buthionine sulfoximine has been researched along with Aging in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.67) | 18.7374 |
| 1990's | 14 (46.67) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naziroğlu, M; Övey, İS | 1 |
| Hashimoto, K; Manabe, S; Sato, I; Takasaki, W; Tsuda, S; Yamoto, T | 1 |
| Baker, BA; Cutlip, RG; Hollander, MS; Kashon, ML | 1 |
| Baker, BA; Cutlip, RG; Ensey, J; Hollander, MS; Kashon, ML | 1 |
| Bishop, GM; Dringen, R; Liddell, JR; Robinson, SR | 1 |
| Denniss, SG; Levy, AS; Rush, JW | 1 |
| Castagné, V; Cuénod, M; Do, KQ | 1 |
| Sohal, RS; Toroser, D | 1 |
| Aunan, ES; Coleman, MC; Kregel, KC; Morrison, JP; Spitz, DR; Walsh, SA | 1 |
| Robaire, B; Zubkova, EV | 1 |
| Beattie, MC; Brown, TR; Chen, H; Liu, J; Pechenino, AS; Zirkin, BR | 1 |
| Hamazaki, S; Minamiyama, Y; Okada, S; Sotomatsu, A; Toyokuni, S | 1 |
| Cuccurullo, F; D'Orazio, A; Di Febbo, C; Martelli, N; Mezzetti, A; Pandolfi, A; Poggi, A; Porreca, E | 1 |
| Hayek, M; Meydani, M; Meydani, SN; Sastre, J; Wu, D | 1 |
| Appenroth, D; Winnefeld, K | 1 |
| Allen, RG; Cristofalo, VJ; Horton, J; Keogh, BP; Pignolo, R; Tresini, M | 1 |
| Andersen, JK; Hamill, RW; Harnish, P; Hom, DG; Lee, FY; McNeill, TH; Mo, JQ | 1 |
| Denisova, NA; Joseph, JA; Shukitt-Hale, B; Strain, JG | 1 |
| Erat, SA; Joseph, JA; Shukitt-Hale, B | 1 |
| Chen, TS; Lang, CA; Nagasawa, HT; Richie, JP | 1 |
| Delogu, MR; Desole, MS; Esposito, G; Fresu, L; Miele, M; Migheli, R; Rocchitta, G; Serra, PA | 1 |
| Ayala, A; Galigniana, MD; Machado, A; Piwien-Pilipuk, G | 1 |
| Franklin, MR; Galinsky, RE; Kimura, RE; Manning, BW | 1 |
| Auld, PA; Frayer, W; Jain, A; Mårtensson, J; Meister, A; Stole, E | 1 |
| Cammer, W; Tansey, FA | 1 |
| Murray, DL; Rathbun, WB | 1 |
| Auld, PA; Jain, A; Mårtensson, J; Meister, A; Stole, E | 1 |
| Bräunlich, H; Kretzschmar, M | 1 |
| Cheeks, L; Green, K; Greiff, M | 1 |
| Calvin, HI; Cohen, G; Slivka, A; Spina, MB | 1 |
30 other study(ies) available for buthionine sulfoximine and Aging
| Article | Year |
|---|---|
Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: involvement of TRPM2 and TRPV1 channels.
Topics: Aging; Animals; Antimetabolites; Apoptosis; Buthionine Sulfoximine; Calcium; Capsaicin; Cells, Cultured; Cytosol; Glutathione; Hippocampus; Homocysteine; Hydrogen Peroxide; Male; Mice, Inbred C57BL; Neurons; Oxidative Stress; TRPM Cation Channels; TRPV Cation Channels | 2015 |
Effect of glutathione (GSH) depletion on DNA damage and blood chemistry in aged and young rats.
Topics: Aging; Animals; Blood Chemical Analysis; Buthionine Sulfoximine; Comet Assay; DNA Damage; Glutathione; Kidney; Liver; Rats; Rats, Inbred F344 | 2008 |
Effects of glutathione depletion and age on skeletal muscle performance and morphology following chronic stretch-shortening contraction exposure.
Topics: Adaptation, Physiological; Aging; Animals; Antimetabolites; Biomechanical Phenomena; Buthionine Sulfoximine; Glutathione; Male; Models, Animal; Muscle Contraction; Muscle, Skeletal; Rats; Rats, Inbred BN | 2010 |
Effects of age and glutathione levels on oxidative stress in rats after chronic exposure to stretch-shortening contractions.
