Page last updated: 2024-10-24

busulfan and Diffuse Large B-Cell Lymphoma

busulfan has been researched along with Diffuse Large B-Cell Lymphoma in 23 studies

Research Excerpts

ExcerptRelevanceReference
"We retrospectively examined the outcomes of 56 patients with diffuse large B-cell lymphoma (DLBCL) who underwent autologous stem cell transplant (ASCT) with BEAM/BEAC (carmustine, etoposide, cytarabine, melphalan/cyclophosphamide) or busulfan (Bu)-containing conditioning regimens."7.80Busulfan-containing conditioning regimens are optimal preparative regimens for autologous stem cell transplant in patients with diffuse large B-cell lymphoma. ( Chung, JS; Kim, H; Kim, JS; Lee, GW; Lee, HS; Lee, WS; Shin, HJ; Song, MK; Yhim, HY, 2014)
" The graft-versus-host disease (GVHD) prophylaxis consisted of tacrolimus and short-term methotrexate."4.12Donor-derived diffuse large B-cell lymphoma after haploidentical stem cell transplantation for acute myeloid leukemia. ( Ishiguro, C; Kawashiri, A; Kurokawa, T; Maeda, Y; Mochizuki, K; Nakagawa, SI, 2022)
"We retrospectively examined the outcomes of 56 patients with diffuse large B-cell lymphoma (DLBCL) who underwent autologous stem cell transplant (ASCT) with BEAM/BEAC (carmustine, etoposide, cytarabine, melphalan/cyclophosphamide) or busulfan (Bu)-containing conditioning regimens."3.80Busulfan-containing conditioning regimens are optimal preparative regimens for autologous stem cell transplant in patients with diffuse large B-cell lymphoma. ( Chung, JS; Kim, H; Kim, JS; Lee, GW; Lee, HS; Lee, WS; Shin, HJ; Song, MK; Yhim, HY, 2014)
"Vorinostat was given at 200 mg/day to 1000 mg/day (days -8 to -3)."2.80Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas. ( Ahmed, S; Alousi, A; Anderlini, P; Andersson, BS; Bashir, Q; Champlin, R; Dabaja, B; Fanale, M; Gulbis, A; Hagemeister, F; Hosing, C; Jones, RB; Liu, Y; Nieto, Y; Oki, Y; Pinnix, C; Popat, U; Qazilbash, M; Shah, N; Shpall, EJ; Thall, PF; Valdez, BC, 2015)
"Since bone marrow biopsy revealed myelofibrosis, she received anabolic hormone therapy."1.35[Long-term remission of non-Hodgkin lymphoma secondary to the treatment for essential thrombocythemia]. ( Kubota, Y; Waki, M, 2009)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19907 (30.43)18.7374
1990's0 (0.00)18.2507
2000's6 (26.09)29.6817
2010's5 (21.74)24.3611
2020's5 (21.74)2.80

