butaprost and Chronic-Disease

butaprost has been researched along with Chronic-Disease* in 1 studies

Other Studies

1 other study(ies) available for butaprost and Chronic-Disease

Article	Year
Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia. Annals of neurology, 2005, Volume: 57, Issue:5 Recent studies suggest a neuroprotective function of the PGE2 EP2 receptor in excitotoxic neuronal injury. The function of the EP2 receptor was examined at time points after excitotoxicity in an organotypic hippocampal model of N-methyl-D-aspartate (NMDA) challenge and in a permanent model of focal forebrain ischemia. Activation of EP2 led to significant neuroprotection in hippocampal slices up to 3 hours after a toxic NMDA stimulus. Genetic deletion of EP2 resulted in a marked increase in stroke volume in the permanent middle cerebral artery occlusion model. These findings support further investigation into therapeutic strategies targeting the EP2 receptor in stroke. Topics: Aging; Alprostadil; Animals; Brain Ischemia; Cell Death; Cerebral Infarction; Chronic Disease; Excitatory Amino Acid Agonists; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype	2005

Article

Year

Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia.

Annals of neurology, 2005, Volume: 57, Issue:5

Recent studies suggest a neuroprotective function of the PGE2 EP2 receptor in excitotoxic neuronal injury. The function of the EP2 receptor was examined at time points after excitotoxicity in an organotypic hippocampal model of N-methyl-D-aspartate (NMDA) challenge and in a permanent model of focal forebrain ischemia. Activation of EP2 led to significant neuroprotection in hippocampal slices up to 3 hours after a toxic NMDA stimulus. Genetic deletion of EP2 resulted in a marked increase in stroke volume in the permanent middle cerebral artery occlusion model. These findings support further investigation into therapeutic strategies targeting the EP2 receptor in stroke.

Topics: Aging; Alprostadil; Animals; Brain Ischemia; Cell Death; Cerebral Infarction; Chronic Disease; Excitatory Amino Acid Agonists; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype

2005