busulfan has been researched along with Sterility, Male in 42 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Busulfan is an alkylating agent commonly used in cancer chemotherapy." | 7.01 | Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan. ( Dong, Z; Wang, D; Xu, S; Zhao, J; Zhao, L, 2023) |
| " In rats, Busulfan administered in pregnancy can cause destruction of gonocytes and lack of spermatogenesis in adult male rats." | 3.65 | [Teratogenic damages of the male genital organs]. ( Krause, W, 1976) |
| "Busulfan is an alkylating agent commonly used in cancer chemotherapy." | 3.01 | Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan. ( Dong, Z; Wang, D; Xu, S; Zhao, J; Zhao, L, 2023) |
| "Male infertility is a global concern, with a noticeable increase in the decline of spermatogenesis and sperm quality." | 1.91 | Puerarin improves busulfan-induced disruption of spermatogenesis by inhibiting MAPK pathways. ( Chen, TX; Chen, XQ; Li, HT; Song, J; Xia, YF; Zeng, XH; Zhao, W; Zhong, K, 2023) |
| " Loboob at a dosage of 140mg/kg improved sperm viability." | 1.72 | Preserving effect of Loboob (a traditional multi-herbal formulation) on sperm parameters of male rats with busulfan-induced subfertility. ( Badr, P; Bahmanpour, S; Dabbaghmanesh, MH; Jahromi, BN; Keshavarz, M; Koohpeyma, F; Najib, FS; Namazi, N; Noori, A; Poordast, T; Zare, N, 2022) |
| "Busulfan (BSU) is a chemotherapeutic drug that can cause subfertility or sterility in males." | 1.72 | Impaired spermatogenesis caused by busulfan is partially ameliorated by treatment with conditioned medium of adipose tissue derived mesenchymal stem cells. ( Abbaszadeh, HA; Abdi, S; Abdollahifar, MA; Aliaghaei, A; Azad, N; Ebrahimi, V; Fadaei Fathabadi, F; Faraji Sani, M; Ghanimat, F; Movahedi, M; Raoofi, A, 2022) |
| "Molybdenum (Mo) plays an important role in maintaining normal metabolism." | 1.51 | Effect of molybdenum on reproductive function of male mice treated with busulfan. ( Dong, WY; Liu, FJ; Shi, XH; Zhang, YL; Zhao, H, 2019) |
| "Busulfan is a widely used chemotherapeutic drug for chronic myelogenous leukemia and bone marrow transplantation." | 1.51 | Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species. ( Lin, Z; Mi, J; Song, H; Sun, Z; Wei, R; Xia, Q; Yang, Y; Zhang, X; Zou, K, 2019) |
| "Busulfan is a chemotherapy drug that has side effects on spermatogonial stem cells (SSC)." | 1.43 | Gonadotoxic effects of busulfan in two strains of mice. ( Bordignon, V; Chemeris, RO; Comim, FV; Glanzner, WG; Gonçalves, PB; Gutierrez, K; Rigo, ML, 2016) |
| " Our study indicated that intratesticular injection busulfan for the preparation of recipients in mice is safe and feasible." | 1.43 | Testicular Busulfan Injection in Mice to Prepare Recipients for Spermatogonial Stem Cell Transplantation Is Safe and Non-Toxic. ( Chen, X; Hao, H; He, Y; Liang, M; Liu, L; Qin, T; Qin, Y; Wang, C; Wang, D; Zhao, X, 2016) |
| "Busulfan was used to induce testicular failure in 3-week-old immature FVB/NJNarl wild-type recipient mice." | 1.38 | Bioluminescence imaging as a tool to evaluate germ cells in vitro and transplantation in vivo as fertility preservation of prepubertal male mice. ( Chen, CH; Hsu, MI; Huang, YH; Lai, WF; Tzeng, CR; Wang, CW, 2012) |
