busulfan has been researched along with Multiple Sclerosis in 4 studies
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "BUF rats suffering from severe relapsing experimental autoimmune encephalomyelitis (R-EAE), a model for multiple sclerosis, were treated with intensive cytoreductive therapy and grafting of allogeneic bone marrow (BM)." | 1.29 | Treatment of relapsing experimental autoimmune encephalomyelitis with largely MHC-matched allogeneic bone marrow transplantation. ( Mulder, AH; van Bekkum, DW; van Gelder, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Atkins, HL | 1 |
| Bowman, M | 1 |
| Allan, D | 1 |
| Anstee, G | 1 |
| Arnold, DL | 1 |
| Bar-Or, A | 1 |
| Bence-Bruckler, I | 1 |
| Birch, P | 1 |
| Bredeson, C | 1 |
| Chen, J | 1 |
| Fergusson, D | 1 |
| Halpenny, M | 1 |
| Hamelin, L | 1 |
| Huebsch, L | 1 |
| Hutton, B | 1 |
| Laneuville, P | 1 |
| Lapierre, Y | 1 |
| Lee, H | 1 |
| Martin, L | 1 |
| McDiarmid, S | 1 |
| O'Connor, P | 1 |
| Ramsay, T | 1 |
| Sabloff, M | 1 |
| Walker, L | 1 |
| Freedman, MS | 1 |
| Atkins, H | 1 |
| Freedman, M | 1 |
| van Gelder, M | 1 |
| Mulder, AH | 1 |
| van Bekkum, DW | 1 |
| Openshaw, H | 1 |
| Lund, BT | 1 |
| Kashyap, A | 1 |
| Atkinson, R | 1 |
| Sniecinski, I | 1 |
| Weiner, LP | 1 |
| Forman, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Targeting Multiple Sclerosis as an Autoimmune Disease With Intensive Immunoablative Therapy and Immunological Reconstitution: A Potential Curative Therapy for Patients With a Predicted Poor Prognosis[NCT01099930] | Phase 2 | 24 participants (Actual) | Interventional | 2001-08-31 | Completed | ||
| Hematopoietic Stem Cell Transplantation for Treatment of Multiple Sclerosis in Sweden - a Register-based Retrospective Observational Study[NCT05029206] | 174 participants (Actual) | Observational | 2021-05-05 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for busulfan and Multiple Sclerosis
| Article | Year |
|---|---|
Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial.
Topics: Adolescent; Adult; Antilymphocyte Serum; Busulfan; Cyclophosphamide; Disease Progression; Female; He | 2016 |
Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial.
Topics: Adolescent; Adult; Antilymphocyte Serum; Busulfan; Cyclophosphamide; Disease Progression; Female; He | 2016 |
Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial.
Topics: Adolescent; Adult; Antilymphocyte Serum; Busulfan; Cyclophosphamide; Disease Progression; Female; He | 2016 |
Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial.
Topics: Adolescent; Adult; Antilymphocyte Serum; Busulfan; Cyclophosphamide; Disease Progression; Female; He | 2016 |
3 other studies available for busulfan and Multiple Sclerosis
| Article | Year |
|---|---|
Immune ablation followed by autologous hematopoietic stem cell transplantation for the treatment of poor prognosis multiple sclerosis.
Topics: Animals; Antineoplastic Agents; Busulfan; Cyclophosphamide; Diagnosis, Differential; Disease Progres | 2009 |
Treatment of relapsing experimental autoimmune encephalomyelitis with largely MHC-matched allogeneic bone marrow transplantation.
Topics: Animals; Antibodies, Monoclonal; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Disease Mo | 1996 |
Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning: report of toxicity and immunological monitoring.
Topics: Adult; Autoantibodies; Autoantigens; Autoimmune Diseases; Brain; Busulfan; Cells, Cultured; Combined | 2000 |