Page last updated: 2024-10-17

bupropion and Mood Disorders

bupropion has been researched along with Mood Disorders in 12 studies

Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.

Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.

Research Excerpts

ExcerptRelevanceReference
"US Clinical Trials registration was systematically searched for studies examining the effects of dextromethorphan in mood disorders."9.41Combinations of dextromethorphan for the treatment of mood disorders - a review of the evidence. ( Iosifescu, DV; Parincu, Z, 2023)
"The identification of nicotine dependence as a psychiatric disorder and increased knowledge of nicotine's neuropharmacologic effects have stimulated researchers to search for new pharmacologic interventions for smoking cessation."8.80Bupropion sustained release and smoking cessation. ( Goldstein, MG, 1998)
"These naturalistic data suggest that bupropion is well tolerated and may be an effective medication for the treatment of substance abusing adolescents with comorbid mood disorders and ADHD."7.73Bupropion SR for the treatment of substance-abusing outpatient adolescents with attention-deficit/hyperactivity disorder and mood disorders. ( Biederman, J; Daly, J; Prince, JB; Solhkhah, R; Van Patten, SL; Wilens, TE, 2005)
"US Clinical Trials registration was systematically searched for studies examining the effects of dextromethorphan in mood disorders."5.41Combinations of dextromethorphan for the treatment of mood disorders - a review of the evidence. ( Iosifescu, DV; Parincu, Z, 2023)
"Data came from 8120 smokers willing to make a quit attempt, randomized to varenicline, bupropion, nicotine replacement therapy (NRT) or placebo in Evaluating Adverse Events in a Global Smoking Cessation Study (EAGLES) between 30 November 2011 and 13 January 2015."5.27Factors associated with the efficacy of smoking cessation treatments and predictors of smoking abstinence in EAGLES. ( Anthenelli, RM; Benowitz, NL; Evins, AE; Krishen, A; Lawrence, D; Maravic, MC; McRae, T; Russ, C; St Aubin, L; West, R, 2018)
"The identification of nicotine dependence as a psychiatric disorder and increased knowledge of nicotine's neuropharmacologic effects have stimulated researchers to search for new pharmacologic interventions for smoking cessation."4.80Bupropion sustained release and smoking cessation. ( Goldstein, MG, 1998)
" Lorcaserin (Belviq(®)), phentermine/topiramate combination (Qsymia(®)), and bupropion/naltrexone combination have been demonstrated to be effective for the treatment of obesity, as an adjunct to a reduced-calorie diet and physical activity, although their absolute safety has yet to be established with more widespread use or longer use."3.79Therapies for obesity and medication-associated weight gain. ( Howland, RH, 2013)
"These naturalistic data suggest that bupropion is well tolerated and may be an effective medication for the treatment of substance abusing adolescents with comorbid mood disorders and ADHD."3.73Bupropion SR for the treatment of substance-abusing outpatient adolescents with attention-deficit/hyperactivity disorder and mood disorders. ( Biederman, J; Daly, J; Prince, JB; Solhkhah, R; Van Patten, SL; Wilens, TE, 2005)
" Central nervous system-active medications have the potential to affect mood; therefore, post hoc analysis of clinical trial data was conducted to evaluate psychiatric adverse events (PAEs) and effects on mood of NB therapy versus placebo."1.51Psychiatric adverse events and effects on mood with prolonged-release naltrexone/bupropion combination therapy: a pooled analysis. ( Acevedo, LM; Apovian, CM; Dunayevich, E; Greenway, FL; McElroy, SL; Pi-Sunyer, X, 2019)
"Tranylcypromine was effective in the treatment of 14 patients meeting both the National Institute of Mental Health and DSM-III-R criteria for winter depression."1.28Pharmacological responsiveness of winter depression. ( Del Medico, VJ; Dilsaver, SC; Jaeckle, S; Quadri, A, 1990)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (33.33)18.2507
2000's1 (8.33)29.6817
2010's6 (50.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Parincu, Z1
Iosifescu, DV1
West, R1
Evins, AE1
Benowitz, NL1
Russ, C1
McRae, T1
Lawrence, D1
St Aubin, L1
Krishen, A1
Maravic, MC1
Anthenelli, RM1
Pi-Sunyer, X1
Apovian, CM1
McElroy, SL1
Dunayevich, E1
Acevedo, LM1
Greenway, FL1
Howland, RH1
Carvalho, MM1
Campos, FL1
Coimbra, B1
Pêgo, JM1
Rodrigues, C1
Lima, R1
Rodrigues, AJ1
Sousa, N1
Salgado, AJ1
Muheim, L1
Krivisky, K1
Ashkenazy, T1
Kronfeld-Schor, N1
Einat, H1
Solhkhah, R1
Wilens, TE1
Daly, J1
Prince, JB1
Van Patten, SL1
Biederman, J1
Labbate, LA1
Grimes, JB1
Hines, A1
Pollack, MH1
Ashton, AK1
Rosen, RC1
Goldstein, MG1
Dilsaver, SC1
Del Medico, VJ1
Quadri, A1
Jaeckle, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 4, Randomized, Double-blind, Active And Placebo-controlled, Multicenter Study Evaluating The Neuropsychiatric Safety And Efficacy Of 12 Weeks Varenicline Tartrate 1mg Bid And Bupropion Hydrochloride 150mg Bid For Smoking Cessation In Subjects With[NCT01456936]Phase 48,144 participants (Actual)Interventional2011-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

