buspirone has been researched along with Aggression in 43 studies
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Buspirone, a new anxiolytic agent, was used in a multiple-baseline, placebo lead-in study for the treatment of aggression and anxiety in six mentally retarded adult patients." | 9.07 | Buspirone treatment of aggression and anxiety in mentally retarded patients: a multiple-baseline, placebo lead-in study. ( Parks, A; Ratey, J; Rogentine, K; Sovner, R, 1991) |
| "To describe a case of an intellectually disabled patient who was diagnosed with autistic disorder (AD) and responded positively to buspirone, demonstrated by a reduction in target behaviors of self-injury, property destruction, and physical aggression." | 7.74 | Buspirone for autistic disorder in a woman with an intellectual disability. ( Brahm, NC; Brown, RC; Fast, GA, 2008) |
| "This case examined the efficacy of buspirone therapy as a reductive technique for severe treatment resistant paramenstrual aggression." | 7.68 | Paramenstrual aggression in mentally retarded adult ameliorated by buspirone. ( Colella, RF; Glaser, AI; Ratey, JJ, 1992) |
| "Buspirone was discontinued in 6 children (25%): 4 developed increased aggression and agitation, and 2 developed euphoric mania." | 6.68 | Buspirone treatment of psychiatrically hospitalized prepubertal children with symptoms of anxiety and moderately severe aggression. ( Domeshek, LJ; Jiang, H; Pfeffer, CR, 1997) |
| "Buspirone HCl (Buspar) is a novel anxiolytic agent unrelated to the benzodiazepines or other psychotherapeutic agents." | 6.65 | Buspirone: an anxioselective alternative for the management of anxiety disorders. ( Eison, AS; Eison, MS; Newton, RE; Riblet, LA; Taylor, DP; Temple, DL, 1983) |
| " 10 male cocaine dependent patients and 10 sex matched controls were administered several behavioral measures of aggression including the Buss-Durkee Hostility Inventory, and The Brown-Goodwin Life History of Aggression." | 5.07 | Serotonin and impulsive/aggressive behavior in cocaine dependent subjects. ( Cherek, DR; Fulton, M; Garver, DL; Kramer, G; Moeller, FG; Petty, F; Steinberg, JL, 1994) |
| "Buspirone, a new anxiolytic agent, was used in a multiple-baseline, placebo lead-in study for the treatment of aggression and anxiety in six mentally retarded adult patients." | 5.07 | Buspirone treatment of aggression and anxiety in mentally retarded patients: a multiple-baseline, placebo lead-in study. ( Parks, A; Ratey, J; Rogentine, K; Sovner, R, 1991) |
| "To describe a case of an intellectually disabled patient who was diagnosed with autistic disorder (AD) and responded positively to buspirone, demonstrated by a reduction in target behaviors of self-injury, property destruction, and physical aggression." | 3.74 | Buspirone for autistic disorder in a woman with an intellectual disability. ( Brahm, NC; Brown, RC; Fast, GA, 2008) |
