Page last updated: 2024-10-24

busulfan and Blast Phase

busulfan has been researched along with Blast Phase in 31 studies

Research Excerpts

ExcerptRelevanceReference
"An attempt to prevent the blast crisis in chronic myeloid leukemia by the use of pulsed doses of (cytarabine cytosine arabinoside) and lomustine was attempted as a cooperative group study by Cancer and Leukemia Group B."9.07Attempted prevention of blast crisis in chronic myeloid leukemia by the use of pulsed doses of cytarabine and lomustine. A Cancer and Leukemia Group B study. ( Brunner, K; Dear, KB; Haurani, F; Holland, JF; Karanas, A; Silver, RT; Weil, M, 1992)
"The frequency of induced sister chromatid exchange (SCE) as a sensitive parameter for chemotherapy resistance was studied after in vitro treatment with busulfan in four cases of myeloid blast crisis of Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML)."7.68Biclonal analysis of busulfan-induced sister chromatid exchange in blast crisis of Philadelphia chromosome-positive chronic myeloid leukemia. ( Becher, R; Prescher, G, 1991)
"Thirty-six adults with chronic myelogenous leukemia (CML) in second or greater chronic phase, accelerated phase, or blast crisis underwent marrow or blood stem cell transplantation from an HLA-matched sibling using high-dose thiotepa, busulfan and cyclophosphamide (TBC) as the preparative regimen."5.09Thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic transplantation for advanced chronic myelogenous leukemia. ( Andersson, B; Champlin, R; Deisseroth, AB; Gajewski, J; Giralt, S; Ippoliti, C; Khouri, I; Körbling, M; Lee, MS; Mehra, R; Przepiorka, D; Thall, P; van Besien, K, 1999)
"A national cooperative group trial was conducted in 153 patients with chronic myelogenous leukemia (CML) in chronic phase treated with oral pulse busulfan to determine if oral vitamin A can increase the time to blast crisis and enhance survival of patients."5.08Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial. ( Appelbaum, FR; Balcerzak, SP; Hynes, H; Kopecky, KJ; Meyskens, FL; Samlowski, W, 1995)
"Six patients with either acceleration or blast crisis of transformed chronic myeloid leukemia (CML) were treated with high-dose interferon alpha in combination with hydroxyurea."5.08Successful treatment of accelerated and blastic phase of chronic myeloid leukemia with high-dose interferon alpha and hydroxyurea: a novel approach. ( Heinemann, V; Jehn, U; Pötscher, C, 1995)
"An attempt to prevent the blast crisis in chronic myeloid leukemia by the use of pulsed doses of (cytarabine cytosine arabinoside) and lomustine was attempted as a cooperative group study by Cancer and Leukemia Group B."5.07Attempted prevention of blast crisis in chronic myeloid leukemia by the use of pulsed doses of cytarabine and lomustine. A Cancer and Leukemia Group B study. ( Brunner, K; Dear, KB; Haurani, F; Holland, JF; Karanas, A; Silver, RT; Weil, M, 1992)
"A 57-year-old male who had suffered from polycythemia vera (PV) and had been treated with pipobroman, carbazilquinon and busulfan for ten years presented with fever."4.78[Megakaryoblastic transformation associated with disseminated intravascular coagulation in the course of polycythemia vera: a case report]. ( Hino, K; Koike, T; Sakashita, A; Sato, S; Tomoyasu, S; Tsuruoka, N, 1992)
" All the patients were conditioned with cyclophosphamide and busulfan, and treated with cyclosporin (CsA)/methotrexate (MTX)/mycophenolate mofetil (MMF) for graft-versus-host disease (GVHD) prophylaxis."3.77Imatinib combined with myeloablative allogeneic hematopoietic stem cell transplantation for advanced phases of chronic myeloid leukemia. ( Cai, Z; Han, X; He, J; Huang, H; Li, L; Lin, M; Luo, Y; Shi, J; Tan, Y; Xie, W; Ye, X; Zhao, Y; Zheng, Y, 2011)
