Page last updated: 2024-10-24

busulfan and Liver Dysfunction

busulfan has been researched along with Liver Dysfunction in 11 studies

Research Excerpts

ExcerptRelevanceReference
"Transfusion of platelet concentrates containing ABO-incompatible plasma increases the risk of hepatic veno-occlusive disease in young children treated with a busulfan-containing regimen."3.73Platelet transfusion containing ABO-incompatible plasma and hepatic veno-occlusive disease after hematopoietic transplantation in young children. ( Aupérin, A; Benhamou, E; Hartmann, O; Lapierre, V; Mahé, C; Oubouzar, N; Stambouli, F; Tiberghien, P; Tramalloni, D, 2005)
" In the (T)BU/CY patients only, the association of the pharmacokinetic data with liver toxicity, relapse, and survival was evaluated."2.73Cyclophosphamide following targeted oral busulfan as conditioning for hematopoietic cell transplantation: pharmacokinetics, liver toxicity, and mortality. ( Batchelder, A; Cole, S; Deeg, HJ; Gooley, T; McCune, JS; McDonald, GB; Phillips, B; Schoch, HG, 2007)
"Hyperbilirubinemia was graded according to a report by Hogan et al (Blood."1.33Hepatic injury following reduced intensity unrelated cord blood transplantation for adult patients with hematological diseases. ( Fujiwara, M; Hori, A; Kami, M; Kanda, Y; Komatsu, T; Koyama, R; Kusumi, E; Masuoka, K; Matsumura, T; Miyakoshi, S; Murashige, N; Seki, K; Tanaka, Y; Taniguchi, S; Wake, A; Yuji, K, 2006)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's5 (45.45)18.2507
2000's3 (27.27)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Simon, N1
Coiteux, V1
Bruno, B1
Taque, S1
Charbonnier, A1
Souchet, L1
Vincent, L1
Yakoub-Agha, I1
Chalandon, Y1
Duchartre, Y1
Petit, N1
Moya, C1
Lalanne, M1
Dubus, P1
Verneuil, Hd1
Moreau-Gaudry, F1
Richard, E1
OISHI, N1
SWISHER, SN1
TROUP, SB1
Lapierre, V1
Mahé, C1
Aupérin, A2
Stambouli, F1
Oubouzar, N1
Tramalloni, D1
Benhamou, E2
Tiberghien, P1
Hartmann, O2
Kusumi, E1
Kami, M1
Kanda, Y1
Murashige, N1
Seki, K1
Fujiwara, M1
Koyama, R1
Komatsu, T1
Hori, A1
Tanaka, Y1
Yuji, K1
Matsumura, T1
Masuoka, K1
Wake, A1
Miyakoshi, S1
Taniguchi, S1
McCune, JS1
Batchelder, A1
Deeg, HJ1
Gooley, T2
Cole, S1
Phillips, B1
Schoch, HG1
McDonald, GB2
Giardini, C2
Galimberti, M2
Lucarelli, G2
Polchi, P2
Baronciani, D2
Angelucci, E2
Erer, B1
Gaziev, D1
Maiello, A1
Styler, MJ1
Crilley, P1
Biggs, J1
Moul, J1
Copelan, E1
Topolsky, D1
Avalos, B1
Penza, S1
Sabol, P1
Downs, K1
Szer, J1
Brodsky, I1
Marks, DI1
Lassau, N1
Leclère, J1
Bourhis, JH1
Valteau-Couanet, D1
Bosq, J1
Ibrahim, A1
Girinski, T1
Pico, JL1
Roche, A1
Lee, JL1
Bensinger, W1
Schiffman, K1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Revisiting the Universal Donor: Does Exposure to O Blood Products Affect Patient Outcomes[NCT04859218]30 participants (Anticipated)Interventional2023-11-30Recruiting
Validating Ultrasound Biomarkers for Hepatic Sinusoidal Obstruction Syndrome in Pediatric Hematopoietic Cell Transplant Patients[NCT03963999]Phase 40 participants (Actual)Interventional2020-04-01Withdrawn (stopped due to We did not receive grant funding. We will reapply in June of 2020)
Usefulness of Liver Stiffness Measurement in Predicting Hepatic Veno-Occlusive Disease Development in Patients Who Undergo HSCT: a Multicentric Prospective Study[NCT03426358]1,101 participants (Actual)Interventional2015-04-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for busulfan and Liver Dysfunction

