buspirone has been researched along with Injuries, Spinal Cord in 13 studies
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " At higher doses, 50 mg/500 mg/125 mg SpinalonTM was considered to have reached maximum tolerated dose (MTD) since 3 out of 4 subjects experienced related adverse events including vomiting." | 2.84 | Double-Blind, Placebo-Controlled, Randomized Phase I/IIa Study (Safety and Efficacy) with Buspirone/Levodopa/Carbidopa (SpinalonTM) in Subjects with Complete AIS A or Motor-Complete AIS B Spinal Cord Injury. ( Dyck, S; Guertin, PA; Kia, M; Matte, G; Mongeon, D; Prince, F; Radhakrishna, M; Roberts, M; Steuer, I; Vaillancourt, M, 2017) |
| "The aim of this review is to describe the rationale and main underlying reasons for undertaking, during clinical development, the study of drug candidates used separately and/or in combination with other technologies." | 2.55 | Rationale for Assessing Safety and Efficacy of Drug Candidates Alone and in Combination with Medical Devices: The Case Study of SpinalonTM. ( Guertin, PA, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 5 (38.46) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, R | 1 |
| Nikooyan, AA | 1 |
| Moore, LD | 1 |
| Zdunowski, S | 2 |
| Morikawa, E | 2 |
| Sierro, T | 1 |
| Sayenko, D | 1 |
| Gad, P | 1 |
| Homsey, T | 1 |
| Le, T | 1 |
| Madhavan, MA | 1 |
| Abdelshahid, M | 2 |
| Zhou, Y | 1 |
| Nuwer, MR | 1 |
| Sarrafzadeh, M | 1 |
| Edgerton, VR | 3 |
| Leiter, JC | 1 |
| Lu, DC | 3 |
| Jin, B | 1 |
| Alam, M | 1 |
| Tierno, A | 1 |
| Zhong, H | 1 |
| Roy, RR | 1 |
| Gerasimenko, Y | 2 |
| Morgan, JW | 1 |
| Solinsky, R | 1 |
| Borrelli, C | 1 |
| Emdin, M | 1 |
| Passino, C | 1 |
| Giannoni, A | 1 |
| Maresh, S | 1 |
| Prowting, J | 1 |
| Vaughan, S | 1 |
| Yarandi, H | 1 |
| Badr, MS | 1 |
| Sankari, A | 1 |
| Jeffrey-Gauthier, R | 1 |
| Josset, N | 1 |
| Bretzner, F | 1 |
| Leblond, H | 1 |
| Freyvert, Y | 1 |
| Yong, NA | 1 |
| Sarino, ME | 1 |
| Moshonkina, TR | 1 |
| Shapkova, EY | 1 |
| Sukhotina, IA | 1 |
| Emeljannikov, DV | 1 |
| Gerasimenko, YP | 1 |
| Guertin, PA | 3 |
| Radhakrishna, M | 1 |
| Steuer, I | 1 |
| Prince, F | 1 |
| Roberts, M | 1 |
| Mongeon, D | 1 |
| Kia, M | 1 |
| Dyck, S | 1 |
| Matte, G | 1 |
| Vaillancourt, M | 1 |
| Ung, RV | 1 |
| Rouleau, P | 1 |
| Teng, YD | 2 |
| Bingaman, M | 1 |
| Taveira-DaSilva, AM | 1 |
| Pace, PP | 1 |
| Gillis, RA | 1 |
| Wrathall, JR | 1 |
| Choi, H | 1 |
| Liao, WL | 1 |
| Newton, KM | 1 |
| Onario, RC | 1 |
| King, AM | 1 |
| Desilets, FC | 1 |
| Woodard, EJ | 1 |
| Eichler, ME | 1 |
| Frontera, WR | 1 |
| Sabharwal, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Study on the еffectiveness of the Integration of a Device Based on a Neural Interface and Neurostimulation of the Spinal Cord in the Rehabilitation of Patients With Upper Limb Movement Impairments Due to Neurological Disorders.[NCT05115149] | 60 participants (Anticipated) | Interventional | 2021-10-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for buspirone and Injuries, Spinal Cord
| Article | Year |
|---|---|
Rationale for Assessing Safety and Efficacy of Drug Candidates Alone and in Combination with Medical Devices: The Case Study of SpinalonTM.
Topics: Animals; Buspirone; Carbidopa; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinati | 2017 |
2 trials available for buspirone and Injuries, Spinal Cord
| Article | Year |
|---|---|
Minimal handgrip force is needed for transcutaneous electrical stimulation to improve hand functions of patients with severe spinal cord injury.
Topics: Buspirone; Cross-Over Studies; Hand Strength; Humans; Spinal Cord; Spinal Cord Injuries; Spinal Cord | 2022 |
Double-Blind, Placebo-Controlled, Randomized Phase I/IIa Study (Safety and Efficacy) with Buspirone/Levodopa/Carbidopa (SpinalonTM) in Subjects with Complete AIS A or Motor-Complete AIS B Spinal Cord Injury.
Topics: Administration, Oral; Adult; Buspirone; Carbidopa; Dose-Response Relationship, Drug; Double-Blind Me | 2017 |
10 other studies available for buspirone and Injuries, Spinal Cord
| Article | Year |
|---|---|
Serotonergic Facilitation of Forelimb Functional Recovery in Rats with Cervical Spinal Cord Injury.
Topics: Animals; Buspirone; Cervical Cord; Electromyography; Evoked Potentials, Motor; Female; Fluoxetine; F | 2021 |
Buspirone for functional improvement after acute traumatic spinal cord injury: a propensity score-matched cohort study.
Topics: Buspirone; Cohort Studies; Humans; Propensity Score; Recovery of Function; Retrospective Studies; Sp | 2021 |
Central apneas, chemoreflex sensitivity, and buspirone in spinal cord injury: a word of caution.
Topics: Buspirone; Humans; Reflex; Sleep Apnea, Central; Spinal Cord Injuries | 2021 |
Does buspirone ameliorate the susceptibility to central sleep apnea?
Topics: Buspirone; Humans; Sleep Apnea Syndromes; Sleep Apnea, Central; Spinal Cord Injuries | 2021 |
Facilitation of Locomotor Spinal Networks Activity by Buspirone after a Complete Spinal Cord Lesion in Mice.
Topics: Animals; Buspirone; Efferent Pathways; Locomotion; Mice; Recovery of Function; Serotonin Receptor Ag | 2018 |
Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients.
Topics: Adolescent; Adult; Buspirone; Combined Modality Therapy; Electric Stimulation Therapy; Evoked Potent | 2018 |
Effect of Combination of Non-Invasive Spinal Cord Electrical Stimulation and Serotonin Receptor Activation in Patients with Chronic Spinal Cord Lesion.
Topics: Adult; Aged; Buspirone; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Nociception; R | 2016 |
Functional and physiological effects of treadmill training induced by buspirone, carbidopa, and L-DOPA in clenbuterol-treated paraplegic mice.
Topics: Adipose Tissue; Analysis of Variance; Animals; Biomechanical Phenomena; Body Composition; Body Weigh | 2012 |
Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Buspirone; Female; Piperazines; Rat | 2003 |
Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Buspirone; | 2005 |