Page last updated: 2024-10-17

bupropion and Drug Overdose

bupropion has been researched along with Drug Overdose in 82 studies

Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.

Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Research Excerpts

ExcerptRelevanceReference
"Here we describe a wide complex tachycardia after bupropion overdose that was responsive to sodium bicarbonate."7.81Wide complex tachycardia after bupropion overdose. ( Franco, V, 2015)
"Delayed seizures have been reported with overdoses of bupropion extended-release (XL)."7.75Incidence and onset of delayed seizures after overdoses of extended-release bupropion. ( Ekleberry, SE; Kern, P; Klein-Schwartz, W; Kunkel, S; Spiller, H; Starr, P, 2009)
"Bupropion was the first alternative to nicotine replacement therapy in the pharmacological treatment for smoking cessation."7.74Serious adverse reactions of bupropion for smoking cessation: analysis of the French Pharmacovigilance Database from 2001 to 2004. ( Beyens, MN; Guy, C; Laporte, S; Mounier, G; Ollagnier, M, 2008)
"Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD."5.72Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022)
"She had a seizure and required sedation and intubation."5.62Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine. ( Beau, J; Bolton, TA; Carpenter, JE; Kazzi, Z; Kiernan, EA; Murray, BP; Sayers, J; Wolf, MJ; Yeh, M, 2021)
"BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone."5.48Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018)
"Bupropion is a monocyclic antidepressant in the aminoketone class, structurally related to amphetamines."5.42Bupropion Overdose Presenting as Status Epilepticus in an Infant. ( Morgan, R; Patterson, AL; Rivas-Coppola, MS; Wheless, JW, 2015)
"Bupropion hydrochloride is a monocyclic antidepressant which is used in a slow-release formulation as a smoking cessation aid."4.81Zyban-- is there a cause for concern? ( Tracey, JA, 2002)
"Bupropion cardiotoxicity widens QRS complexes by inhibiting cardiac gap junctions."4.31Sodium bicarbonate treatment for QRS widening in bupropion overdoses. ( Goldfine, C; Johnson, L; Simpson, M, 2023)
"Here we describe a wide complex tachycardia after bupropion overdose that was responsive to sodium bicarbonate."3.81Wide complex tachycardia after bupropion overdose. ( Franco, V, 2015)
"Bupropion overdose commonly causes generalized seizures and central nervous system depression."3.79Delayed bupropion cardiotoxicity associated with elevated serum concentrations of bupropion but not hydroxybupropion. ( Al-Abri, SA; Benowitz, NL; Hayashi, S; Olson, KR; Orengo, JP; Thoren, KL, 2013)
"Delayed seizures have been reported with overdoses of bupropion extended-release (XL)."3.75Incidence and onset of delayed seizures after overdoses of extended-release bupropion. ( Ekleberry, SE; Kern, P; Klein-Schwartz, W; Kunkel, S; Spiller, H; Starr, P, 2009)
"Bupropion was the first alternative to nicotine replacement therapy in the pharmacological treatment for smoking cessation."3.74Serious adverse reactions of bupropion for smoking cessation: analysis of the French Pharmacovigilance Database from 2001 to 2004. ( Beyens, MN; Guy, C; Laporte, S; Mounier, G; Ollagnier, M, 2008)
"Bupropion overdose mainly is characterized by tachycardia, agitation, and seizures."3.73Intraventricular conduction delay after bupropion overdose. ( Curry, SC; Holubek, W; Kashani, JS; LoVecchio, F, 2005)
"Bupropion (Zyban) has recently been launched in the UK as an aid to smoking cessation."3.71Bupropion overdose: a potential problem with the new 'miracle' anti-smoking drug. ( Bhattacharjee, C; Gillespie, M; Smith, M; Todd, F, 2001)
"Bupropion is a unique monocyclic antidepressant that has been known to cause seizures in high therapeutic doses and in acute overdoses."3.69Fatal bupropion overdose. ( Gualtieri, J; Harris, CR; Stark, G, 1997)
"Clinical features associated with seizure were QTc >500 (OR = 3."2.72Factors associated with seizure development after bupropion overdose: a review of the toxicology investigators consortium. ( Hendrickson, RG; Lin, AL; Murray, BP; Prather, CT; Rianprakaisang, TN, 2021)
"Preferred drugs for treating depression in epilepsy are serotonin reuptake inhibitors."2.49[Antidepressants in epilepsy]. ( Castaño-Monsalve, B, 2013)
"Bupropion is a relatively new monocyclic antidepressant whose mechanism of action remains unknown."2.41Bupropion overdose in an adolescent. ( Ayers, S; Tobias, JD, 2001)
"Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD."1.72Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022)
"Bupropion is an antidepressant with unique mechanisms of action leading to a narrow therapeutic window."1.72Disposition, outcomes, and lengths of stay due to bupropion overdose at a tertiary care center with a medical toxicology service. ( McCabe, DJ; Radke, JB; Wilson, BZ, 2022)
"She had a seizure and required sedation and intubation."1.62Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine. ( Beau, J; Bolton, TA; Carpenter, JE; Kazzi, Z; Kiernan, EA; Murray, BP; Sayers, J; Wolf, MJ; Yeh, M, 2021)