Authors

AuthorsStudies
Puckrin, R1
Chua, N1
Shafey, M1
Stewart, DA1
Kawashiri, A1
Nakagawa, SI1
Ishiguro, C1
Mochizuki, K1
Maeda, Y1
Kurokawa, T1
Kodama, Y1
Saburi, M1
Maruyama, R1
Sakata, M1
Takata, H1
Miyazaki, Y1
Kawano, K1
Wada, J1
Urabe, S1
Hazuku, T1
Ohtsuka, E1
Morita, K1
Ashizawa, M1
Toda, Y1
Ikeda, T1
Kawaguchi, SI1
Ito, S1
Ochi, SI1
Nagayama, T1
Mashima, K1
Umino, K1
Minakata, D1
Nakano, H1
Yamasaki, R1
Yamamoto, C1
Hatano, K1
Fujiwara, SI1
Sato, K1
Oh, I1
Ohmine, K1
Muroi, K1
Matsumoto, K1
Kanda, Y1
Epperla, N1
Ahn, KW1
Khanal, M1
Litovich, C1
Ahmed, S2
Ghosh, N1
Fenske, TS1
Kharfan-Dabaja, MA1
Sureda, A1
Hamadani, M1
Shin, HJ1
Lee, WS1
Lee, HS1
Kim, H1
Lee, GW1
Song, MK1
Kim, JS1
Yhim, HY1
Chung, JS1
Nieto, Y1
Valdez, BC1
Thall, PF1
Jones, RB1
Hosing, C1
Popat, U1
Shpall, EJ1
Qazilbash, M1
Gulbis, A1
Anderlini, P1
Alousi, A1
Shah, N1
Bashir, Q1
Liu, Y1
Oki, Y1
Hagemeister, F1
Fanale, M1
Dabaja, B1
Pinnix, C1
Champlin, R1
Andersson, BS1
Lee, MY1
Kim, HS1
Lee, JY1
Lim, SH1
Kang, ES1
Ko, YH1
Kim, SJ1
Kim, WS1
Kubota, Y1
Waki, M1
Miura, Y1
Toyooka, N1
Iwai, F1
Matsui, Y1
Hirai, M1
Kaneko, H1
Watanabe, M1
Tsudo, M1
Papageorgiou, SG1
Diamantopoulos, P1
Levidou, G1
Angelopoulou, MK1
Economopoulou, P1
Efthimiou, A1
Constantinou, N1
Katsigiannis, A1
Korkolopoulou, P1
Pappa, V1
Economopoulou, C1
Georgiou, G1
Dimou, M1
Tsirigotis, P1
Kyrtsonis, MC1
Kotsianidis, I1
Kalpadakis, C1
Dimopoulos, MA1
Beris, P1
Meletis, J1
Pangalis, GA1
Dervenoulas, J1
Panayiotidis, P1
Vassilakopoulos, TP1
PITNEY, WR1
ORIGENES, ML1
BEATTY, EC1
BRUBAKER, C1
HAMMOND, D1
HARTMANN, JR1
SHORE, N1
WILLIAMS, KO1
HUTCHISON, JL1
MORROW, LB1
ANDERSON, RE1
Soussain, C3
Hoang-Xuan, K3
Levy, V2
Rodriguez, R1
Nademanee, A1
Ruel, N1
Smith, E1
Krishnan, A1
Popplewell, L1
Zain, J1
Patane, K1
Kogut, N1
Nakamura, R1
Sarkodee-Adoo, C1
Forman, SJ1
Taillandier, L1
Fourme, E1
Choquet, S1
Witz, F1
Casasnovas, O1
Dupriez, B1
Souleau, B1
Taksin, AL1
Gisselbrecht, C1
Jaccard, A1
Omuro, A1
Sanson, M1
Janvier, M1
Kolb, B1
Zini, JM1
Leblond, V2
Suzan, F1
Cassoux, N1
Azar, N1
Belanger, C1
Achour, E1
Ribrag, V1
Gerber, S1
Delattre, JY1
Bolwell, B1
Kalaycio, M1
Andresen, S1
Goormastic, M1
McBee, M1
Kuczkowski, E1
Wise, K1
Sobecks, R1
Pohlman, B1
Armstrong, JG1
Schmidt, M1
Havemann, K1
Hartwich, G1
Butzler, W1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Study for Safety and Efficacy of BEB (Bendamustine, Etoposide, Busulfan) Conditioning Regimen for ASCT in Non-Hodgkin's Lymphoma[NCT02836639]Phase 220 participants (Anticipated)Interventional2016-02-29Recruiting
Vorinostat (SAHA) Combined With High-Dose Gemcitabine, Busulfan, and Melphalan With Autologous Hematopoietic Cell Support for Patients With Relapsed or Refractory Lymphoid Malignancies[NCT01421173]Phase 178 participants (Actual)Interventional2011-08-31Completed
Safety and Efficacy of Ibritumomab Tiuxetan (Zevalin®) in Association With a Fludarabine Based Reduced Conditioning Regimen and Allogenic Stem Cell Support in Chemo-sensitive Relapsed CD20 Positive Aggressive Non-Hodgkin's Lymphoma Patients.[NCT00607854]Phase 231 participants (Actual)Interventional2008-02-29Completed
A Phase 2a Study of the Addition of Temozolomide to a Standard Conditioning Regimen for Autologous Stem Cell Transplantation in Relapsed and Refractory Central Nervous System (CNS) Lymphoma[NCT01235793]Phase 211 participants (Actual)Interventional2010-10-14Terminated (stopped due to The clinical trial was terminated due to poor enrollment)
High-dose Chemotherapy and Autologous Stem Cell Transplant or Consolidating Conventional Chemotherapy in Primary CNS Lymphoma - Randomized Phase III Trial[NCT02531841]Phase 3250 participants (Anticipated)Interventional2014-07-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Safest Dose of Temozolomide for the DRBEAT Regimen