| "Busulfan treatment caused acute declines in testis volume and sperm counts, indicating a disruption of spermatogenesis." | 1.34 | Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques. ( Hermann, BP; Hobbs, RM; Lin, CC; McFarland, D; Orwig, KE; Pandolfi, PP; Rodriguez, M; Schatten, GP; Sheng, Y; Shuttleworth, JJ; Sukhwani, M; Tomko, J, 2007) |
| " However, because the steepness of the dose-response curves indicates that direct administration of busulfan is not ideal for this purpose, 15 mg busulfan kg(-1) was administered to pregnant females at various times between day 10." | 1.32 | Dose-response of RAG2-/-/gammac-/- mice to busulfan in preparation for spermatogonial transplantation. ( Betteridge, KJ; Foster, RA; Hahnel, AC; Moisan, AE, 2003) |
| " Azoospermia at 56 days after treatment, which is a result of stem cell killing, was achieved at doses of over 30 mg/kg; this dose is below the LD50 for animal survival, which was over 40 mg/kg." | 1.27 | Effects of busulfan on murine spermatogenesis: cytotoxicity, sterility, sperm abnormalities, and dominant lethal mutations. ( Bucci, LR; Meistrich, ML, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (21.43) | 18.7374 |
| 1990's | 2 (4.76) | 18.2507 |
| 2000's | 8 (19.05) | 29.6817 |
| 2010's | 17 (40.48) | 24.3611 |
| 2020's | 6 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, S | 1 |
| Xu, Y | 1 |
| Fan, Y | 1 |
| Hu, Y | 2 |
| Zhang, Q | 1 |
| Su, W | 1 |
| Bahmanpour, S | 1 |
| Keshavarz, M | 1 |
| Koohpeyma, F | 1 |
| Badr, P | 1 |
| Noori, A | 1 |
| Dabbaghmanesh, MH | 1 |
| Poordast, T | 1 |
| Najib, FS | 1 |
| Zare, N | 1 |
| Namazi, N | 1 |
| Jahromi, BN | 1 |
| Zhao, L | 1 |
| Zhao, J | 1 |
| Dong, Z | 1 |
| Xu, S | 1 |
| Wang, D | 2 |
| Li, HT | 1 |
| Zhong, K | 1 |
| Xia, YF | 1 |
| Song, J | 1 |
| Chen, XQ | 1 |
| Zhao, W | 1 |
| Zeng, XH | 1 |
| Chen, TX | 1 |
| Yu, S | 1 |
| Zhao, Y | 1 |
| Zhang, FL | 1 |
| Li, YQ | 1 |
| Shen, W | 1 |
| Sun, ZY | 1 |
| Abdollahifar, MA | 1 |
| Azad, N | 1 |
| Faraji Sani, M | 1 |
| Raoofi, A | 1 |
| Abdi, S | 1 |
| Aliaghaei, A | 1 |
| Abbaszadeh, HA | 1 |
| Ebrahimi, V | 1 |
| Fadaei Fathabadi, F | 1 |
| Ghanimat, F | 1 |
| Movahedi, M | 1 |
| Kang, Z | 1 |
| Qiao, N | 1 |
| Tan, Z | 1 |
| Tang, Z | 1 |
| Li, Y | 1 |
| Dehghani, F | 1 |
| Sotoude, N | 1 |
| Bordbar, H | 1 |
| Panjeshahin, MR | 1 |
| Karbalay-Doust, S | 1 |
| Kadam, P | 1 |
| Ntemou, E | 1 |
| Baert, Y | 2 |
| Van Laere, S | 1 |
| Van Saen, D | 2 |
| Goossens, E | 2 |
| AbuMadighem, A | 1 |
| Solomon, R | 1 |
| Stepanovsky, A | 1 |
| Kapelushnik, J | 1 |
| Shi, Q | 1 |
| Meese, E | 1 |
| Lunenfeld, E | 1 |
| Huleihel, M | 1 |
| Liu, FJ | 1 |
| Dong, WY | 1 |
| Zhao, H | 1 |
| Shi, XH | 1 |
| Zhang, YL | 1 |
| Liu, Y | 1 |
| Wu, X | 1 |
| Jiang, H | 1 |
| Zhang, X | 2 |
| Xia, Q | 1 |
| Wei, R | 1 |
| Song, H | 1 |
| Mi, J | 1 |
| Lin, Z | 1 |
| Yang, Y | 1 |
| Sun, Z | 1 |
| Zou, K | 1 |
| Cai, YT | 1 |
| Xiong, CL | 1 |
| Shen, SL | 1 |
| Rao, JP | 1 |
| Liu, TS | 1 |
| Qiu, F | 1 |
| Wilhelmsson, M | 1 |
| Vatanen, A | 1 |
| Borgström, B | 1 |
