buspirone has been researched along with Chemical Dependence in 39 studies
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Comparisons between buspirone and the benzodiazepines in treating patients with generalised anxiety disorder reveal that long term use of benzodiazepines is associated with adverse effects, particularly in elderly patients." | 6.40 | A risk-benefit assessment of buspirone in the treatment of anxiety disorders. ( Pecknold, JC, 1997) |
| " 10 male cocaine dependent patients and 10 sex matched controls were administered several behavioral measures of aggression including the Buss-Durkee Hostility Inventory, and The Brown-Goodwin Life History of Aggression." | 5.07 | Serotonin and impulsive/aggressive behavior in cocaine dependent subjects. ( Cherek, DR; Fulton, M; Garver, DL; Kramer, G; Moeller, FG; Petty, F; Steinberg, JL, 1994) |
| "Scientific evidence regarding the drug abuse potential of buspirone and gepirone is reviewed." | 3.76 | Abuse potential of buspirone and related drugs. ( Balster, RL, 1990) |
| "Tandospirone is a novel nonbenzodiazepine anxiolytic/antidepressant that acts primarily at the serotonin-1A receptor." | 2.67 | Tandospirone and alprazolam: comparison of behavioral effects and abuse liability in humans. ( Evans, SM; Griffiths, RR; Troisi, JR, 1994) |
| "Lorazepam was liked better than were other drugs only at 1 hour and only compared with buspirone 20 and placebo." | 2.67 | Comparative drug effects and abuse liability of lorazepam, buspirone, and secobarbital in nondependent subjects. ( Kaplan, HL; Romach, MK; Schneiderman, JF; Sellers, EM; Somer, GR, 1992) |
| " Mean daily diazepam dosage at entry was significantly higher in the buspirone group, but overall initial diazepam dosage was not related to outcome." | 2.67 | A double-blind placebo-controlled study of buspirone in diazepam withdrawal in chronic benzodiazepine users. ( Ashton, CH; Rawlins, MD; Tyrer, SP, 1990) |
| "Studies of buspirone for substance use disorders have had disappointing outcomes, although it may be useful for treating coexisting anxiety and one controlled study suggested efficacy for heroin detoxification." | 2.52 | Buspirone: Back to the Future. ( Howland, RH, 2015) |
| " Comparisons between buspirone and the benzodiazepines in treating patients with generalised anxiety disorder reveal that long term use of benzodiazepines is associated with adverse effects, particularly in elderly patients." | 2.40 | A risk-benefit assessment of buspirone in the treatment of anxiety disorders. ( Pecknold, JC, 1997) |
| "Although essentially limited to alcohol abusers, clinical studies seem to support the preclinical findings that a number of 5-HT reuptake inhibitors decrease interest in and intake of alcohol in mild-moderate ethanol-dependent individuals." | 2.38 | Opportunities for treatment of psychoactive substance use disorders with serotonergic medications. ( Higgins, GA; Romach, MK; Sellers, EM; Tomkins, DM; Toneatto, T, 1991) |
| "Buspirone is a newer anxiolytic which differs chemically and pharmacologically from the benzodiazepines." | 2.38 | Can buspirone induce rebound, dependence or abuse? ( Lader, M, 1991) |
| "Buspirone has a unique structure and a pharmacologic profile which distinguishes it from the benzodiazepines." | 2.37 | Pharmacological and clinical effects of buspirone. ( Eison, MS; Riblet, LA; Taylor, DP; Vandermaelen, CP, 1985) |
| "Enciprazine was selected for clinical investigations." | 1.28 | Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds. ( Engel, J; Fleischhauer, I; Jakovlev, V; Johanson, CE; Kleemann, A; Kutscher, B; Nickel, B; Rauer, H; Szelenyi, I; Werner, U, 1990) |
| "Buspirone is a clinically effective anxiolytic with a unique structure and pharmacology which distinguishes it from the benzodiazepines." | 1.27 | Neuropharmacology of buspirone. ( Eison, AS; Eison, MS; Riblet, LA; Taylor, DP; Temple, DL; VanderMaelen, CP, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (38.46) | 18.7374 |
| 1990's | 20 (51.28) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (10.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Engel, J | 1 |
| Fleischhauer, I | 1 |
| Jakovlev, V | 1 |
| Kleemann, A | 1 |
| Kutscher, B | 1 |
| Nickel, B | 1 |
| Rauer, H | 1 |
| Werner, U | 1 |
| Szelenyi, I | 1 |
| Johanson, CE | 1 |
| Langleben, DD | 1 |
| Howland, RH | 1 |
| Rutten, K | 1 |
| Van Der Kam, EL | 1 |
| De Vry, J | 1 |
| Bruckmann, W | 1 |