Topics: Administration, Oral; Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Glutathione; Hydrogen Peroxide; Isoprostanes; Lipid Peroxidation; Male; Malondialdehyde; Models, Animal; Muscle Contraction; Muscle, Skeletal; Oxidative Stress; Rats; Rats, Inbred BN; Rats, Inbred F344 | 2010 |
Astrocytes retain their antioxidant capacity into advanced old age.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Astrocytes; Brain; Buthionine Sulfoximine; CD11b Antigen; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Female; Glial Fibrillary Acidic Protein; Glutathione; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins | 2010 |
Effects of glutathione-depleting drug buthionine sulfoximine and aging on activity of endothelium-derived relaxing and contracting factors in carotid artery of Sprague-Dawley rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aging; Animals; Blood Pressure; Buthionine Sulfoximine; Carotid Artery, Common; Drug Administration Schedule; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Enzyme Inhibitors; Glutathione; Heart Rate; Hemodynamics; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Vasoconstrictor Agents | 2011 |
An animal model with relevance to schizophrenia: sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain Chemistry; Buthionine Sulfoximine; Cognition Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Embryonic and Fetal Development; Enzyme Inhibitors; Exploratory Behavior; Female; Glutathione; Lipid Peroxidation; Male; Maze Learning; Medulla Oblongata; Motor Activity; Pharmacy and Therapeutics Committee; Piperazines; Pons; Pregnancy; Psychomotor Performance; Rats; Rats, Mutant Strains; Recognition, Psychology; Schizophrenia; Sex Characteristics; Time Factors | 2004 |
Kinetic characteristics of native gamma-glutamylcysteine ligase in the aging housefly, Musca domestica L.
Topics: Adenosine Triphosphate; Aging; Animals; Buthionine Sulfoximine; Cysteine; Feedback, Physiological; Glutamate-Cysteine Ligase; Glutamic Acid; Glutathione; Houseflies; Kinetics | 2005 |
Aging reduces responsiveness to BSO- and heat stress-induced perturbations of glutathione and antioxidant enzymes.
Topics: Aging; Animals; Antioxidants; Buthionine Sulfoximine; Catalase; Glutathione; Heat Stress Disorders; Liver; Male; Rats; Rats, Inbred F344; Reactive Oxygen Species; Superoxide Dismutase | 2005 |
Effects of ageing on spermatozoal chromatin and its sensitivity to in vivo and in vitro oxidative challenge in the Brown Norway rat.
Topics: Aging; Animals; Buthionine Sulfoximine; Chromatin; DNA Damage; Epididymis; Male; Oxidative Stress; Rats; Rats, Inbred BN; Spermatozoa; Sulfhydryl Compounds | 2006 |
Effect of glutathione depletion on Leydig cell steroidogenesis in young and old brown Norway rats.
Topics: Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Glutathione; Leydig Cells; Male; Rats; Rats, Inbred BN; Steroids; Testosterone | 2008 |
Glutathione cycle dependency of ferric nitrilotriacetate-induced lipid peroxidation in mouse proximal renal tubules.
Topics: Aging; Animals; Buthionine Sulfoximine; Cysteine; Fatty Acids; Fatty Acids, Unsaturated; Female; Ferric Compounds; gamma-Glutamyltransferase; Glutathione; Glutathione Synthase; Kidney Cortex; Kidney Medulla; Kidney Tubules, Proximal; Lipid Peroxidation; Male; Methionine Sulfoximine; Mice; Nitrilotriacetic Acid; Sex Characteristics; Thiobarbiturates | 1993 |
Differences in the glutathione system of cultured aortic smooth muscle cells from young and aged rats.
Topics: Aging; Animals; Aorta, Thoracic; Buthionine Sulfoximine; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Methionine Sulfoximine; Muscle, Smooth, Vascular; Rats; Sulfhydryl Compounds | 1993 |
In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects.
Topics: Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Antibody Formation; Antimetabolites; Buthionine Sulfoximine; Dinoprostone; Glutathione; Humans; Interleukin-1; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Methionine Sulfoximine | 1994 |
Role of glutathione for cisplatin nephrotoxicity in young and adult rats.
Topics: Acetylcysteine; Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Cisplatin; Drug Interactions; Female; Glutathione; Kidney; Methionine Sulfoximine; Rats; Rats, Wistar | 1993 |
Expression of hydrogen peroxide and glutathione metabolizing enzymes in human skin fibroblasts derived from donors of different ages.
Topics: Adolescent; Aged; Aged, 80 and over; Aging; Buthionine Sulfoximine; Catalase; Cell Line; Fetus; Fibroblasts; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Humans; Hydrogen Peroxide; Methionine Sulfoximine; RNA, Messenger; Skin | 1996 |
Effect of buthionine sulfoximine, a synthesis inhibitor of the antioxidant glutathione, on the murine nigrostriatal neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Antioxidants; Buthionine Sulfoximine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Glutathione; Homovanillic Acid; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Neurons; Substantia Nigra; Tyrosine 3-Monooxygenase | 1996 |
Psychomotor effects of dopamine infusion under decreased glutathione conditions.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Brain; Buthionine Sulfoximine; Dopamine; Glutathione; Male; Oxidative Stress; Psychomotor Performance; Rats; Rats, Inbred F344 | 1997 |
Spatial learning and memory deficits induced by dopamine administration with decreased glutathione.