| "The present study characterized the effects of the novel, selective, and potent 5-hydroxytryptamine1A (serotonin) (5-HT1A) receptor agonist, alnespirone [S-20499, (S)-N-4-[5-methoxychroman-3-yl)propylamino)butyl- 8-azaspiro-(4,5)-diacetamide, hydrochloride] on offensive and defensive resident-intruder aggression in wild-type rats and compared its actions with those of the prototypical full 5-HT1A agonist 8-hydroxy-2- dipropylaminotetralin (8-OH-DPAT), the partial 5-HT1A agonists ipsapirone and buspirone, and the mixed 5-HT1A/1B agonist eltoprazine." | 3.70 | Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. ( de Boer, SF; Koolhaas, JM; Lesourd, M; Mocaer, E, 1999) |
| "This case examined the efficacy of buspirone therapy as a reductive technique for severe treatment resistant paramenstrual aggression." | 3.68 | Paramenstrual aggression in mentally retarded adult ameliorated by buspirone. ( Colella, RF; Glaser, AI; Ratey, JJ, 1992) |
| "Buspirone was discontinued in 6 children (25%): 4 developed increased aggression and agitation, and 2 developed euphoric mania." | 2.68 | Buspirone treatment of psychiatrically hospitalized prepubertal children with symptoms of anxiety and moderately severe aggression. ( Domeshek, LJ; Jiang, H; Pfeffer, CR, 1997) |
| "Buspirone HCl (Buspar) is a novel anxiolytic agent unrelated to the benzodiazepines or other psychotherapeutic agents." | 2.65 | Buspirone: an anxioselective alternative for the management of anxiety disorders. ( Eison, AS; Eison, MS; Newton, RE; Riblet, LA; Taylor, DP; Temple, DL, 1983) |
| "Studies of buspirone for substance use disorders have had disappointing outcomes, although it may be useful for treating coexisting anxiety and one controlled study suggested efficacy for heroin detoxification." | 2.52 | Buspirone: Back to the Future. ( Howland, RH, 2015) |
| " The findings demonstrate that buspirone, in a daily dosage varying between 20 and 50 mg, may be effective in reducing this type of behavioural disturbance and associated with an improvement in sociability." | 1.29 | The effect of buspirone on challenging behaviour in mentally retarded patients: an open prospective multiple-case study. ( Tuinier, S; Verhoeven, WM, 1996) |
| "Enciprazine was selected for clinical investigations." | 1.28 | Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds. ( Engel, J; Fleischhauer, I; Jakovlev, V; Johanson, CE; Kleemann, A; Kutscher, B; Nickel, B; Rauer, H; Szelenyi, I; Werner, U, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (9.30) | 18.7374 |
| 1990's | 27 (62.79) | 18.2507 |
| 2000's | 5 (11.63) | 29.6817 |
| 2010's | 7 (16.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Engel, J | 1 |
| Fleischhauer, I | 1 |
| Jakovlev, V | 1 |
| Kleemann, A | 1 |
| Kutscher, B | 1 |
| Nickel, B | 1 |
| Rauer, H | 1 |
| Werner, U | 1 |
| Szelenyi, I | 1 |
| Johanson, CE | 1 |
| Borns-Weil, S | 1 |
| Kuchiiwa, S | 2 |
| Kuchiiwa, T | 2 |
| Howland, RH | 1 |
| Luauté, J | 1 |
| Plantier, D | 1 |
| Wiart, L | 1 |
| Tell, L | 1 |
| Santa Cruz, MR | 1 |
| Hidalgo, PC | 1 |
| Lee, MS | 1 |
| Thomas, CW | 1 |
| Holroyd, S | 1 |
| Avgustinovich, DF | 1 |
| Fomina, MK | 1 |
| Haller, J | 1 |
| Horváth, Z | 1 |
| Bakos, N | 1 |
| Brahm, NC | 1 |
| Fast, GA | 1 |
| Brown, RC | 1 |
| Olivier, B | 1 |