| Tzschentke, TM | 1 |
| Le Foll, B | 1 |
| Boileau, I | 1 |
| Cole, JO | 1 |
| Orzack, MH | 1 |
| Beake, B | 1 |
| Bird, M | 1 |
| Bar-Tal, Y | 1 |
| Schuckit, MA | 2 |
| Riblet, LA | 2 |
| Eison, AS | 1 |
| Eison, MS | 2 |
| Taylor, DP | 2 |
| Temple, DL | 1 |
| VanderMaelen, CP | 2 |
| Cugurra, F | 1 |
| Moeller, FG | 1 |
| Steinberg, JL | 1 |
| Petty, F | 1 |
| Fulton, M | 1 |
| Cherek, DR | 1 |
| Kramer, G | 1 |
| Garver, DL | 1 |
| Mizoguchi, H | 1 |
| Suzuki, T | 1 |
| Misawa, M | 1 |
| Evans, SM | 1 |
| Troisi, JR | 1 |
| Griffiths, RR | 2 |
| Sussman, N | 1 |
| Sannerud, CA | 1 |
| Ator, NA | 1 |
| Ciraulo, DA | 1 |
| Barnhill, JG | 1 |
| Ciraulo, AM | 1 |
| Sarid-Segal, O | 1 |
| Knapp, C | 1 |
| Greenblatt, DJ | 1 |
| Shader, RI | 1 |
| Pecknold, JC | 1 |
| Healy, B | 1 |
| Sellers, EM | 2 |
| Schneiderman, JF | 1 |
| Romach, MK | 2 |
| Kaplan, HL | 1 |
| Somer, GR | 1 |
| Travers, R | 1 |
| Higgins, GA | 1 |
| Tomkins, DM | 1 |
| Toneatto, T | 1 |
| Lader, M | 3 |
| Critchfield, TS | 1 |
| Griffiths, R | 1 |
| Balster, RL | 1 |
| Ashton, CH | 1 |
| Rawlins, MD | 1 |
| Tyrer, SP | 1 |
| Rock, NL | 1 |
| Raleigh, FR | 1 |
| Kranzler, HR | 1 |
| Tyrer, P | 1 |
| Murphy, S | 1 |
| Owen, RT | 1 |
| Perry, PJ | 1 |
| Nelson, RC | 1 |
| Goa, KL | 1 |
| Ward, A | 1 |
| Rickels, K | 1 |
| Griffith, JD | 1 |
| Jasinski, DR | 1 |
| Casten, GP | 1 |
| McKinney, GR | 1 |
12 reviews available for buspirone and Chemical Dependence
| Article | Year |
|---|---|
Buspirone: Back to the Future.
Topics: Aggression; Anti-Anxiety Agents; Anxiety Disorders; Buspirone; Cognition Disorders; Dementia; Depres | 2015 |
[Consequences of prolonged use of psychoactive drugs. Substitute natural treatment and individual psychotherapy].
Topics: Anti-Anxiety Agents; Benzodiazepines; Buspirone; Cannabis; Humans; Mental Disorders; Plants, Medicin | 1994 |
Treating anxiety while minimizing abuse and dependence.
Topics: Alprazolam; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Buspirone; Clorazepate Dipotass | 1993 |
Recent developments in the pharmacotherapy of alcohol dependence.
Topics: Acamprosate; Alcohol Deterrents; Anti-Anxiety Agents; Buspirone; Disulfiram; Ethanol; Female; Humans | 1996 |
A risk-benefit assessment of buspirone in the treatment of anxiety disorders.
Topics: Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Buspirone; Humans; Substance Withdrawal Syn | 1997 |
Opportunities for treatment of psychoactive substance use disorders with serotonergic medications.
Topics: Alcoholism; Animals; Buspirone; Comorbidity; Humans; Mental Disorders; Psychotropic Drugs; Rats; Rec | 1991 |
Can buspirone induce rebound, dependence or abuse?
Topics: Anxiety Disorders; Buspirone; Humans; Risk Factors; Substance-Related Disorders | 1991 |
Abuse potential of buspirone and related drugs.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Clinical Trials as Topic; Double-Blind Method; Drug Evaluat | 1990 |
Pharmacological and clinical effects of buspirone.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Autoradiography; Brain; Buspiro | 1985 |
Buspirone. A preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Buspirone; Depression; Diazepam; Drug Administration | 1986 |
Long-term anxiolytic therapy: the issue of drug withdrawal.
Topics: Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Buspirone; Drug Tolerance; Humans; Substanc | 1987 |
Assessing the potential for buspirone dependence or abuse and effects of its withdrawal.
Topics: Animals; Anxiety Disorders; Buspirone; Humans; Pyrimidines; Risk; Substance Withdrawal Syndrome; Sub | 1987 |
8 trials available for buspirone and Chemical Dependence
| Article | Year |
|---|---|
Assessment of the abuse liability of buspirone in recreational sedative users.
Topics: Anti-Anxiety Agents; Buspirone; Diazepam; Dose-Response Relationship, Drug; Emotions; Euphoria; Fema | 1982 |
Serotonin and impulsive/aggressive behavior in cocaine dependent subjects.
Topics: Adult; Aggression; Buspirone; Cocaine; Growth Hormone; Humans; Impulsive Behavior; Male; Psychiatric | 1994 |
Tandospirone and alprazolam: comparison of behavioral effects and abuse liability in humans.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Buspirone; Cross-Over Studies; Dose-Response Relationship, D | 1994 |
Alterations in pharmacodynamics of anxiolytics in abstinent alcoholic men: subjective responses, abuse liability, and electroencephalographic effects of alprazolam, diazepam, and buspirone.
