; Cell Line; Cyclooxygenase 2; Drug Synergism; Enzyme Activation; Gene Expression; Glutamate-Cysteine Ligase; Glutathione; HeLa Cells; Humans; I-kappa B Kinase; Intercellular Adhesion Molecule-1; Isoenzymes; Jurkat Cells; Lymphoma, Large B-Cell, Diffuse; Membrane Glycoproteins; Membrane Proteins; Mice; Nerve Tissue Proteins; NF-kappa B; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Synaptotagmin I; Synaptotagmins; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Xanthones

2004
Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.
    Cancer research, 2006, Feb-01, Volume: 66, Issue:3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Buthionine Sulfoximine; Cell Line, Tumor; Deoxyglucose; Drug Synergism; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Humans; Oxidative Stress; RNA, Messenger

2006
Cytotoxicity of antitumor platinum complexes with L-buthionine-(R,S)-sulfoximine and/or etanidazole in human carcinoma cell lines sensitive and resistant to cisplatin.
    Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:5

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Buthionine Sulfoximine; Carboplatin; Cisplatin; Drug Resistance; Etanidazole; Female; Humans; Methionine Sulfoximine; Organoplatinum Compounds; Ovarian Neoplasms; Tumor Cells, Cultured

1995
Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation.
    British journal of cancer, 1995, Volume: 71, Issue:4

    Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Buthionine Sulfoximine; Cell Line; Cell Survival; Drug Resistance, Multiple; Etoposide; Female; Glutathione; Humans; Kinetics; Methionine Sulfoximine; Tumor Cells, Cultured; Vincristine

1995
Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells.
    Biochemical pharmacology, 1995, May-26, Volume: 49, Issue:11

    Topics: Aldehyde Dehydrogenase; Aldehydes; Breast Neoplasms; Buthionine Sulfoximine; Cell Line; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Resistance; Ethacrynic Acid; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Humans; Methionine Sulfoximine

1995
Evaluation of methods for measuring cellular glutathione content using flow cytometry.
    Cytometry, 1994, Apr-01, Volume: 15, Issue:4

    Topics: Animals; Breast Neoplasms; Bridged Bicyclo Compounds; Buthionine Sulfoximine; Carcinoma; Carcinosarcoma; CHO Cells; Colonic Neoplasms; Cricetinae; Ethylmaleimide; Eukaryotic Cells; Evaluation Studies as Topic; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Glutathione; Humans; Maleates; Mammary Neoplasms, Experimental; Methionine Sulfoximine; Mice; o-Phthalaldehyde; Phenylmercury Compounds; Pyrazoles; Species Specificity; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1994
Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells.
    Biochemical pharmacology, 1994, Mar-15, Volume: 47, Issue:6

    Topics: Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Buthionine Sulfoximine; Cell Survival; Ethacrynic Acid; Glutathione; Glutathione Transferase; Humans; Methionine Sulfoximine; Tumor Cells, Cultured

1994
Physiological melatonin inhibition of human breast cancer cell growth in vitro: evidence for a glutathione-mediated pathway.
    Cancer research, 1997, May-15, Volume: 57, Issue:10

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Breast Neoplasms; Buthionine Sulfoximine; Cell Division; Diuretics; Ethacrynic Acid; Female; Glutathione; Humans; Melatonin; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured

1997
Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase.
    Pigment cell research, 1997, Volume: 10, Issue:4

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Breast Neoplasms; Buthionine Sulfoximine; Carmustine; Drug Synergism; Female; Glutathione; Glutathione Transferase; Humans; Melanins; Melanoma; Ovarian Neoplasms; Tumor Cells, Cultured

1997
Eicosapentaenoic acid and sulphur substituted fatty acid analogues inhibit the proliferation of human breast cancer cells in culture.
    Breast cancer research and treatment, 1997, Volume: 45, Issue:3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antioxidants; Arachidonic Acid; Breast Neoplasms; Buthionine Sulfoximine; Cell Division; Drug Interactions; Eicosapentaenoic Acid; Fatty Acids; Glutathione; Humans; Oxidants; Oxidation-Reduction; Oxidative Stress; Sulfides; Sulfur Compounds; Tumor Cells, Cultured

1997
Melanin content and downregulation of glutathione S-transferase contribute to the action of L-buthionine-S-sulfoximine on human melanoma.
    Chemico-biological interactions, 1998, Apr-24, Volume: 111-112

