Page last updated: 2024-10-24

buspirone and Pregnancy

buspirone has been researched along with Pregnancy in 24 studies

Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-HT1A receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress."8.02Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation. ( Butkevich, IP; Mikhailenko, VA; Vershinina, EA, 2021)
"We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring."7.79Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy. ( Bagaeva, TR; Butkevich, IP; Makukhina, GV; Mikhailenko, VA; Stolyarova, YA, 2013)
" In the present study we test the hypothesis that injections of buspirone, a 5-HT1A agonist, to rat dams before restraint stress during the last week of pregnancy (between pregnant days 15 and 20) can improve the characteristics of emotional and inflammatory pain-related behaviors in the adult offspring."7.77Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring. ( Butkevich, I; Makukhina, G; Mikhailenko, V; Otellin, V; Semionov, P; Vershinina, E, 2011)
"Buspirone was injected to female rats from the 9th to 21st days of pregnancy; during the last week of pregnancy buspirone was injected 10 min before immobilization stress."5.36[Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats]. ( Butkevich, IP; Mikhaĭlenko, VA; Otellin, VA; Semenov, PO; Vershinina, EA, 2010)
"Previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-HT1A receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress."4.02Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation. ( Butkevich, IP; Mikhailenko, VA; Vershinina, EA, 2021)
"We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring."3.79Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy. ( Bagaeva, TR; Butkevich, IP; Makukhina, GV; Mikhailenko, VA; Stolyarova, YA, 2013)
" In the present study we test the hypothesis that injections of buspirone, a 5-HT1A agonist, to rat dams before restraint stress during the last week of pregnancy (between pregnant days 15 and 20) can improve the characteristics of emotional and inflammatory pain-related behaviors in the adult offspring."3.77Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring. ( Butkevich, I; Makukhina, G; Mikhailenko, V; Otellin, V; Semionov, P; Vershinina, E, 2011)
" We recently showed that maternal buspirone, a 5-HT1A receptor agonist, protects against the adverse effects of in utero stress on depression and pain in adult rat offspring."1.37Buspirone before prenatal stress protects against adverse effects of stress on emotional and inflammatory pain-related behaviors in infant rats: age and sex differences. ( Aloisi, AM; Butkevich, IP; Mikhailenko, VA; Otellin, VA; Vershinina, EA, 2011)
"Buspirone was injected to female rats from the 9th to 21st days of pregnancy; during the last week of pregnancy buspirone was injected 10 min before immobilization stress."1.36[Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats]. ( Butkevich, IP; Mikhaĭlenko, VA; Otellin, VA; Semenov, PO; Vershinina, EA, 2010)
"6."1.28[Reproductive and developmental toxicity studies of buspirone hydrochloride (I)--Oral administration to rats during the period of fetal organogenesis]. ( Chikazawa, H; Ishikawa, K; Kadota, T; Kai, S; Kawano, S; Kohmura, H; Kondo, H; Kuroyanagi, K; Ohta, S; Takahashi, N, 1990)
"5."1.28[Reproductive and developmental toxicity studies of buspirone hydrochloride (II)--Oral administration to rats during perinatal and lactation periods]. ( Chikazawa, H; Ishikawa, K; Kadota, T; Kai, S; Kawano, S; Kohmura, H; Kondo, H; Kuroyanagi, K; Ohta, S; Takahashi, N, 1990)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (33.33)18.2507
2000's6 (25.00)29.6817
2010's7 (29.17)24.3611
2020's3 (12.50)2.80

Authors

AuthorsStudies
Freeman, MP1
Szpunar, MJ1
Kobylski, LA1
Harmon, H1
Viguera, AC1
Cohen, LS1
Butkevich, IP7
Mikhailenko, VA7
Vershinina, EA3
Lavrova, YA1
Bagaeva, TR2
Otellin, VA3
Miyazaki, I1
Asanuma, M1
Murakami, S1
Takeshima, M1
Torigoe, N1
Kitamura, Y1
Miyoshi, K1
Makukhina, GV1
Stolyarova, YA1
Semenov, PO1
Butkevich, I1
Mikhailenko, V1
Vershinina, E1
Semionov, P1
Makukhina, G1
Otellin, V1
Aloisi, AM1
Eriksen, JL4
Gillespie, R1
Druse, MJ7
Furuya, H1
Komaki, Y1
Okazaki, I1
Tajuddin, NF1
Nishikouri, Y1
Klint, T1
Andersson, G1
Kim, JA2
Gillespie, RA2
Nishio, H1
Kasuga, S1
Ushijima, M1
Harada, Y1
Whitaker-Azmitia, PM1
Molino, LJ1
Caruso, J1
Shemer, AV1
Kai, S2
Kohmura, H2
Ishikawa, K2
Ohta, S2
Kuroyanagi, K2
Kawano, S2
Kadota, T2
Chikazawa, H2
Kondo, H2
Takahashi, N2

Reviews

1 review available for buspirone and Pregnancy

ArticleYear
[Review of neurobehavioral effects of alcohol-related neurodevelopmental disorder in an animal model].
    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 2006, Volume: 41, Issue:1

    Topics: Animals; Antioxidants; Buspirone; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disorders;

2006

Other Studies

23 other studies available for buspirone and Pregnancy

ArticleYear
Pregnancy outcomes after first-trimester exposure to buspirone: prospective longitudinal outcomes from the MGH National Pregnancy Registry for Psychiatric Medications.
    Archives of women's mental health, 2022, Volume: 25, Issue:5

    Topics: Abnormalities, Drug-Induced; Adult; Buspirone; Female; Humans; Pregnancy; Pregnancy Complications; P

