Page last updated: 2024-10-17

bupropion and Opioid-Related Disorders

bupropion has been researched along with Opioid-Related Disorders in 13 studies

Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.

Opioid-Related Disorders: Disorders related to or resulting from abuse or misuse of OPIOIDS.

Research Excerpts

ExcerptRelevanceReference
" In the United States there are medications available to treat tobacco use disorders (nicotine replacement, bupropion, and varenicline), alcohol use disorders (naltrexone and acamprosate), and opioid use disorders (methadone and buprenorphine)."4.93Pharmacotherapy for Substance Use Disorders. ( Klein, JW, 2016)
" In this commentary, we briefly summarize the extant literature on pharmacotherapies in opioid-maintained smokers and contribute new data investigating the contribution of bupropion on smoking outcomes in 81 methadone- and buprenorphine-maintained participants from two randomized trials of financial incentives for smoking cessation."4.91Are Pharmacotherapies Ineffective in Opioid-Dependent Smokers? Reflections on the Scientific Literature and Future Directions. ( Miller, ME; Sigmon, SC, 2015)
" The general population model included age, hepatitis C virus infection, days of opioid used by type, number of cigarettes used daily, and the following medications used in the last 30 day of pregnancy: bupropion, antinausea medicines, benzodiazepines, antipsychotics, and gabapentin."4.02Development and Validation of a Model to Predict Neonatal Abstinence Syndrome. ( Cooper, WO; Dudley, J; Harrell, FE; Hartmann, K; Martin, PR; Patrick, SW; Slaughter, JC; Stratton, S, 2021)
"Pregnant smokers recruited to participate in a placebo-controlled trial of bupropion for smoking cessation provided a blood sample for measurement of NMR."3.96Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study. ( Hand, D; Kranzler, HR; Lynch, KG; Oncken, C; Schnoll, R; Tyndale, RF; Washio, Y; Zindel, LR, 2020)
"New treatments to combat opiate addiction are sorely needed."1.56Dextromethorphan and bupropion reduces high level remifentanil self-administration in rats. ( Blair, G; Davis, JM; Ko, A; Levin, ED; Modarres, J; Pace, C; Rezvani, AH; Rose, JE; Wells, C, 2020)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's2 (15.38)29.6817
2010's4 (30.77)24.3611
2020's6 (46.15)2.80

Authors

AuthorsStudies
Xu, KY1
Mintz, CM1
Presnall, N1
Bierut, LJ1
Grucza, RA1
Ware, OD1
Sweeney, MM1
Cunningham, C1
Umbricht, A1
Stitzer, M1
Dunn, KE2
Blair, G1
Wells, C1
Ko, A1
Modarres, J1
Pace, C1
Davis, JM1
Rezvani, AH1
Rose, JE1
Levin, ED1
Kranzler, HR1
Washio, Y1
Zindel, LR1
Lynch, KG1
Hand, D1
Tyndale, RF1
Oncken, C1
Schnoll, R1
McKendrick, G1
Sharma, S1
Sun, D1
Randall, PA1
Graziane, NM1
Patrick, SW1
Slaughter, JC1
Harrell, FE1
Martin, PR1
Hartmann, K1
Dudley, J1
Stratton, S1
Cooper, WO1
Miller, ME2
Sigmon, SC3
Meyer, AC1
Saulsgiver, K1
Badger, GJ1
Heil, SH1
Higgins, ST1
Klein, JW1
Saulsgiver, KA1
Levin, FR1
Evans, SM1
Brooks, DJ1
Kalbag, AS1
Garawi, F1
Nunes, EV1
Johnson, BA1
Margolin, A1
Kosten, T2
Petrakis, I1
Avants, SK1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Incentive-based Smoking Cessation for Methadone Patients[NCT00718835]Phase 2170 participants (Anticipated)Interventional2007-06-30Completed
Treatment of Adult ADHD in Methadone Patients[NCT00061087]Phase 2/Phase 3115 participants (Actual)Interventional1998-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for bupropion and Opioid-Related Disorders