" Overexpression of P-170 without amplification of MDR-1 was found in four of 11 patients with chronic phase CML at diagnosis, seven of 16 patients treated with busulfan or hydroxyurea in chronic phase and four of 15 patients in blast crisis."3.68The role of the MDR-1/P-170 mechanism in the development of multidrug resistance in chronic myeloid leukemia. ( Dowding, C; Goldman, J; Paulsen, W; Weide, R, 1990)
"The frequency of induced sister chromatid exchange (SCE) as a sensitive parameter for chemotherapy resistance was studied after in vitro treatment with busulfan in four cases of myeloid blast crisis of Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML)."3.68Biclonal analysis of busulfan-induced sister chromatid exchange in blast crisis of Philadelphia chromosome-positive chronic myeloid leukemia. ( Becher, R; Prescher, G, 1991)
"The clinical course of 196 patients with chronic myelocytic leukemia (CML) was studied."2.67[Evaluation of 196 patients with chronic myeloid leukemia based on a standard prognosis model]. ( Anger, B; Carbonell, F; Ganser, A; Heimpel, H; Robertson, J; Schmeiser, T; Sokal, JE, 1990)
"Splenomegaly and hepatomegaly were present in 90% and 48% respectively."1.28Chronic granulocytic leukaemia. A study of 160 cases. ( Kumar, L; Maitreyan, V; Majhi, U; Sagar, TG; Shanta, V, 1990)
"A case of chronic myelogenous leukemia (CML) of 10-year survival in described."1.28[Bone marrow aplasia without blast crisis in a case of CML of 10-year survival]. ( Abe, R; Ishibashi, T; Kariyone, S; Kimura, H; Matsuda, S; Shichishima, T; Shiga, Y; Uchida, T; Yokoyama, A; Yui, T, 1989)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19908 (25.81)18.7374
1990's18 (58.06)18.2507
2000's3 (9.68)29.6817
2010's2 (6.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, JH1
Stein, A1
Tsai, N1
Schultheiss, TE1
Palmer, J1
Liu, A1
Rosenthal, J1
Forman, SJ1
Wong, JY1
Luo, Y1
Zhao, Y1
Tan, Y1
Shi, J1
Han, X1
Zheng, Y1
Li, L1
He, J1
Xie, W1
Ye, X1
Cai, Z1
Lin, M1
Huang, H1
Oyekunle, AA1
Kröger, N1
Zabelina, T1
Ayuk, F1
Schieder, H1
Renges, H1
Fehse, N1
Waschke, O1
Fehse, B1
Kabisch, H1
Zander, AR1
Busuttil, DP1
Meyskens, FL1
Kopecky, KJ1
Appelbaum, FR1
Balcerzak, SP1
Samlowski, W1
Hynes, H1
Kiyoi, H1
Fukutani, H1
Yamauchi, T1
Kubo, K1
Ohno, R1
Yamamori, S1
Naoe, T1
Hehlmann, R2
Heimpel, H3
Hasford, J2
Kolb, HJ2
Pralle, H2
Hossfeld, DK2
Queisser, W2
Löffler, H2
Hochhaus, A1
Heinze, B2
Goldman, JM2
Shibata, A1
Reiffers, J1
Montastruc, M1
Marit, G1
Cony-Makhoul, P1
Faberes, C1
Bilhou-Nabera, C1
Gharbi, MJ1
Bernard, P1
Vezon, G1
Broustet, A1
Georgii, A1
Grande, M1
Jehn, U1
Pötscher, C1
Heinemann, V1
Manley, R1
Cochrane, J1
McDonald, M1
Rigby, S1
Moore, A1
Kirk, A1
Clarke, S1
Crossen, PE1
Morris, CM1
Patton, WN1
Przepiorka, D1
Khouri, I1
Thall, P1
Mehra, R1
Lee, MS1
Ippoliti, C1
Giralt, S1
Gajewski, J1
van Besien, K1
Andersson, B1
Körbling, M1
Deisseroth, AB1
Champlin, R1
Takami, A1
Chuhjo, T1
Nakao, S1
Silver, RT2
Karanas, A1
Dear, KB1
Weil, M1
Brunner, K1
Haurani, F1
Holland, JF2
Glejzer, O1
Sedzimirska, M1
Tomaszewska-Toporska, B1
Tomeczko, J1
Kołodziej, J1
Pacuszko, T1
Was, A1
Bocheńska, J1
Jaźwiec, B1
Klimczak, A1
Hino, K1
Sato, S1
Sakashita, A1
Tomoyasu, S1
Tsuruoka, N1
Koike, T1
Anger, B1
Schmeiser, T1
Robertson, J1
Sokal, JE1
Ganser, A1
Carbonell, F1
Weide, R1
Dowding, C1
Paulsen, W1
Goldman, J1
Becher, R1
Prescher, G1
Kumar, L1
Sagar, TG1
Maitreyan, V1
Majhi, U1
Shanta, V1
Kotelnikov, VM1
Lishmanova, NG1
Khoroshko, ND1
Alieva, TM1
Kozinets, GI1
Allan, NC2
Shepherd, PC1
Shiga, Y1
Yokoyama, A1
Ishibashi, T1
Shichishima, T1
Abe, R1
Yui, T1
Kimura, H1
Matsuda, S1
Uchida, T1
Kariyone, S1
Mick, R1
Degnan, TJ1
Cavelli, F1
Avilés, A1
Ibarrola, JL1
Sigler, L1
Pizzuto, J1
Inoue, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Pegylated Proline Interferon Alpha 2b (AOP2014) in Maintaining Deep Molecular Remissions in Patients With Chronic Myeloid Leukemia (CML) Who Discontinue ABL-Kinase Inhibitor Therapy - a Randomized Phase III, Multicenter Trial With P[NCT03117816]Phase 3214 participants (Actual)Interventional2017-05-04Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for busulfan and Blast Phase

