Page last updated: 2024-10-24

buspirone and Ache

buspirone has been researched along with Ache in 28 studies

Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.

Research Excerpts

ExcerptRelevanceReference
" In a randomized, double-blind crossover study, we compared single doses of two 5-HT1 agonists, buspirone and m-chlorophenylpiperazine, to placebo in 20 patients with post-herpetic neuralgia or painful neuropathy."9.06Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain. ( Kishore-Kumar, R; Lawlor, BA; Max, MB; Murphy, DL; Schafer, SC, 1989)
"Previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-HT1A receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress."8.02Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation. ( Butkevich, IP; Mikhailenko, VA; Vershinina, EA, 2021)
"The present study concerned extending the therapeutic use of buspirone for treating pain and improving cognition."7.88Dose related effects of buspirone on pain, learning / memory and food intake. ( Haleem, DJ; Nawaz, S; Salman, T, 2018)
" In the present study, we investigated the influence of inflammatory pain and/or stress of isolation from the mother in newborn female rats to pain sensitivity when they reached adulthood; an attempt was undertaken to correct identified deviations using 5-HT1A-receptor agonist buspirone."7.83[THE DAMAGING EFFECTS AT AN EARLY AGE ALTER PAIN SENSITIVITY IN ADULT FEMALE RATS, CORRECTION WITH BUSPIRONE]. ( Butkevich, IP; Mikhailenko, VA, 2016)
"We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring."7.79Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy. ( Bagaeva, TR; Butkevich, IP; Makukhina, GV; Mikhailenko, VA; Stolyarova, YA, 2013)
" In the present study we test the hypothesis that injections of buspirone, a 5-HT1A agonist, to rat dams before restraint stress during the last week of pregnancy (between pregnant days 15 and 20) can improve the characteristics of emotional and inflammatory pain-related behaviors in the adult offspring."7.77Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring. ( Butkevich, I; Makukhina, G; Mikhailenko, V; Otellin, V; Semionov, P; Vershinina, E, 2011)
"The analgesic efficacy of the novel anxiolytic buspirone in tests of acute thermal, mechanical and formalin-induced chemical-inflammatory pain were examined."7.67Antinociceptive effects of the novel anxiolytic buspirone in three pain tests in rats. ( Giordano, J; Rogers, L, 1989)
"Buspirone was injected to female rats from the 9th to 21st days of pregnancy; during the last week of pregnancy buspirone was injected 10 min before immobilization stress."5.36[Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats]. ( Butkevich, IP; Mikhaĭlenko, VA; Otellin, VA; Semenov, PO; Vershinina, EA, 2010)
" In a randomized, double-blind crossover study, we compared single doses of two 5-HT1 agonists, buspirone and m-chlorophenylpiperazine, to placebo in 20 patients with post-herpetic neuralgia or painful neuropathy."5.06Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain. ( Kishore-Kumar, R; Lawlor, BA; Max, MB; Murphy, DL; Schafer, SC, 1989)
"Previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-HT1A receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress."4.02Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation. ( Butkevich, IP; Mikhailenko, VA; Vershinina, EA, 2021)
"The present study concerned extending the therapeutic use of buspirone for treating pain and improving cognition."3.88Dose related effects of buspirone on pain, learning / memory and food intake. ( Haleem, DJ; Nawaz, S; Salman, T, 2018)
" In the present study, we investigated the influence of inflammatory pain and/or stress of isolation from the mother in newborn female rats to pain sensitivity when they reached adulthood; an attempt was undertaken to correct identified deviations using 5-HT1A-receptor agonist buspirone."3.83[THE DAMAGING EFFECTS AT AN EARLY AGE ALTER PAIN SENSITIVITY IN ADULT FEMALE RATS, CORRECTION WITH BUSPIRONE]. ( Butkevich, IP; Mikhailenko, VA, 2016)
"We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring."3.79Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy. ( Bagaeva, TR; Butkevich, IP; Makukhina, GV; Mikhailenko, VA; Stolyarova, YA, 2013)
" In the present study we test the hypothesis that injections of buspirone, a 5-HT1A agonist, to rat dams before restraint stress during the last week of pregnancy (between pregnant days 15 and 20) can improve the characteristics of emotional and inflammatory pain-related behaviors in the adult offspring."3.77Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring. ( Butkevich, I; Makukhina, G; Mikhailenko, V; Otellin, V; Semionov, P; Vershinina, E, 2011)
"In the nociception test, the pain-induced functional impairment rat model, uric acid at 3."3.73Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. ( Fernández-Guasti, A; López-Muñoz, FJ; Martínez-Mota, L; Reyes, R, 2005)
"The analgesic efficacy of the novel anxiolytic buspirone in tests of acute thermal, mechanical and formalin-induced chemical-inflammatory pain were examined."3.67Antinociceptive effects of the novel anxiolytic buspirone in three pain tests in rats. ( Giordano, J; Rogers, L, 1989)
"buspirone or placebo."2.73The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphine-induced respiratory depression in humans. ( Geisslinger, G; Lötsch, J; Oertel, BG; Rohrbacher, M; Schmidt, H; Schneider, A; Tegeder, I, 2007)
"Buspirone has an indication for generalized anxiety disorder though studies show only a minimal benefit."2.53Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD. ( Bielefeldt, K; Szigethy, E; Thorkelson, G, 2016)
"Ventilatory depression is a serious side-effect of opioid analgesics."1.39Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats. ( Haji, A; Kimura, S; Ohi, Y, 2013)
"Buspirone was injected to female rats from the 9th to 21st days of pregnancy; during the last week of pregnancy buspirone was injected 10 min before immobilization stress."1.36[Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats]. ( Butkevich, IP; Mikhaĭlenko, VA; Otellin, VA; Semenov, PO; Vershinina, EA, 2010)
" pretreatment (25 min) with morphine sulfate, 8-OH-DPAT, buspirone and 5-CT shifted the morphine sulfate dose-response curve 3- to 5-fold to the right."1.29Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice. ( Alhaider, AA; Wilcox, GL, 1993)
"Procaine was shown to elicit theta at a mean latency of 52 s and for a mean duration of 21."1.29Pharmacological suppression of the median raphe nucleus with serotonin1A agonists, 8-OH-DPAT and buspirone, produces hippocampal theta rhythm in the rat. ( Fortin, WJ; Kinney, GG; Kocsis, B; Vertes, RP, 1994)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19903 (10.71)18.7374
1990's8 (28.57)18.2507
2000's5 (17.86)29.6817
2010's10 (35.71)24.3611
2020's2 (7.14)2.80

