buspirone has been researched along with Seizures in 9 studies
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We studied the buspirone effects on oxidative stress in rat hippocampus after seizures and status epilepticus (SE) induced by pilocarpine." | 7.76 | Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone. ( de Freitas, RL; de Freitas, RM; de Souza, GF; Saldanha, GB; Santos, IM; Tomé, Ada R, 2010) |
| "Buspirone HCl (Buspar) is a novel anxiolytic agent unrelated to the benzodiazepines or other psychotherapeutic agents." | 6.65 | Buspirone: an anxioselective alternative for the management of anxiety disorders. ( Eison, AS; Eison, MS; Newton, RE; Riblet, LA; Taylor, DP; Temple, DL, 1983) |
| " We studied the buspirone effects on oxidative stress in rat hippocampus after seizures and status epilepticus (SE) induced by pilocarpine." | 3.76 | Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone. ( de Freitas, RL; de Freitas, RM; de Souza, GF; Saldanha, GB; Santos, IM; Tomé, Ada R, 2010) |
| "The effect of buspirone on the protection of chemically and electrically-induced seizures by anticonvulsant drugs was studied in mice." | 3.70 | NORADRENERGIC MECHANISMS IN THE PROCONVULSANT EFFECTS OF BUSPIRONE. ( Pillai, KK; Vohora, D, 1999) |
| "Buspirone, gepirone and ipsaperone administered intraperitoneally (40 mg/kg) to naive rats were found to be proconvulsive for strychnine-induced seizures." | 3.67 | Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats. ( Anderson, MC; Chung, E; Van Woert, MH, 1988) |
| "Buspirone HCl (Buspar) is a novel anxiolytic agent unrelated to the benzodiazepines or other psychotherapeutic agents." | 2.65 | Buspirone: an anxioselective alternative for the management of anxiety disorders. ( Eison, AS; Eison, MS; Newton, RE; Riblet, LA; Taylor, DP; Temple, DL, 1983) |
| " Combining of xanthone with piperazine moiety resulted in obtaining of compounds with increased bioavailability after oral administration." | 1.39 | Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety. ( Bojarski, AJ; Gunia, A; Marona, H; Pytka, K; Satała, G; Siwek, A; Szkaradek, N; Szneler, E; Waszkielewicz, AM, 2013) |
| " Drug-related toxic signs included decreased activity and convulsions accompanied with salivation and opisthotonus in mice and rats treated with BH regardless of administration routes, and tremors and clonic convulsions accompanied with salivation in dogs treated with BH orally." | 1.28 | [Acute toxicity study of buspirone hydrochloride in mice, rats and dogs]. ( Chikazawa, H; Ishikawa, K; Kadota, T; Kai, S; Kawano, S; Kohmura, H; Kondoh, H; Kuroyanagi, K; Ohta, S; Takahashi, N, 1990) |
| "Postdecapitation convulsions were analyzed in rats after the administration of a variety of adrenergic and serotonergic agents." | 1.27 | Modulation of postdecapitation convulsions in rats by alpha-adrenergic and 5-hydroxytryptamine1A agents. ( Gonzales, DA; Peroutka, SJ; Shapiro, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia, A | 1 |
| Szkaradek, N | 1 |
| Pytka, K | 1 |
| Siwek, A | 1 |
| Satała, G | 1 |
| Bojarski, AJ | 1 |
| Szneler, E | 1 |
| Marona, H | 1 |
| Vohora, D | 1 |
| Pillai, KK | 1 |
| de Freitas, RL | 1 |
| Santos, IM | 1 |
| de Souza, GF | 1 |
| Tomé, Ada R | 1 |
| Saldanha, GB | 1 |
| de Freitas, RM | 1 |
| Riblet, LA | 2 |
| Taylor, DP | 2 |
| Eison, MS | 2 |
| Stanton, HC | 1 |
| Eison, AS | 1 |
| Newton, RE | 1 |
| Temple, DL | 1 |
| Kadota, T | 1 |
| Kawano, S | 1 |
| Chikazawa, H | 1 |
| Kondoh, H | 1 |
| Kuroyanagi, K | 1 |
| Ohta, S | 1 |
| Ishikawa, K | 1 |
| Kai, S | 1 |
| Kohmura, H | 1 |
| Takahashi, N | 1 |
| Perry, PJ | 1 |
| Peroutka, SJ | 1 |
| Gonzales, DA | 1 |
| Shapiro, M | 1 |
| Anderson, MC | 1 |
| Chung, E | 1 |
| Van Woert, MH | 1 |
1 trial available for buspirone and Seizures
| Article | Year |
|---|---|
Buspirone: an anxioselective alternative for the management of anxiety disorders.
Topics: Aggression; Animals; Anxiety Disorders; Arousal; Avoidance Learning; Buspirone; Clinical Trials as T | 1983 |
8 other studies available for buspirone and Seizures
| Article | Year |
|---|---|
Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.
Topics: Administration, Oral; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroshock; Half-Lif | 2013 |
NORADRENERGIC MECHANISMS IN THE PROCONVULSANT EFFECTS OF BUSPIRONE.
Topics: Animals; Anticonvulsants; Buspirone; Male; Mice; Picrotoxin; Receptors, Adrenergic, alpha-2; Seizure | 1999 |
Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone.
Topics: Animals; Anticonvulsants; Buspirone; Catalase; Hippocampus; Lipid Peroxidation; Male; Nitrites; Oxid | 2010 |
Pharmacology and neurochemistry of buspirone.
Topics: Aggression; Animals; Anti-Anxiety Agents; Avoidance Learning; Buspirone; Chemical Phenomena; Chemist | 1982 |
[Acute toxicity study of buspirone hydrochloride in mice, rats and dogs].
Topics: Administration, Oral; Animals; Buspirone; Chemical Phenomena; Chemistry; Dogs; Female; Gastric Juice | 1990 |
Assessment of addiction liability of benzodiazepines and buspirone.
Topics: Anti-Anxiety Agents; Benzodiazepines; Buspirone; Humans; Insurance, Liability; Pyrimidines; Seizures | 1985 |
Modulation of postdecapitation convulsions in rats by alpha-adrenergic and 5-hydroxytryptamine1A agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Animals; Buspirone; Death; Dioxan | 1987 |
Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Drug Synergism; Male; Olivary Nucleus; Pyridines; Pyrimidin | 1988 |