"Bupropion overdose is a commonly encountered presentation in the emergency department (ED)."1.56Bupropion Overdose Complicated by Cardiogenic Shock Requiring Vasopressor Support and Lipid Emulsion Therapy. ( Fung, C; Herrman, NWC; Kalisieski, MJ, 2020)
"Bupropion is a commonly used antidepressant, and overdose can lead to both neurologic and cardiovascular toxicity, including agitation, seizure, tachycardia, QT and QRS prolongation, and rhythm disturbances."1.51Pediatric Toxidrome Simulation Curriculum: Bupropion Overdose. ( Burns, R; Hartford, E; Keilman, A; Reid, J; Stone, K; Thomas, A; Uspal, N, 2019)
" Case Discussion: "Ghost tablets," the insoluble remnant of some extended-release dosage forms, have been previously reported to appear in patients' stool in the course of therapeutic dosing."1.51"Ghost tablet" husks excreted in feces in large bupropion XL overdose. ( Nanagas, K; Overberg, A; Purpura, A, 2019)
"Bupropion exposure was significantly associated with death (0."1.51Toxicity of Bupropion Overdose Compared With Selective Serotonin Reuptake Inhibitors. ( Froberg, B; Morton, S; Overberg, A; Wagner, E, 2019)
"BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone."1.48Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018)
"Its primary toxic effects include seizure, sinus tachycardia, hypertension, and agitation; however, at higher amounts of ingestion, paradoxical cardiac effects are seen."1.43Atypical Findings in Massive Bupropion Overdose: A Case Report and Discussion of Psychopharmacologic Issues. ( Jimenez, XF; Kolawole, T; Zhu, Y, 2016)
"The FDA addressed interchangeability problems with generic modified-release alternatives of bupropion and methylphenidate including lack of bioequivalence, reduced efficacy, and increased incidence of adverse events."1.43Interchangeability, Safety and Efficacy of Modified-Release Drug Formulations in the USA: The Case of Opioid and Other Nervous System Drugs. ( Hansen, R; Rodriguez-Monguio, R; Seoane-Vazquez, E, 2016)
"Bupropion is a monocyclic antidepressant in the aminoketone class, structurally related to amphetamines."1.42Bupropion Overdose Presenting as Status Epilepticus in an Infant. ( Morgan, R; Patterson, AL; Rivas-Coppola, MS; Wheless, JW, 2015)
"Bupropion is a relatively new and popular medication for depression, with seizures as its major side effect."1.40Charcoal hemoperfusion in bupropion overdose. ( Akdemir, HU; Calışkan, F; Duran, L; Güngörer, B; Katı, C; Ocak, M, 2014)
"Bupropion is an I(Kr) blocker."1.38QRS widening and QT prolongation under bupropion: a unique cardiac electrophysiological profile. ( Caillier, B; Castonguay, A; Daleau, P; De Koninck, Y; Drolet, B; Hreiche, R; Ménard-Desrosiers, V; Patoine, D; Pilote, S; Simard, C; Turgeon, J; Vigneault, P, 2012)
"Bupropion is an antidepressant, which in Denmark is only used as an aid for smoking cessation."1.35[Acute psychosis following bupropion overdosage]. ( Braendholt, V; Hansen, MB; Rasmussen, KB, 2008)
" Other prominent adverse effects were agitation (39 patients [8."1.33Adverse effects associated with extra doses of bupropion. ( Shepherd, G, 2005)
"Bupropion is an antidepressant that is structurally related to amphetamines and enhances dopamine neurotransmission through inhibiting neuronal dopamine re-uptake."1.33Acute psychosis following sustained release bupropion overdose. ( Chang, CC; Shiah, IS; Wang, TS; Yeh, CB, 2005)
"Seizures were dose-dependent, with those having seizures ingesting a significantly higher median dose (P = 0."1.32Bupropion poisoning: a case series. ( Balit, CR; Isbister, GK; Lynch, CN, 2003)
" They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses."1.32Cardiotoxicity associated with intentional ziprasidone and bupropion overdose. ( Biswas, AK; Mayes, KL; Morris-Kukoski, CL; Zabrocki, LA, 2003)
"However, seizures may occur beyond this time frame, particularly if persistent tachycardia, agitation, or hallucinations are noted."1.32Intentional bupropion overdoses. ( Keyes, DC; Shepherd, G; Velez, LI, 2004)
" They have apparently safe cardiac safety profiles in both therapeutic and supratherapeutic doses, but recently the Federal Drug Administration has issued a caution regarding ziprasidone use in combination with other drugs that are known to prolong the QTc interval."1.32Cardiotoxicity associated with intentional ziprasidone and bupropion overdose. ( Biswas, AK; Mayes, KL; Morris-Kukoski, CL; Zabrocki, LA, 2003)
"Bupropion is an antidepressant and smoking cessation aid."1.31Bupropion exposures: clinical manifestations and medical outcome. ( Belson, MG; Kelley, TR, 2002)
" The potential toxic effects should be considered when prescribing it as a smoking cessation aid."1.31Bupropion (Zyban) toxicity. ( Ali, I; Casey, PB; Cassidy, N; Tracey, JA, 2002)
"Seizure is the primary adverse reaction associated with bupropion overdoses."1.30ECG conduction delays associated with massive bupropion overdose. ( Paris, PA; Saucier, JR, 1998)

