buspirone has been researched along with Obsessive-Compulsive Disorder in 40 studies
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors found that buspirone added to the treatment of 33 patients with obsessive-compulsive disorder who were refractory to the serotonin reuptake inhibitor fluvoxamine was no better than placebo in reducing obsessive-compulsive, depressive, or anxiety symptoms." | 9.07 | Limited therapeutic effect of addition of buspirone in fluvoxamine-refractory obsessive-compulsive disorder. ( Barr, LC; Goodman, WK; Heninger, GR; Holzer, JC; Leckman, JF; McCance-Katz, E; McDougle, CJ; Price, LH, 1993) |
| "In a double-blind, crossover study, 13 fluoxetine-treated patients with obsessive-compulsive disorder were given adjuvant buspirone and placebo for 4 weeks each." | 9.07 | Double-blind study of adjuvant buspirone for fluoxetine-treated patients with obsessive-compulsive disorder. ( Bernstein, SE; Grady, TA; Hill, JL; L'Heureux, F; Murphy, DL; Pigott, TA, 1993) |
| "In this study, 14 patients with obsessive-compulsive disorder (OCD) who had received at least 3 months of treatment with clomipramine were treated with the anxiolytic agent buspirone in a 10-week, double-blind study." | 9.07 | A double-blind study of adjuvant buspirone hydrochloride in clomipramine-treated patients with obsessive-compulsive disorder. ( Bernstein, SE; Bihari, K; Hill, JL; L'Heureux, F; Murphy, DL; Pigott, TA, 1992) |
| "Eighteen outpatients with obsessive-compulsive disorder were treated with either buspirone, a partial serotonin agonist, or clomipramine, a serotonin uptake inhibitor, in a double-blind, random-assignment study." | 9.07 | Controlled comparison of buspirone and clomipramine in obsessive-compulsive disorder. ( Bernstein, S; Grover, GN; Hill, JL; Murphy, DL; Pato, MT; Pigott, TA, 1991) |
| "Of 14 patients with obsessive-compulsive disorder who entered an 8-week open trial of buspirone, none improved." | 9.06 | An open trial of buspirone in obsessive-compulsive disorder. ( Baer, L; Jenike, MA, 1988) |
| "Preliminary clinical findings, supported by preclinical studies employing behavioral paradigms such as marble burying, suggest that psilocybin may be effective in treating obsessive-compulsive disorder." | 8.31 | Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. ( Botvinnik, A; Lerer, B; Lifschytz, T; Lotan, A; Saban, M; Salama, A; Shahar, O; Singh, S; Wolf, G; Yakobi, C, 2023) |
| "We report a severe case of obsessive-compulsive disorder (OCD) that responded to very high doses of citalopram (160 mg/day) after a poor response to clomipramine 250 mg/day for several years, alone or in combination with buspirone 30 mg/day or flupenthixol 4 mg/day." | 7.70 | Response to high doses of citalopram in treatment-resistant obsessive-compulsive disorder. ( Bejerot, S; Bodlund, O, 1998) |
| "Clomipramine appeared much more effective and better tolerated than fluoxetine in this very old patient despite its potential anticholinergic effect and the coexistence of Alzheimer disease." | 7.70 | Treatment of obsessive-compulsive disorder using clomipramine in a very old patient. ( Trappler, B, 1999) |
| "Prolactin and cortisol responses to buspirone, a partial serotonin agonist with effects on the 5-HT1A receptor, were measured in 16 patients with DSM-III-R obsessive-compulsive disorder (OCD) and 16 normal controls." | 7.69 | Neuroendocrine responses to single doses of buspirone in obsessive-compulsive disorder. ( Apostolopoulos, M; Burrows, GD; Judd, FK; Norman, TR, 1994) |