CO-Confirmed Continuous Abstinence for Weeks 9 Through 12 (Overall)

"A responder to this endpoint requires the answer no to both questions 1 and 2 on the Nicotine Use Inventory at every visit from Week 9 to Week 12 (inclusive)." (NCT01456936)
Timeframe: Week 9 through Week 12

Interventionpercentage of participants (Number)
Varenicline 1.0 mg BID33.5
Bupropion 150 mg BID22.6
NRT Patch23.4
Placebo12.5

CO-Confirmed Continuous Abstinence for Weeks 9 Through 12, Non-psychiatric History Cohort

"A responder to this endpoint requires the answer no to both questions 1 and 2 on the Nicotine Use Inventory at every visit from Week 9 to Week 12 (inclusive)." (NCT01456936)
Timeframe: Week 9 through Week 12

Interventionpercentage of participants (Number)
Varenicline 1.0 mg BID38.0
Bupropion 150 mg BID26.1
NRT Patch26.4
Placebo13.7

CO-Confirmed Continuous Abstinence for Weeks 9 Through 12, Psychiatric History Cohort

"A responder to this endpoint requires the answer no to both questions 1 and 2 on the Nicotine Use Inventory at every visit from Week 9 to Week 12 (inclusive)." (NCT01456936)
Timeframe: Week 9 through Week 12

Interventionpercentage of participants (Number)
Varenicline 1.0 mg BID29.2
Bupropion 150 mg BID19.3
NRT Patch20.4
Placebo11.4

CO-confirmed Continuous Abstinence From Week 9 Through Week 24 (Overall)

"A responder to this endpoint requires the answer no to both questions 1 and 2 on the Nicotine Use Inventory at every visit from Week 9 to Week 24 (inclusive)." (NCT01456936)
Timeframe: Week 9 through Week 24

Interventionpercentage of participants (Number)
Varenicline 1.0 mg BID21.8
Bupropion 150 mg BID16.2
NRT Patch15.7
Placebo9.4

CO-confirmed Continuous Abstinence From Week 9 Through Week 24, Non-psychiatric History Cohort

"A responder to this endpoint requires the answer no to both questions 1 and 2 on the Nicotine Use Inventory at every visit from Week 9 to Week 24 (inclusive)." (NCT01456936)
Timeframe: Week 9 through Week 24

Interventionpercentage of participants (Number)
Varenicline 1.0 mg BID25.5
Bupropion 150 mg BID18.8
NRT Patch18.5
Placebo10.5

CO-confirmed Continuous Abstinence From Week 9 Through Week 24, Psychiatric History Cohort

"A responder to this endpoint requires the answer no to both questions 1 and 2 on the Nicotine Use Inventory at every visit from Week 9 to Week 24 (inclusive)." (NCT01456936)
Timeframe: Week 9 through Week 24

Interventionpercentage of participants (Number)
Varenicline 1.0 mg BID18.3
Bupropion 150 mg BID13.7
NRT Patch13.0
Placebo8.3

"Clinical Global Impression of Improvement (CGI-I), No Change Rating by Visit"