Safety will be assessed using a dose escalation design for temozolomide's use to determine the target dose and also to evaluate any and all acute treatment related toxicities. During the course of patient follow up and therapy, toxicities will be evaluated, particularly as the investigators will be determining the target dose of temozolomide. One of the major criteria for dose limiting toxicity for the study will be any Grade 3 or 4 nonhematologic toxicity from a list of commonly expected toxicities associated with autologous transplantation and temozolomide. (NCT01235793)
Timeframe: One Year

Interventiondose in mg/m^2 (Number)
DRBEAT Regimen773.25

One-year Progression-free Survival and Overall Survival

"Efficacy of the DRBEAT Regimen will be assessed by analysis of~one-year progression-free survival (PFS), defined as the time interval from maximal response from therapy to tumor regrowth, progression*, or death, (*Progression is defined as meeting the response criteria listed in Table 4: Response Criteria for Primary Central Nervous System Lymphoma according to Abrey LE, Batchelor TT, Ferreri AJM et al.)~and~Overall survival, defined as the time interval between the date of transplant and the date of death from any cause." (NCT01235793)
Timeframe: (1) One Year (2) Until date of death from any cause, assessed up to 2 years

InterventionDays (Median)
Progression Free SurvivalOverall Survival
DRBEAT Regimen132564

Trials

3 trials available for busulfan and Diffuse Large B-Cell Lymphoma

ArticleYear
Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2015, Volume: 21, Issue:11

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Deoxycytidine; Dr

2015
Intensive chemotherapy followed by hematopoietic stem-cell rescue for refractory and recurrent primary CNS and intraocular lymphoma: Société Française de Greffe de Moëlle Osseuse-Thérapie Cellulaire.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, May-20, Volume: 26, Issue:15

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Busulfan; Combined Mod

2008
Intensive chemotherapy followed by hematopoietic stem-cell rescue for refractory and recurrent primary CNS and intraocular lymphoma: Société Française de Greffe de Moëlle Osseuse-Thérapie Cellulaire.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, May-20, Volume: 26, Issue:15

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Busulfan; Combined Mod

2008
Intensive chemotherapy followed by hematopoietic stem-cell rescue for refractory and recurrent primary CNS and intraocular lymphoma: Société Française de Greffe de Moëlle Osseuse-Thérapie Cellulaire.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, May-20, Volume: 26, Issue:15

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Busulfan; Combined Mod

2008
Intensive chemotherapy followed by hematopoietic stem-cell rescue for refractory and recurrent primary CNS and intraocular lymphoma: Société Française de Greffe de Moëlle Osseuse-Thérapie Cellulaire.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, May-20, Volume: 26, Issue:15

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Busulfan; Combined Mod

2008
Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Feb-01, Volume: 19, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neoplasms; C

2001

Other Studies

20 other studies available for busulfan and Diffuse Large B-Cell Lymphoma

ArticleYear
Improving the outcomes of secondary CNS lymphoma with high-dose thiotepa, busulfan, melphalan, rituximab conditioning and autotransplant.
    Leukemia & lymphoma, 2022, Volume: 63, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Autografts; Busulfan; Central Nervous S

2022
Donor-derived diffuse large B-cell lymphoma after haploidentical stem cell transplantation for acute myeloid leukemia.
    Journal of clinical and experimental hematopathology : JCEH, 2022, Volume: 62, Issue:3

    Topics: Antilymphocyte Serum; Azacitidine; Busulfan; Epstein-Barr Virus Infections; Graft vs Host Disease; H

2022
[Busulfan/thiotepa followed by autologous peripheral blood stem cell transplantation for refractory diffuse large B-cell lymphoma accompanied by hypopyon].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2022, Volume: 63, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cyclophosphamide; Doxorubicin; Humans; Lym

2022
Salvage Chemotherapy Followed by Autologous Stem-Cell Transplantation Using Targeted Busulfan for Refractory Diffuse Large B-Cell Lymphoma With Dialysis-Dependent End-Stage Renal Disease.
    Clinical lymphoma, myeloma & leukemia, 2020, Volume: 20, Issue:2

