buspirone and Cirrhosis, Liver
buspirone has been researched along with Cirrhosis, Liver in 5 studies
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Buspirone is an anxiolytic drug given at a dosage of 15 mg/day." | 2.40 | Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug. ( Mahmood, I; Sahajwalla, C, 1999) |
"Buspirone was not removed by hemodialysis." | 2.37 | Metabolism and disposition of buspirone. ( Gammans, RE; LaBudde, JA; Mayol, RF, 1986) |
"Patho-physiological changes in liver cirrhosis create portacaval shunts that allow blood flow to bypass the hepatic portal vein into the systemic circulation affecting drug pharmacokinetics (PKs)." | 1.91 | Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis. ( Gardner, I; Hatley, O; Jamei, M; Johnson, TN; Small, BG, 2023) |
"7 h), but mean maximum concentration Cmax was higher in patients (18." | 1.27 | Buspirone pharmacokinetics in patients with cirrhosis. ( Dalhoff, K; Gammans, RE; Garred, P; Mayol, RF; Pfeffer, M; Placchi, M; Poulsen, HE, 1987) |
Research
Studies (5)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (40.00) | 18.7374 |
1990's | 2 (40.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Small, BG | 1 |
Hatley, O | 1 |
Jamei, M | 1 |
Gardner, I | 1 |
Johnson, TN | 1 |
Barbhaiya, RH | 1 |
Shukla, UA | 1 |
Pfeffer, M | 2 |
Pittman, KA | 1 |
Shrotriya, R | 1 |
Laroudie, C | 1 |
Gammans, RE | 3 |
Mahmood, I | 1 |
Sahajwalla, C | 1 |
Mayol, RF | 2 |
LaBudde, JA | 1 |
Dalhoff, K | 1 |
Poulsen, HE | 1 |
Garred, P | 1 |
Placchi, M | 1 |
Reviews
2 reviews available for buspirone and Cirrhosis, Liver
Article | Year |
---|---|
Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug.
Topics: Aged; Anti-Anxiety Agents; Area Under Curve; Buspirone; Clinical Trials as Topic; Cross-Over Studies | 1999 |
Metabolism and disposition of buspirone.
Topics: Absorption; Administration, Oral; Adolescent; Adult; Aged; Aging; Amitriptyline; Animals; Anxiety Di | 1986 |
Trials
1 trial available for buspirone and Cirrhosis, Liver
Article | Year |
---|---|
Disposition kinetics of buspirone in patients with renal or hepatic impairment after administration of single and multiple doses.
Topics: Adult; Anti-Anxiety Agents; Buspirone; Female; Humans; Kidney Diseases; Liver Cirrhosis; Liver Disea | 1994 |
Other Studies
2 other studies available for buspirone and Cirrhosis, Liver
Article | Year |
---|---|
Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis.
Topics: Buspirone; Humans; Liver Cirrhosis; Midazolam; Models, Biological; Propranolol; Simvastatin | 2023 |
Buspirone pharmacokinetics in patients with cirrhosis.
Topics: Adult; Buspirone; Galactose; Half-Life; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver F | 1987 |