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busulfan and Uveal Neoplasms

busulfan has been researched along with Uveal Neoplasms in 12 studies

Uveal Neoplasms: Tumors or cancer of the UVEA.

Research Excerpts

ExcerptRelevanceReference
"Chemotherapy-naive patients with proven metastatic uveal melanoma were randomly assigned to receive 1000 mg/m(2) of gemcitabine plus 3500 mg/m(2) of treosulfan (GeT) or 3500 mg/m(2) of T."9.12A randomized phase II trial of gemcitabine plus treosulfan versus treosulfan alone in patients with metastatic uveal melanoma. ( Bechrakis, NE; Foerster, MH; Keilholz, U; Martus, P; Schmidt-Hieber, M; Schmittel, A; Schuster, R; Siehl, JM; Thiel, E, 2006)
"This trial was performed to define the maximum tolerated dose (MTD) of treosulfan administered in combination with a fixed dose of gemcitabine in uveal melanoma patients."9.11A clinical phase I trial of gemcitabine and treosulfan in uveal melanoma and other solid tumours. ( Bechrakis, N; Foerster, MH; Keilholz, U; Schmittel, A; Schuster, R; Siehl, J; Thiel, E, 2004)
"Gemcitabine plus treosulfan (GeT) is under investigation in metastatic uveal melanoma."9.11Phase II trial of cisplatin, gemcitabine and treosulfan in patients with metastatic uveal melanoma. ( Baumgart, J; Bechrakis, NE; Bornfeld, N; Foerster, MH; Keilholz, U; Scheulen, ME; Schmittel, A; Strumberg, D; Thiel, E, 2005)
"The efficacy of cisplatin, gemcitabine, and treosulfan (CGT) was evaluated in patients with chemotherapy pretreated relapsed AJCC stage IV uveal malignant melanoma."7.74Cisplatin, gemcitabine and treosulfan is effective in chemotherapy-pretreated relapsed stage IV uveal melanoma patients. ( Atzpodien, J; Fluck, M; Reitz, M; Terfloth, K, 2008)
"Uveal melanoma is relatively uncommon accounting for fewer than 5% of all melanoma cases."6.72A prospective single arm phase II study of dacarbazine and treosulfan as first-line therapy in metastatic uveal melanoma. ( Butt, M; Eswar, CV; Gillis, P; Marshall, E; O'Neill, PA, 2006)
"Chemotherapy-naive patients with proven metastatic uveal melanoma were randomly assigned to receive 1000 mg/m(2) of gemcitabine plus 3500 mg/m(2) of treosulfan (GeT) or 3500 mg/m(2) of T."5.12A randomized phase II trial of gemcitabine plus treosulfan versus treosulfan alone in patients with metastatic uveal melanoma. ( Bechrakis, NE; Foerster, MH; Keilholz, U; Martus, P; Schmidt-Hieber, M; Schmittel, A; Schuster, R; Siehl, JM; Thiel, E, 2006)
"Results from in vitro chemosensitivity testing recommend treosulfan/gemcitabine chemotherapy for the treatment of stage IV uveal melanoma."5.11Clinical evaluation of in vitro chemosensitivity testing: the example of uveal melanoma. ( Becker, JC; Bröcker, EB; Terheyden, P, 2004)
"This trial was performed to define the maximum tolerated dose (MTD) of treosulfan administered in combination with a fixed dose of gemcitabine in uveal melanoma patients."5.11A clinical phase I trial of gemcitabine and treosulfan in uveal melanoma and other solid tumours. ( Bechrakis, N; Foerster, MH; Keilholz, U; Schmittel, A; Schuster, R; Siehl, J; Thiel, E, 2004)
"Gemcitabine plus treosulfan (GeT) is under investigation in metastatic uveal melanoma."5.11Phase II trial of cisplatin, gemcitabine and treosulfan in patients with metastatic uveal melanoma. ( Baumgart, J; Bechrakis, NE; Bornfeld, N; Foerster, MH; Keilholz, U; Scheulen, ME; Schmittel, A; Strumberg, D; Thiel, E, 2005)
"The efficacy of cisplatin, gemcitabine, and treosulfan (CGT) was evaluated in patients with chemotherapy pretreated relapsed AJCC stage IV uveal malignant melanoma."3.74Cisplatin, gemcitabine and treosulfan is effective in chemotherapy-pretreated relapsed stage IV uveal melanoma patients. ( Atzpodien, J; Fluck, M; Reitz, M; Terfloth, K, 2008)
"In this study we have used a standardised ATP-based tumour chemosensitivity assay (ATP-TCA) to measure the activity of gefitinib alone or in combination with different cytotoxic drugs (cisplatin, gemcitabine, oxaliplatin and treosulfan) against a variety of solid tumours (n = 86), including breast, colorectal, oesophageal and ovarian cancer, carcinoma of unknown primary site, cutaneous and uveal melanoma, non-small cell lung cancer (NSCLC) and sarcoma."3.72The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours. ( Cree, IA; Di Nicolantonio, F; Glaysher, S; Johnson, P; Knight, LA; Mercer, S; Sharma, S; Whitehouse, P, 2004)
"Uveal melanoma is relatively uncommon accounting for fewer than 5% of all melanoma cases."2.72A prospective single arm phase II study of dacarbazine and treosulfan as first-line therapy in metastatic uveal melanoma. ( Butt, M; Eswar, CV; Gillis, P; Marshall, E; O'Neill, PA, 2006)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (91.67)29.6817
2010's0 (0.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Saakyan, SV1
Tsygankov, АY1
Moiseeva, NI1
Karamysheva, АF1
Garri, DD1
Pföhler, C1
Cree, IA4
Ugurel, S1
Kuwert, C1
Haass, N1
Neuber, K1
Hengge, U1
Corrie, PG2
Zutt, M1
Tilgen, W1
Reinhold, U2
Terheyden, P1
Bröcker, EB1
Becker, JC1
Keilholz, U4
Schuster, R3
Schmittel, A4
Bechrakis, N1
Siehl, J1
Foerster, MH4
Thiel, E4
Knight, LA1
Di Nicolantonio, F1
Whitehouse, P1
Mercer, S1
Sharma, S1
Glaysher, S1
Johnson, P1
Neale, MH1
Kurbacher, CM1
Shaw, J1
Spanswick, VJ1
Sehmbi, R1
Jonson, A1
Mayer, A1
Bulusu, R1
Hartley, JA1
Scheulen, ME1
Bechrakis, NE3
Strumberg, D1
Baumgart, J1
Bornfeld, N1
Siehl, JM2
O'Neill, PA1
Butt, M1
Eswar, CV1
Gillis, P1
Marshall, E1
Schmidt-Hieber, M1
Martus, P1
Atzpodien, J1
Terfloth, K1
Fluck, M1
Reitz, M1

