buspirone has been researched along with Ache in 28 studies
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a randomized, double-blind crossover study, we compared single doses of two 5-HT1 agonists, buspirone and m-chlorophenylpiperazine, to placebo in 20 patients with post-herpetic neuralgia or painful neuropathy." | 9.06 | Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain. ( Kishore-Kumar, R; Lawlor, BA; Max, MB; Murphy, DL; Schafer, SC, 1989) |
| "Previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-HT1A receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress." | 8.02 | Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation. ( Butkevich, IP; Mikhailenko, VA; Vershinina, EA, 2021) |
| "The present study concerned extending the therapeutic use of buspirone for treating pain and improving cognition." | 7.88 | Dose related effects of buspirone on pain, learning / memory and food intake. ( Haleem, DJ; Nawaz, S; Salman, T, 2018) |
| " In the present study, we investigated the influence of inflammatory pain and/or stress of isolation from the mother in newborn female rats to pain sensitivity when they reached adulthood; an attempt was undertaken to correct identified deviations using 5-HT1A-receptor agonist buspirone." | 7.83 | [THE DAMAGING EFFECTS AT AN EARLY AGE ALTER PAIN SENSITIVITY IN ADULT FEMALE RATS, CORRECTION WITH BUSPIRONE]. ( Butkevich, IP; Mikhailenko, VA, 2016) |
| "We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring." | 7.79 | Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy. ( Bagaeva, TR; Butkevich, IP; Makukhina, GV; Mikhailenko, VA; Stolyarova, YA, 2013) |
| " In the present study we test the hypothesis that injections of buspirone, a 5-HT1A agonist, to rat dams before restraint stress during the last week of pregnancy (between pregnant days 15 and 20) can improve the characteristics of emotional and inflammatory pain-related behaviors in the adult offspring." | 7.77 | Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring. ( Butkevich, I; Makukhina, G; Mikhailenko, V; Otellin, V; Semionov, P; Vershinina, E, 2011) |
| "The analgesic efficacy of the novel anxiolytic buspirone in tests of acute thermal, mechanical and formalin-induced chemical-inflammatory pain were examined." | 7.67 | Antinociceptive effects of the novel anxiolytic buspirone in three pain tests in rats. ( Giordano, J; Rogers, L, 1989) |
| "Buspirone was injected to female rats from the 9th to 21st days of pregnancy; during the last week of pregnancy buspirone was injected 10 min before immobilization stress." | 5.36 | [Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats]. ( Butkevich, IP; Mikhaĭlenko, VA; Otellin, VA; Semenov, PO; Vershinina, EA, 2010) |
| " In a randomized, double-blind crossover study, we compared single doses of two 5-HT1 agonists, buspirone and m-chlorophenylpiperazine, to placebo in 20 patients with post-herpetic neuralgia or painful neuropathy." | 5.06 | Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain. ( Kishore-Kumar, R; Lawlor, BA; Max, MB; Murphy, DL; Schafer, SC, 1989) |
| "Previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-HT1A receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress." | 4.02 | Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation. ( Butkevich, IP; Mikhailenko, VA; Vershinina, EA, 2021) |
| "The present study concerned extending the therapeutic use of buspirone for treating pain and improving cognition." | 3.88 | Dose related effects of buspirone on pain, learning / memory and food intake. ( Haleem, DJ; Nawaz, S; Salman, T, 2018) |
| " In the present study, we investigated the influence of inflammatory pain and/or stress of isolation from the mother in newborn female rats to pain sensitivity when they reached adulthood; an attempt was undertaken to correct identified deviations using 5-HT1A-receptor agonist buspirone." | 3.83 | [THE DAMAGING EFFECTS AT AN EARLY AGE ALTER PAIN SENSITIVITY IN ADULT FEMALE RATS, CORRECTION WITH BUSPIRONE]. ( Butkevich, IP; Mikhailenko, VA, 2016) |
| "We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring." | 3.79 | Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy. ( Bagaeva, TR; Butkevich, IP; Makukhina, GV; Mikhailenko, VA; Stolyarova, YA, 2013) |
| " In the present study we test the hypothesis that injections of buspirone, a 5-HT1A agonist, to rat dams before restraint stress during the last week of pregnancy (between pregnant days 15 and 20) can improve the characteristics of emotional and inflammatory pain-related behaviors in the adult offspring." | 3.77 | Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring. ( Butkevich, I; Makukhina, G; Mikhailenko, V; Otellin, V; Semionov, P; Vershinina, E, 2011) |