"The CGI-I is a clinician rated instrument that measures change in participant's psychiatric condition (or lack thereof in the stratum without psychiatric disorders) on a 7 point scale ranging from 1 (very much improved) to 7 (very much worse), with 4 = no change. The ratings were applicable even to those without psychiatric diagnoses (eg, those with no psychiatric symptoms would be rated as normal, not at all ill on the CGI-S at baseline and assuming no psychiatric symptoms emerge during the trial, would be rated as no change on the CGI-I at follow-up visits). For those participants with a psychiatric diagnosis, the clinician should rate the severity of the mental illness with respect to the clinician's experience with the psychiatric population to which the participant belongs." (NCT01456936)
Timeframe: Baseline to Week 24

,,,
Interventionpercentage of participants (Number)
Week 1 (N= 1986, 1974, 1986, 1982)Week 2 (N= 1934, 1936, 1927, 1926)Week 3 (N= 1880, 1892, 1880, 1863)Week 4 (N= 1860, 1856, 1858, 1834)Week 5 (N= 1828, 1816, 1822, 1802)Week 6 (N= 1816, 1808, 1820, 1773)Week 8 (N= 1758, 1756, 1755, 1738)Week 10 (N= 1717, 1707, 1715, 1675)Week 12 (N= 1558, 1572, 1540, 1492)Week 13 (N= 1612, 16081602, 1575)Week 16 (N= 1586, 1606, 1568, 1541)Week 20 (N= 1563, 1573, 1523, 1510)Week 24 (N= 1533, 1515, 1499, 1497)
Bupropion 150 mg BID93.290.889.888.086.586.583.681.775.176.776.775.072.3
NRT Patch94.690.588.787.185.585.182.880.472.275.273.972.271.1
Placebo95.191.287.986.385.484.181.979.271.374.973.471.771.1
Varenicline 1.0 mg BID94.290.888.386.685.785.282.480.672.975.974.273.471.8

7-Day Point Prevalence of Abstinence (Overall)

"A responder to this endpoint requires the answer no to both questions 3 and 6 on the nicotine use inventory at that specific visit.~NUI Question 3 (Baseline through Week 24): Has the subject smoked any cigarettes (even a puff) in the last 7 days? NUI Question 6 (Baseline through Week 12): Has the subject used any other nicotine containing products in the last 7 days? NUI Question 6 (Week 13 through Week 24): Has the subject used any other tobacco products in the last 7 days?" (NCT01456936)
Timeframe: 24 Weeks

,,,
Interventionpercentage of participants (Number)
Week 1Week 2Week 3Week 4Week 5Week 6Week 7Week 8Week 9Week 10Week 11Week 12Week 13Week 14Week 15Week 16Week 17Week 18Week 19Week 20Week 21Week 22Week 23Week 24
Bupropion 150 mg BID1.117.922.324.425.726.930.226.530.427.630.727.126.529.229.225.127.927.827.923.926.726.427.023.2
NRT Patch0.914.220.023.525.126.831.328.032.128.032.127.626.929.429.224.928.128.228.123.726.526.325.323.6
Placebo1.010.312.113.113.614.617.915.918.115.518.816.016.019.119.816.118.819.519.216.318.818.418.315.7
Varenicline 1.0 mg BID1.318.826.330.433.435.839.537.441.638.742.539.636.839.538.533.136.436.235.730.833.933.833.029.8

7-Day Point Prevalence of Abstinence, Non-psychiatric History Cohort

"A responder to this endpoint requires the answer no to both questions 3 and 6 on the nicotine use inventory at that specific visit.~NUI Question 3 (Baseline through Week 24): Has the subject smoked any cigarettes (even a puff) in the last 7 days? NUI Question 6 (Baseline through Week 12): Has the subject used any other nicotine containing products in the last 7 days? NUI Question 6 (Week 13 through Week 24): Has the subject used any other tobacco products in the last 7 days?" (NCT01456936)
Timeframe: 24 Weeks

,,,
Interventionpercentage of participants (Number)
Week 1Week 2Week 3Week 4Week 5Week 6Week 7Week 8Week 9Week 10Week 11Week 12Week 13Week 14Week 15Week 16Week 17Week 18Week 19Week 20Week 21Week 22Week 23Week 24
Bupropion 150 mg BID1.021.326.627.729.831.435.231.034.931.034.130.530.733.533.228.531.931.331.227.530.329.930.626.0
NRT Patch1.215.522.125.927.830.435.131.434.831.134.930.429.932.032.428.131.431.731.226.329.329.028.327.0
Placebo1.511.413.614.514.915.919.216.719.016.920.817.817.220.421.318.220.120.820.818.220.120.320.317.4
Varenicline 1.0 mg BID1.720.930.034.338.441.044.442.347.142.446.644.441.144.543.837.240.740.939.935.138.138.737.633.6