2022
Effects of Stress Exposure during Adolescent Period on Inflammatory Pain Response, Psychoemotional Behavior, and Action of Antidepressants in Prenatally Stressed Adult Male Rats.
    Bulletin of experimental biology and medicine, 2020, Volume: 169, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Buspirone; Female; Fluoxetine; Inflammation; Male;

2020
Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation.
    Canadian journal of physiology and pharmacology, 2021, Volume: 99, Issue:6

    Topics: Animals; Buspirone; Female; Fluoxetine; Male; Pain; Pregnancy; Rats

2021
Prenatal Stimulation of 5-HT
    Bulletin of experimental biology and medicine, 2019, Volume: 166, Issue:3

    Topics: Adaptation, Psychological; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buspirone; Depressi

2019
Effect of tonic pain on the corticosterone level in rat pups of various ages subjected to prenatal stress and opportunities for correction of stress-induced impairments.
    Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2013, Volume: 450

    Topics: Animals; Buspirone; Corticosterone; Female; Male; Pain; Pain Management; Pregnancy; Prenatal Exposur

2013
Targeting 5-HT(1A) receptors in astrocytes to protect dopaminergic neurons in Parkinsonian models.
    Neurobiology of disease, 2013, Volume: 59

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Agents; Animals; Astrocytes; Brain; Buspirone; Ce

2013
Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy.
    Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:2

    Topics: Animals; Behavior, Animal; Buspirone; Corticosterone; Female; Inflammation; Nociceptors; Pain; Pain

2013
[Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2010, Volume: 96, Issue:4

    Topics: Animals; Behavior, Animal; Buspirone; Depression; Female; Immobilization; Inflammation; Male; Pain;

2010
Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring.
    Physiology & behavior, 2011, Feb-01, Volume: 102, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Emotions; Female; M

2011
Buspirone before prenatal stress protects against adverse effects of stress on emotional and inflammatory pain-related behaviors in infant rats: age and sex differences.
    Brain research, 2011, Oct-24, Volume: 1419

    Topics: Aging; Animals; Animals, Newborn; Buspirone; Chronic Pain; Depressive Disorder; Female; Inflammation

2011
Effects of ethanol and 5-HT1A agonists on astroglial S100B.
    Brain research. Developmental brain research, 2002, Dec-15, Volume: 139, Issue:2

    Topics: Alcohol-Induced Disorders, Nervous System; Animals; Astrocytes; Buspirone; Cell Differentiation; Cel

2002
Treatment of pregnant alcohol-consuming rats with buspirone: effects on serotonin and 5-hydroxyindoleacetic acid content in offspring.
    Alcoholism, clinical and experimental research, 1993, Volume: 17, Issue:1

    Topics: Animals; Buspirone; Cerebral Cortex; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Gestational

1993
[Effect of prenatal administration of diazepam and buspirone on brain monoamines and avoidance learning behavior in offspring rats in relation to the influence of maternal stress caused by subcutaneous injection].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1995, Volume: 15, Issue:1

    Topics: Animals; Animals, Newborn; Avoidance Learning; Biogenic Monoamines; Brain; Buspirone; Diazepam; Fema

1995
Ultrasound vocalization is not related to corticosterone response in isolated rat pups.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Anxiety; Buspirone; Corticosteron

1994
Protective effects of maternal buspirone treatment on serotonin reuptake sites in ethanol-exposed offspring.
    Brain research. Developmental brain research, 1996, Apr-30, Volume: 92, Issue:2

    Topics: Animals; Autoradiography; Brain; Brain Chemistry; Buspirone; Central Nervous System Depressants; Cit

1996
Effects of maternal ethanol consumption and buspirone treatment on 5-HT1A and 5-HT2A receptors in offspring.
    Alcoholism, clinical and experimental research, 1997, Volume: 21, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Autoradiography; Brain; Brain Map

1997
Effects of in utero ethanol exposure and maternal treatment with a 5-HT(1A) agonist on S100B-containing glial cells.
    Brain research. Developmental brain research, 2000, Jun-30, Volume: 121, Issue:2

    Topics: Animals; Buspirone; Calcium-Binding Proteins; Cell Count; Central Nervous System Depressants; Ethano

2000
Prenatal stress and postnatal development of neonatal rats--sex-dependent effects on emotional behavior and learning ability of neonatal rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2001, Volume: 19, Issue:1

    Topics: Acoustic Stimulation; Age Factors; Animals; Animals, Newborn; Anti-Anxiety Agents; Behavior, Animal;

2001
Potential involvement of S100B in the protective effects of a serotonin-1a agonist on ethanol-treated astrocytes.
    Brain research. Developmental brain research, 2001, Jun-29, Volume: 128, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Astrocytes; Buspirone; Calcium-Binding Proteins; Cell Division; Cel

2001
Astrocyte-mediated trophic support of developing serotonin neurons: effects of ethanol, buspirone, and S100B.
    Brain research. Developmental brain research, 2001, Nov-26, Volume: 131, Issue:1-2

    Topics: Animals; Antibodies, Monoclonal; Astrocytes; Buspirone; Calcium-Binding Proteins; Cell Communication

2001
Serotonergic agents restore appropriate decision-making in neonatal rats displaying dopamine D1 receptor-mediated vacillatory behavior.
    European journal of pharmacology, 1990, May-16, Volume: 180, Issue:2-3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Ani

1990
[Reproductive and developmental toxicity studies of buspirone hydrochloride (I)--Oral administration to rats during the period of fetal organogenesis].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 1

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Bone and Bones; Brain; Buspirone; Embryo

1990
[Reproductive and developmental toxicity studies of buspirone hydrochloride (II)--Oral administration to rats during perinatal and lactation periods].
    The Journal of toxicological sciences, 1990, Volume: 15 Suppl 1

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Brain; Buspirone; Embryonic and Fetal De

1990