| van Aken, H | 1 |
| Jaarsma, I | 1 |
| van Oorschot, R | 1 |
| Zethof, T | 1 |
| Bradford, D | 1 |
| Riblet, LA | 2 |
| Taylor, DP | 2 |
| Eison, MS | 2 |
| Stanton, HC | 1 |
| Eison, AS | 1 |
| Newton, RE | 1 |
| Temple, DL | 1 |
| Holzer, JC | 1 |
| Gitelman, DR | 1 |
| Price, BH | 1 |
| Overall, KL | 2 |
| Moeller, FG | 2 |
| Steinberg, JL | 1 |
| Petty, F | 1 |
| Fulton, M | 1 |
| Cherek, DR | 2 |
| Kramer, G | 1 |
| Garver, DL | 1 |
| Byrne, A | 1 |
| Martin, W | 1 |
| Hnatko, G | 1 |
| Stanislav, SW | 1 |
| Fabre, T | 1 |
| Crismon, ML | 1 |
| Childs, A | 1 |
| Blanchard, DC | 1 |
| Veniegas, R | 1 |
| Elloran, I | 1 |
| Blanchard, RJ | 1 |
| Zamoshchina, TA | 1 |
| Ladyzhets, EN | 1 |
| Saratikov, AS | 1 |
| Zayas, EM | 1 |
| Grossberg, GT | 1 |
| Mintzer, JE | 1 |
| Brawman-Mintzer, O | 1 |
| Hillbrand, M | 1 |
| Scott, K | 1 |
| Verhoeven, WM | 1 |
| Tuinier, S | 1 |
| Millan, MJ | 1 |
| Hjorth, S | 1 |
| Samanin, R | 1 |
| Schreiber, R | 1 |
| Jaffard, R | 1 |
| De Ladonchamps, B | 1 |
| Veiga, S | 1 |
| Goument, B | 1 |
| Peglion, JL | 1 |
| Spedding, M | 1 |
| Brocco, M | 1 |
| Pfeffer, CR | 1 |
| Jiang, H | 1 |
| Domeshek, LJ | 1 |
| Matto, V | 2 |
| Allikmets, L | 2 |
| Skrebuhhova, T | 1 |
| Abe, M | 1 |
| Nakai, H | 1 |
| Tabata, R | 1 |
| Saito, K | 1 |
| Egawa, M | 1 |
| Moechars, D | 1 |
| Gilis, M | 1 |
| Kuipéri, C | 1 |
| Laenen, I | 1 |
| Van Leuven, F | 1 |
| de Boer, SF | 1 |
| Lesourd, M | 1 |
| Mocaer, E | 1 |
| Koolhaas, JM | 1 |
| Khan-Dawood, F | 1 |
| Swann, A | 1 |
| Lane, SD | 1 |
| Ferreira, A | 1 |
| Picazo, O | 1 |
| Uriarte, N | 1 |
| Pereira, M | 1 |
| Fernández-Guasti, A | 1 |
| Stork, O | 1 |
| Welzl, H | 1 |
| Wolfer, D | 1 |
| Schuster, T | 1 |
| Mantei, N | 1 |
| Stork, S | 1 |
| Hoyer, D | 1 |
| Lipp, H | 1 |
| Obata, K | 1 |
| Schachner, M | 1 |
| Pruus, K | 1 |
| Skrebuhhova-Malmros, T | 1 |
| Rudissaar, R | 1 |
| Colella, RF | 1 |
| Ratey, JJ | 3 |
| Glaser, AI | 1 |
| Leveroni, CL | 1 |
| Miller, AC | 1 |
| Komry, V | 1 |
| Gaffar, K | 1 |
| Quiason, N | 1 |
| Ward, D | 1 |
| Kitchen, T | 1 |
| Gedye, A | 1 |
| Yudofsky, SC | 1 |
| Silver, JM | 1 |
| Hales, RE | 1 |
| Ratey, J | 1 |
| Sovner, R | 2 |
| Parks, A | 1 |
| Rogentine, K | 1 |
| Coccaro, EF | 1 |
| Gabriel, S | 1 |
| Siever, LJ | 1 |
| Mikkelsen, E | 1 |
| Chmielinski, HE | 1 |
4 reviews available for buspirone and Aggression
| Article | Year |
|---|---|
Buspirone: Back to the Future.
Topics: Aggression; Anti-Anxiety Agents; Anxiety Disorders; Buspirone; Cognition Disorders; Dementia; Depres | 2015 |
Care management of the agitation or aggressiveness crisis in patients with TBI. Systematic review of the literature and practice recommendations.
Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anti-Anxiety Agents; Anticonvulsants; Antipsych | 2016 |
Agitation as a possible expression of generalized anxiety disorder in demented elderly patients: toward a treatment approach.
Topics: Aged; Aggression; Antipsychotic Agents; Anxiety Disorders; Behavior Therapy; Buspirone; Carbamazepin | 1996 |
Pharmacologic management of aggression in the elderly.