Trials

8 trials available for busulfan and Uveal Neoplasms

ArticleYear
Treosulfan and gemcitabine in metastatic uveal melanoma patients: results of a multicenter feasibility study.
    Anti-cancer drugs, 2003, Volume: 14, Issue:5

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Ch

2003
Clinical evaluation of in vitro chemosensitivity testing: the example of uveal melanoma.
    Journal of cancer research and clinical oncology, 2004, Volume: 130, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols

2004
A clinical phase I trial of gemcitabine and treosulfan in uveal melanoma and other solid tumours.
    European journal of cancer (Oxford, England : 1990), 2004, Volume: 40, Issue:14

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Deoxycytidine; Female; Gemcit

2004
Phase I trial combining gemcitabine and treosulfan in advanced cutaneous and uveal melanoma patients.
    British journal of cancer, 2005, Jun-06, Volume: 92, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Comet Assay; Deoxycytidine; D

2005
Phase II trial of cisplatin, gemcitabine and treosulfan in patients with metastatic uveal melanoma.
    Melanoma research, 2005, Volume: 15, Issue:3

    Topics: Adult; Aged; Anemia; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplas

2005
A two-cohort phase II clinical trial of gemcitabine plus treosulfan in patients with metastatic uveal melanoma.
    Melanoma research, 2005, Volume: 15, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cohort Studies; Deoxycytidine

2005
A prospective single arm phase II study of dacarbazine and treosulfan as first-line therapy in metastatic uveal melanoma.
    Melanoma research, 2006, Volume: 16, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Dacarbazine; Female; Humans;

2006
A randomized phase II trial of gemcitabine plus treosulfan versus treosulfan alone in patients with metastatic uveal melanoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Volume: 17, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Deoxycytid

2006

Other Studies

4 other studies available for busulfan and Uveal Neoplasms

ArticleYear
Assessment of the Chemosensitivity of Uveal Melanoma Cells Ex Vivo.
    Bulletin of experimental biology and medicine, 2020, Volume: 170, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Benzeneacetamides; Busulfan; Cell Proliferation; Cell Survival;

2020
The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours.
    BMC cancer, 2004, Nov-23, Volume: 4

    Topics: Adenocarcinoma; Adenosine Triphosphate; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl

2004
Treosulfan and gemcitabine.
    Journal of cancer research and clinical oncology, 2005, Volume: 131, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Deoxycytidine; Gemcitabine; Humans; Melano

2005
Cisplatin, gemcitabine and treosulfan is effective in chemotherapy-pretreated relapsed stage IV uveal melanoma patients.
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cisplatin; Deoxycytidine; Fem

2008