Authors

AuthorsStudies
Butkevich, IP8
Mikhailenko, VA8
Vershinina, EA3
Astapova, MK1
Haleem, DJ1
Nawaz, S1
Salman, T1
Kimura, S1
Ohi, Y1
Haji, A1
Lavrova, YA1
Bagaeva, TR2
Otellin, VA2
Makukhina, GV1
Stolyarova, YA1
Thorkelson, G1
Bielefeldt, K1
Szigethy, E1
Semenov, PO1
Butkevich, I1
Mikhailenko, V1
Vershinina, E1
Semionov, P1
Makukhina, G1
Otellin, V1
Shyu, BC1
Chai, SC1
Kung, JC1
Fan, RJ1
Chial, HJ1
Camilleri, M1
Ferber, I1
Delgado-Aros, S1
Burton, D1
McKinzie, S1
Zinsmeister, AR1
Fernández-Guasti, A1
Reyes, R1
Martínez-Mota, L1
López-Muñoz, FJ1
Oertel, BG1
Schneider, A1
Rohrbacher, M1
Schmidt, H1
Tegeder, I1
Geisslinger, G1
Lötsch, J1
Alhaider, AA1
Wilcox, GL1
Vertes, RP1
Kinney, GG1
Kocsis, B1
Fortin, WJ1
Korneyev, AY1
Seredenin, SB1
Tokuyama, S1
Takahashi, M1
Kaneto, H1
Galeotti, N1
Ghelardini, C1
Bartolini, A1
Jain, NK1
Kulkarni, SK1
Chen, DY1
Ho, SH1
Liang, KC1
Pascual, J1
Max, MB2
Kishore-Kumar, R2
Lawlor, BA2
Murphy, DL2
Giordano, J1
Rogers, L1
Schafer, SC1
Korneev, AIa1
Vasilenko, GF1
Bragin, EO1

Reviews

1 review available for buspirone and Ache

ArticleYear
Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD.
    Inflammatory bowel diseases, 2016, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Affect; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Bupropion

2016

Trials

3 trials available for buspirone and Ache

ArticleYear
Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:3

    Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Buspirone; Colon; Compliance;

2003
The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphine-induced respiratory depression in humans.
    Clinical pharmacology and therapeutics, 2007, Volume: 81, Issue:1

    Topics: Adult; Analgesics, Opioid; Buspirone; Cross-Over Studies; Dose-Response Relationship, Drug; Double-B

2007
Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain.
    Pain, 1989, Volume: 37, Issue:2

    Topics: Adult; Aged; Buspirone; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle

1989

Other Studies

24 other studies available for buspirone and Ache

ArticleYear
Effects of Stress Exposure during Adolescent Period on Inflammatory Pain Response, Psychoemotional Behavior, and Action of Antidepressants in Prenatally Stressed Adult Male Rats.
    Bulletin of experimental biology and medicine, 2020, Volume: 169, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Buspirone; Female; Fluoxetine; Inflammation; Male;

2020
Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation.
    Canadian journal of physiology and pharmacology, 2021, Volume: 99, Issue:6

    Topics: Animals; Buspirone; Female; Fluoxetine; Male; Pain; Pregnancy; Rats

2021
[INVOLVEMENT OF 5-HT1A RECEPTORS IN LONG-TERM INFLUENCE OF INFLAMMATORY PAIN AND STRESS IN EARLY AGE ON REACTIVITY OF NOCICEPTIVE SYSTEM].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2016, Volume: 102, Issue:8