ArticleYear
[Dose adaptation of the drugs used for hematopoietic stem-cell transplantation in patients with comorbidity: Obesity, chronic renal disease or hepatopathy: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-T
    Bulletin du cancer, 2017, Volume: 104, Issue:12S

    Topics: Adult; Age Factors; Busulfan; Child; Comorbidity; Cyclophosphamide; Etoposide; France; Hematopoietic

2017

Trials

2 trials available for busulfan and Liver Dysfunction

ArticleYear
Cyclophosphamide following targeted oral busulfan as conditioning for hematopoietic cell transplantation: pharmacokinetics, liver toxicity, and mortality.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2007, Volume: 13, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Aged; Busulfan; Chemical and Drug Induced Liver Injury; Cyc

2007
Veno-occlusive disease of the liver after busulfan, melphalan, and thiotepa conditioning therapy: incidence, risk factors, and outcome.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 1999, Volume: 5, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Busulfan; Child; Child, Preschool; Cyclo

1999

Other Studies

8 other studies available for busulfan and Liver Dysfunction

ArticleYear
Neonatal bone marrow transplantation prevents liver disease in a murine model of erythropoietic protoporphyria.
    Journal of hepatology, 2011, Volume: 55, Issue:1

    Topics: Animals; Animals, Newborn; Bone Marrow Transplantation; Busulfan; Disease Models, Animal; Disease Pr

2011
Busulfan therapy in myeloid metaplasia.
    Blood, 1960, Volume: 15

    Topics: Busulfan; Disease; Liver Diseases; Myeloproliferative Disorders; Primary Myelofibrosis; Spleen; Sple

1960
Platelet transfusion containing ABO-incompatible plasma and hepatic veno-occlusive disease after hematopoietic transplantation in young children.
    Transplantation, 2005, Aug-15, Volume: 80, Issue:3

    Topics: ABO Blood-Group System; Adolescent; Antineoplastic Agents; Brain Neoplasms; Busulfan; Chemical and D

2005
Hepatic injury following reduced intensity unrelated cord blood transplantation for adult patients with hematological diseases.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2006, Volume: 12, Issue:12

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Busulfan; Chemical and Drug In

2006
Bone marrow transplantation in class 2 thalassemia patients.
    Bone marrow transplantation, 1993, Volume: 12 Suppl 1

    Topics: Adolescent; Bone Marrow Purging; Bone Marrow Transplantation; Busulfan; Child; Child, Preschool; Cyc

1993
CsA-associated neurotoxicity and ineffective prophylaxis with clonazepam in patients transplanted for thalassemia major: analysis of risk factors.
    Bone marrow transplantation, 1996, Volume: 18, Issue:1

    Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; beta-Thalassemia; Blood

1996
Hepatic dysfunction following busulfan and cyclophosphamide myeloablation: a retrospective, multicenter analysis.
    Bone marrow transplantation, 1996, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bone Marrow Transplantation; Busulfan; Child; Child,

1996
Hepatic veno-occlusive disease after myeloablative treatment and bone marrow transplantation: value of gray-scale and Doppler US in 100 patients.
    Radiology, 1997, Volume: 204, Issue:2

    Topics: Adult; Busulfan; Child; Diagnosis, Differential; Female; Graft vs Host Disease; Hematopoietic Stem C

1997
Hepatic veno-occlusive disease after myeloablative treatment and bone marrow transplantation: value of gray-scale and Doppler US in 100 patients.
    Radiology, 1997, Volume: 204, Issue:2

    Topics: Adult; Busulfan; Child; Diagnosis, Differential; Female; Graft vs Host Disease; Hematopoietic Stem C

1997
Hepatic veno-occlusive disease after myeloablative treatment and bone marrow transplantation: value of gray-scale and Doppler US in 100 patients.
    Radiology, 1997, Volume: 204, Issue:2

    Topics: Adult; Busulfan; Child; Diagnosis, Differential; Female; Graft vs Host Disease; Hematopoietic Stem C

1997
Hepatic veno-occlusive disease after myeloablative treatment and bone marrow transplantation: value of gray-scale and Doppler US in 100 patients.
    Radiology, 1997, Volume: 204, Issue:2

    Topics: Adult; Busulfan; Child; Diagnosis, Differential; Female; Graft vs Host Disease; Hematopoietic Stem C

1997