7-Day Point Prevalence of Abstinence, Psychiatric History Cohort

"A responder to this endpoint requires the answer no to both questions 3 and 6 on the nicotine use inventory at that specific visit.~NUI Question 3 (Baseline through Week 24): Has the subject smoked any cigarettes (even a puff) in the last 7 days? NUI Question 6 (Baseline through Week 12): Has the subject used any other nicotine containing products in the last 7 days? NUI Question 6 (Week 13 through Week 24): Has the subject used any other tobacco products in the last 7 days?" (NCT01456936)
Timeframe: 24 Weeks

,,,
Interventionpercentage of participants (Number)
Week 1Week 2Week 3Week 4Week 5Week 6Week 7Week 8Week 9Week 10Week 11Week 12Week 13Week 14Week 15Week 16Week 17Week 18Week 19Week 20Week 21Week 22Week 23Week 24
Bupropion 150 mg BID1.214.618.121.321.822.725.422.126.024.327.423.922.625.025.321.924.024.524.720.423.222.923.520.4
NRT Patch0.713.017.921.122.423.327.524.629.425.029.424.924.026.826.021.824.824.725.125.123.723.622.220.1
Placebo0.59.210.711.812.413.416.615.017.214.017.214.214.817.818.313.917.418.217.617.617.516.516.414.0
Varenicline 1.0 mg BID1.016.822.726.628.530.834.832.736.235.138.635.032.734.733.429.132.331.731.626.629.729.128.526.1

Estimated NPS AE Rate (%), by Cohort

"The primary safety endpoint is the occurrence of at least one treatment emergent severe adverse event of anxiety, depression, feeling abnormal, or hostility and/or the occurrence of at least one treatment emergent moderate or severe adverse event of: agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, suicidal ideation, suicidal behavior, or completed suicide. Estimated NPS AE rate (%) was calculated based on least-squares means analysis." (NCT01456936)
Timeframe: Treatment emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionpercentage of participants (Least Squares Mean)
Non-psychiatric cohort (N=3984)Psychiatric cohort (N= 4074)
Bupropion 150 mg BID2.446.62
NRT Patch2.315.20
Placebo2.524.83
Varenicline 1.0 mg BID1.256.42

HADS Total Score (Overall)

The HADS is a subject self-reporting scale completed in person at clinic visits at Baseline and Weeks 1 through 6, 8, 10, 12, 13, 16, 20, and 24. It contains 14 individual item responses ranging in increasing severity from 0 (normal) to 3 (most severe) for a total range of 0 to 42. Of the 14 items, 7 assess anxiety and 7 assess depression, providing 2 subscales with ranges of 0 to 21. For each subscale, 0 to 7 is considered normal, while 15 to 21 represents severe symptoms. (NCT01456936)
Timeframe: Baseline to Week 24

,,,
InterventionUnits on a scale (Mean)
Week 1 (N= 1989, 1976, 1985, 1987)Week 2 (N= 1938, 1937, 1931, 1929)Week 3 (N= 1882, 1891, 1881, 1867)Week 4 (N= 1858, 1854, 1863, 1831)Week 5 (N= 1829, 1815, 1820, 1797)Week 6 (N= 1816, 1807, 1821, 1771)Week 8 (N= 1755, 1754, 1755, 1736)Week 10 (N= 1717, 1709, 1716, 1669)Week 12 (N= 1562, 1571, 1548, 1491)Week 13 (N= 1610, 1608, 1603, 1570)Week 16 (N= 1579, 1602, 1566, 1537)Week 20 (N= 1555, 1569, 1525, 1509)Week 24 (N= 1528, 1512, 1495, 1487)
Bupropion 150 mg BID5.615.064.604.394.164.054.103.863.793.663.773.733.80
NRT Patch4.954.744.484.314.084.013.964.003.783.713.783.723.82
Placebo5.054.804.384.394.144.094.124.043.953.703.823.753.62
Varenicline 1.0 mg BID5.034.684.314.153.943.823.823.853.643.603.673.653.62

