buspirone has been researched along with Brain Ischemia in 7 studies
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamei, K | 2 |
| Maeda, N | 2 |
| Ogino, R | 1 |
| Koyama, M | 2 |
| Nakajima, M | 2 |
| Tatsuoka, T | 2 |
| Ohno, T | 2 |
| Inoue, T | 2 |
| Katsuragi-Ogino, R | 1 |
| van der Worp, HB | 1 |
| Macleod, MR | 1 |
| Bath, PM | 1 |
| Demotes, J | 1 |
| Durand-Zaleski, I | 1 |
| Gebhardt, B | 1 |
| Gluud, C | 1 |
| Kollmar, R | 2 |
| Krieger, DW | 2 |
| Lees, KR | 1 |
| Molina, C | 1 |
| Montaner, J | 1 |
| Roine, RO | 1 |
| Petersson, J | 1 |
| Staykov, D | 1 |
| Szabo, I | 1 |
| Wardlaw, JM | 1 |
| Schwab, S | 2 |
| Schellinger, PD | 1 |
| Steigleder, T | 1 |
| Köhrmann, M | 1 |
| De Georgia, MA | 1 |
| Abou-Chebl, A | 1 |
| Devlin, TG | 1 |
| Jauss, M | 1 |
| Davis, SM | 1 |
| Koroshetz, WJ | 1 |
| Rordorf, G | 1 |
| Warach, S | 1 |
| Suzuki, M | 1 |
| Matsuda, T | 1 |
| Somboonthum, P | 1 |
| Asano, S | 1 |
| Takuma, K | 1 |
| Nogi, H | 1 |
| Baba, A | 1 |
| Nakata, N | 1 |
| Suda, H | 1 |
| Izumi, J | 1 |
| Tanaka, Y | 1 |
| Ikeda, Y | 1 |
| Kato, H | 1 |
| Itoyama, Y | 1 |
| Kogure, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| EuroHYP-1: European Multicentre, Randomised, Phase III Clinical Trial of Therapeutic Hypothermia Plus Best Medical Treatment Versus Best Medical Treatment Alone for Acute Ischaemic Stroke[NCT01833312] | Phase 3 | 98 participants (Actual) | Interventional | 2013-07-31 | Terminated (stopped due to Slow recruitment, cessation of funding) | ||
| The Øresund Copenhagen-Malmø Acute Stroke Cooling Trial[NCT01500421] | Phase 2 | 31 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for buspirone and Brain Ischemia
| Article | Year |
|---|---|
EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Brain Ischemia; Buspirone; Clinical Protocols; Europe; Huma | 2014 |
Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling.
Topics: Acute Disease; Aged; Body Temperature; Brain; Brain Ischemia; Buspirone; Catheterization; Diffusion | 2004 |
5 other studies available for buspirone and Brain Ischemia
| Article | Year |
|---|---|
New 5-HT1A receptor agonists possessing 1,4-benzoxazepine scaffold exhibit highly potent anti-ischemic effects.
Topics: Animals; Body Temperature; Brain Ischemia; Neuroprotective Agents; Rats; Receptors, Serotonin; Recep | 2001 |
New piperidinyl- and 1,2,3,6-tetrahydropyridinyl-pyrimidine derivatives as selective 5-HT1A receptor agonists with highly potent anti-ischemic effects.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Arterial Occlusive Diseases; Brain Ischemia; Cerebrov | 2005 |
Ice-cold saline for the induction of mild hypothermia in patients with acute ischemic stroke: a pilot study.
Topics: Acute Disease; Aged; Analgesics, Opioid; Blood Cell Count; Blood Chemical Analysis; Brain Ischemia; | 2009 |
Effects of serotonin1A agonists on anoxia-induced impairment of protein synthesis in rat brain slices.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Brain Ischemia; Buspirone; Carbon Isotopes; | 1995 |
Role of hippocampal serotonergic neurons in ischemic neuronal death.
Topics: 5,7-Dihydroxytryptamine; Animals; Brain Ischemia; Buspirone; Carotid Arteries; Cell Death; Citalopra | 1997 |