Page last updated: 2024-10-17

bupropion and Serotonin Syndrome

bupropion has been researched along with Serotonin Syndrome in 10 studies

Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.

Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.

Research Excerpts

ExcerptRelevanceReference
"Although there are no documented cases of serotonin syndrome (SS) following bupropion ingestion alone in the literature, the ability of bupropion to potentiate serotonin levels and lead to SS is known."7.76Bupropion induced serotonin syndrome: a case report. ( Boyer, J; Lynch, MJ; Pizon, AF; Thorpe, EL, 2010)
"She had a seizure and required sedation and intubation."5.62Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine. ( Beau, J; Bolton, TA; Carpenter, JE; Kazzi, Z; Kiernan, EA; Murray, BP; Sayers, J; Wolf, MJ; Yeh, M, 2021)
"BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone."5.48Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018)
"Of the 266 recorded single bupropion overdoses, the most common symptoms were seizures (47."3.96Single-Agent Bupropion Exposures: Clinical Characteristics and an Atypical Cause of Serotonin Toxicity. ( Alsukaiti, WS; Calello, DP; Carpenter, J; Dunkley, C; Kazzi, Z; Kiernan, EA; Moran, TP; Murray, B; Rianprakaisang, T, 2020)
"Although there are no documented cases of serotonin syndrome (SS) following bupropion ingestion alone in the literature, the ability of bupropion to potentiate serotonin levels and lead to SS is known."3.76Bupropion induced serotonin syndrome: a case report. ( Boyer, J; Lynch, MJ; Pizon, AF; Thorpe, EL, 2010)
"She had a seizure and required sedation and intubation."1.62Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine. ( Beau, J; Bolton, TA; Carpenter, JE; Kazzi, Z; Kiernan, EA; Murray, BP; Sayers, J; Wolf, MJ; Yeh, M, 2021)
"BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone."1.48Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's7 (70.00)24.3611
2020's2 (20.00)2.80

Authors

AuthorsStudies
Murray, B1
Carpenter, J1
Dunkley, C1
Moran, TP1
Kiernan, EA2
Rianprakaisang, T1
Alsukaiti, WS1
Calello, DP1
Kazzi, Z2
Murray, BP1
Carpenter, JE1
Sayers, J1
Yeh, M1
Beau, J1
Wolf, MJ1
Bolton, TA1
Little, K1
Lin, CM1
Reynolds, PM1
French, S1
Wray, C1
Kawai, Y1
DeMonbrun, AG1
Chambers, RS1
Nolan, DA1
Dolcourt, BA1
Malas, NM1
Quasney, MW1
Szakaly, B1
Strauss, R1
Thorpe, EL1
Pizon, AF1
Lynch, MJ1
Boyer, J1
Gillman, PK1
Gollapudy, S1
Kumar, V1
Dhamee, MS1
Shahani, L1

Reviews

1 review available for bupropion and Serotonin Syndrome

ArticleYear
Serotonin syndrome in the oral and maxillofacial surgery office: a review of the literature and report of a case.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2008, Volume: 66, Issue:9

    Topics: Abscess; Adult; Anesthesia, Dental; Antidepressive Agents, Second-Generation; Bupropion; Dental Care

2008

Other Studies

9 other studies available for bupropion and Serotonin Syndrome

ArticleYear
Single-Agent Bupropion Exposures: Clinical Characteristics and an Atypical Cause of Serotonin Toxicity.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2020, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxicity; Dyskinesia,

2020
Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine.
    The Journal of emergency medicine, 2021, Volume: 60, Issue:4

    Topics: Adolescent; Adult; Bupropion; Cyproheptadine; Drug Overdose; Female; Humans; Male; Seizures; Seroton

2021
Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose.
    The American journal of case reports, 2018, May-25, Volume: 19

    Topics: Benzodiazepines; Bupropion; Cyproheptadine; Dopamine Uptake Inhibitors; Drug Overdose; Fluoxetine; H

2018
Serotonin Syndrome and Hippocampal Infarction.
    Pediatric neurology, 2019, Volume: 90

    Topics: Adolescent; Brain Infarction; Bupropion; Drug Overdose; Fever; Hallucinations; Hippocampus; Humans;

2019
A Previously Healthy Adolescent With Acute Encephalopathy and Decorticate Posturing.
    Pediatrics, 2017, Volume: 139, Issue:1

    Topics: Acute Febrile Encephalopathy; Adolescent; Amitriptyline; Brain; Bupropion; Decerebrate State; Diagno

2017
Bupropion induced serotonin syndrome: a case report.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010, Volume: 6, Issue:2

    Topics: Adolescent; Bupropion; Delayed-Action Preparations; Delirium; Dopamine Uptake Inhibitors; Gas Chroma

2010
Bupropion, bayesian logic and serotonin toxicity.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010, Volume: 6, Issue:2

    Topics: Animals; Bupropion; Dopamine Uptake Inhibitors; Humans; Mianserin; Mirtazapine; Serotonin; Serotonin

2010
A case of serotonin syndrome precipitated by fentanyl and ondansetron in a patient receiving paroxetine, duloxetine, and bupropion.
    Journal of clinical anesthesia, 2012, Volume: 24, Issue:3

    Topics: Aged; Analgesics, Opioid; Anesthesia, General; Bupropion; Drug Therapy, Combination; Duloxetine Hydr

2012
Tramadol precipitating serotonin syndrome in a patient on antidepressants.
    The Journal of neuropsychiatry and clinical neurosciences, 2012,Fall, Volume: 24, Issue:4

    Topics: Analgesics, Opioid; Antidepressive Agents; Bupropion; Citalopram; Depressive Disorder; Drug Therapy,

2012