ArticleYear
Management of chronic myeloid leukaemia.
    Blood reviews, 1994, Volume: 8, Issue:1

    Topics: Actuarial Analysis; Adolescent; Adult; Aged; Blast Crisis; Bone Marrow Transplantation; Busulfan; Ch

1994
[Allogeneic bone marrow transplantation in myeloid leukemia: chemical conditioning, clinical course and results].
    Acta haematologica Polonica, 1992, Volume: 23, Issue:2 Suppl 1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Bone Marrow Transpl

1992
[Megakaryoblastic transformation associated with disseminated intravascular coagulation in the course of polycythemia vera: a case report].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1992, Volume: 33, Issue:4

    Topics: Blast Crisis; Busulfan; Carbazilquinone; Disseminated Intravascular Coagulation; Humans; Leukemia, M

1992
Treatment of chronic myeloid leukaemia.
    Bailliere's clinical haematology, 1987, Volume: 1, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Busulfan; Dose-Response Relationship,

1987
Therapeutic options in chronic myeloid leukaemia.
    Blood reviews, 1989, Volume: 3, Issue:1

    Topics: Blast Crisis; Bone Marrow Transplantation; Busulfan; Humans; Hydroxyurea; Leukemia, Myelogenous, Chr

1989
[Bone marrow transplantation in pediatric patients: review of progress].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:4

    Topics: Anemia, Aplastic; Blast Crisis; Bone Marrow Transplantation; Busulfan; Child; Cyclosporins; Graft vs

1987

Trials

9 trials available for busulfan and Blast Phase

ArticleYear
Extramedullary relapse following total marrow and lymphoid irradiation in patients undergoing allogeneic hematopoietic cell transplantation.
    International journal of radiation oncology, biology, physics, 2014, May-01, Volume: 89, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents; Blast Crisis; Bone Marrow; Busulfan; Ch

2014
Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial.
    Leukemia research, 1995, Volume: 19, Issue:9

    Topics: Antineoplastic Agents, Alkylating; Blast Crisis; Busulfan; Female; Humans; Leukemia, Myelogenous, Ch

1995
Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia. The German CML Study Group.
    Blood, 1994, Dec-15, Volume: 84, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blast Crisis; Busulfan; Cross-Over Studies; Drug Resista

1994
Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group.
    Blood, 1993, Jul-15, Volume: 82, Issue:2

    Topics: Blast Crisis; Busulfan; Drug Resistance; Female; Humans; Hydroxyurea; Leukemia, Myelogenous, Chronic

1993
Successful treatment of accelerated and blastic phase of chronic myeloid leukemia with high-dose interferon alpha and hydroxyurea: a novel approach.
    Leukemia & lymphoma, 1995, Volume: 19, Issue:1-2

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Antineoplastic Agents; Antineoplastic Combined

1995
Thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic transplantation for advanced chronic myelogenous leukemia.
    Bone marrow transplantation, 1999, Volume: 23, Issue:10

    Topics: Adult; Antineoplastic Agents, Alkylating; Blast Crisis; Bone Marrow Transplantation; Busulfan; Cyclo

1999
Attempted prevention of blast crisis in chronic myeloid leukemia by the use of pulsed doses of cytarabine and lomustine. A Cancer and Leukemia Group B study.
    Leukemia & lymphoma, 1992, Volume: 7, Issue:1-2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Busulfan; Cytarabine; Female; Follow-U

1992
[Evaluation of 196 patients with chronic myeloid leukemia based on a standard prognosis model].
    Onkologie, 1990, Volume: 13, Issue:2

    Topics: Biomarkers, Tumor; Blast Crisis; Busulfan; Clinical Trials as Topic; Female; Follow-Up Studies; Huma

1990
Attempted prevention of blast crisis in chronic myeloid leukemia by the use of pulsed doses of cytosine arabinoside and cis-chloronitrosurea during the course of busulfan-maintained remission.
    Cancer investigation, 1988, Volume: 6, Issue:3

    Topics: Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Busulfan; Clinical

1988

Other Studies

16 other studies available for busulfan and Blast Phase

ArticleYear
Imatinib combined with myeloablative allogeneic hematopoietic stem cell transplantation for advanced phases of chronic myeloid leukemia.
    Leukemia research, 2011, Volume: 35, Issue:10