    Topics: Animals; Animals, Newborn; Buspirone; Inflammation; Nociception; Pain; Rats; Rats, Wistar; Receptors

2016
[THE DAMAGING EFFECTS AT AN EARLY AGE ALTER PAIN SENSITIVITY IN ADULT FEMALE RATS, CORRECTION WITH BUSPIRONE].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2016, Volume: 102, Issue:10

    Topics: Animals; Animals, Newborn; Buspirone; Female; Hyperalgesia; Inflammation; Male; Pain; Rats; Rats, Wi

2016
Dose related effects of buspirone on pain, learning / memory and food intake.
    Regulatory toxicology and pharmacology : RTP, 2018, Volume: 99

    Topics: Analgesics; Animals; Buspirone; Cognition; Dose-Response Relationship, Drug; Eating; Male; Maze Lear

2018
Prenatal Stimulation of 5-HT
    Bulletin of experimental biology and medicine, 2019, Volume: 166, Issue:3

    Topics: Adaptation, Psychological; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buspirone; Depressi

2019
Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats.
    European journal of pharmacology, 2013, Mar-05, Volume: 703, Issue:1-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Buspirone; Cholinesterase Inhibitors; Do

2013
Effect of tonic pain on the corticosterone level in rat pups of various ages subjected to prenatal stress and opportunities for correction of stress-induced impairments.
    Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2013, Volume: 450

    Topics: Animals; Buspirone; Corticosterone; Female; Male; Pain; Pain Management; Pregnancy; Prenatal Exposur

2013
Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy.
    Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:2

    Topics: Animals; Behavior, Animal; Buspirone; Corticosterone; Female; Inflammation; Nociceptors; Pain; Pain

2013
[Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2010, Volume: 96, Issue:4

    Topics: Animals; Behavior, Animal; Buspirone; Depression; Female; Immobilization; Inflammation; Male; Pain;

2010
Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring.
    Physiology & behavior, 2011, Feb-01, Volume: 102, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Emotions; Female; M

2011
A quantitative method for assessing of the affective component of the pain: conditioned response associated with CO2 laser-induced nocifensive reaction.
    Brain research. Brain research protocols, 2003, Volume: 12, Issue:1

    Topics: Acoustic Stimulation; Affect; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Buspirone; Condition

2003
Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats.
    Psychopharmacology, 2005, Volume: 180, Issue:3

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Buspirone; D

2005
Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Male; Mice; Morphine;

1993
Pharmacological suppression of the median raphe nucleus with serotonin1A agonists, 8-OH-DPAT and buspirone, produces hippocampal theta rhythm in the rat.
    Neuroscience, 1994, Volume: 60, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Electroencephalography; Hippocampus; Mal

1994
Effect of 5-HT-1A receptor agonists on paw licking reaction on hot plate and unpunished drinking in rat.
    Life sciences, 1993, Volume: 52, Issue:12

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Drinking Behavior; Indoles; Male; Pain;

1993
Involvement of serotonergic receptor subtypes in the production of antinociception by psychological stress in mice.
    Japanese journal of pharmacology, 1993, Volume: 61, Issue:3

    Topics: Animals; Buspirone; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Pain; Pi

1993
5-HT1A agonists induce central cholinergic antinociception.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 57, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; GTP-Binding Proteins; Male; Mice; Motor

1997
L-NAME, a nitric oxide synthase inhibitor, modulates cholinergic antinociception.
    Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:3

    Topics: Acetic Acid; Analgesics; Animals; Buspirone; Cholinergic Agents; Drug Synergism; Enzyme Inhibitors;

1999
Startle responses to electric shocks: measurement of shock sensitivity and effects of morphine, buspirone and brain lesions.
    The Chinese journal of physiology, 2000, Mar-31, Volume: 43, Issue:1

    Topics: Animals; Brain; Buspirone; Conditioning, Psychological; Dose-Response Relationship, Drug; Electrosho

2000
Serotonin, serotonin receptors, serotonin receptor subtype agonists and pain.
    Pain, 1990, Volume: 40, Issue:1

    Topics: Analgesics; Brain; Buspirone; Humans; Pain; Piperazines; Receptors, Serotonin; Serotonin

1990
Response to Julio Pascual regarding Kishore-Kumar et al. (Pain, 37 (1989) 223-227)
    Pain, 1990, Volume: 40, Issue:1

    Topics: Analgesics; Buspirone; Humans; Pain; Piperazines; Serotonin

1990
Antinociceptive effects of the novel anxiolytic buspirone in three pain tests in rats.
    Pain, 1989, Volume: 39, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Buspirone; Hot Temperature; Nociceptors; Pain; Pain Measurement; Physi

1989
[Analysis of the influence of anxiolytics on the pain reactions of rats compared to the effect of morphine].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Buspirone; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation

1987