busulfan has been researched along with Primary Ovarian Insufficiency in 27 studies
Primary Ovarian Insufficiency: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In 1990, a woman aged 20 years, presenting with beta-thalassemia major, underwent chemotherapy (busulfan and cyclophosphamide) and total body irradiation (TBI) before bone marrow transplantation (BMT), the donor being her 17-year-old HLA-compatible sister." | 3.74 | Allograft of ovarian cortex between two genetically non-identical sisters: case report. ( Demylle, D; Dolmans, MM; Donnez, J; Jadoul, P; Pirard, C; Squifflet, J; Van Langendonckt, A, 2007) |
| "Berberine (BBR) is a compound with anti-inflammatory, antioxidant, and anti-apoptotic activities." | 1.91 | Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency in mouse model. ( Fan, X; Guo, W; Liu, Z; Peng, Y; Sun, L; Wang, T; Yang, X; Zhou, J; Zou, T, 2023) |
| " In this study, cyclophosphamide combined with busulfan was used to establish an animal model." | 1.62 | Experimental study for the establishment of a chemotherapy-induced ovarian insufficiency model in rats by using cyclophosphamide combined with busulfan. ( Feng, X; Ling, L; Luo, Y; Tang, D; Wang, Y; Xiong, Z; Zhang, W, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 14 (51.85) | 24.3611 |
| 2020's | 8 (29.63) | 2.80 |
| Authors | Studies |
|---|---|
| Umair, Z | 1 |
| Baek, MO | 1 |
| Song, J | 1 |
| An, S | 1 |
| Chon, SJ | 1 |
| Yoon, MS | 1 |
| Li, X | 1 |
| Ye, H | 1 |
| Su, T | 1 |
| Hu, C | 2 |
| Huang, Y | 1 |
| Fu, X | 1 |
| Zhong, Z | 1 |
| Du, X | 1 |
| Zheng, Y | 1 |
| Peng, Y | 1 |
| Sun, L | 1 |
| Guo, W | 1 |
| Liu, Z | 1 |
| Wang, T | 1 |
| Zou, T | 1 |
| Zhou, J | 1 |
| Yang, X | 1 |
| Fan, X | 1 |
| Shuyuan, Y | 1 |
| Meimei, W | 1 |
| Fenghua, L | 1 |
| Huishan, Z | 1 |
| Min, C | 1 |
| Hongchu, B | 1 |
| Xuemei, L | 1 |
| Noory, P | 2 |
| Navid, S | 2 |
| Zanganeh, BM | 1 |
| Talebi, A | 1 |
| Borhani-Haghighi, M | 1 |
| Gholami, K | 1 |
| Manshadi, MD | 2 |
| Abbasi, M | 2 |
| Luo, Q | 2 |
| Liu, R | 1 |
| Wang, L | 1 |
| Hou, Y | 1 |
| Zhang, H | 2 |
| Chen, C | 1 |
| Li, S | 1 |
| Cao, W | 1 |
| Fu, Q | 1 |
| Li, J | 1 |
| Zheng, L | 1 |
| Huang, J | 2 |
| Tang, D | 1 |
| Feng, X | 1 |
| Ling, L | 1 |
| Zhang, W | 1 |
| Luo, Y | 1 |
| Wang, Y | 1 |
| Xiong, Z | 1 |
| Mohamed, SA | 1 |
| Shalaby, SM | 1 |
| Abdelaziz, M | 1 |
| Brakta, S | 1 |
| Hill, WD | 1 |
| Ismail, N | 1 |
| Al-Hendy, A | 1 |
| Yin, N | 1 |
| Zhang, L | 1 |
| Yuan, W | 1 |
| Zhao, W | 1 |
| Luan, X | 1 |
| Zhang, Q | 2 |
| Bu, S | 1 |
| Sun, J | 1 |
| Xu, M | 1 |
| Yao, X | 2 |
| He, K | 1 |
| Lai, D | 2 |
| Hoshino, Y | 1 |
| Daneshi, E | 1 |
| Zhang, C | 1 |
| Zhu, H | 1 |
| Cui, H | 1 |
| Chang, X | 1 |
| Wang, Z | 2 |
| Jiang, Y | 1 |
| Zhang, Z | 1 |
| Cha, L | 1 |
| Li, L | 2 |
| Zhu, D | 1 |
| Fang, Z | 1 |
| He, Z | 1 |
| Pan, Z | 1 |
| Skaznik-Wikiel, ME | 1 |
| McGuire, MM | 1 |
| Sukhwani, M | 1 |
| Donohue, J | 1 |
| Chu, T | 1 |
| Krivak, TC | 1 |
| Rajkovic, A | 1 |
| Orwig, KE | 1 |
| Champagne, C | 1 |
| Taylor, M | 1 |
| Farrant, P | 1 |
| Wang, F | 1 |
| Wu, X | 1 |
| Xiang, C | 1 |
| Elchuri, SV | 1 |
| Williamson, RS | 1 |
| Clark Brown, R | 1 |
| Haight, AE | 1 |
| Spencer, JB | 1 |