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (6.10)18.2507
2000's28 (34.15)29.6817
2010's34 (41.46)24.3611
2020's15 (18.29)2.80

Authors

AuthorsStudies
McCabe, DJ1
Radke, JB1
Wilson, BZ1
Robinson, S1
Simpson, M1
Johnson, L2
Goldfine, C1
Lothet, E1
Fredrickson, C1
Nguyen, KL1
Bertels, K1
Mullins, ME2
Herrman, NWC1
Kalisieski, MJ1
Fung, C1
Hartford, E1
Thomas, A1
Keilman, A1
Uspal, N1
Stone, K1
Reid, J1
Burns, R1
Offerman, S1
Gosen, J1
Thomas, SH1
Padilla-Jones, A1
Ruha, AM1
Levine, M1
Seger, DL1
Sidlak, AM2
Koivisto, KO1
Marino, RT2
Abesamis, MG2
Taub, ES1
Hoffman, RS1
Howland, MA1
Su, MK1
Prakash, S1
Lee, SH1
Sohn, JT1
Murray, BP2
Carpenter, JE1
Sayers, J1
Yeh, M1
Beau, J1
Kiernan, EA1
Wolf, MJ1
Bolton, TA1
Kazzi, Z1
Rianprakaisang, TN1
Prather, CT1
Lin, AL1
Hendrickson, RG1
Sathe, AR1
Thiemann, A1
Toulouie, S1
Durant, E1
Schmit, G1
De Boosere, E1
Vanhaebost, J1
Capron, A1
Xiang, XM1
Phillips, DJ1
Little, K1
Lin, CM1
Reynolds, PM1
Overberg, A2
Purpura, A1
Nanagas, K1
Cartier R, L1
Romero O, C1
Pérez P, G1
French, S1
Wray, C1
Morton, S1
Wagner, E1
Froberg, B1
Wilson, B1
Paul, P1
Mehta, S1
Coffey, BJ1
Hilliard, WT1
Barloon, L1
Farley, P1
Penn, JV1
Koranek, A1
Castaño-Monsalve, B1
Bucklin, MH1
Gorodetsky, RM1
Wiegand, TJ1
Al-Abri, SA1
Orengo, JP1
Hayashi, S1
Thoren, KL1
Benowitz, NL1
Olson, KR1
Akdemir, HU1
Calışkan, F1
Duran, L1
Katı, C1
Güngörer, B1
Ocak, M1
Stall, N1
Godwin, J1
Juurlink, D1
Fettiplace, MR1
Akpa, BS1
Rubinstein, I1
Weinberg, G1
Weerdenburg, K1
Finkelstein, Y1
Rivas-Coppola, MS1
Patterson, AL1
Morgan, R1
Wheless, JW1
Franco, V1
Seoane-Vazquez, E1
Rodriguez-Monguio, R1
Hansen, R1
Heise, CW1
Skolnik, AB1
Raschke, RA1
Owen-Reece, H1
Graeme, KA1
Fulton, LV1
Fabich, RA1
Bhatta, J1
Fletcher, B1
Leininger, K1
Lienesch, K1
Rodriguez, TA1
Coyner, JL1
Johnson, AD1
O'Sullivan, J1
Bolen, RD1
Campbell, Z1
Bonilha, L1
Edwards, JC1
Farias-Moeller, R1
Carpenter, JL1
Zhu, Y1
Kolawole, T1
Jimenez, XF1
Spiller, HA3
Schaeffer, SE1
Beyens, MN1
Guy, C1
Mounier, G1
Laporte, S1
Ollagnier, M1
Hansen, MB1
Rasmussen, KB1
Braendholt, V1
Bottei, E1
Kalin, L1
Garg, U1
Frazee, C1
Turner, JW1
Starr, P1
Klein-Schwartz, W1
Spiller, H1
Kern, P1
Ekleberry, SE1
Kunkel, S1
Donnelly, K1
Walkowiak, HB1
Donnelly, C1
Jenkinson, E1
Rizkalla, J1
Langford, N1
Boora, K1
Cummings, MR1
Marshall, DR1
Shenoi, AN1
Gertz, SJ1
Mikkilineni, S1
Kalyanaraman, M1
Caillier, B1
Pilote, S1