| "Buspirone (BUSP) is a serotonergic (5-HT) agonist with activity at the 5-HT1A receptor." | 5.28 | Buspirone induced prolactin responses in obsessive-compulsive disorder (OCD): is OCD a 5-HT2 receptor disorder? ( Butcher, G; Clare, AW; Dinan, TG; Lucey, JV, 1992) |
| "The authors found that buspirone added to the treatment of 33 patients with obsessive-compulsive disorder who were refractory to the serotonin reuptake inhibitor fluvoxamine was no better than placebo in reducing obsessive-compulsive, depressive, or anxiety symptoms." | 5.07 | Limited therapeutic effect of addition of buspirone in fluvoxamine-refractory obsessive-compulsive disorder. ( Barr, LC; Goodman, WK; Heninger, GR; Holzer, JC; Leckman, JF; McCance-Katz, E; McDougle, CJ; Price, LH, 1993) |
| "In a double-blind, crossover study, 13 fluoxetine-treated patients with obsessive-compulsive disorder were given adjuvant buspirone and placebo for 4 weeks each." | 5.07 | Double-blind study of adjuvant buspirone for fluoxetine-treated patients with obsessive-compulsive disorder. ( Bernstein, SE; Grady, TA; Hill, JL; L'Heureux, F; Murphy, DL; Pigott, TA, 1993) |
| "In this study, 14 patients with obsessive-compulsive disorder (OCD) who had received at least 3 months of treatment with clomipramine were treated with the anxiolytic agent buspirone in a 10-week, double-blind study." | 5.07 | A double-blind study of adjuvant buspirone hydrochloride in clomipramine-treated patients with obsessive-compulsive disorder. ( Bernstein, SE; Bihari, K; Hill, JL; L'Heureux, F; Murphy, DL; Pigott, TA, 1992) |
| "Eighteen outpatients with obsessive-compulsive disorder were treated with either buspirone, a partial serotonin agonist, or clomipramine, a serotonin uptake inhibitor, in a double-blind, random-assignment study." | 5.07 | Controlled comparison of buspirone and clomipramine in obsessive-compulsive disorder. ( Bernstein, S; Grover, GN; Hill, JL; Murphy, DL; Pato, MT; Pigott, TA, 1991) |
| "Of 14 patients with obsessive-compulsive disorder who entered an 8-week open trial of buspirone, none improved." | 5.06 | An open trial of buspirone in obsessive-compulsive disorder. ( Baer, L; Jenike, MA, 1988) |
| "Preliminary clinical findings, supported by preclinical studies employing behavioral paradigms such as marble burying, suggest that psilocybin may be effective in treating obsessive-compulsive disorder." | 4.31 | Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. ( Botvinnik, A; Lerer, B; Lifschytz, T; Lotan, A; Saban, M; Salama, A; Shahar, O; Singh, S; Wolf, G; Yakobi, C, 2023) |
| "We report a severe case of obsessive-compulsive disorder (OCD) that responded to very high doses of citalopram (160 mg/day) after a poor response to clomipramine 250 mg/day for several years, alone or in combination with buspirone 30 mg/day or flupenthixol 4 mg/day." | 3.70 | Response to high doses of citalopram in treatment-resistant obsessive-compulsive disorder. ( Bejerot, S; Bodlund, O, 1998) |
| "Clomipramine appeared much more effective and better tolerated than fluoxetine in this very old patient despite its potential anticholinergic effect and the coexistence of Alzheimer disease." | 3.70 | Treatment of obsessive-compulsive disorder using clomipramine in a very old patient. ( Trappler, B, 1999) |
