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buspirone and Cirrhosis, Liver

buspirone has been researched along with Cirrhosis, Liver in 5 studies

Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.

Research Excerpts

ExcerptRelevanceReference
"Buspirone is an anxiolytic drug given at a dosage of 15 mg/day."2.40Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug. ( Mahmood, I; Sahajwalla, C, 1999)
"Buspirone was not removed by hemodialysis."2.37Metabolism and disposition of buspirone. ( Gammans, RE; LaBudde, JA; Mayol, RF, 1986)
"Patho-physiological changes in liver cirrhosis create portacaval shunts that allow blood flow to bypass the hepatic portal vein into the systemic circulation affecting drug pharmacokinetics (PKs)."1.91Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis. ( Gardner, I; Hatley, O; Jamei, M; Johnson, TN; Small, BG, 2023)
"7 h), but mean maximum concentration Cmax was higher in patients (18."1.27Buspirone pharmacokinetics in patients with cirrhosis. ( Dalhoff, K; Gammans, RE; Garred, P; Mayol, RF; Pfeffer, M; Placchi, M; Poulsen, HE, 1987)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Small, BG1
Hatley, O1
Jamei, M1
Gardner, I1
Johnson, TN1
Barbhaiya, RH1
Shukla, UA1
Pfeffer, M2
Pittman, KA1
Shrotriya, R1
Laroudie, C1
Gammans, RE3
Mahmood, I1
Sahajwalla, C1
Mayol, RF2
LaBudde, JA1
Dalhoff, K1
Poulsen, HE1
Garred, P1
Placchi, M1

Reviews

2 reviews available for buspirone and Cirrhosis, Liver

ArticleYear
Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug.
    Clinical pharmacokinetics, 1999, Volume: 36, Issue:4

    Topics: Aged; Anti-Anxiety Agents; Area Under Curve; Buspirone; Clinical Trials as Topic; Cross-Over Studies

1999
Metabolism and disposition of buspirone.
    The American journal of medicine, 1986, Mar-31, Volume: 80, Issue:3B

    Topics: Absorption; Administration, Oral; Adolescent; Adult; Aged; Aging; Amitriptyline; Animals; Anxiety Di

1986

Trials

1 trial available for buspirone and Cirrhosis, Liver

ArticleYear
Disposition kinetics of buspirone in patients with renal or hepatic impairment after administration of single and multiple doses.
    European journal of clinical pharmacology, 1994, Volume: 46, Issue:1

    Topics: Adult; Anti-Anxiety Agents; Buspirone; Female; Humans; Kidney Diseases; Liver Cirrhosis; Liver Disea

1994

Other Studies

2 other studies available for buspirone and Cirrhosis, Liver

ArticleYear
Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis.
    Clinical pharmacology and therapeutics, 2023, Volume: 114, Issue:6

    Topics: Buspirone; Humans; Liver Cirrhosis; Midazolam; Models, Biological; Propranolol; Simvastatin

2023
Buspirone pharmacokinetics in patients with cirrhosis.
    British journal of clinical pharmacology, 1987, Volume: 24, Issue:4

    Topics: Adult; Buspirone; Galactose; Half-Life; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver F

1987
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