| Gustafsson, B | 1 |
| Taskinen, M | 1 |
| Saarinen-Pihkala, UM | 1 |
| Winiarski, J | 1 |
| Jahnukainen, K | 1 |
| Benavides-Garcia, R | 1 |
| Joachim, R | 1 |
| Pina, NA | 1 |
| Mutoji, KN | 1 |
| Reilly, MA | 1 |
| Hermann, BP | 2 |
| Gutierrez, K | 1 |
| Glanzner, WG | 1 |
| Chemeris, RO | 1 |
| Rigo, ML | 1 |
| Comim, FV | 1 |
| Bordignon, V | 1 |
| Gonçalves, PB | 1 |
| Qin, Y | 1 |
| Liu, L | 1 |
| He, Y | 1 |
| Wang, C | 1 |
| Liang, M | 1 |
| Chen, X | 1 |
| Hao, H | 1 |
| Qin, T | 1 |
| Zhao, X | 1 |
| Hirabayashi, M | 1 |
| Yoshizawa, Y | 1 |
| Kato, M | 1 |
| Tsuchiya, T | 1 |
| Nagao, S | 1 |
| Hochi, S | 1 |
| Yuan, Z | 1 |
| Hou, R | 1 |
| Wu, J | 1 |
| Zohni, K | 1 |
| Tan, SL | 1 |
| Chan, P | 1 |
| Nagano, MC | 1 |
| Ning, L | 1 |
| in't Veld, P | 1 |
| Tournaye, H | 1 |
| Chen, CH | 1 |
| Wang, CW | 1 |
| Hsu, MI | 1 |
| Huang, YH | 1 |
| Lai, WF | 1 |
| Tzeng, CR | 1 |
| Koruji, M | 1 |
| Shahverdi, A | 1 |
| Janan, A | 1 |
| Piryaei, A | 1 |
| Lakpour, MR | 1 |
| Gilani Sedighi, MA | 1 |
| Niu, Z | 1 |
| Chu, Z | 1 |
| Yu, M | 1 |
| Bai, Y | 1 |
| Wang, L | 1 |
| Hua, J | 1 |
| Shinohara, T | 1 |
| Orwig, KE | 3 |
| Avarbock, MR | 2 |
| Brinster, RL | 3 |
| Brinster, CJ | 1 |
| Ryu, BY | 1 |
| Karagenc, L | 1 |
| Moisan, AE | 1 |
| Foster, RA | 1 |
| Betteridge, KJ | 1 |
| Hahnel, AC | 1 |
| Udagawa, K | 1 |
| Ogawa, T | 1 |
| Watanabe, T | 1 |
| Tamura, Y | 1 |
| Kita, K | 1 |
| Kubota, Y | 1 |
| Sukhwani, M | 1 |
| Lin, CC | 1 |
| Sheng, Y | 1 |
| Tomko, J | 1 |
| Rodriguez, M | 1 |
| Shuttleworth, JJ | 1 |
| McFarland, D | 1 |
| Hobbs, RM | 1 |
| Pandolfi, PP | 1 |
| Schatten, GP | 1 |
| Wang, X | 1 |
| Ding, Q | 1 |
| Zhang, Y | 1 |
| Wang, H | 1 |
| Ma, L | 1 |
| Xie, X | 1 |
| Zimmermann, JW | 1 |
| Krause, W | 1 |
| Schein, PS | 1 |
| Winokur, SH | 1 |
| Bousquet, J | 1 |
| Vanhems, E | 1 |
| Dubuisson, L | 1 |
| Boujrad, N | 1 |
| Guillaumin, JM | 1 |
| Bardos, P | 1 |
| Hochereau de Reviers, MT | 1 |
| Drosdowsky, MA | 1 |
| Carreau, S | 1 |
| Bucci, LR | 1 |
| Meistrich, ML | 1 |
| Hilscher, W | 1 |
| Jones, P | 1 |
| Jackson, H | 3 |
| Craig, AW | 1 |
| Eberle, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Intratesticular PRP Injection[NCT04237779] | 200 participants (Actual) | Interventional | 2020-01-27 | Completed | |||
| Filgrastim for Treatment of Premature Ovarian Insufficiency: Randomized Clinical Trial[NCT02783937] | Phase 4 | 10 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for busulfan and Sterility, Male
| Article | Year |
|---|---|
Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan.
Topics: Busulfan; Humans; Infertility, Male; Male; Orchitis; Spermatogonia; Testis | 2023 |
Immunosuppressive and cytotoxic chemotherapy: long-term complications.
Topics: Alkylating Agents; Antineoplastic Agents; Azathioprine; Bleomycin; Busulfan; Carcinogens; Chemical a | 1975 |
["Environment and fertility". A contribution to the sensitivity of male germ cells to environmental pollutants].
Topics: Animals; Busulfan; Cell Division; Environmental Pollutants; Germ Cells; Gestational Age; Humans; Inf | 1985 |
Effects of alkylating chemicals on reproductive cells.