| "In the nociception test, the pain-induced functional impairment rat model, uric acid at 3." | 3.73 | Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. ( Fernández-Guasti, A; López-Muñoz, FJ; Martínez-Mota, L; Reyes, R, 2005) |
| "The analgesic efficacy of the novel anxiolytic buspirone in tests of acute thermal, mechanical and formalin-induced chemical-inflammatory pain were examined." | 3.67 | Antinociceptive effects of the novel anxiolytic buspirone in three pain tests in rats. ( Giordano, J; Rogers, L, 1989) |
| "buspirone or placebo." | 2.73 | The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphine-induced respiratory depression in humans. ( Geisslinger, G; Lötsch, J; Oertel, BG; Rohrbacher, M; Schmidt, H; Schneider, A; Tegeder, I, 2007) |
| "Buspirone has an indication for generalized anxiety disorder though studies show only a minimal benefit." | 2.53 | Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD. ( Bielefeldt, K; Szigethy, E; Thorkelson, G, 2016) |
| "Ventilatory depression is a serious side-effect of opioid analgesics." | 1.39 | Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats. ( Haji, A; Kimura, S; Ohi, Y, 2013) |
| "Buspirone was injected to female rats from the 9th to 21st days of pregnancy; during the last week of pregnancy buspirone was injected 10 min before immobilization stress." | 1.36 | [Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats]. ( Butkevich, IP; Mikhaĭlenko, VA; Otellin, VA; Semenov, PO; Vershinina, EA, 2010) |
| " pretreatment (25 min) with morphine sulfate, 8-OH-DPAT, buspirone and 5-CT shifted the morphine sulfate dose-response curve 3- to 5-fold to the right." | 1.29 | Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice. ( Alhaider, AA; Wilcox, GL, 1993) |
| "Procaine was shown to elicit theta at a mean latency of 52 s and for a mean duration of 21." | 1.29 | Pharmacological suppression of the median raphe nucleus with serotonin1A agonists, 8-OH-DPAT and buspirone, produces hippocampal theta rhythm in the rat. ( Fortin, WJ; Kinney, GG; Kocsis, B; Vertes, RP, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.71) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 10 (35.71) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Butkevich, IP | 8 |
| Mikhailenko, VA | 8 |
| Vershinina, EA | 3 |
| Astapova, MK | 1 |
| Haleem, DJ | 1 |
| Nawaz, S | 1 |
| Salman, T | 1 |
| Kimura, S | 1 |
| Ohi, Y | 1 |
| Haji, A | 1 |
| Lavrova, YA | 1 |
| Bagaeva, TR | 2 |
| Otellin, VA | 2 |
| Makukhina, GV | 1 |
| Stolyarova, YA | 1 |
| Thorkelson, G | 1 |
| Bielefeldt, K | 1 |
| Szigethy, E | 1 |
| Semenov, PO | 1 |
| Butkevich, I | 1 |
| Mikhailenko, V | 1 |
| Vershinina, E | 1 |
| Semionov, P | 1 |
| Makukhina, G | 1 |
| Otellin, V | 1 |
| Shyu, BC | 1 |
| Chai, SC | 1 |
| Kung, JC | 1 |
| Fan, RJ | 1 |
| Chial, HJ | 1 |
| Camilleri, M | 1 |
| Ferber, I | 1 |
| Delgado-Aros, S | 1 |
| Burton, D | 1 |
| McKinzie, S | 1 |
| Zinsmeister, AR | 1 |
| Fernández-Guasti, A | 1 |
| Reyes, R | 1 |
| Martínez-Mota, L | 1 |
| López-Muñoz, FJ | 1 |
| Oertel, BG | 1 |
| Schneider, A | 1 |
| Rohrbacher, M | 1 |
| Schmidt, H | 1 |
| Tegeder, I | 1 |
| Geisslinger, G | 1 |
| Lötsch, J | 1 |
| Alhaider, AA | 1 |
| Wilcox, GL | 1 |
| Vertes, RP | 1 |
| Kinney, GG | 1 |
| Kocsis, B | 1 |
| Fortin, WJ | 1 |
| Korneyev, AY | 1 |
| Seredenin, SB | 1 |
| Tokuyama, S | 1 |
| Takahashi, M | 1 |
| Kaneto, H | 1 |
| Galeotti, N | 1 |
| Ghelardini, C | 1 |
| Bartolini, A | 1 |
| Jain, NK | 1 |
| Kulkarni, SK | 1 |
| Chen, DY | 1 |
| Ho, SH | 1 |
| Liang, KC | 1 |
| Pascual, J | 1 |
| Max, MB | 2 |
| Kishore-Kumar, R | 2 |
| Lawlor, BA | 2 |
| Murphy, DL | 2 |
| Giordano, J | 1 |
| Rogers, L | 1 |
| Schafer, SC | 1 |
| Korneev, AIa | 1 |
| Vasilenko, GF | 1 |
| Bragin, EO | 1 |
1 review available for buspirone and Ache
| Article | Year |
|---|---|
Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD.
Topics: Adolescent; Adult; Affect; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Bupropion | 2016 |
3 trials available for buspirone and Ache
| Article | Year |
|---|---|
Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Buspirone; Colon; Compliance; | 2003 |
The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphine-induced respiratory depression in humans.