Topics: Aged; Aggression; Antipsychotic Agents; Benzodiazepines; Buspirone; Dementia; Haloperidol; Humans; L | 1990 |
5 trials available for buspirone and Aggression
| Article | Year |
|---|---|
Buspirone: an anxioselective alternative for the management of anxiety disorders.
Topics: Aggression; Animals; Anxiety Disorders; Arousal; Avoidance Learning; Buspirone; Clinical Trials as T | 1983 |
Serotonin and impulsive/aggressive behavior in cocaine dependent subjects.
Topics: Adult; Aggression; Buspirone; Cocaine; Growth Hormone; Humans; Impulsive Behavior; Male; Psychiatric | 1994 |
Buspirone treatment of psychiatrically hospitalized prepubertal children with symptoms of anxiety and moderately severe aggression.
Topics: Aggression; Anxiety; Buspirone; Child; Child Behavior Disorders; Female; Humans; Male; Psychiatric S | 1997 |
Buspirone alone or with serotonergic diet reduced aggression in a developmentally disabled adult.
Topics: Adult; Aggression; Buspirone; Combined Modality Therapy; Female; Humans; Intellectual Disability; Se | 1991 |
Buspirone treatment of aggression and anxiety in mentally retarded patients: a multiple-baseline, placebo lead-in study.
Topics: Adult; Aggression; Anxiety Disorders; Buspirone; Dose-Response Relationship, Drug; Female; Humans; I | 1991 |
34 other studies available for buspirone and Aggression
| Article | Year |
|---|---|
Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds.
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Chemical Phenomena; Chemistry; Explorato | 1990 |
Animal Behavior Case of the Month.
Topics: Aggression; Animals; Behavior Therapy; Behavior, Animal; Buspirone; Clonidine; Dogs; Female; Fluoxet | 2019 |
A novel semi-automated apparatus for measurement of aggressive biting behavior in mice.
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Dose-Response Relationship, D | 2014 |
Evaluation of aggressiveness of female mice using a semi-automated apparatus for measurement of aggressive biting behavior toward an inanimate object.
Topics: Aggression; Animals; Automation, Laboratory; Buspirone; Drug Evaluation, Preclinical; Electric Imped | 2016 |
Buspirone for the treatment of dementia with behavioral disturbance.
Topics: Aged; Aged, 80 and over; Aggression; Buspirone; Dementia; Female; Humans; Male; Psychiatric Status R | 2017 |
[Effects of buspirone on the behavior of female mice in a model of social discomfort].
Topics: Aggression; Animals; Anti-Anxiety Agents; Apathy; Behavior, Animal; Buspirone; Conflict, Psychologic | 2012 |
The effect of buspirone on normal and hypoarousal-driven abnormal aggression in rats.
Topics: Adrenalectomy; Aggression; Animals; Anti-Anxiety Agents; Arousal; Buspirone; Dose-Response Relations | 2007 |
Buspirone for autistic disorder in a woman with an intellectual disability.
Topics: Adult; Aggression; Anti-Anxiety Agents; Antipsychotic Agents; Autistic Disorder; Buspirone; Epilepsy | 2008 |
Behavioural effects of psychoactive drugs on agonistic behaviour of male territorial rats (resident-intruder model).
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aggression; Agonistic Behavior; Animals; | 1984 |
Pharmacology and neurochemistry of buspirone.
Topics: Aggression; Animals; Anti-Anxiety Agents; Avoidance Learning; Buspirone; Chemical Phenomena; Chemist | 1982 |
Efficacy of buspirone in the treatment of dementia with aggression.
Topics: Age Factors; Aged; Aged, 80 and over; Aggression; Buspirone; Dementia; Humans; Male | 1995 |
Animal behavior case of the month. Periodic aggression toward the owner.
Topics: Aggression; Animals; Animals, Domestic; Behavior Therapy; Buspirone; Combined Modality Therapy; Dogs | 1995 |
Animal behavior case of the month. Urine spraying by a cat in a multicat household.