| Buchanan, I | 1 |
| Hassen-Schilling, L | 1 |
| Brown, MR | 1 |
| Mertens, AC | 1 |
| Meacham, LR | 1 |
| Zhang, T | 1 |
| Yan, D | 1 |
| Yang, Y | 1 |
| Ma, A | 1 |
| Pan, Q | 1 |
| Sun, Z | 1 |
| Batchvarov, IS | 1 |
| Taylor, RW | 1 |
| Bustamante-Marín, X | 1 |
| Czerwinski, M | 1 |
| Johnson, ES | 1 |
| Kornbluth, S | 1 |
| Capel, B | 1 |
| Tan, SJ | 1 |
| Yeh, YC | 1 |
| Shang, WJ | 1 |
| Wu, GJ | 1 |
| Liu, JY | 1 |
| Chen, CH | 1 |
| Cho, WK | 1 |
| Lee, JW | 1 |
| Chung, NG | 1 |
| Jung, MH | 1 |
| Cho, B | 1 |
| Suh, BK | 1 |
| Kim, HK | 1 |
| Donnez, J | 1 |
| Dolmans, MM | 1 |
| Pirard, C | 1 |
| Van Langendonckt, A | 1 |
| Demylle, D | 1 |
| Jadoul, P | 1 |
| Squifflet, J | 1 |
| Vergauwen, P | 1 |
| Ferster, A | 1 |
| Valsamis, J | 1 |
| Chanoine, JP | 1 |
| Teinturier, C | 1 |
| Hartmann, O | 1 |
| Valteau-Couanet, D | 1 |
| Benhamou, E | 1 |
| Bougneres, PF | 1 |
| Giorgiani, G | 1 |
| Bozzola, M | 1 |
| Cisternino, M | 1 |
| Locatelli, F | 1 |
| Gambarana, D | 1 |
| Bonetti, F | 1 |
| Zecca, M | 1 |
| Lorini, R | 1 |
| Severi, F | 1 |
| Triantafilo, Y | 1 |
| Arteaga, E | 1 |
| Duque, G | 1 |
| Fernández, C | 1 |
| Grebe, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Filgrastim for Treatment of Premature Ovarian Insufficiency: Randomized Clinical Trial[NCT02783937] | Phase 4 | 10 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| Effects of Adipose Derived Stem Cell Therapy in Women With Premature Ovarian Failure[NCT01853501] | Phase 4 | 4 participants (Anticipated) | Interventional | 2012-09-30 | Enrolling by invitation | ||
| Use of the GnRH Agonist Leuprolide Acetate (Lupron(Registered Trademark)) to Preserve Ovarian Function in Women Undergoing Chemotherapy[NCT00507780] | Phase 4 | 0 participants (Actual) | Interventional | 2007-07-18 | Withdrawn | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
27 other studies available for busulfan and Primary Ovarian Insufficiency
| Article | Year |
|---|---|
MicroRNA-4516 in Urinary Exosomes as a Biomarker of Premature Ovarian Insufficiency.
Topics: Animals; Biomarkers; Busulfan; Cyclophosphamide; Estrogens; Exosomes; Female; Follicle Stimulating H | 2022 |
Immunity and reproduction protective effects of Chitosan Oligosaccharides in Cyclophosphamide/Busulfan-induced premature ovarian failure model mice.
Topics: Animals; Busulfan; Chitosan; Cyclophosphamide; Estrogens; Female; Humans; Interleukin-2; Interleukin | 2023 |
Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency in mouse model.
Topics: Animals; Berberine; Busulfan; Cyclophosphamide; Estradiol; Female; Humans; Mice; Primary Ovarian Ins | 2023 |
hUMSC transplantation restores follicle development in ovary damaged mice via re-establish extracellular matrix (ECM) components.
Topics: Animals; Busulfan; Collagen; Extracellular Matrix; Female; Humans; Laminin; Menopause, Premature; Mi | 2023 |
Human Menstrual Blood Stem Cell-Derived Granulosa Cells Participate in Ovarian Follicle Formation in a Rat Model of Premature Ovarian Failure
Topics: Adult; Alkylating Agents; Animals; Blood Cells; Busulfan; Female; Granulosa Cells; Humans; Menstruat | 2019 |
The Effects of Inhibin B in the Chemotherapy Drug-Induced Premature Ovarian Insufficiency Mice and hPMSCs Treatment.