| "Prolactin and cortisol responses to buspirone, a partial serotonin agonist with effects on the 5-HT1A receptor, were measured in 16 patients with DSM-III-R obsessive-compulsive disorder (OCD) and 16 normal controls." | 3.69 | Neuroendocrine responses to single doses of buspirone in obsessive-compulsive disorder. ( Apostolopoulos, M; Burrows, GD; Judd, FK; Norman, TR, 1994) |
| "Anxiety disorders are chronic illnesses requiring long-term treatment." | 2.38 | Chronic anxiety: deciding the length of treatment. ( Gorman, JM; Papp, LA, 1990) |
| "Kleptomania is currently classified in psychiatric nomenclature as one of the impulse control disorders (DSM-IV, 1994)." | 1.30 | [Kleptomania: phenomenological, clinical and legal aspects]. ( Durst, R; Jabotinsky-Rubin, K; Katz, G; Knobler, HY, 1997) |
| "Buspirone (BUSP) is a serotonergic (5-HT) agonist with activity at the 5-HT1A receptor." | 1.28 | Buspirone induced prolactin responses in obsessive-compulsive disorder (OCD): is OCD a 5-HT2 receptor disorder? ( Butcher, G; Clare, AW; Dinan, TG; Lucey, JV, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.50) | 18.7374 |
| 1990's | 33 (82.50) | 18.2507 |
| 2000's | 2 (5.00) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, S | 1 |
| Botvinnik, A | 1 |
| Shahar, O | 1 |
| Wolf, G | 1 |
| Yakobi, C | 1 |
| Saban, M | 1 |
| Salama, A | 1 |
| Lotan, A | 1 |
| Lerer, B | 1 |
| Lifschytz, T | 1 |
| Ravindran, LN | 1 |
| Stein, MB | 1 |
| Serby, M | 1 |
| Menkes, DB | 1 |
| Farid, BT | 1 |
| Bulto, M | 1 |
| Jenike, MA | 3 |
| Rauch, SL | 1 |
| Norman, TR | 1 |
| Apostolopoulos, M | 1 |
| Burrows, GD | 1 |
| Judd, FK | 1 |
| Goodman, WK | 4 |
| McDougle, CJ | 4 |
| Barr, LC | 3 |
| Aronson, SC | 1 |
| Price, LH | 5 |
| Sternlicht, HC | 1 |
| Leckman, JF | 1 |
| Holzer, JC | 1 |
| McCance-Katz, E | 1 |
| Heninger, GR | 1 |
| Grady, TA | 2 |
| Pigott, TA | 5 |
| L'Heureux, F | 3 |
| Hill, JL | 3 |
| Bernstein, SE | 2 |
| Murphy, DL | 5 |
| Baetz, M | 1 |
| Malcolm, D | 1 |
| Harvey, KV | 1 |
| Balon, R | 1 |
| Nijhawan, PK | 1 |
| Katz, G | 2 |
| Winter, S | 1 |
| Blier, P | 1 |
| Bergeron, R | 1 |
| Carpenter, LL | 1 |
| Epperson, CN | 1 |
| Durst, R | 1 |
| Jabotinsky-Rubin, K | 1 |
| Knobler, HY | 1 |
| Bejerot, S | 1 |
| Bodlund, O | 1 |
| Trappler, B | 1 |
| Dunne, JE | 1 |
| Thomsen, PH | 1 |
| Mikkelsen, HU | 1 |
| Juarbe-Díaz, SV | 1 |
| Maruno, CA | 1 |
| Hart, LL | 1 |
| Judd, F | 1 |
| Ellen, S | 1 |
| Norman, T | 1 |
| Pato, MT | 3 |
| Gluhoski, V | 1 |
| Bihari, K | 1 |
| Lucey, JV | 1 |
| Butcher, G | 1 |
| Clare, AW | 1 |
| Dinan, TG | 1 |
| Alessi, N | 1 |
| Bos, T | 1 |
| Gorman, JM | 1 |
| Papp, LA | 1 |
| Grover, GN | 1 |
| Bernstein, S | 1 |
| Baer, L | 2 |
| Buttolph, L | 1 |
| Markovitz, PJ | 1 |
| Stagno, SJ | 1 |
| Calabrese, JR | 1 |
| Tanquary, J | 1 |
| Masand, P | 1 |
| Hoehn-Saric, R | 1 |
| McLeod, DR | 1 |
| Watts, VS | 1 |
| Neill, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Initial Evaluation of Efficacy and Adverse Events of Single Lesions in Bilateral Ventral-capsular and Ventral Capsulotomy-striatal by Linear Accelerator Radiosurgery in Severe and Refractory Obsessive-compulsive Disorder[NCT02500888] | 10 participants (Anticipated) | Interventional | 2015-06-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for buspirone and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
The pharmacologic treatment of anxiety disorders: a review of progress.
Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Anxiety Disorders; Benzodiazepines; Bu | 2010 |
Managing the patient with treatment-resistant obsessive compulsive disorder: current strategies.
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Behavior Therapy; Buspirone; Clonazepam; Com | 1994 |
Biological approaches to treatment-resistant obsessive compulsive disorder.
Topics: Behavior Therapy; Buspirone; Clonazepam; Combined Modality Therapy; Decision Trees; Drug Therapy, Co | 1993 |
The pharmacotherapy of obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Buspirone; Clomipramine; Desipramine; Fluoxetine; Fluvoxamine; Humans; Obsessive-Co | 1993 |
Augmentation with buspirone: a review.
Topics: Anti-Anxiety Agents; Buspirone; Depressive Disorder; Drug Interactions; Humans; Obsessive-Compulsive | 1995 |
A risk-benefit assessment of drugs used in the management of obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Adult; Aged; Antidepressive Agents; Buspirone; Child; Clomipramine; Clonazepam; Cos | 1996 |
Buspirone in obsessive-compulsive disorder.
Topics: Adult; Buspirone; Clinical Trials as Topic; Clomipramine; Drug Therapy, Combination; Female; Fluoxet | 1992 |
Serotonin and effect sizes of antiobsessive agents.
Topics: Buspirone; Clinical Trials as Topic; Clomipramine; Humans; Meta-Analysis as Topic; Obsessive-Compuls | 1992 |
Chronic anxiety: deciding the length of treatment.
Topics: Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Buspirone; Chronic Disease; Drug Administra | 1990 |
Obsessive-compulsive disorder: treatment with serotonin-selective uptake inhibitors, azapirones, and other agents.
Topics: Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Buspirone; Clinical Trials as Topic; Clomipra | 1990 |
Generalized anxiety disorder.
Topics: Adrenergic beta-Antagonists; Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyc | 1985 |
10 trials available for buspirone and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Buspirone in obsessional compulsive disorder. A prospective case study.
Topics: Adult; Affect; Brain; Buspirone; Humans; Longitudinal Studies; Male; Obsessive-Compulsive Disorder; | 1994 |
Limited therapeutic effect of addition of buspirone in fluvoxamine-refractory obsessive-compulsive disorder.
Topics: Adult; Anxiety Disorders; Buspirone; Depressive Disorder; Double-Blind Method; Drug Therapy, Combina | 1993 |
Double-blind study of adjuvant buspirone for fluoxetine-treated patients with obsessive-compulsive disorder.
Topics: Adult; Anxiety Disorders; Buspirone; Depressive Disorder; Double-Blind Method; Drug Therapy, Combina | 1993 |
The addition of buspirone to SSRI in the treatment of adolescent obsessive-compulsive disorder. A study of six cases.
Topics: Adolescent; Adult; Buspirone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; F | 1999 |
A double-blind study of adjuvant buspirone hydrochloride in clomipramine-treated patients with obsessive-compulsive disorder.
Topics: Adult; Analysis of Variance; Buspirone; Clomipramine; Double-Blind Method; Drug Therapy, Combination | 1992 |
Obsessive-compulsive disorder: treatment with serotonin-selective uptake inhibitors, azapirones, and other agents.
Topics: Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Buspirone; Clinical Trials as Topic; Clomipra | 1990 |
Controlled comparison of buspirone and clomipramine in obsessive-compulsive disorder.
Topics: Adult; Ambulatory Care; Buspirone; Clomipramine; Double-Blind Method; Humans; Obsessive-Compulsive D | 1991 |
Buspirone augmentation of fluoxetine in patients with obsessive compulsive disorder.
Topics: Buspirone; Drug Therapy, Combination; Fluoxetine; Humans; Obsessive-Compulsive Disorder; Pilot Proje | 1991 |
Buspirone augmentation of fluoxetine in obsessive-compulsive disorder.