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Buthionine Sulfoximine; Carmustine; Down-Regulation; Drug Resistance; Enzyme Inhibitors; Female; Glutamate-Cysteine Ligase; Glutathione Transferase; Humans; Melanins; Melanoma; Melphalan; Ovarian Neoplasms; Tumor Cells, Cultured

1998
Effects of melatonin on proliferation of cancer cell lines.
    Journal of pineal research, 1998, Volume: 25, Issue:4

    Topics: Breast Neoplasms; Buthionine Sulfoximine; Cell Division; Cell Survival; Colonic Neoplasms; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Ethacrynic Acid; Female; Glutathione; Humans; Melatonin; Ovarian Neoplasms; Tumor Cells, Cultured; Uterine Cervical Neoplasms

1998
Regulation of cellular glutathione modulates nuclear accumulation of daunorubicin in human MCF7 cells overexpressing multidrug resistance associated protein.
    European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:3

    Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Breast Neoplasms; Buthionine Sulfoximine; Cell Nucleus; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Female; Flow Cytometry; Glutathione; Glutathione Synthase; Humans; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Fluorescence; Tumor Cells, Cultured

2000
Vitamin D is a prooxidant in breast cancer cells.
    Cancer research, 2001, Feb-15, Volume: 61, Issue:4

    Topics: Antimetabolites; Breast Neoplasms; Buthionine Sulfoximine; Calcitriol; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glyceraldehyde-3-Phosphate Dehydrogenases; Homeostasis; Humans; Oxidants; Oxidation-Reduction; Reactive Oxygen Species; Tumor Cells, Cultured

2001
Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells.
    Molecular pharmacology, 2001, Volume: 60, Issue:3

    Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Buthionine Sulfoximine; Ceramides; Doxorubicin; Drug Interactions; Free Radical Scavengers; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Reactive Oxygen Species; Signal Transduction; Transfection; Tumor Cells, Cultured

2001
Modulation by D,L-buthionine-S,R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines.
    European journal of cancer (Oxford, England : 1990), 1992, Volume: 28A, Issue:8-9

    Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma, Non-Small-Cell Lung; Cisplatin; Doxorubicin; Drug Synergism; Etoposide; Female; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured; Verapamil

1992
Hepsulfam sensitivity in human breast cancer cell lines: the role of glutathione and glutathione S-transferase in resistance.
    Cancer research, 1992, Mar-15, Volume: 52, Issue:6

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Buthionine Sulfoximine; Glutathione; Glutathione Transferase; Humans; Isoenzymes; Methionine Sulfoximine; Sulfonic Acids; Tumor Cells, Cultured; Tumor Stem Cell Assay

1992
Effect of selenium compounds and thiols on human mammary tumor cells.
    Biological trace element research, 1991, Volume: 30, Issue:2

    Topics: Aged; Antimetabolites; Breast Neoplasms; Buthionine Sulfoximine; Cell Survival; Cysteine; Female; Glutathione; Glutathione Peroxidase; Humans; Mercaptoethanol; Methionine Sulfoximine; Organoselenium Compounds; Selenic Acid; Selenious Acid; Selenium; Selenium Compounds; Selenocysteine; Selenomethionine; Sodium Selenite; Sulfhydryl Compounds; Trypan Blue; Tumor Cells, Cultured

1991
Glutathione depletion in human and in rat multi-drug resistant breast cancer cell lines.
    Biochemical pharmacology, 1991, Feb-15, Volume: 41, Issue:4

    Topics: Animals; Breast Neoplasms; Buthionine Sulfoximine; Doxorubicin; Drug Resistance; Female; Glutathione; Glutathione Transferase; Humans; Mammary Neoplasms, Experimental; Methionine Sulfoximine; Rats; Rats, Inbred F344; Tumor Cells, Cultured; Verapamil

1991
Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers.
    Cancer letters, 1991, Volume: 56, Issue:1

    Topics: Alkylating Agents; Animals; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma 256, Walker; Carmustine; Cell Division; Cell Line; Chlorambucil; Cisplatin; Drug Antagonism; Drug Resistance; Glutathione Transferase; Gossypol; Humans; In Vitro Techniques; Isomerism; Melphalan; Methionine Sulfoximine; Rats

1991
Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells.
    Cancer research, 1989, Feb-01, Volume: 49, Issue:3

    Topics: Breast Neoplasms; Buthionine Sulfoximine; Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Drug Synergism; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Methionine Sulfoximine

1989