Topics: Alkylating Agents; Animals; Anthracenes; Autoradiography; Azirines; Busulfan; Esters; Female; Fertil | 1969 |
Antispermatogenic agents.
Topics: Alkylating Agents; Animals; Antimetabolites; Busulfan; Chemosterilants; Contraceptive Agents; Cricet | 1970 |
37 other studies available for busulfan and Sterility, Male
| Article | Year |
|---|---|
Busulfan impairs blood-testis barrier and spermatogenesis by increasing noncollagenous 1 domain peptide via matrix metalloproteinase 9.
Topics: Animals; Antineoplastic Agents, Alkylating; Autoantigens; Blood-Testis Barrier; Busulfan; Cell Membr | 2022 |
Preserving effect of Loboob (a traditional multi-herbal formulation) on sperm parameters of male rats with busulfan-induced subfertility.
Topics: Animals; Busulfan; Humans; Infertility, Male; Male; Rats; Semen; Sperm Count; Sperm Motility; Sperma | 2022 |
Puerarin improves busulfan-induced disruption of spermatogenesis by inhibiting MAPK pathways.
Topics: Animals; Busulfan; Humans; Infertility, Male; Male; Mice; Semen; Spermatogenesis; Testis | 2023 |
Chestnut polysaccharides benefit spermatogenesis through improvement in the expression of important genes.
Topics: Animals; Busulfan; Disease Models, Animal; Drugs, Chinese Herbal; Fagaceae; Gene Expression Regulati | 2020 |
Impaired spermatogenesis caused by busulfan is partially ameliorated by treatment with conditioned medium of adipose tissue derived mesenchymal stem cells.
Topics: Animals; Busulfan; Culture Media, Conditioned; Infertility, Male; Male; Mesenchymal Stem Cells; Mice | 2022 |
Expression patterns and changes of the LCN2 gene in the testes of induced cryptorchidism and busulfan-treated mice.
Topics: Aging; Animals; Busulfan; Cryptorchidism; Gene Expression; In Situ Hybridization; Infertility, Male; | 2017 |
The use of platelet-rich plasma (PRP) to improve structural impairment of rat testis induced by busulfan.
Topics: Animals; Busulfan; Cell Differentiation; Infertility, Male; Male; Platelet-Rich Plasma; Rats; Rats, | 2019 |
Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice.
Topics: Adult Germline Stem Cells; Animals; Busulfan; Cadmium Chloride; Cell Survival; Disease Models, Anima | 2018 |
Development of Spermatogenesis In Vitro in Three-Dimensional Culture from Spermatogonial Cells of Busulfan-Treated Immature Mice.
Topics: Animals; Busulfan; Cell Differentiation; Cells, Cultured; DEAD-box RNA Helicases; DNA-Binding Protei | 2018 |
Effect of molybdenum on reproductive function of male mice treated with busulfan.
Topics: Animals; Apoptosis; Busulfan; Gonadal Steroid Hormones; Infertility, Male; Male; Mice; Molybdenum; O | 2019 |
Raman spectroscopic analysis of testicular lamina propria predicts spermatogenesis in a mouse infertility model.
Topics: Animals; Busulfan; Disease Models, Animal; Infertility, Male; Male; Mice; Mucous Membrane; Seminifer | 2019 |
Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species.
Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Apoptosis; Busulfan; Cells, Cultured; Drug | 2019 |
Mesenchymal stem cell-secreted factors delayed spermatogenesis injuries induced by busulfan involving intercellular adhesion molecule regulation.
Topics: Animals; Apoptosis; Blood-Testis Barrier; Busulfan; Cadherins; Cell Adhesion; Culture Media, Conditi | 2019 |
Adult testicular volume predicts spermatogenetic recovery after allogeneic HSCT in childhood and adolescence.
Topics: Adolescent; Allografts; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; Child, Pres | 2014 |
Granulocyte colony-stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Busulfan; Dose-Response Relationship, Drug; Drug Interac | 2015 |
Gonadotoxic effects of busulfan in two strains of mice.
Topics: Animals; Antineoplastic Agents, Alkylating; Busulfan; Cell Shape; Female; Fertility; Gene Expression | 2016 |
Testicular Busulfan Injection in Mice to Prepare Recipients for Spermatogonial Stem Cell Transplantation Is Safe and Non-Toxic.
Topics: Adult Stem Cells; Animals; Busulfan; Female; Fertility; Immunosuppressive Agents; Infertility, Male; | 2016 |
Availability of subfertile transgenic rats expressing the c-myc gene as recipients for spermatogonial transplantation.