Castonguay, A1
Patoine, D1
Ménard-Desrosiers, V1
Vigneault, P1
Hreiche, R1
Turgeon, J1
Daleau, P1
De Koninck, Y1
Simard, C1
Drolet, B1
Skjei, KL1
Kessler, SK1
Abend, NS1
Chao, CT1
Wu, VC1
Wang, WJ1
Lung, D1
Yeh, K1
Kiang, C1
Kolluru, A1
Kumar, P1
Kanwar, M1
Singh, T1
Lin, YH1
Huang, E1
Chien, YL1
Druteika, D1
Zed, PJ1
Belson, MG1
Kelley, TR1
Balit, CR1
Lynch, CN1
Isbister, GK1
Biswas, AK2
Zabrocki, LA2
Mayes, KL2
Morris-Kukoski, CL2
Tracey, JA2
Jepsen, F1
Matthews, J1
Andrews, FJ1
Jaffe, R1
Leavitt, R1
Wind, T1
Shepherd, G2
Velez, LI1
Keyes, DC1
Wang, TS1
Shiah, IS1
Yeh, CB1
Chang, CC1
Curry, SC1
Kashani, JS1
LoVecchio, F1
Holubek, W1
Suma, R1
Kosanam, H1
Sai Prakash, PK1
Dattilo, PB1
Nordin, C1
Mercerolle, M1
Denooz, R1
Lachâtre, G1
Charlier, C1
Storrow, AB1
Ramoska, EA1
Krenzelok, EP1
Sheen, SR1
Borys, DJ1
Villalobos, D1
Muir, S1
Jones-Easom, L1
Gittelman, DK1
Kirby, MG1
Harris, CR1
Gualtieri, J1
Stark, G1
Paris, PA1
Saucier, JR1
Shrier, M1
Díaz, JE1
Tsarouhas, N1
Ayers, S1
Tobias, JD1
Bhattacharjee, C1
Smith, M1
Todd, F1
Gillespie, M1
Mainie, I1
McGurk, C1
McClintock, G1
Robinson, J1
Cassidy, N1
Casey, PB1
Ali, I1
Paoloni, R1
Szekely, I1
White, RS1
Langford, JR1

Reviews

7 reviews available for bupropion and Drug Overdose

ArticleYear
Factors associated with seizure development after bupropion overdose: a review of the toxicology investigators consortium.
    Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:12

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Humans;

2021
Bupropion diversion and misuse in the correctional facility.
    Journal of correctional health care : the official journal of the National Commission on Correctional Health Care, 2013, Volume: 19, Issue:3

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Humans; Mental Disorders; Prison

2013
[Antidepressants in epilepsy].
    Revista de neurologia, 2013, Aug-01, Volume: 57, Issue:3

    Topics: Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bupropion; Clinical Trials

2013
Cardiotoxicity following bupropion overdose.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:11

    Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Electrocardio

2002
Zyban-- is there a cause for concern?
    Expert opinion on drug safety, 2002, Volume: 1, Issue:4

    Topics: Animals; Antidepressive Agents, Second-Generation; Area Under Curve; Bupropion; Drug Overdose; Half-