ArticleYear
Are Pharmacotherapies Ineffective in Opioid-Dependent Smokers? Reflections on the Scientific Literature and Future Directions.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015, Volume: 17, Issue:8

    Topics: Analgesics, Opioid; Bupropion; Forecasting; Humans; Methadone; Opioid-Related Disorders; Randomized

2015
Pharmacotherapy for Substance Use Disorders.
    The Medical clinics of North America, 2016, Volume: 100, Issue:4

    Topics: Age Factors; Alcohol Deterrents; Alcoholism; Antidepressive Agents; Buprenorphine; Bupropion; Drug T

2016

Trials

3 trials available for bupropion and Opioid-Related Disorders

ArticleYear
Bupropion Slow Release vs Placebo With Adaptive Incentives for Cocaine Use Disorder in Persons Receiving Methadone for Opioid Use Disorder: A Randomized Clinical Trial.
    JAMA network open, 2023, 03-01, Volume: 6, Issue:3

    Topics: Bupropion; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Humans; Male; Methadone;

2023
Financial incentives to promote extended smoking abstinence in opioid-maintained patients: a randomized trial.
    Addiction (Abingdon, England), 2016, Volume: 111, Issue:5

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Analgesics, Opioid; Breath Tests; Bupropion; Carbon Monoxi

2016
Treatment of methadone-maintained patients with adult ADHD: double-blind comparison of methylphenidate, bupropion and placebo.
    Drug and alcohol dependence, 2006, Feb-01, Volume: 81, Issue:2

    Topics: Adult; Algorithms; Analgesics, Opioid; Antidepressive Agents, Second-Generation; Attention Deficit D

2006

Other Studies

8 other studies available for bupropion and Opioid-Related Disorders

ArticleYear
Association of Bupropion, Naltrexone, and Opioid Agonist Treatment With Stimulant-Related Admissions Among People With Opioid Use Disorder: A Case-Crossover Analysis.
    The Journal of clinical psychiatry, 2022, 06-20, Volume: 83, Issue:4

    Topics: Analgesics, Opioid; Buprenorphine; Bupropion; Central Nervous System Stimulants; Cross-Over Studies;

2022
Dextromethorphan and bupropion reduces high level remifentanil self-administration in rats.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 193

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bupropion; Dextromethorphan; Disease Models, Animal;

2020
Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020, 10-08, Volume: 22, Issue:10

    Topics: Analgesics, Opioid; Bupropion; Cotinine; Female; Humans; Methadone; Nicotine; Opiate Substitution Tr

2020
Acute and chronic bupropion treatment does not prevent morphine-induced conditioned place preference in mice.
    European journal of pharmacology, 2020, Dec-15, Volume: 889

    Topics: Analgesics, Opioid; Animals; Bupropion; Conditioning, Psychological; Dopamine Uptake Inhibitors; Dru

2020
Development and Validation of a Model to Predict Neonatal Abstinence Syndrome.
    The Journal of pediatrics, 2021, Volume: 229

    Topics: Adult; Analgesics; Antiemetics; Antipsychotic Agents; Benzodiazepines; Bupropion; Female; Gabapentin

2021
Contingency management for behavior change: applications to promote brief smoking cessation among opioid-maintained patients.
    Experimental and clinical psychopharmacology, 2011, Volume: 19, Issue:1

    Topics: Analgesics, Opioid; Behavior Therapy; Bupropion; Female; Humans; Male; Motivation; Opiate Substituti

2011
Pills for speedballing or cocaine dependence.
    Lancet (London, England), 2006, May-27, Volume: 367, Issue:9524

    Topics: Bupropion; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Humans; Methadone; Narcotics; Opio

2006
An open pilot study of bupropion and psychotherapy for the treatment of cocaine abuse in methadone-maintained patients.
    NIDA research monograph, 1990, Volume: 105

    Topics: Antidepressive Agents; Bupropion; Cocaine; Humans; Methadone; Opioid-Related Disorders; Propiophenon

1990