    Topics: Adult; Benzamides; Blast Crisis; Busulfan; Combined Modality Therapy; Cyclophosphamide; Cyclosporine

2011
Allogeneic stem-cell transplantation in patients with refractory acute leukemia: a long-term follow-up.
    Bone marrow transplantation, 2006, Volume: 37, Issue:1

    Topics: Adolescent; Adult; Blast Crisis; Busulfan; Child; Child, Preschool; Cyclophosphamide; Disease-Free S

2006
Prolonged imatinib-induced myelosuppression in chronic myeloid leukaemia with an unusually long survival.
    International journal of laboratory hematology, 2008, Volume: 30, Issue:1

    Topics: Adult; Antineoplastic Agents; Benzamides; Blast Crisis; Busulfan; Fatal Outcome; Humans; Imatinib Me

2008
Continuing immunoglobulin heavy chain gene rearrangements in chronic myeloid leukemia with recurrent B-lymphoid blast crises after bone marrow transplantation.
    Leukemia, 1995, Volume: 9, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Base Sequence; Blast Crisis; B

1995
[Clinical study of chronic myelogenous leukemia].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1993, Sep-10, Volume: 82, Issue:9

    Topics: Blast Crisis; Bone Marrow Transplantation; Busulfan; Granulocytes; Humans; Hydroxyurea; Interferon-a

1993
Autologous blood stem cell transplantation followed by recombinant alpha interferon as treatment for patients with high-risk chronic myelogenous leukemia. A report of 32 cases.
    Leukemia & lymphoma, 1993, Volume: 11 Suppl 1

    Topics: Adult; Blast Crisis; Blood Component Transfusion; Blood Transfusion, Autologous; Bone Marrow Purging

1993
Central nervous system granulocytic sarcoma in a patient with essential thrombocythemia.
    American journal of hematology, 1996, Volume: 51, Issue:1

    Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Blast Crisi

1996
Clonally unrelated BCR-ABL-negative acute myeloblastic leukemia masquerading as blast crisis after busulphan and interferon therapy for BCR-ABL-positive chronic myeloid leukemia.
    Leukemia, 1999, Volume: 13, Issue:1

    Topics: Acute Disease; Adult; Blast Crisis; Bone Marrow; Busulfan; Diagnosis, Differential; Female; Fusion P

1999
Relapse of chronic myeloid leukemia (CML) in lymphoid crisis after allogeneic bone marrow transplantation for CML in chronic phase with busulfan plus cyclophosphamide regimen.
    Haematologica, 2002, Volume: 87, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Bone Marrow Transplantation; Bu

2002
The role of the MDR-1/P-170 mechanism in the development of multidrug resistance in chronic myeloid leukemia.
    Leukemia, 1990, Volume: 4, Issue:10

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Busulfan; Drug Resistance; Ge

1990
Biclonal analysis of busulfan-induced sister chromatid exchange in blast crisis of Philadelphia chromosome-positive chronic myeloid leukemia.
    Cancer genetics and cytogenetics, 1991, Volume: 52, Issue:1

    Topics: Blast Crisis; Busulfan; Cell Cycle; Diploidy; Drug Resistance; Humans; Leukemia, Myelogenous, Chroni

1991
Chronic granulocytic leukaemia. A study of 160 cases.
    The Journal of the Association of Physicians of India, 1990, Volume: 38, Issue:12

    Topics: Adolescent; Adult; Aged; Blast Crisis; Busulfan; Female; Follow-Up Studies; Hepatomegaly; Humans; In

1990
Cytophotometry of granulocytes in chronic granulocytic leukaemia patients. Part II. Effects of chemotherapy on cell kinetics and cytochemical parameters of granulocytes.
    Folia haematologica (Leipzig, Germany : 1928), 1987, Volume: 114, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Bone Marrow; Busulfan; Cell Division;

1987
Current treatment of chronic myelogenous leukemia.
    Pathologie-biologie, 1989, Volume: 37, Issue:2

    Topics: Blast Crisis; Bone Marrow Transplantation; Busulfan; Humans; Hydroxyurea; Interferons; Leukemia, Mye

1989
[Bone marrow aplasia without blast crisis in a case of CML of 10-year survival].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1989, Volume: 30, Issue:5

    Topics: Adult; Anemia, Aplastic; Blast Crisis; Bone Marrow; Busulfan; Humans; Leukemia, Myelogenous, Chronic

1989
[Early splenectomy in chronic granulocytic leukemia. 15 years' experience].
    Sangre, 1986, Volume: 31, Issue:6

    Topics: Adult; Blast Crisis; Busulfan; Combined Modality Therapy; Follow-Up Studies; Humans; Leukemia, Myelo

1986