HADS Total Score, Psychiatric History Cohort

The HADS is a subject self-reporting scale completed in person at clinic visits at Baseline and Weeks 1 through 6, 8, 10, 12, 13, 16, 20, and 24. It contains 14 individual item responses ranging in increasing severity from 0 (normal) to 3 (most severe) for a total range of 0 to 42. Of the 14 items, 7 assess anxiety and 7 assess depression, providing 2 subscales with ranges of 0 to 21. For each subscale, 0 to 7 is considered normal, while 15 to 21 represents severe symptoms. (NCT01456936)
Timeframe: Baseline to Week 24

,,,
InterventionUnits on a scale (Mean)
Week 1 (N= 1026, 1017, 1015, 1015)Week 2 (N= 1005, 1004, 996, 995)Week 3 (N= 947, 961, 945, 926)Week 4 (N= 935, 938, 929, 908)Week 5 (N= 918, 918, 914, 895)Week 6 (N= 917, 914, 912, 874)Week 8 (N= 887, 893, 878, 859)Week 10 (N= 864, 865, 864, 823)Week 12 (N= 790, 803, 798, 749)Week 13 (N= 813, 812, 814, 763)Week 16 (N= 795, 805, 791, 748)Week 20 (N= 784, 784, 763, 737)Week 24 (N= 770, 764, 758, 729)
Bupropion 150 mg BID7.586.996.516.366.035.875.965.725.665.445.625.545.69
NRT Patch6.826.646.306.165.825.625.635.645.445.365.445.465.57
Placebo6.706.426.026.045.805.755.635.555.425.095.375.265.04
Varenicline 1.0 mg BID6.766.425.995.875.585.395.435.385.175.065.265.175.21

Hospital Anxiety and Depression Scale (HADS) Total Score, Non-psychiatric History Cohort

The HADS is a subject self-reporting scale completed in person at clinic visits at Baseline and Weeks 1 through 6, 8, 10, 12, 13, 16, 20, and 24. It contains 14 individual item responses ranging in increasing severity from 0 (normal) to 3 (most severe) for a total range of 0 to 42. Of the 14 items, 7 assess anxiety and 7 assess depression, providing 2 subscales with ranges of 0 to 21. For each subscale, 0 to 7 is considered normal, while 15 to 21 represents severe symptoms. (NCT01456936)
Timeframe: Baseline to Week 24

,,,
InterventionUnits on a scale (Mean)
Week 1 (N= 984, 972, 989, 992)Week 2 (N= 961, 954, 963, 970)Week 3 (N= 935, 930, 936, 941)Week 4 (N= 923, 916, 934, 923)Week 5 (N= 911, 897, 906, 902)Week 6 (N= 899, 893, 909, 897)Week 8 (N= 868, 861, 877, 877)Week 10 (N= 853, 844, 852, 846)Week 12 (N= 772, 768, 750, 742)Week 13 (N= 797, 796, 789, 807)Week 16 (N= 784, 797, 775, 789)Week 20 (N= 771, 785, 762, 772)Week 24 (N= 758, 748, 737, 758)
Bupropion 150 mg BID3.583.072.642.362.242.182.161.961.831.851.901.931.87
NRT Patch3.062.842.632.462.322.402.282.332.012.012.091.972.01
Placebo3.383.202.772.772.482.482.642.572.462.382.342.312.25
Varenicline 1.0 mg BID3.262.912.612.402.292.232.172.292.072.112.052.102.01

Occurrence of Neuropsychiatric (NPS) Adverse Events (AE) - the Primary Study Endpoint

"The primary safety endpoint is the occurrence of at least one treatment emergent severe adverse event of anxiety, depression, feeling abnormal, or hostility and/or the occurrence of at least one treatment emergent moderate or severe adverse event of: agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, suicidal ideation, suicidal behavior, or completed suicide." (NCT01456936)
Timeframe: Treatment emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionpercentage of participants (Number)
Non-psychiatric cohort (N= 990, 989, 1006, 999)Psychiatric cohort (N= 1026, 1017, 1016, 1015)Overall (N= 2016, 2006, 2022, 2014)
Bupropion 150 mg BID2.26.74.5
NRT Patch2.55.23.9
Placebo2.44.93.7
Varenicline 1.0 mg BID1.36.54.0