Topics: Adult; Analgesics, Opioid; Buspirone; Cross-Over Studies; Dose-Response Relationship, Drug; Double-B | 2007 |
Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain.
Topics: Adult; Aged; Buspirone; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle | 1989 |
24 other studies available for buspirone and Ache
| Article | Year |
|---|---|
Effects of Stress Exposure during Adolescent Period on Inflammatory Pain Response, Psychoemotional Behavior, and Action of Antidepressants in Prenatally Stressed Adult Male Rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Buspirone; Female; Fluoxetine; Inflammation; Male; | 2020 |
Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation.
Topics: Animals; Buspirone; Female; Fluoxetine; Male; Pain; Pregnancy; Rats | 2021 |
[INVOLVEMENT OF 5-HT1A RECEPTORS IN LONG-TERM INFLUENCE OF INFLAMMATORY PAIN AND STRESS IN EARLY AGE ON REACTIVITY OF NOCICEPTIVE SYSTEM].
Topics: Animals; Animals, Newborn; Buspirone; Inflammation; Nociception; Pain; Rats; Rats, Wistar; Receptors | 2016 |
[THE DAMAGING EFFECTS AT AN EARLY AGE ALTER PAIN SENSITIVITY IN ADULT FEMALE RATS, CORRECTION WITH BUSPIRONE].
Topics: Animals; Animals, Newborn; Buspirone; Female; Hyperalgesia; Inflammation; Male; Pain; Rats; Rats, Wi | 2016 |
Dose related effects of buspirone on pain, learning / memory and food intake.
Topics: Analgesics; Animals; Buspirone; Cognition; Dose-Response Relationship, Drug; Eating; Male; Maze Lear | 2018 |
Prenatal Stimulation of 5-HT
Topics: Adaptation, Psychological; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buspirone; Depressi | 2019 |
Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Buspirone; Cholinesterase Inhibitors; Do | 2013 |
Effect of tonic pain on the corticosterone level in rat pups of various ages subjected to prenatal stress and opportunities for correction of stress-induced impairments.
Topics: Animals; Buspirone; Corticosterone; Female; Male; Pain; Pain Management; Pregnancy; Prenatal Exposur | 2013 |
Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy.
Topics: Animals; Behavior, Animal; Buspirone; Corticosterone; Female; Inflammation; Nociceptors; Pain; Pain | 2013 |
[Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats].
Topics: Animals; Behavior, Animal; Buspirone; Depression; Female; Immobilization; Inflammation; Male; Pain; | 2010 |
Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Emotions; Female; M | 2011 |
A quantitative method for assessing of the affective component of the pain: conditioned response associated with CO2 laser-induced nocifensive reaction.
Topics: Acoustic Stimulation; Affect; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Buspirone; Condition | 2003 |
Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Buspirone; D | 2005 |
Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Male; Mice; Morphine; | 1993 |
Pharmacological suppression of the median raphe nucleus with serotonin1A agonists, 8-OH-DPAT and buspirone, produces hippocampal theta rhythm in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Electroencephalography; Hippocampus; Mal | 1994 |
Effect of 5-HT-1A receptor agonists on paw licking reaction on hot plate and unpunished drinking in rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Drinking Behavior; Indoles; Male; Pain; | 1993 |
Involvement of serotonergic receptor subtypes in the production of antinociception by psychological stress in mice.
Topics: Animals; Buspirone; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Pain; Pi | 1993 |
5-HT1A agonists induce central cholinergic antinociception.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; GTP-Binding Proteins; Male; Mice; Motor | 1997 |
L-NAME, a nitric oxide synthase inhibitor, modulates cholinergic antinociception.
Topics: Acetic Acid; Analgesics; Animals; Buspirone; Cholinergic Agents; Drug Synergism; Enzyme Inhibitors; | 1999 |
Startle responses to electric shocks: measurement of shock sensitivity and effects of morphine, buspirone and brain lesions.
Topics: Animals; Brain; Buspirone; Conditioning, Psychological; Dose-Response Relationship, Drug; Electrosho | 2000 |
Serotonin, serotonin receptors, serotonin receptor subtype agonists and pain.
Topics: Analgesics; Brain; Buspirone; Humans; Pain; Piperazines; Receptors, Serotonin; Serotonin | 1990 |
Response to Julio Pascual regarding Kishore-Kumar et al. (Pain, 37 (1989) 223-227)
Topics: Analgesics; Buspirone; Humans; Pain; Piperazines; Serotonin | 1990 |
Antinociceptive effects of the novel anxiolytic buspirone in three pain tests in rats.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Hot Temperature; Nociceptors; Pain; Pain Measurement; Physi | 1989 |
[Analysis of the influence of anxiolytics on the pain reactions of rats compared to the effect of morphine].
Topics: Animals; Anti-Anxiety Agents; Buspirone; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation | 1987 |