2002
Bupropion overdose and seizure.
    The American journal of emergency medicine, 1994, Volume: 12, Issue:2

    Topics: Adolescent; Bupropion; Charcoal; Diazepam; Drug Overdose; Electrocardiography; Emergency Service, Ho

1994
Bupropion overdose in an adolescent.
    Pediatric emergency care, 2001, Volume: 17, Issue:2

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Bupropion; Dopamine Uptake Inhibitors; Dr

2001

Other Studies

75 other studies available for bupropion and Drug Overdose

ArticleYear
Disposition, outcomes, and lengths of stay due to bupropion overdose at a tertiary care center with a medical toxicology service.
    The American journal of emergency medicine, 2022, Volume: 54

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Humans; Seizures; Tertiary Care

2022
Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine.
    The American journal of emergency medicine, 2022, Volume: 55

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxicity; Drug Overdose; Fema

2022
Sodium bicarbonate treatment for QRS widening in bupropion overdoses.
    Clinical toxicology (Philadelphia, Pa.), 2023, Volume: 61, Issue:6

    Topics: Adult; Bicarbonates; Bupropion; Cardiotoxicity; Drug Overdose; Electrocardiography; Female; Humans;

2023
Intentional overdose of a novel dextromethorphan-bupropion combination antidepressant.
    The American journal of emergency medicine, 2023, Volume: 72

    Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Bupropion; Dextromethorphan; Drug O

2023
Bupropion Overdose Complicated by Cardiogenic Shock Requiring Vasopressor Support and Lipid Emulsion Therapy.
    The Journal of emergency medicine, 2020, Volume: 58, Issue:2

    Topics: Bupropion; Drug Overdose; Fat Emulsions, Intravenous; Female; Humans; Shock, Cardiogenic; Vasoconstr

2020
Pediatric Toxidrome Simulation Curriculum: Bupropion Overdose.
    MedEdPORTAL : the journal of teaching and learning resources, 2019, 10-25, Volume: 15

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Cardiopulmonary Resuscitation; Clin

2019
Bupropion associated seizures following acute overdose: who develops late seizures.
    Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:12

    Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Bupropion; Dose-Response Relationship,

2020
Antidotal use of lipid emulsion - the pendulum swings.
    Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:12

    Topics: Animals; Antidotes; Bupropion; Calcium Channel Blockers; Drug Overdose; Fat Emulsions, Intravenous;

2020
Serotonin toxicity from isolated bupropion overdoses.
    Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:12

    Topics: Adolescent; Adult; Bupropion; Drug Overdose; Female; Humans; Male; Middle Aged; Retrospective Studie

2020
Response to Comment on serotonin toxicity from isolated bupropion overdoses.
    Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:1

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Humans; Serotonin

2021
Comment on Serotonin toxicity from isolated bupropion overdoses.
    Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:12

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Humans; Serotonin

2020
Comment on Serotonin toxicity from isolated bupropion overdoses.
    Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:12

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Humans; Serotonin

2020
Lipid Emulsion Treatment of Cardiogenic Shock Induced by Toxic Dose of Bupropion.
    The Journal of emergency medicine, 2020, Volume: 59, Issue:1

    Topics: Bupropion; Drug Overdose; Fat Emulsions, Intravenous; Humans; Lipids; Shock, Cardiogenic

2020
Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine.
    The Journal of emergency medicine, 2021, Volume: 60, Issue:4

    Topics: Adolescent; Adult; Bupropion; Cyproheptadine; Drug Overdose; Female; Humans; Male; Seizures; Seroton

2021
A 19-Year-Old Woman with a History of Depression and Fatal Cardiorespiratory Failure Following an Overdose of Prescribed Bupropion.
    The American journal of case reports, 2021, Jul-26, Volume: 22

    Topics: Adolescent; Adult; Bupropion; Depression; Drug Overdose; Female; Humans; Seizures; Shock, Cardiogeni

2021
Bupropion Overdose Resulted in a Pharmacobezoar in a Fatal Bupropion (Wellbutrin
    Journal of forensic sciences, 2017, Volume: 62, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Bezoars; Bile; Bupropion; Delayed-Action Preparatio

2017
Nonepileptic Myoclonus Following Bupropion Overdose.
    Clinical pediatrics, 2018, Volume: 57, Issue:9

    Topics: Adolescent; Anticonvulsants; Antidepressive Agents, Second-Generation; Bupropion; Depressive Disorde