Occurrence of Severe-only NPS AEs in the Primary Endpoint, by Cohort

"The primary safety endpoint is the occurrence of at least one treatment emergent severe adverse event of anxiety, depression, feeling abnormal, or hostility and/or the occurrence of at least one treatment emergent moderate or severe adverse event of: agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, suicidal ideation, suicidal behavior, or completed suicide. Only those events rated as severe are reported; this excludes any moderate events in the primary NPS AE endpoint." (NCT01456936)
Timeframe: Treatment emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionpercentage of participants (Number)
Non-psychiatric cohort (N= 990, 989, 1006, 999)Psychiatric cohort (N= 1026, 1017, 1016, 1015)Overall (N= 2016, 2006, 2022, 2014)
Bupropion 150 mg BID0.41.40.9
NRT Patch0.31.40.8
Placebo0.51.30.9
Varenicline 1.0 mg BID0.11.40.7

Occurrence of the Components of NPS AE Primary Endpoint (Overall)

The NPS AE composite results (as previously described) are for the two cohorts combined and are presented below. (NCT01456936)
Timeframe: Treatment emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionparticipants (Number)
AnxietyDepressionFeeling AbnormalHostilityAgitationAggressionDelusionsHallucinationManiaPanic DisorderParanoiaPsychosisHomicidal IdeationSuicidal BehaviorSuicidal IdeationSuicide
Bupropion 150 mg BID54114012141020120230
NRT Patch670140922514041150
Placebo5600331102810210151
Varenicline 1.0 mg BID570035171677140150

Occurrence of the Components of Severe-only NPS AE Endpoint (Overall)

"The NPS AE endpoint was the occurrence of at least 1 treatment-emergent severe AE of anxiety, depression, feeling abnormal, or hostility and/or the occurrence of at least 1 treatment-emergent severe AE of agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, suicidal ideation, suicidal behavior, or completed suicide. Only those events rated as severe are reported; this excludes any moderate events in the primary NPS AE endpoint." (NCT01456936)
Timeframe: Treatment emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionparticipants (Number)
AnxietyDepressionFeeling AbnormalHostilityAgitationAggressionDelusionsHallucinationManiaPanic DisorderParanoiaPsychosisSuicidal BehaviorSuicidal IdeationSuicideHomicidal Ideation
Bupropion 150 mg BID5411120112122000
NRT Patch6701600001040101
Placebo5600210002211010
Varenicline 1.0 mg BID5700120020141100

Occurrence of the Components of the NPS AE Primary Endpoint, Non-psychiatric History Cohort

"The safety endpoint is the occurrence of at least one treatment emergent severe adverse event of anxiety, depression, feeling abnormal, or hostility and/or the occurrence of at least one treatment emergent moderate or severe adverse event of: agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, suicidal ideation, suicidal behavior, or completed suicide. Each of these 16 components is reported below." (NCT01456936)
Timeframe: Treatment emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionparticipants (Number)
Anxiety (severe)Depression (severe)Feeling abnormal (severe only)Hostility (severe)Agitation (moderate and severe)Aggression (moderate and severe)Delusions (moderate and severe)Hallucinations (moderate and severe)Mania (moderate and severe)Panic (moderate and severe)Paranoia (moderate and severe)Psychosis (moderate and severe)Homicidal ideation (moderate and severe)Suicidal behavior (moderate and severe)Suicidal ideation (moderate and severe)Suicide (moderate and severe)
Bupropion 150 mg BID10011130014100110
NRT Patch00011921021011120
Placebo30001130023000031
Varenicline 1.0 mg BID01001030100000000

Occurrence of the Components of the NPS AE Primary Endpoint, Psychiatric History Cohort

"The safety endpoint is the occurrence of at least one treatment emergent severe adverse event of anxiety, depression, feeling abnormal, or hostility and/or the occurrence of at least one treatment emergent moderate or severe adverse event of: agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, suicidal ideation, suicidal behavior, or completed suicide. Each of these 16 components is reported below." (NCT01456936)
Timeframe: Treatment emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionparticipants (Number)
Anxiety (severe)Depression (severe)Feeling abnormal (severe only)Hostility (severe)Agitation (moderate and severe)Aggression (moderate and severe)Delusions (moderate and severe)Hallucinations (moderate and severe)Mania (moderate and severe)Panic (moderate and severe)Paranoia (moderate and severe)Psychosis (moderate and severe)Homicidal ideation (moderate and severe)Suicidal behavior (moderate and severe)Suicidal ideation (moderate and severe)Suicide (moderate and severe)
Bupropion 150 mg BID441029914916020120
NRT Patch670021712313030030
Placebo26002280267210120
Varenicline 1.0 mg BID560025141577140150