Topics: Aggression; Animals; Behavior, Animal; Buspirone; Cat Diseases; Cats; Diazepam; Female; Follow-Up St | 1994 |
Beneficial effects of buspirone therapy in Huntington's disease.
Topics: Aggression; Buspirone; Humans; Huntington Disease; Irritable Mood; Male; Middle Aged | 1994 |
Buspirone's efficacy in organic-induced aggression.
Topics: Adolescent; Adult; Aggression; Buspirone; Female; Humans; Male; Middle Aged; Neurocognitive Disorder | 1994 |
Alcohol and anxiety: effects on offensive and defensive aggression.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Buspirone; Ethanol; Female; Male; R | 1993 |
[Dependence of the anti-aggression properties of buspirone on time of day].
Topics: Aggression; Animals; Buspirone; Circadian Rhythm; Male; Mesencephalon; Mice; Protein Binding; Rats; | 1996 |
Treating the agitated Alzheimer patient.
Topics: Adrenergic beta-Antagonists; Aged; Aggression; Alzheimer Disease; Antipsychotic Agents; Buspirone; C | 1996 |
The use of buspirone with aggressive behavior.
Topics: Adult; Aggression; Anti-Anxiety Agents; Autistic Disorder; Buspirone; Hospitalization; Hospitals, Ps | 1995 |
The effect of buspirone on challenging behaviour in mentally retarded patients: an open prospective multiple-case study.
Topics: Adult; Aggression; Arousal; Buspirone; Dose-Response Relationship, Drug; Drug Administration Schedul | 1996 |
S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: II. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties.
Topics: Aggression; Animals; Anti-Anxiety Agents; Buspirone; Columbidae; Female; Hippocampus; Male; Mice; Mi | 1997 |
Apomorphine-induced aggressiveness and [3H]citalopram binding after antidepressant treatment in rats.
Topics: Aggression; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Binding Sites; Buspirone; | 1998 |
Effect of 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole HCl (MKC-242), a novel 5-HT1A-receptor agonist, on aggressive behavior and marble burying behavior in mice.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Diazepam; Dioxanes; Dioxoles; Disease | 1998 |
Aggressive behaviour in transgenic mice expressing APP is alleviated by serotonergic drugs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Amyloid beta-Protein Precursor; Animals; Behavio | 1998 |
Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Behavior, Animal; Buspirone; Male; Pipe | 1999 |
Prolactin response to buspirone was reduced in violent compared to nonviolent parolees.
Topics: Adult; Aggression; Analysis of Variance; Buspirone; Dopamine; Female; Humans; Male; Prolactin; Serot | 1999 |
Inhibitory effect of buspirone and diazepam, but not of 8-OH-DPAT, on maternal behavior and aggression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Anti-Anxiety Agents; Body Temperature; | 2000 |
Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Body Weight | 2000 |
5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Apomorphine; Behavior, Animal; Buspiron | 2000 |
Paramenstrual aggression in mentally retarded adult ameliorated by buspirone.
Topics: Adaptation, Psychological; Adult; Aggression; Behavior Therapy; Buspirone; Female; Humans; Instituti | 1992 |
Low-dose buspirone to treat agitation and maladaptive behavior in brain-injured patients: two case reports.
Topics: Adult; Aggression; Brain Injuries; Buspirone; Dose-Response Relationship, Drug; Drug Administration | 1992 |
Buspirone for aggression.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Buspirone; Child; Child Behavior Disorder | 1991 |
Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans.
Topics: Adult; Aggression; Buspirone; Female; Humans; Male; Metergoline; Personality Disorders; Pindolol; Pr | 1990 |
Buspirone therapy for maladaptive behavior and anxiety in developmentally disabled persons.
Topics: Adjustment Disorders; Adult; Aggression; Anxiety Disorders; Buspirone; Female; Humans; Intellectual | 1989 |