bupropion has been researched along with Long QT Syndrome in 9 studies
Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD." | 5.72 | Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022) |
| "Increasing age, seizures, QRS widening, and QTc prolongation were associated with adverse cardiovascular events in bupropion exposures." | 4.31 | Clinical and electrocardiographic factors associated with adverse cardiovascular events in bupropion exposures. ( Burns, MM; Feng, C; Monuteaux, M; Simpson, M; Troger, A; Whitledge, JD, 2023) |
| "Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD." | 1.72 | Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022) |
| "Bupropion is an I(Kr) blocker." | 1.38 | QRS widening and QT prolongation under bupropion: a unique cardiac electrophysiological profile. ( Caillier, B; Castonguay, A; Daleau, P; De Koninck, Y; Drolet, B; Hreiche, R; Ménard-Desrosiers, V; Patoine, D; Pilote, S; Simard, C; Turgeon, J; Vigneault, P, 2012) |
| " They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses." | 1.32 | Cardiotoxicity associated with intentional ziprasidone and bupropion overdose. ( Biswas, AK; Mayes, KL; Morris-Kukoski, CL; Zabrocki, LA, 2003) |
| " They have apparently safe cardiac safety profiles in both therapeutic and supratherapeutic doses, but recently the Federal Drug Administration has issued a caution regarding ziprasidone use in combination with other drugs that are known to prolong the QTc interval." | 1.32 | Cardiotoxicity associated with intentional ziprasidone and bupropion overdose. ( Biswas, AK; Mayes, KL; Morris-Kukoski, CL; Zabrocki, LA, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Robinson, S | 1 |
| Simpson, M | 1 |
| Troger, A | 1 |
| Feng, C | 1 |
| Whitledge, JD | 1 |
| Monuteaux, M | 1 |
| Burns, MM | 1 |
| Naguy, A | 1 |
| Alamiri, B | 1 |
| Caillier, B | 1 |
| Pilote, S | 1 |
| Castonguay, A | 1 |
| Patoine, D | 1 |
| Ménard-Desrosiers, V | 1 |
| Vigneault, P | 1 |
| Hreiche, R | 1 |
| Turgeon, J | 1 |
| Daleau, P | 1 |
| De Koninck, Y | 1 |
| Simard, C | 1 |
| Drolet, B | 1 |
| Biswas, AK | 2 |
| Zabrocki, LA | 2 |
| Mayes, KL | 2 |
| Morris-Kukoski, CL | 2 |
| Jaffe, R | 1 |
| Leavitt, R | 1 |
| Wind, T | 1 |
| Dattilo, PB | 1 |
| Nordin, C | 1 |
| Shrier, M | 1 |
| Díaz, JE | 1 |
| Tsarouhas, N | 1 |
9 other studies available for bupropion and Long QT Syndrome
| Article | Year |
|---|---|
Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine.
Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxicity; Drug Overdose; Fema | 2022 |
Clinical and electrocardiographic factors associated with adverse cardiovascular events in bupropion exposures.
Topics: Adult; Arrhythmias, Cardiac; Bupropion; Female; Humans; Long QT Syndrome; Male; Retrospective Studie | 2023 |
Probable Bupropion-Related QTc Prolongation in an Adolescent With Major Depressive Disorder.
Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Depressive Disorder, Major; Electro | 2020 |
QRS widening and QT prolongation under bupropion: a unique cardiac electrophysiological profile.
Topics: Animals; Antidepressive Agents, Second-Generation; Bupropion; Cell Communication; Cell Line; CHO Cel | 2012 |
Cardiotoxicity associated with intentional ziprasidone and bupropion overdose.
Topics: Adult; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Bupro | 2003 |
Cardiotoxicity associated with intentional ziprasidone and bupropion overdose.
Topics: Adolescent; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Antipsychotic Agents; | 2003 |
QTc prolongation in multiple drug overdose.
Topics: Adult; Bupropion; Drug Overdose; Fluoxetine; Humans; Long QT Syndrome; Male; Piperazines; Psychotic | 2004 |
Prolonged QT associated with an overdose of trazodone.
Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Depression; Drug Overdose; Electrocardio | 2007 |
Cardiotoxicity associated with bupropion overdose.
Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Emergency Treatment; | 2000 |