Occurrence of the Components of the Observed Severe-only NPS AE Primary Endpoint, Non-psychiatric History Cohort

"The safety endpoint is the occurrence of at least one treatment emergent severe adverse event of anxiety, depression, feeling abnormal, or hostility and/or the occurrence of at least one treatment emergent moderate or severe adverse event of: agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, suicidal ideation, suicidal behavior, or completed suicide. Only those events rated as severe are reported; this excludes any moderate events in the primary NPS AE endpoint." (NCT01456936)
Timeframe: Treatment emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionparticipants (Number)
AnxietyDepressionFeeling abnormalHostilityAgitationAggressionDelusionsHallucinationsManiaPanicParanoiaPsychosisHomicidal ideationSuicidal behaviorSuicidal ideationSuicide
Bupropion 150 mg BID1001010001000100
NRT Patch0001200001000000
Placebo3000000001000011
Varenicline 1.0 mg BID0100010000000000

Occurrence of the Components of the Observed Severe-only NPS AE Primary Endpoint, Psychiatric History Cohort

"The safety endpoint is the occurrence of at least one treatment emergent severe adverse event of anxiety, depression, feeling abnormal, or hostility and/or the occurrence of at least one treatment emergent moderate or severe adverse event of: agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, suicidal ideation, suicidal behavior, or completed suicide. Only those events rated as severe are reported; this excludes any moderate events in the primary NPS AE endpoint." (NCT01456936)
Timeframe: Treatment emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionparticipants (Number)
AnxietyDepressionFeeling abnormalHostilityAgitationAggressionDelusionsHallucinationsManiaPanicParanoiaPsychosisHomicidal ideationSuicidal behaviorSuicidal ideationSuicide
Bupropion 150 mg BID4410110111010100
NRT Patch6700400000010010
Placebo2600210001000100
Varenicline 1.0 mg BID5600110020000110

Positive Responses for Suicidal Behavior and/or Ideation by Columbia Suicide Severity Rating Scale (C-SSRS) - Non-psychiatric History Cohort

"The C-SSRS is a semi-structured interview designed to evaluate an individual's degree of suicidal ideation, preparatory acts or behavior to actual attempt, ranging from wish to be dead to active suicidal ideation with specific plan and intent. Answers at screening are for lifetime history. Answers for all other visits are since last visit.The scale is also used to record any completed suicides." (NCT01456936)
Timeframe: Lifetime, Baseline and Treatment-Emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionparticipants with positive responses (Number)
Suicidal Behavior (Screening lifetime)Suicidal Ideation (Screening lifetime)Suicidal Behavior (Baseline)Suicidal Ideation (Baseline)Suicidal Behavior (treatment emergent 12 weeks)Suicidal Ideation (treatment emergent 12 weeks)
Bupropion 150 mg BID9430104
NRT Patch7500013
Placebo6490116
Varenicline 1.0 mg BID6480007

Positive Responses for Suicidal Behavior and/or Ideation by Columbia Suicide Severity Rating Scale (C-SSRS) - Overall

"The C-SSRS is a semi-structured interview designed to evaluate an individual's degree of suicidal ideation, preparatory acts or behavior to actual attempt, ranging from wish to be dead to active suicidal ideation with specific plan and intent. Answers at screening are for lifetime history. Answers for all other visits are since last visit. The scale is also used to record any completed suicides." (NCT01456936)
Timeframe: Lifetime, Baseline and Treatment-Emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionparticipants with positive responses (Number)
Suicidal Behavior (Screening lifetime)Suicidal Ideation (Screening lifetime)Suicidal Behavior (Baseline)Suicidal Ideation (Baseline)Suicidal Behavior (treatment emergent 12 weeks)Suicidal Ideation (treatment emergent 12 weeks)
Bupropion 150 mg BID15240006119
NRT Patch11838302123
Placebo12939814331
Varenicline 1.0 mg BID14338606034

Positive Responses for Suicidal Behavior and/or Ideation by Columbia Suicide Severity Rating Scale (C-SSRS) - Psychiatric History Cohort

"The C-SSRS is a semi-structured interview designed to evaluate an individual's degree of suicidal ideation, preparatory acts or behavior to actual attempt, ranging from wish to be dead to active suicidal ideation with specific plan and intent. Answers at screening are for lifetime history. Answers for all other visits are since last visit. The scale is also used to record any completed suicides." (NCT01456936)
Timeframe: Lifetime, Baseline and Treatment-Emergent is first dose date to last dose date (up to 12 weeks) plus 30 days.