Topics: Animals; Busulfan; Cell Differentiation; Fluorescent Antibody Technique; Genes, myc; Green Fluoresce | 2009 |
Generation of mice by transplantation of an adult spermatogonial cell line after cryopreservation.
Topics: Animals; Animals, Newborn; Busulfan; Cell Line; Cell Proliferation; Cryopreservation; Female; Hair C | 2009 |
The efficiency of male fertility restoration is dependent on the recovery kinetics of spermatogonial stem cells after cytotoxic treatment with busulfan in mice.
Topics: Animals; Busulfan; Cytotoxins; Dose-Response Relationship, Drug; Infertility, Male; Kinetics; Male; | 2012 |
Orthotopic grafting of cryopreserved prepubertal testicular tissue: in search of a simple yet effective cryopreservation protocol.
Topics: Animals; Busulfan; Cryopreservation; Disease Models, Animal; Fertility Preservation; Graft Survival; | 2012 |
Bioluminescence imaging as a tool to evaluate germ cells in vitro and transplantation in vivo as fertility preservation of prepubertal male mice.
Topics: Animals; Benzothiazoles; Busulfan; Disease Models, Animal; Feasibility Studies; Female; Fertility Pr | 2012 |
Proliferation of small number of human spermatogonial stem cells obtained from azoospermic patients.
Topics: Analysis of Variance; Animals; Azoospermia; Biomarkers; Biopsy; Busulfan; Cell Count; Cell Culture T | 2012 |
Germ-like cell differentiation from induced pluripotent stem cells (iPSCs).
Topics: Animals; Busulfan; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Culture Media; Em | 2013 |
Restoration of spermatogenesis in infertile mice by Sertoli cell transplantation.
Topics: Animals; Busulfan; Cadmium; Histocytochemistry; Immunosuppressive Agents; Infertility, Male; Male; M | 2003 |
Restoration of fertility by germ cell transplantation requires effective recipient preparation.
Topics: Alkylating Agents; Animals; Busulfan; Female; Fertility; Germ Cells; Haplotypes; Infertility, Male; | 2003 |
Dose-response of RAG2-/-/gammac-/- mice to busulfan in preparation for spermatogonial transplantation.
Topics: Alkylating Agents; Animals; Busulfan; Cell Death; DNA-Binding Proteins; Dose-Response Relationship, | 2003 |
Testosterone administration promotes regeneration of chemically impaired spermatogenesis in rats.
Topics: Animals; Busulfan; Contraindications; Gonadotropin-Releasing Hormone; Infertility, Male; Male; Rats; | 2006 |
Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques.
Topics: Animals; Antineoplastic Agents, Alkylating; Busulfan; Cryopreservation; Dose-Response Relationship, | 2007 |
Two allogeneic descendents derived from the high-dose busulfan-treated infertile mouse model after freeze-thawed spermatogonial stem cell transplantation.
Topics: Animals; Busulfan; Cell Differentiation; Cell Proliferation; Cell Survival; Cryopreservation; Female | 2008 |
Spermatogenesis following male germ-cell transplantation.
Topics: Animals; Busulfan; Infertility, Male; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Microinj | 1994 |
[Teratogenic damages of the male genital organs].
Topics: Abnormalities, Drug-Induced; Adult; Busulfan; Cryptorchidism; Cyproterone; Female; Genitalia, Male; | 1976 |
[Ultrastructure of testicular Sertoli cells in normal and dysgenesic rats, during the fetal and postnatal periods].
Topics: Animals; Animals, Newborn; Busulfan; Fetus; Infertility, Male; Male; Microscopy, Electron; Rats; Ser | 1978 |
Germ cell-Sertoli cell interactions and production of testosterone by purified Leydig cells from mature rat.
Topics: Animals; Busulfan; Cell Communication; Cells, Cultured; Cryptorchidism; Follicle Stimulating Hormone | 1992 |
Effects of busulfan on murine spermatogenesis: cytotoxicity, sterility, sperm abnormalities, and dominant lethal mutations.
Topics: Alkylating Agents; Animals; Busulfan; Cell Differentiation; Cell Survival; DNA; DNA Damage; Fertilit | 1987 |
Estimation of the duration of spermatogenesis in japanese quail, Coturnix coturnix japonica, using antispermatogonial chemicals.
Topics: Alkanesulfonates; Animals; Busulfan; Coturnix; Cyclohexanols; Infertility, Male; Male; Spermatogenes | 1972 |
[Myleran and damage to spermatozoa in man].
Topics: Adult; Busulfan; Humans; Infertility, Male; Male; Primary Myelofibrosis; Spermatozoa | 1969 |