Topics: Animals; Antineoplastic Agents; Apoptosis; Busulfan; Cyclophosphamide; Disease Models, Animal; Femal | 2020 |
Protective Effects of Puerarin on Premature Ovarian Failure via Regulation of Wnt/β-catenin Signaling Pathway and Oxidative Stress.
Topics: Animals; Apoptosis; Busulfan; Cyclophosphamide; Disease Models, Animal; Female; Isoflavones; Mice; O | 2021 |
Experimental study for the establishment of a chemotherapy-induced ovarian insufficiency model in rats by using cyclophosphamide combined with busulfan.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Busulfan; Cyclophosphamide; Disea | 2021 |
Human Mesenchymal Stem Cells Partially Reverse Infertility in Chemotherapy-Induced Ovarian Failure.
Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Busulfan; Cyclophosphamide; Female; Humans; Mesen | 2018 |
Role of SDF-1/CXCR4 and cytokines in the development of ovary injury in chemotherapy drug induced premature ovarian failure mice.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Busulfan; Chemokine CXCL12 | 2017 |
Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage.
Topics: Amnion; Animals; Busulfan; Coculture Techniques; Culture Media, Conditioned; Cyclophosphamide; Epith | 2017 |
The effects of human menstrual blood stem cells-derived granulosa cells on ovarian follicle formation in a rat model of premature ovarian failure.
Topics: Animals; Anti-Mullerian Hormone; Busulfan; Cell Transplantation; Disease Models, Animal; Female; Fol | 2019 |
Successful pregnancy and childbirth in a patient with acute lymphoblastic leukaemia after busulfan-based myeloablative conditioning allogeneic haematopoietic stem cell transplantation: a case report.
Topics: Adult; Antineoplastic Agents, Alkylating; Busulfan; Female; Hematopoietic Stem Cell Transplantation; | 2020 |
Resveratrol Plays a Protective Role against Premature Ovarian Failure and Prompts Female Germline Stem Cell Survival.
Topics: Animals; Antioxidants; Body Weight; Busulfan; Catalase; Cell Survival; Coculture Techniques; DEAD-bo | 2019 |
Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cyclophosphamide; Disease Models, | 2013 |
Permanent chemotherapy-induced nonscarring alopecia and premature ovarian failure.
Topics: Adult; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Female; Humans; Primary O | 2015 |
Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian failure.
Topics: Adult; Animals; Body Weight; Busulfan; Cell Differentiation; Cyclophosphamide; Disease Models, Anima | 2015 |
The effects of hydroxyurea and bone marrow transplant on Anti-Müllerian hormone (AMH) levels in females with sickle cell anemia.
Topics: Adolescent; Anemia, Sickle Cell; Anti-Mullerian Hormone; Antisickling Agents; Biomarkers; Bone Marro | 2015 |
The comparison of animal models for premature ovarian failure established by several different source of inducers.
Topics: Animals; Busulfan; Cisplatin; Cyclohexenes; Cyclophosphamide; Disease Models, Animal; Dose-Response | 2016 |
A grafted ovarian fragment rescues host fertility after chemotherapy.
Topics: Animals; Apoptosis; Blotting, Western; Busulfan; Cyclophosphamide; Female; Fertility Preservation; G | 2016 |
Protective effect of a gonadotropin-releasing hormone analogue on chemotherapeutic agent-induced ovarian gonadotoxicity: a mouse model.
Topics: Animals; Antineoplastic Agents; Busulfan; Female; Gonadotropin-Releasing Hormone; Mice; Ovarian Foll | 2010 |
Primary ovarian dysfunction after hematopoietic stem cell transplantation during childhood: busulfan-based conditioning is a major concern.
Topics: Adolescent; Busulfan; Child; Female; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myel | 2011 |
Allograft of ovarian cortex between two genetically non-identical sisters: case report.
Topics: Adolescent; Adult; beta-Thalassemia; Busulfan; Combined Modality Therapy; Cyclophosphamide; Female; | 2007 |
Primary ovarian failure after prepubertal marrow transplant in a girl.
Topics: Adolescent; Anemia, Sickle Cell; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Female; Hu | 1994 |
Ovarian function after autologous bone marrow transplantation in childhood: high-dose busulfan is a major cause of ovarian failure.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Bone Marrow Transplantation; Busulfan; Child; | 1998 |
Gonadal function in adolescents receiving different conditioning regimens for bone marrow transplantation.
Topics: Adolescent; Bone Marrow Transplantation; Busulfan; Child; Cyclophosphamide; Female; Humans; Ovary; P | 1991 |
[Pregnancy in a patient with premature ovarian failure secondary to chemotherapy].
Topics: Adult; Amenorrhea; Busulfan; Estrogens; Female; Follicle Stimulating Hormone; Humans; Ovarian Functi | 1991 |