,,,
Interventionparticipants with positive responses (Number)
Suicidal Behavior (Screening lifetime)Suicidal Ideation (Screening lifetime)Suicidal Behavior (Baseline)Suicidal Ideation (Baseline)Suicidal Behavior (treatment emergent 12 weeks)Suicidal Ideation (treatment emergent 12 weeks)
Bupropion 150 mg BID14335705115
NRT Patch11133302020
Placebo12334913225
Varenicline 1.0 mg BID13733806027

Reviews

2 reviews available for bupropion and Mood Disorders

ArticleYear
Combinations of dextromethorphan for the treatment of mood disorders - a review of the evidence.
    Expert review of neurotherapeutics, 2023, Volume: 23, Issue:3

    Topics: Adult; Bipolar Disorder; Bupropion; Depressive Disorder, Major; Depressive Disorder, Treatment-Resis

2023
Bupropion sustained release and smoking cessation.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 4

    Topics: Administration, Cutaneous; Adult; Ambulatory Care; Bupropion; Clinical Trials as Topic; Delayed-Acti

1998

Trials

2 trials available for bupropion and Mood Disorders

ArticleYear
Factors associated with the efficacy of smoking cessation treatments and predictors of smoking abstinence in EAGLES.
    Addiction (Abingdon, England), 2018, Volume: 113, Issue:8

    Topics: Adult; Age Factors; Anxiety Disorders; Bupropion; Double-Blind Method; Ethnicity; Female; Humans; In

2018
    Praxis, 2016, Volume: 105, Issue:24

    Topics: Adolescent; Adult; Aged; Anxiety Disorders; Bupropion; Cohort Studies; Comorbidity; Double-Blind Met

2016

Other Studies

8 other studies available for bupropion and Mood Disorders

ArticleYear
Psychiatric adverse events and effects on mood with prolonged-release naltrexone/bupropion combination therapy: a pooled analysis.
    International journal of obesity (2005), 2019, Volume: 43, Issue:10

    Topics: Anti-Obesity Agents; Bupropion; Double-Blind Method; Drug Combinations; Humans; Mood Disorders; Nalt

2019
Therapies for obesity and medication-associated weight gain.
    Journal of psychosocial nursing and mental health services, 2013, Volume: 51, Issue:5

    Topics: Animals; Appetite Depressants; Bariatric Surgery; Benzazepines; Bupropion; Chronic Disease; Combined

2013
Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits.
    Molecular neurodegeneration, 2013, Apr-26, Volume: 8

    Topics: Adrenergic Agents; Animals; Antidepressive Agents; Antiparkinson Agents; Behavior, Animal; Bupropion

2013
Antidepressants reverse short-photoperiod-induced, forced swim test depression-like behavior in the diurnal fat sand rat: further support for the utilization of diurnal rodents for modeling affective disorders.
    Neuropsychobiology, 2011, Volume: 63, Issue:3

    Topics: Animals; Antidepressive Agents; Bupropion; Choice Behavior; Circadian Rhythm; Disease Models, Animal

2011
Bupropion SR for the treatment of substance-abusing outpatient adolescents with attention-deficit/hyperactivity disorder and mood disorders.
    Journal of child and adolescent psychopharmacology, 2005, Volume: 15, Issue:5

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Bupropion; Child; Delayed-Action P

2005
Bupropion treatment of serotonin reuptake antidepressant-associated sexual dysfunction.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1997, Volume: 9, Issue:4

    Topics: 1-Naphthylamine; Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Anxiety Dis

1997
Bupropion as an antidote for serotonin reuptake inhibitor-induced sexual dysfunction.
    The Journal of clinical psychiatry, 1998, Volume: 59, Issue:3

    Topics: Adult; Aged; Ambulatory Care; Anxiety Disorders; Bupropion; Dose-Response Relationship, Drug; Drug A

1998
Pharmacological responsiveness of winter depression.
    Psychopharmacology bulletin, 1990, Volume: 26, Issue:3

    Topics: Adult; Antidepressive Agents; Bupropion; Depressive Disorder; Desipramine; Disorders of Excessive So

1990