2018
Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose.
    The American journal of case reports, 2018, May-25, Volume: 19

    Topics: Benzodiazepines; Bupropion; Cyproheptadine; Dopamine Uptake Inhibitors; Drug Overdose; Fluoxetine; H

2018
"Ghost tablet" husks excreted in feces in large bupropion XL overdose.
    Clinical toxicology (Philadelphia, Pa.), 2019, Volume: 57, Issue:2

    Topics: Bupropion; Delayed-Action Preparations; Drug Overdose; Feces; Humans; Male; Tablets; Young Adult

2019
[Sustained upgaze in a patient who ingested high doses of bupropion. Report of one case].
    Revista medica de Chile, 2018, Volume: 146, Issue:5

    Topics: Aged; Antidepressive Agents, Second-Generation; Bupropion; Coma; Drug Overdose; Fatal Outcome; Femal

2018
Serotonin Syndrome and Hippocampal Infarction.
    Pediatric neurology, 2019, Volume: 90

    Topics: Adolescent; Brain Infarction; Bupropion; Drug Overdose; Fever; Hallucinations; Hippocampus; Humans;

2019
Toxicity of Bupropion Overdose Compared With Selective Serotonin Reuptake Inhibitors.
    Pediatrics, 2019, Volume: 144, Issue:2

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Child; Drug Overdose; Female; Human

2019
Hypokalemia secondary to bupropion sustained release overdose.
    Journal of child and adolescent psychopharmacology, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Delayed-Action Preparations; Drug O

2013
Prolonged lipemia and pancreatitis due to extended infusion of lipid emulsion in bupropion overdose.
    Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:9

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Dopamine Uptake Inhibitors; Drug Ov

2013
Delayed bupropion cardiotoxicity associated with elevated serum concentrations of bupropion but not hydroxybupropion.
    Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:10

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxins; Drug Overdose; Electrocard

2013
Charcoal hemoperfusion in bupropion overdose.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2014, Volume: 113, Issue:10

    Topics: Antidepressive Agents, Second-Generation; Antidotes; Bupropion; Charcoal; Depressive Disorder; Drug

2014
Bupropion abuse and overdose.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014, Sep-16, Volume: 186, Issue:13

    Topics: Antidepressive Agents; Bupropion; Drug Overdose; Humans; Seizures; Substance-Related Disorders; Toba

2014
Confusion About Infusion: Rational Volume Limits for Intravenous Lipid Emulsion During Treatment of Oral Overdoses.
    Annals of emergency medicine, 2015, Volume: 66, Issue:2

    Topics: Bupropion; Drug Overdose; Fat Emulsions, Intravenous; Humans; Lamotrigine; Triazines

2015
A 12-year-old girl with seizures after intentional drug overdose. Bupropion overdose.
    Pediatric emergency care, 2015, Volume: 31, Issue:3

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Child; Diagnosis, Differential; Drug Overdose;

2015
Bupropion Overdose Presenting as Status Epilepticus in an Infant.
    Pediatric neurology, 2015, Volume: 53, Issue:3

    Topics: Antidepressive Agents, Second-Generation; Brain; Bupropion; Diagnosis, Differential; Drug Overdose;

2015
Wide complex tachycardia after bupropion overdose.
    The American journal of emergency medicine, 2015, Volume: 33, Issue:10

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Electrocardiography; Emer

2015
Interchangeability, Safety and Efficacy of Modified-Release Drug Formulations in the USA: The Case of Opioid and Other Nervous System Drugs.
    Clinical drug investigation, 2016, Volume: 36, Issue:4

    Topics: Analgesics, Opioid; Antidepressive Agents, Second-Generation; Bupropion; Centers for Medicare and Me

2016
Two Cases of Refractory Cardiogenic Shock Secondary to Bupropion Successfully Treated with Veno-Arterial Extracorporeal Membrane Oxygenation.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:3

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Arizona; Bupropion; Combined Modality Therapy;

2016
Comparison of Resuscitative Protocols for Bupropion Overdose Using Lipid Emulsion in a Swine Model.
    Military medicine, 2016, Volume: 181, Issue:5

    Topics: Animals; Bupropion; Cardiopulmonary Resuscitation; Drug Overdose; Epinephrine; Fat Emulsions, Intrav