Topics: Aging; Animals; Brain; Buthionine Sulfoximine; Dopamine; Free Radicals; Glutathione; Male; Maze Learning; Memory; Oxidants; Oxidative Stress; Rats; Rats, Inbred F344; Spatial Behavior | 1998 |
Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice.
Topics: Acetaminophen; Aging; Animals; Buthionine Sulfoximine; Cysteine; Glutathione; Kidney Cortex; Liver; Male; Mice; Mice, Inbred C57BL | 2000 |
Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats.
Topics: Aging; Animals; Antimetabolites; Ascorbic Acid; Brain; Buthionine Sulfoximine; Dehydroascorbic Acid; Drug Synergism; Energy Metabolism; Glutathione; Hypoxanthine; Inosine; Male; Manganese; Phosphates; Rats; Rats, Wistar; Tissue Distribution; Uric Acid; Xanthine | 2000 |
Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging: correlation with post-translational modification of MR and decreased ADP-ribosylatable level of elongating factor 2 in kidney cells.
Topics: ADP-Ribosylation Factors; Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Cytosol; Enzyme Inhibitors; Glutathione; HSP90 Heat-Shock Proteins; Kidney; Male; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Oxidative Stress; Oxygen; Peptide Elongation Factor 2; Polyribosomes; Precipitin Tests; Protein Binding; Protein Biosynthesis; Protein Processing, Post-Translational; Receptors, Mineralocorticoid; Reticulocytes; Time Factors; Transcription, Genetic | 2002 |
Changes in conjugative enzyme activity and acetaminophen metabolism in young and senescent male F-344 rats following prolonged exposure to buthionine sulfoximine.
Topics: Acetaminophen; Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Glutathione; Glutathione Transferase; Liver; Male; Methionine Sulfoximine; Oxidoreductases, O-Demethylating; Rats; Rats, Inbred F344; Sulfotransferases | 1992 |
Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress.
Topics: Aging; Animals; Animals, Newborn; Buthionine Sulfoximine; Female; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Isomerism; Male; Methionine Sulfoximine; Mitochondria; Organ Specificity; Rats; Rats, Inbred Strains | 1991 |
Depletion of glutathione interferes with induction of glycerolphosphate dehydrogenase in the brains of young rats.
Topics: Aging; Animals; Antimetabolites; Brain; Buthionine Sulfoximine; Cyclohexanones; Enzyme Induction; Glutathione; Glutathione Transferase; Glycerolphosphate Dehydrogenase; Hydrocortisone; Immunohistochemistry; Isoenzymes; Maleates; Methionine Sulfoximine; Neuroglia; Rats; Rats, Inbred Strains | 1991 |
Age-related cysteine uptake as rate-limiting in glutathione synthesis and glutathione half-life in the cultured human lens.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Buthionine Sulfoximine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Half-Life; Humans; Infant; Infant, Newborn; Lens, Crystalline; Methionine Sulfoximine; Middle Aged | 1991 |
Glutathione deficiency leads to mitochondrial damage in brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Buthionine Sulfoximine; Female; Glutathione; Glutathione Disulfide; Male; Methionine Sulfoximine; Microscopy, Electron; Mitochondria; Mitochondrial Swelling; Rats; Rats, Inbred Strains | 1991 |
Role of glutathione in vanadate reduction in young and mature rats: evidence for direct participation of glutathione in vanadate inactivation.
Topics: Aging; Anesthesia; Animals; Buthionine Sulfoximine; Diuresis; Female; Glutathione; Kidney; Kidney Function Tests; Male; Methionine Sulfoximine; Oxidation-Reduction; Rats; Rats, Inbred Strains; Vanadates | 1990 |
Influence of hydrogen peroxide on adenine uptake by iris, ciliary epithelium and corneal endothelium.
Topics: Adenine; Aging; Amitrole; Animals; Anterior Chamber; Buthionine Sulfoximine; Catalase; Ciliary Body; Endothelium, Corneal; Epithelium; Glutathione; Hydrogen Peroxide; Iris; Methionine Sulfoximine; Rabbits | 1989 |
Depletion of brain glutathione in preweanling mice by L-buthionine sulfoximine.
Topics: Aging; Animals; Antimetabolites; Brain; Buthionine Sulfoximine; Cerebellum; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Spinal Cord; Weaning | 1988 |