Topics: Adult; Buspirone; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluoxetine; Humans; M | 1990 |
An open trial of buspirone in obsessive-compulsive disorder.
Topics: Adult; Ambulatory Care; Buspirone; Clinical Trials as Topic; Female; Humans; Male; Obsessive-Compuls | 1988 |
20 other studies available for buspirone and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Escitalopram; Hallucinogens; Male; Mice; | 2023 |
Methylphenidate-induced obsessive-compulsive symptoms in an elderly man.
Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety Diso | 2003 |
Buspirone augmentation of sertraline.
Topics: 1-Naphthylamine; Adult; Anorexia Nervosa; Antidepressive Agents; Buspirone; Drug Therapy, Combinatio | 1995 |
Neuroendocrine responses to single doses of buspirone in obsessive-compulsive disorder.
Topics: Adult; Buspirone; Female; Humans; Hydrocortisone; Male; Obsessive-Compulsive Disorder; Prolactin; Re | 1994 |
Obsessive-compulsive disorder, fluoxetine, and buspirone.
Topics: Buspirone; Drug Administration Schedule; Drug Therapy, Combination; Fluoxetine; Humans; Male; Middle | 1993 |
Serotonin syndrome from fluvoxamine and buspirone.
Topics: Buspirone; Drug Therapy, Combination; Fluvoxamine; Humans; Male; Middle Aged; Obsessive-Compulsive D | 1995 |
Psychiatric illness and the serotonin syndrome: an emerging adverse drug effect leading to intensive care unit admission.
Topics: Alcohol Withdrawal Delirium; Buspirone; Clomipramine; Diagnosis, Differential; Drug Therapy, Combina | 1996 |
Sequential administration of augmentation strategies in treatment-resistant obsessive-compulsive disorder: preliminary findings.
Topics: Adrenergic beta-Antagonists; Adult; Buspirone; Depression; Drug Resistance; Drug Therapy, Combinatio | 1996 |
[Kleptomania: phenomenological, clinical and legal aspects].
Topics: Adult; Buspirone; Disruptive, Impulse Control, and Conduct Disorders; Fluvoxamine; Humans; Male; Obs | 1997 |
Response to high doses of citalopram in treatment-resistant obsessive-compulsive disorder.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl | 1998 |
Treatment of obsessive-compulsive disorder using clomipramine in a very old patient.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; B | 1999 |
Buspirone in ODD.
Topics: Buspirone; Child; Humans; Obsessive-Compulsive Disorder; Serotonin Receptor Agonists | 1999 |
Animal behavior case of the month. Congo African Grey parrot examined because of feather picking and self-injurious behavior.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Bird Diseases; Bus | 2000 |
Acute exacerbation of body dysmorphic disorder during tryptophan depletion.
Topics: Acute Disease; Adult; Body Image; Buspirone; Clomipramine; Delusions; Female; Humans; Neurotransmitt | 1992 |
Buspirone and fluoxetine in the treatment of OCD.
Topics: Adult; Arousal; Buspirone; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Obsessive-Co | 1992 |
Seizure associated with fluoxetine and adjuvant buspirone therapy.
Topics: Adult; Buspirone; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Fluoxetine; Humans; Male; Obses | 1992 |
Buspirone induced prolactin responses in obsessive-compulsive disorder (OCD): is OCD a 5-HT2 receptor disorder?
Topics: Adult; Aged; Buspirone; Female; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Prolactin; | 1992 |
Buspirone augmentation of fluoxetine in a depressed child with obsessive-compulsive disorder.
Topics: Buspirone; Child, Preschool; Depressive Disorder; Drug Therapy, Combination; Female; Fluoxetine; Hum | 1991 |
Paradoxical reaction to buspirone augmentation of fluoxetine.
Topics: Adult; Buspirone; Depressive Disorder; Drug Therapy, Combination; Female; Fluoxetine; Humans; Impuls | 1990 |
Buspirone in obsessive-compulsive disorder.
Topics: Adult; Buspirone; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Male; Obse | 1988 |