    Topics: Busulfan; Humans; Kidney Failure, Chronic; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Renal

2020
Impact of Reduced-Intensity Conditioning Regimens on Outcomes in Diffuse Large B Cell Lymphoma Undergoing Allogeneic Transplantation.
    Transplantation and cellular therapy, 2021, Volume: 27, Issue:1

    Topics: Adult; Busulfan; Humans; Lymphoma, Large B-Cell, Diffuse; Neoplasm Recurrence, Local; Transplantatio

2021
Busulfan-containing conditioning regimens are optimal preparative regimens for autologous stem cell transplant in patients with diffuse large B-cell lymphoma.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:11

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Busulfan; Carmustine; Cyclophosphamide; Cytarabine;

2014
Efficacy and feasibility of autologous stem cell transplantation in patients with diffuse large B‑cell lymphoma with secondary central nervous system involvement.
    International journal of hematology, 2015, Volume: 102, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autografts; Busulfan; Central Nervous System Neoplas

2015
[Long-term remission of non-Hodgkin lymphoma secondary to the treatment for essential thrombocythemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2009, Volume: 50, Issue:3

    Topics: Alkylating Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Co

2009
[Sustained complete remission of intravascular large B-cell lymphoma with recurrent CNS involvement by autologous peripheral blood stem cell transplantation preconditioned with TBC regimen].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2011, Volume: 52, Issue:12

    Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neop

2011
Isolated central nervous system relapses in primary mediastinal large B-cell lymphoma after CHOP-like chemotherapy with or without Rituximab.
    Hematological oncology, 2013, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherap

2013
Chemotherapy of malignant disease. II. Diseases of lymphoid tissue and bone marrow.
    The Medical journal of Australia, 1962, Dec-01, Volume: 49(2)

    Topics: Adrenal Cortex Hormones; Aged; Bone Marrow; Busulfan; Chlorambucil; Cyclophosphamide; Hodgkin Diseas

1962
TRIAL OF HYDROXYUREA (NSC-32065) IN CANCER IN CHILDREN.
    Cancer chemotherapy reports, 1964, Volume: 37

    Topics: Antineoplastic Agents; Busulfan; Child; Cyclophosphamide; Dactinomycin; Humans; Hydroxyurea; Leukemi

1964
THE MANAGEMENT OF LEUKEMIA AND LYMPHOMA.
    Applied therapeutics, 1964, Volume: 6

    Topics: Adrenal Cortex Hormones; Busulfan; Chlorambucil; Cortisone; Cyclophosphamide; Hodgkin Disease; Human

1964
ACTIVE TUBERCULOSIS IN LEUKEMIA. MALIGNANT LYMPHOMA AND MYELOFIBROSIS.
    Archives of pathology, 1965, Volume: 79

    Topics: Alkylating Agents; Aminopterin; Busulfan; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leu

1965
[Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma].
    Bulletin du cancer, 2004, Volume: 91, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neopla

2004
Comparison of reduced-intensity and conventional myeloablative regimens for allogeneic transplantation in non-Hodgkin's lymphoma.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2006, Volume: 12, Issue:12

    Topics: Adolescent; Adult; Aged; Busulfan; Cause of Death; Cohort Studies; Cyclophosphamide; Disease-Free Su

2006
Autologous peripheral blood progenitor cell transplantation for transformed diffuse large-cell lymphoma.
    Clinical lymphoma, 2000, Volume: 1, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cell Transformati

2000
Current problems in the use of the oncolytic drugs.
    Acta geneticae medicae et gemellologiae, 1968, Volume: 17, Issue:1

    Topics: Antineoplastic Agents; Busulfan; Carcinoma, Squamous Cell; Child; Chlorambucil; Choriocarcinoma; Dac

1968
[Treatment of chronic myeloid leukemia and lymphoreticular sarcoma with piposulfan].
    Deutsche medizinische Wochenschrift (1946), 1970, May-22, Volume: 95, Issue:21

    Topics: Adult; Aged; Anemia, Aplastic; Antineoplastic Agents; Busulfan; Female; Humans; Leukemia, Myeloid; L

1970
[Secondary tumors in hemoblastoses during cytostatic treatment].
    Medizinische Klinik, 1971, Oct-22, Volume: 66, Issue:43

    Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Agents; Bronchial Neoplasms; Busulfan; Carcinoma; Chlo

1971