butenafine has been researched along with Dermatophytoses in 7 studies
butenafine: studied on experimental dermatophytosis
butenafine : Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Localized tinea cruris and tinea corporis can be treated by topical imidazoles (clotrimazole) or newer topical agents like butenafine, a benzylamine derivative with fungicidal activity." | 9.11 | Comparative efficacy of topical 1% butenafine and 1% clotrimazole in tinea cruris and tinea corporis: a randomized, double-blind trial. ( Agrawal, S; Das, S; Pandhi, D; Singal, A, 2005) |
| "Butenafine hydrochloride, a potent antifungal agent related to the allylamines, has been used in Japan for treating various cutaneous mycoses including tinea cruris." | 9.08 | Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial. ( Babel, DE; Goldman, M; Jones, TM; Kaminester, L; Lesher, JL; Stewart, DM; Weintraub, JS, 1997) |
| "We evaluated short-term treatment of tinea corporis with butenafine hydrochloride, a new benzylamine with in vitro fungicidal activity." | 9.08 | A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine, a new antifungal agent. ( Greer, DL; Hebert, AA; Rodriguez, DA; Swinehart, JM; Weiss, J, 1997) |
| "Superficial dermatophytoses of skin are very common infections seen in clinical practice." | 6.70 | Efficacy and safety of butenafine in superficial dermatophytoses (tinea pedis, tinea cruris, tinea corporis). ( Amar, AK; Desai, A; Korde, KM; Ravichandran, G; Saple, DG, 2001) |
| "Localized tinea cruris and tinea corporis can be treated by topical imidazoles (clotrimazole) or newer topical agents like butenafine, a benzylamine derivative with fungicidal activity." | 5.11 | Comparative efficacy of topical 1% butenafine and 1% clotrimazole in tinea cruris and tinea corporis: a randomized, double-blind trial. ( Agrawal, S; Das, S; Pandhi, D; Singal, A, 2005) |
| "Butenafine hydrochloride, a potent antifungal agent related to the allylamines, has been used in Japan for treating various cutaneous mycoses including tinea cruris." | 5.08 | Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial. ( Babel, DE; Goldman, M; Jones, TM; Kaminester, L; Lesher, JL; Stewart, DM; Weintraub, JS, 1997) |
| "We evaluated short-term treatment of tinea corporis with butenafine hydrochloride, a new benzylamine with in vitro fungicidal activity." | 5.08 | A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine, a new antifungal agent. ( Greer, DL; Hebert, AA; Rodriguez, DA; Swinehart, JM; Weiss, J, 1997) |
| "Butenafine is a synthetic benzylamine antifungal agent that may be fungicidal against susceptible organisms, e." | 1.31 | Butenafine: an update of its use in superficial mycoses. ( Gupta, AK, 2002) |
| "Clotrimazole was active when animals were infected with 10(4) or 10(5) cells but was almost inactive when the inoculum size was 10(6) cells." | 1.29 | Anti-Trichophyton mentagrophytes activity and percutaneous permeation of butenafine in guinea pigs. ( Arika, T; Hase, T; Yokoo, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rossetto, AL | 1 |
| Cruz, RCB | 1 |
| Haddad, V | 1 |
| Gupta, AK | 1 |
| Singal, A | 1 |
| Pandhi, D | 1 |
| Agrawal, S | 1 |
| Das, S | 1 |
| Arika, T | 1 |
| Hase, T | 1 |
| Yokoo, M | 1 |
| Lesher, JL | 1 |
| Babel, DE | 1 |
| Stewart, DM | 1 |
| Jones, TM | 1 |
| Kaminester, L | 1 |
| Goldman, M | 1 |
| Weintraub, JS | 1 |
| Greer, DL | 1 |
| Weiss, J | 1 |
| Rodriguez, DA | 1 |
| Hebert, AA | 1 |
| Swinehart, JM | 1 |
| Saple, DG | 1 |
| Amar, AK | 1 |
| Ravichandran, G | 1 |
| Korde, KM | 1 |
| Desai, A | 1 |
4 trials available for butenafine and Dermatophytoses
| Article | Year |
|---|---|
Comparative efficacy of topical 1% butenafine and 1% clotrimazole in tinea cruris and tinea corporis: a randomized, double-blind trial.
Topics: Administration, Topical; Adult; Antifungal Agents; Benzylamines; Clotrimazole; Double-Blind Method; | 2005 |
Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial.
Topics: Administration, Topical; Adult; Aged; Antifungal Agents; Benzylamines; Double-Blind Method; Female; | 1997 |
A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine, a new antifungal agent.
Topics: Administration, Cutaneous; Adolescent; Adult; Antifungal Agents; Benzylamines; Drug Administration S | 1997 |
Efficacy and safety of butenafine in superficial dermatophytoses (tinea pedis, tinea cruris, tinea corporis).
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Benzylamines | 2001 |
3 other studies available for butenafine and Dermatophytoses
| Article | Year |
|---|---|
Tinea nigra presenting speckled or "salt and pepper" pattern.
Topics: Administration, Topical; Antifungal Agents; Ascomycota; Benzylamines; Brazil; Child; Female; Hand De | 2014 |
Butenafine: an update of its use in superficial mycoses.
Topics: Administration, Topical; Antifungal Agents; Benzylamines; Humans; Naphthalenes; Tinea; Tinea Versico | 2002 |
Anti-Trichophyton mentagrophytes activity and percutaneous permeation of butenafine in guinea pigs.
Topics: Animals; Antifungal Agents; Benzylamines; Clotrimazole; Guinea Pigs; Male; Microbial Sensitivity Tes | 1993 |