bupropion and Suicidal Ideation

bupropion has been researched along with Suicidal Ideation in 13 studies

Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.

Suicidal Ideation: A risk factor for suicide attempts and completions, it is the most common of all suicidal behavior, but only a minority of ideators engage in overt self-harm.

Research

Studies (13)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Quality of Life Inventory

The Quality of Life Inventory (QOLI) is a 32-item comprehensive self-report of satisfaction in 16 areas of life, such as love, work, and health. Each area is rated in terms of satisfaction and the relationship of that area to overall quality of life. It yields an overall raw score and satisfaction ratings for the 16 individual areas of life. The QOLI raw score is an average of weighted satisfaction ratings computed only over areas of life judged to be Important or Extremely Important to the respondent. Higher scores indicate higher reported quality of life. (NCT00590863)
Timeframe: Measured at Month 7

Quick Inventory of Depressive Symptoms

Percentage of patients that achieve remission, as defined as QIDS total score below 6 for last 2 study visits. QIDS depression scores range from 0 (normal) to 27 (very severe). (NCT00590863)
Timeframe: Measured at Month 7

Brain Activity Measured by BOLD Signal With fMRI During a Reward Processing Task.

"Comparison of fMRI results at baseline and after 8 weeks of antidepressant pharmacotherapy with paroxetine vs. bupropion.~Percent change in contrast of parameter estimates (COPE). COPE is measured during Monetary Incentive Delay Task.~Task conditions are:~Reward=BOLD signal when subject wins 5 cents vs. wins 0 cents Punishment=BOLD signal when subject loses 5 cents vs. loses 0 cents" (NCT00429169)
Timeframe: Baseline and Week 8.

Go-No go Test

Change in neuropsychological measure of impulsivity. Computer-based task involving induction of a dominant response tendency and testing of the subject's ability to withhold responding to less frequent non-target stimuli. (NCT00429169)
Timeframe: Measured at Baseline and Week 8

Occurrence of Suicidal Ideation or Acts Necessitating a Change in Treatment

Suicide attempts, other suicidal behavior, or increase in suicidal thoughts that required a change in clinical treatment. (NCT00429169)
Timeframe: Measured at Month 6

Scale for Suicidal Ideation

The clinician-rated Beck Scale for Suicidal Ideation (SSI) (Beck et al 1979)was used weekly for 8 weeks. It has 19 items scaled 0 (least severe) to 2 (most severe) and total score is the sum, ranging 0 to 38 (Beck et al 1979). Items measure frequency, intensity, and attitudes toward suicidal thoughts, feelings of control over them, and suicide plans. Mean score in 90 inpatients hospitalized for suicidal ideation was 9.4±8.4, versus 4.4±5.8 in outpatients as cited in the study by Beck et al, 1979. (NCT00429169)
Timeframe: Baseline and Week 8

Change in Suicidal Ideation (SSI Score)

Beck Scale of Suicidal Ideation Minimum Value = 0 Maximum Value = 38 Higher score is more severe suicidal thoughts (NCT01748955)
Timeframe: Measured at Baseline and Week 8

Percent Change in Contrast of Parameter Estimates (COPE)

"% change in COPE = (Post-treatment COPE - Pre-treatment COPE) / Pre-treatment COPE COPE is measured during Monetary Incentive Delay Task.~Task conditions are:~Reward= BOLD signal when subject wins 5 cents vs. wins 0 cents Punishment= BOLD signal when subject loses 5cents vs. loses 0 cents" (NCT01748955)
Timeframe: Measured at Baseline (pre-treatment) and Week 8 (post-treatment)

Trials

8 trials available for bupropion and Suicidal Ideation

Other Studies

5 other studies available for bupropion and Suicidal Ideation