busulfan has been researched along with Neuroectodermal Tumors, Primitive in 5 studies
Neuroectodermal Tumors, Primitive: A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intrathecal Spartaject Busulfan was well tolerated in children with neoplastic meningitis from brain tumors, and the recommended dose for future phase II studies is 13 mg." | 9.12 | Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004). ( Blaney, SM; Bomgaars, L; Boyett, JM; Friedman, HS; Gururangan, S; Hancock, ML; Kun, LE; Petros, WP; Phillips, PC; Poussaint, TY, 2006) |
| "Intrathecal Spartaject Busulfan was well tolerated in children with neoplastic meningitis from brain tumors, and the recommended dose for future phase II studies is 13 mg." | 5.12 | Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004). ( Blaney, SM; Bomgaars, L; Boyett, JM; Friedman, HS; Gururangan, S; Hancock, ML; Kun, LE; Petros, WP; Phillips, PC; Poussaint, TY, 2006) |
| "Here, we report a case of CNS medulloepithelioma successfully treated with high-dose chemotherapy (HDCTX) followed by autologous stem cell transplantation (auto-SCT) without radiotherapy." | 1.42 | An Infant With Medulloepithelioma Successfully Treated by High-dose Chemotherapy Followed by Autologous Peripheral Blood Stem Cell Transplantation Without Radiotherapy. ( Gomi, A; Hayase, T; Hirato, J; Kanai, N; Kawahara, Y; Morimoto, A; Nobusawa, S; Yagi, M, 2015) |
| "Primitive neuroectodermal tumors (PNET) originating within the spinal cord are extraordinarily rare." | 1.37 | Intramedullary PNET of the spine: long-term survival after combined modality therapy and subsequent relapse. ( Anson, J; Gollard, RP; Khoury, J; Mason, J; Rosen, L, 2011) |
| " The highest bioavailability was obtained with busulphan in DMSO administered i." | 1.30 | Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations. ( Boland, I; Gouyette, A; Hartmann, O; Kalifa, C; Morizet, J; Terrier-Lacombe, MJ; Valteau-Couanet, D; Vassal, G, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayase, T | 1 |
| Morimoto, A | 1 |
| Kawahara, Y | 1 |
| Yagi, M | 1 |
| Kanai, N | 1 |
| Nobusawa, S | 1 |
| Hirato, J | 1 |
| Gomi, A | 1 |
| Gollard, RP | 1 |
| Rosen, L | 1 |
| Anson, J | 1 |
| Mason, J | 1 |
| Khoury, J | 1 |
| Pérez-Martínez, A | 1 |
| Lassaletta, A | 1 |
| González-Vicent, M | 1 |
| Sevilla, J | 1 |
| Díaz, MA | 1 |
| Madero, L | 1 |
| Gururangan, S | 1 |
| Petros, WP | 1 |
| Poussaint, TY | 1 |
| Hancock, ML | 1 |
| Phillips, PC | 1 |
| Friedman, HS | 1 |
| Bomgaars, L | 1 |
| Blaney, SM | 1 |
| Kun, LE | 1 |
| Boyett, JM | 1 |
| Boland, I | 1 |
| Vassal, G | 1 |
| Morizet, J | 1 |
| Terrier-Lacombe, MJ | 1 |
| Valteau-Couanet, D | 1 |
| Kalifa, C | 1 |
| Hartmann, O | 1 |
| Gouyette, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Study of Intrathecal Spartaject-Busulfan in Children With Neoplastic Meningitis[NCT00006246] | Phase 1 | 28 participants (Actual) | Interventional | 2000-11-30 | Completed | ||
| A Phase II Study of Intraventricular Methotrexate With Systemic Topotecan and Cyclophosphamide in Children With Recurrent or Progressive Malignant Brain Tumors[NCT02684071] | Phase 2 | 3 participants (Actual) | Interventional | 2016-02-29 | Terminated (stopped due to Lack of additional funding; patients (3) no longer receiving intervention.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for busulfan and Neuroectodermal Tumors, Primitive
| Article | Year |
|---|---|
High-dose chemotherapy with autologous stem cell rescue for children with high risk and recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cerebel | 2005 |
Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004).
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Busulfan; Child; Child, Preschool; Choroid Ple | 2006 |
Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004).
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Busulfan; Child; Child, Preschool; Choroid Ple | 2006 |
Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004).
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Busulfan; Child; Child, Preschool; Choroid Ple | 2006 |
Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004).
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Busulfan; Child; Child, Preschool; Choroid Ple | 2006 |
3 other studies available for busulfan and Neuroectodermal Tumors, Primitive
| Article | Year |
|---|---|
An Infant With Medulloepithelioma Successfully Treated by High-dose Chemotherapy Followed by Autologous Peripheral Blood Stem Cell Transplantation Without Radiotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child, Preschool; Combined Modality Therap | 2015 |
Intramedullary PNET of the spine: long-term survival after combined modality therapy and subsequent relapse.
Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cerebellar Neoplasms; Chemotherapy, Adjuva | 2011 |
Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations.
Topics: Administration, Oral; Animals; Biological Availability; Brain Neoplasms; Busulfan; Carboxymethylcell | 1999 |