Topics: Adult; Affect; Alcoholism; Alprazolam; Anti-Anxiety Agents; Buspirone; Diazepam; Electrocardiography | 1997 |
Comparative drug effects and abuse liability of lorazepam, buspirone, and secobarbital in nondependent subjects.
Topics: Adult; Affect; Attention; Buspirone; Dose-Response Relationship, Drug; Humans; Lorazepam; Male; Ment | 1992 |
Abuse potential of buspirone and related drugs.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Clinical Trials as Topic; Double-Blind Method; Drug Evaluat | 1990 |
A double-blind placebo-controlled study of buspirone in diazepam withdrawal in chronic benzodiazepine users.
Topics: Adult; Buspirone; Diazepam; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Stu | 1990 |
Investigation of the abuse liability of buspirone in alcohol-dependent patients.
Topics: Administration, Oral; Adult; Alcoholism; Appetite; Buspirone; Diazepam; Euphoria; Humans; Male; Midd | 1986 |
20 other studies available for buspirone and Chemical Dependence
| Article | Year |
|---|---|
Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds.
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Chemical Phenomena; Chemistry; Explorato | 1990 |
Focus on addiction: Buspirone for cocaine relapse and monitoring controlled substances prescribed to dually diagnosed patients.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Buspirone; Cocaine-Related Disorders; Controlled Substances | 2014 |
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates conditioned place preference induced by various addictive and non-addictive drugs in rats.
Topics: Animals; Brain; Buspirone; Choice Behavior; Clonidine; Cocaine; Conditioning, Classical; Dose-Respon | 2011 |
Repurposing buspirone for drug addiction treatment.
Topics: Buspirone; Humans; Serotonin Receptor Agonists; Substance-Related Disorders | 2013 |
Anxiety treatment. A commonsense approach.
Topics: Adrenergic beta-Antagonists; Adult; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Anxiety Dis | 1984 |
Neuropharmacology of buspirone.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Biomechanical Phenomena; Buspirone; | 1984 |
Effects of serotonergic anxiolytics on physical dependence on diazepam in mice.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Carbolines; Diazepam; Drug Synergism; Epilepsy, Tonic-Cloni | 1993 |
Drug watch providing essential information.
Topics: Buspirone; Humans; Lactation; Metronidazole; Neoplasms; Nicotine; Paclitaxel; Substance-Related Diso | 1994 |
Behavioral pharmacology of tandospirone in baboons: chronic administration and withdrawal, self-injection and drug discrimination.
Topics: Animals; Anti-Anxiety Agents; Arousal; Buspirone; Cocaine; Discrimination Learning; Dose-Response Re | 1993 |
Nurses talk about their experiences with drug addiction.
Topics: Benzodiazepines; Buspirone; Female; Humans; Hydroxyzine; Nurses; Professional Impairment; Pruritus; | 1992 |
Buspirone in detoxification.
Topics: Anti-Anxiety Agents; Benzodiazepines; Bias; Buspirone; Humans; Patient Dropouts; Substance Withdrawa | 1991 |
Behavioral and subjective effects of buspirone and lorazepam in sedative abusers: supra-therapeutic doses.
Topics: Adult; Behavior; Buspirone; Double-Blind Method; Humans; Hypnotics and Sedatives; Lorazepam; Male; P | 1990 |
Possible adverse effects of buspirone when used with other psychotropic drugs.
Topics: Adult; Akathisia, Drug-Induced; Bipolar Disorder; Buspirone; Dose-Response Relationship, Drug; Drug | 1990 |
Buspirone: potentials for abuse?
Topics: Adult; Buspirone; Humans; Male; Substance-Related Disorders | 1989 |
Buspirone treatment of anxiety in a patient dependent on alprazolam.
Topics: Adult; Alprazolam; Anxiety; Buspirone; Humans; Male; Substance-Related Disorders | 1989 |
The risk of pharmacological dependence with buspirone.
Topics: Anti-Anxiety Agents; Buspirone; Diazepam; Humans; Pyrimidines; Risk; Substance Withdrawal Syndrome; | 1985 |
Assessment of addiction liability of benzodiazepines and buspirone.
Topics: Anti-Anxiety Agents; Benzodiazepines; Buspirone; Humans; Insurance, Liability; Pyrimidines; Seizures | 1985 |
Comment: Addiction liability of benzodiazepines and buspirone.
Topics: Anti-Anxiety Agents; Benzodiazepines; Buspirone; Humans; Kinetics; Pyrimidines; Substance-Related Di | 1986 |
Buspirone: a non-benzodiazepine for anxiety.
Topics: Anti-Anxiety Agents; Anxiety Disorders; Buspirone; Humans; Kinetics; Pyrimidines; Substance-Related | 1986 |
Clinical studies of "specific" anxiolytics as therapeutic agents.
Topics: Agoraphobia; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Buspirone; Humans; Mental Diso | 1987 |