Compounds > bupropion
Page last updated: 2024-10-17

bupropion and Seasonal Affective Disorder

bupropion has been researched along with Seasonal Affective Disorder in 11 studies

Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.

Seasonal Affective Disorder: A syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence.

Research Excerpts

ExcerptRelevanceReference
"Bupropion was also shown to have efficacy in an open-label study."6.49Bupropion for the treatment of seasonal affective disorder. ( Dumont, GJ; Neels, H; Niemegeers, P; Patteet, L; Sabbe, BG, 2013)
"For a population with a yearly recurrence rate of 30%, the NNTB is 8 (95% CI 6 to 12)."2.61Second-generation antidepressants for preventing seasonal affective disorder in adults. ( Forneris, CA; Gartlehner, G; Gaynes, BN; Greenblatt, A; Lux, LJ; Morgan, LC; Nussbaumer-Streit, B; Van Noord, MG; Winkler, D; Wipplinger, J, 2019)
"Bupropion was also shown to have efficacy in an open-label study."2.49Bupropion for the treatment of seasonal affective disorder. ( Dumont, GJ; Neels, H; Niemegeers, P; Patteet, L; Sabbe, BG, 2013)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's5 (45.45)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gartlehner, G2
Nussbaumer-Streit, B1
Gaynes, BN2
Forneris, CA2
Morgan, LC2
Greenblatt, A2
Wipplinger, J2
Lux, LJ2
Van Noord, MG2
Winkler, D2
Niemegeers, P1
Dumont, GJ1
Patteet, L1
Neels, H1
Sabbe, BG1
Nussbaumer, B1
Kaminski-Hartenthaler, A1
Sonis, JH1
Hofmann, J1
Magovern, MK1
Crawford-Faucher, A1
Simon, HB1
Schwartz, PJ1
Lam, RW1
Kennedy, SH1
Modell, JG1
Rosenthal, NE1
Harriett, AE1
Krishen, A1
Asgharian, A1
Foster, VJ1
Metz, A1
Rockett, CB1
Wightman, DS1
Dilsaver, SC1
Qamar, AB1
Del Medico, VJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Placebo-Controlled Trial of Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder[NCT00502320]Phase 450 participants (Actual)Interventional2006-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Depressive Symptoms at Baseline and Measured Monthly, as Measured by the Structured Interview Guide for the Hamilton Depression Rating - Seasonal Affective Disorder (SIGH-SAD)

Clinician-rated measure of mood; evaluates classical 21 Hamilton Depression items, and 8-item subscale measuring atypical depression symptoms which commonly occur during SAD episodes. Score ranges from 0-89, higher scores indicate higher levels of depression. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)

,
Interventionscores on a scale (Mean)
BaselineMonth 1Month 2Month 3Month 4
Placebo19.9915.9719.4720.6523.68
Ramelteon22.6816.1614.8111.699.15

Depressive Symptoms at Baseline and Measured Monthly, as Measured by the Zung Depression Scale (ZDS)

Self-rated scale to measure severity of depressive symptoms. Score ranges from 25-100, higher scores reflect more depression. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)

,
Interventionscores on a scale (Mean)
BaselineMonth 1Month 2Month 3Month 4
Placebo58.6356.4058.5958.6261.65
Ramelteon63.0654.3553.5149.2646.14

Sleep Satisfaction at Baseline and Measured Monthly, as Measured by the Pittsburgh Sleep Quality Index (PSQI)

Self-rated scale to measure quality of sleep via questions regarding sleep latency, duration, efficiency, disturbances, use of sleep medication, and daytime dysfunction. Score ranges from 0-21, higher scores represent more significant sleep disturbance. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)

,
Interventionscores on a scale (Mean)
BaselineMonth 1Month 2Month 3Month 4
Placebo11.458.678.629.889.61
Ramelteon11.569.527.578.077.05

Reviews

4 reviews available for bupropion and Seasonal Affective Disorder

ArticleYear
Second-generation antidepressants for preventing seasonal affective disorder in adults.
    The Cochrane database of systematic reviews, 2019, 03-18, Volume: 3

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Diarrhea; Headache; Humans; Incidence; N

2019
Bupropion for the treatment of seasonal affective disorder.
    Expert opinion on drug metabolism & toxicology, 2013, Volume: 9, Issue:9

    Topics: Antidepressive Agents; Bupropion; Delayed-Action Preparations; Drug Evaluation, Preclinical; Humans;

2013
Second-generation antidepressants for preventing seasonal affective disorder in adults.
    The Cochrane database of systematic reviews, 2015, Nov-08, Issue:11

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Humans; Randomized Controlled Trials as

2015
Using metaanalysis to evaluate evidence: practical tips and traps.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2005, Volume: 50, Issue:3

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Cyclohexanols; Depressive Disorder, Major; Doub

2005

Trials

2 trials available for bupropion and Seasonal Affective Disorder

ArticleYear
Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL.
    Biological psychiatry, 2005, Oct-15, Volume: 58, Issue:8

    Topics: Adult; Antidepressive Agents, Second-Generation; Body Weight; Bupropion; Double-Blind Method; Drug A

2005
The efficacy of bupropion in winter depression: results of an open trial.
    The Journal of clinical psychiatry, 1992, Volume: 53, Issue:7

    Topics: Adult; Bupropion; Circadian Rhythm; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Sca

1992

Other Studies

5 other studies available for bupropion and Seasonal Affective Disorder

ArticleYear
Extended-Release Bupropion for Preventing Seasonal Affective Disorder in Adults.
    American family physician, 2017, Jan-01, Volume: 95, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Canada; Delayed-Action Preparations; Fem

2017
On call. My wife gets down in the dumps each January. She thinks it's just because of the holidays have come and gone, but I think it's more than that. Is it depression?
    Harvard men's health watch, 2009, Volume: 13, Issue:6

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Female; Humans; Life Style; Phototherapy; Seaso

2009
Bipolar disorder--a focus on depression.
    The New England journal of medicine, 2011, 04-21, Volume: 364, Issue:16

    Topics: Antidepressive Agents, Second-Generation; Bipolar Disorder; Bupropion; Humans; Phototherapy; Seasona

2011
FDA approves antidepressant drug for treatment of seasonal depression.
    Mayo Clinic women's healthsource, 2006, Volume: 10, Issue:11

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Humans; Seasonal Affective Disorder; United Sta

2006
Winter blues: when to consider drugs.
    Consumer reports, 2007, Volume: 72, Issue:11

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Diagnosis, Differential; Humans; Phototherapy;

2007