bupropion has been researched along with Huntington Disease in 2 studies
Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed the effects of acute administration of bupropion (a dopamine-norepinephrine reuptake inhibitor) on spontaneous locomotor activity and depression-like behaviour (using the forced-swim test)." | 3.78 | Antidepressant-Like Effect of the Norepinephrine-Dopamine Reuptake Inhibitor Bupropion in a Mouse Model of Huntington's Disease with Dopaminergic Dysfunction. ( Argyropoulos, A; Hannan, AJ; Renoir, T, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gelderblom, H | 1 |
| Wüstenberg, T | 1 |
| McLean, T | 1 |
| Mütze, L | 1 |
| Fischer, W | 1 |
| Saft, C | 1 |
| Hoffmann, R | 1 |
| Süssmuth, S | 1 |
| Schlattmann, P | 1 |
| van Duijn, E | 1 |
| Landwehrmeyer, B | 1 |
| Priller, J | 1 |
| Renoir, T | 1 |
| Argyropoulos, A | 1 |
| Hannan, AJ | 1 |
1 trial available for bupropion and Huntington Disease
| Article | Year |
|---|---|
Bupropion for the treatment of apathy in Huntington's disease: A multicenter, randomised, double-blind, placebo-controlled, prospective crossover trial.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Apathy; Brain; Bupropion; Cross-Over Studies; | 2017 |
1 other study available for bupropion and Huntington Disease
| Article | Year |
|---|---|
Antidepressant-Like Effect of the Norepinephrine-Dopamine Reuptake Inhibitor Bupropion in a Mouse Model of Huntington's Disease with Dopaminergic Dysfunction.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bupropion; Depression; Dopamine Uptake Inhibitors; | 2012 |