2016
Alpha coma related to intentional bupropion overdose.
    Journal of the neurological sciences, 2016, Jun-15, Volume: 365

    Topics: Antidepressive Agents, Second-Generation; Brain; Bupropion; Coma; Depressive Disorder; Drug Overdose

2016
Coma with Absent Brainstem Reflexes and Burst Suppression after Bupropion Overdose in a Child.
    Neurocritical care, 2017, Volume: 26, Issue:1

    Topics: Adolescent; Brain Edema; Brain Stem; Bupropion; Coma; Drug Overdose; Fatal Outcome; Female; Humans;

2017
Atypical Findings in Massive Bupropion Overdose: A Case Report and Discussion of Psychopharmacologic Issues.
    Journal of psychiatric practice, 2016, Volume: 22, Issue:5

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Electrocardiography; Fema

2016
Multiple seizures after bupropion overdose in a small child.
    Pediatric emergency care, 2008, Volume: 24, Issue:7

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Child; Drug Overdose; Emergency Service, Hospit

2008
Serious adverse reactions of bupropion for smoking cessation: analysis of the French Pharmacovigilance Database from 2001 to 2004.
    Drug safety, 2008, Volume: 31, Issue:11

    Topics: Adolescent; Adult; Aged; Angioedema; Antidepressive Agents, Second-Generation; Bupropion; Cerebrovas

2008
[Acute psychosis following bupropion overdosage].
    Ugeskrift for laeger, 2008, Nov-10, Volume: 170, Issue:46

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Hallucinations; Huma

2008
Fatal bupropion overdose with post mortem blood concentrations.
    Forensic science, medicine, and pathology, 2008, Volume: 4, Issue:1

    Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Bupropion; Delayed-Action Preparations;

2008
A fatal case involving extremely high levels of ethylene glycol without elevation of its metabolites or crystalluria.
    The American journal of forensic medicine and pathology, 2009, Volume: 30, Issue:3

    Topics: Antidepressive Agents; Bupropion; Drug Overdose; Ethylene Glycol; Forensic Toxicology; Glycolates; G

2009
Incidence and onset of delayed seizures after overdoses of extended-release bupropion.
    The American journal of emergency medicine, 2009, Volume: 27, Issue:8

    Topics: Adolescent; Adult; Aged; Bupropion; Chi-Square Distribution; Child; Child, Preschool; Dopamine Uptak

2009
Bupropion toxicokinetic: a case report.
    Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:4

    Topics: Adult; Antidepressive Agents; Bupropion; Delayed-Action Preparations; Drug Overdose; Humans; Male

2010
Generalized seizure in three adolescents with bupropion overdose.
    Journal of child and adolescent psychopharmacology, 2010, Volume: 20, Issue:2

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Female; Humans; Male

2010
Refractory hypotension from massive bupropion overdose successfully treated with extracorporeal membrane oxygenation.
    Pediatric emergency care, 2011, Volume: 27, Issue:1

    Topics: Antidepressive Agents, Second-Generation; Blood Pressure; Bupropion; Drug Overdose; Extracorporeal M

2011
QRS widening and QT prolongation under bupropion: a unique cardiac electrophysiological profile.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:5

    Topics: Animals; Antidepressive Agents, Second-Generation; Bupropion; Cell Communication; Cell Line; CHO Cel

2012
Stimulus-induced rhythmic, periodic, or ictal discharges in a 13-year-old girl after an overdose and respiratory arrest.
    Pediatric neurology, 2011, Volume: 45, Issue:5

    Topics: Adolescent; Baclofen; Bupropion; Drug Overdose; Female; Heart Arrest; Humans; Periodicity; Seizures

2011
Charcoal hemoperfusion for bupropion overdose with ventricular tachycardia and status epilepticus.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2012, Volume: 111, Issue:1

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Charcoal; Drug Overdose; Electrocar

2012
Delayed, fatal cardiotoxicity associated with bupropion and citalopram overdose.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxins; Citalopram; Delayed-Action

2012
Heart connection of the mind medication.
    BMJ case reports, 2011, Apr-26, Volume: 2011

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Dizziness; Drug Overdose; Electroca

2011
Bilateral pallidal necrosis and cardiac toxicity in a patient with venlafaxine and bupropion overdose.
    The American journal of psychiatry, 2012, Volume: 169, Issue:9

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Cyclohexanols; Drug Overdose; Female; Gl

2012
Bupropion exposures: clinical manifestations and medical outcome.
    The Journal of emergency medicine, 2002, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Antidepressive Agents, Second-Generation; Bupropion

2002
Bupropion poisoning: a case series.
    The Medical journal of Australia, 2003, Jan-20, Volume: 178, Issue:2

    Topics: Accidents, Home; Adult; Australia; Bupropion; Child, Preschool; Dopamine Uptake Inhibitors; Drug Ove

2003
Cardiotoxicity associated with intentional ziprasidone and bupropion overdose.
    Journal of toxicology. Clinical toxicology, 2003, Volume: 41, Issue:1

    Topics: Adult; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Bupro

2003
Cardiotoxicity associated with intentional ziprasidone and bupropion overdose.
    Journal of toxicology. Clinical toxicology, 2003, Volume: 41, Issue:2

    Topics: Adolescent; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Antipsychotic Agents;

2003
Sustained release bupropion overdose: an important cause of prolonged symptoms after an overdose.
    Emergency medicine journal : EMJ, 2003, Volume: 20, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Delayed-Action Preparations; Drug Overdo

2003
QTc prolongation in multiple drug overdose.
    Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:3

    Topics: Adult; Bupropion; Drug Overdose; Fluoxetine; Humans; Long QT Syndrome; Male; Piperazines; Psychotic

2004
Intentional bupropion overdoses.
    The Journal of emergency medicine, 2004, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Bupropion; Child; Drug Overdose; Female

2004
Acute psychosis following sustained release bupropion overdose.
    Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Antidotes; Bupropion; Charcoal; Delayed-Action Prep

2005
Intraventricular conduction delay after bupropion overdose.
    The Journal of emergency medicine, 2005, Volume: 29, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Electrocardiography; Fema

2005
Adverse effects associated with extra doses of bupropion.
    Pharmacotherapy, 2005, Volume: 25, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Bupropion; Dru

2005
Stability study of bupropion and olanzapine in formaldehyde solutions.
    Rapid communications in mass spectrometry : RCM, 2006, Volume: 20, Issue:8

    Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepines; Bupropion; Chemistr

2006
Prolonged QT associated with an overdose of trazodone.
    The Journal of clinical psychiatry, 2007, Volume: 68, Issue:8

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Depression; Drug Overdose; Electrocardio

2007
A fatal case of bupropion (Zyban) overdose.
    Journal of analytical toxicology, 2008, Volume: 32, Issue:2

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Cause of Death; Chromatography, High Pre

2008
Bupropion overdose: a 3-year multi-center retrospective analysis.
    The American journal of emergency medicine, 1994, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Aged; Benzodiazepines; Bupropion; Child; Child, Preschool; Drug Overdose; Female;

1994
A seizure following bupropion overdose.
    The Journal of clinical psychiatry, 1993, Volume: 54, Issue:4

    Topics: Adult; Bupropion; Depressive Disorder; Drug Overdose; Female; Humans; Seizures

1993
Fatal bupropion overdose.
    Journal of toxicology. Clinical toxicology, 1997, Volume: 35, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Dopamine; Drug Overdose; Fatal Outcome;

1997
ECG conduction delays associated with massive bupropion overdose.
    Journal of toxicology. Clinical toxicology, 1998, Volume: 36, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Arrhythmias, Cardiac; Bupropion; Delirium; Drug Ove

1998
Cardiotoxicity associated with bupropion overdose.
    Annals of emergency medicine, 2000, Volume: 35, Issue:1

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Emergency Treatment;

2000
Bupropion overdose: a potential problem with the new 'miracle' anti-smoking drug.
    International journal of clinical practice, 2001, Volume: 55, Issue:3

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Dopamine; Drug Overdose; Epinephrin

2001
Seizures after buproprion overdose.
    Lancet (London, England), 2001, May-19, Volume: 357, Issue:9268

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Female; Follow-Up Studies

2001
Bupropion (Zyban) toxicity.
    Irish medical journal, 2002, Volume: 95, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Drug Overdose; Female; Humans; Ireland;

2002
Sustained-release bupropion overdose: a new entity for Australian emergency departments.
    Emergency medicine (Fremantle, W.A.), 2002, Volume: 14, Issue:1

    Topics: Adult; Australia; Bupropion; Combined Modality Therapy; Delayed-Action Preparations; Drug Overdose;

2002
Sustained release bupropion: overdose and treatment.
    The American journal of emergency medicine, 2002, Volume: 20, Issue:4

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Delayed-Action Preparations; Drug Overdose; Epi

2002