Page last updated: 2024-10-17

bupropion and Delayed Effects, Prenatal Exposure

bupropion has been researched along with Delayed Effects, Prenatal Exposure in 14 studies

Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.

Research Excerpts

ExcerptRelevanceReference
" Smoking cessation drugs such as nicotine replacement therapy (NRT) and bupropion are recommended for pregnant women."7.79Postnatal metabolic and reproductive consequences of fetal and neonatal exposure to the smoking cessation drug bupropion. ( De Long, N; Gerstein, HC; Holloway, AC; Hyslop, JR; Morrison, KM; Nicholson, CJ, 2013)
" The mother had received bupropion, an antidepressant and aid to smoking cessation, throughout pregnancy."7.77Hyperinsulinism associated with gestational exposure to bupropion in a newborn infant. ( Gisslen, T; Nathan, B; Rao, R; Thompson, T, 2011)
" Exposure categories included first-trimester bupropion alone or in combination with other antidepressants, first-trimester antidepressants other than bupropion, and no exposure to any antidepressant at any time from 2 months prior to pregnancy through delivery."3.80First-trimester exposure to bupropion and risk of cardiac malformations. ( Kerr, S; Louik, C; Mitchell, AA, 2014)
" Smoking cessation drugs such as nicotine replacement therapy (NRT) and bupropion are recommended for pregnant women."3.79Postnatal metabolic and reproductive consequences of fetal and neonatal exposure to the smoking cessation drug bupropion. ( De Long, N; Gerstein, HC; Holloway, AC; Hyslop, JR; Morrison, KM; Nicholson, CJ, 2013)
" The mother had received bupropion, an antidepressant and aid to smoking cessation, throughout pregnancy."3.77Hyperinsulinism associated with gestational exposure to bupropion in a newborn infant. ( Gisslen, T; Nathan, B; Rao, R; Thompson, T, 2011)
" Exposure to bupropion during pregnancy (OR = 3."3.76Use of antidepressants during pregnancy and risk of attention-deficit/hyperactivity disorder in the offspring. ( Figueroa, R, 2010)
"Smoking during pregnancy has detrimental effects on mother and fetus."2.87Smoking Cessation Following Text Message Intervention in Pregnant Women. ( Chamness, D; Forinash, AB; Gross, G; Inteso, C; Koerner, J; Mathews, K; Miller, C; Yancey, A, 2018)
"When considering treating perinatal depression with a drug indicated for the treatment of depression, the major concerns are whether the drug increases the risks of teratogenicity, pregnancy complications, poor neonatal adaptation, or neurodevelopmental disorders."2.58Pharmacotherapy for Perinatal Depression. ( Albertini, ES; Ernst, C; Fersh, ME; Habib, S; Khan, SJ; Lusskin, SI, 2018)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (21.43)29.6817
2010's10 (71.43)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Marks, C1
Silvola, R1
Teal, E1
Quinney, SK1
Haas, DM1
Lusskin, SI1
Khan, SJ1
Ernst, C1
Habib, S1
Fersh, ME1
Albertini, ES1
Forinash, AB1
Yancey, A1
Chamness, D1
Koerner, J1
Inteso, C1
Miller, C1
Gross, G1
Mathews, K1
Sanches, ESAM1
Tsuzuki, F1
Joinhas, F1
Figueiras, GB1
Moreira, EG1
Salles, MJS1
De Long, N1
Hyslop, JR1
Nicholson, CJ1
Morrison, KM1
Gerstein, HC1
Holloway, AC1
Louik, C1
Kerr, S1
Mitchell, AA1
Gopalakrishnan, K1
More, AS1
Hankins, GD1
Nanovskaya, TN1
Kumar, S1
Figueroa, R1
Gisslen, T1
Nathan, B1
Thompson, T1
Rao, R1
Schroeder, JW1
Smith, AK1
Brennan, PA1
Conneely, KN1
Kilaru, V1
Knight, BT1
Newport, DJ1
Cubells, JF1
Stowe, ZN1
Thyagarajan, V1
Robin Clifford, C1
Wurst, KE1
Ephross, SA1
Seeger, JD1
Hsiao, SY1
Cherng, CF2
Yang, YK1
Yeh, TL1
Yu, L2
Su, SW1
Lin, YC1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Smoking Cessation Following Text Message Intervention in Pregnant Women[NCT03024606]49 participants (Actual)Interventional2014-03-31Completed
Perinatal Stress and Gene Influences: Pathways to Infant Vulnerability[NCT00525226]1,431 participants (Actual)Observational2007-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Exhaled Carbon Monoxide Levels

self-reported cessation rates at 1 month, as verified by exhaled carbon monoxide levels (NCT03024606)
Timeframe: 1 month

InterventionParticipants (Count of Participants)
Texting Group8
Control Group5

Reviews

1 review available for bupropion and Delayed Effects, Prenatal Exposure

ArticleYear
Pharmacotherapy for Perinatal Depression.
    Clinical obstetrics and gynecology, 2018, Volume: 61, Issue:3

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Antidepressive Agents, Tricyclic; Autism Spectru

2018

Trials

1 trial available for bupropion and Delayed Effects, Prenatal Exposure

ArticleYear
Smoking Cessation Following Text Message Intervention in Pregnant Women.
    The Annals of pharmacotherapy, 2018, Volume: 52, Issue:11

    Topics: Adult; Bupropion; Female; Follow-Up Studies; Humans; Maternal Health; Motivation; Pregnancy; Prenata

2018

Other Studies

12 other studies available for bupropion and Delayed Effects, Prenatal Exposure

ArticleYear
Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study.
    Pharmacotherapy, 2021, Volume: 41, Issue:11

    Topics: Antidepressive Agents; Bupropion; Citalopram; Duloxetine Hydrochloride; Escitalopram; Female; Fluoxe

2021
Paternal exposure to bupropion affects postnatal development in the offspring.
    Reproduction, fertility, and development, 2019, Volume: 31, Issue:10

    Topics: Animals; Animals, Newborn; Behavior, Animal; Bupropion; Female; Growth and Development; Male; Mice;

2019
Postnatal metabolic and reproductive consequences of fetal and neonatal exposure to the smoking cessation drug bupropion.
    Reproductive sciences (Thousand Oaks, Calif.), 2013, Volume: 20, Issue:10

    Topics: Animals; Animals, Newborn; Bupropion; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; Ra

2013
First-trimester exposure to bupropion and risk of cardiac malformations.
    Pharmacoepidemiology and drug safety, 2014, Volume: 23, Issue:10

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antidepressive Agents, Second-Generation; Bupropion;

2014
Postnatal Cardiovascular Consequences in the Offspring of Pregnant Rats Exposed to Smoking and Smoking Cessation Pharmacotherapies.
    Reproductive sciences (Thousand Oaks, Calif.), 2017, Volume: 24, Issue:6

    Topics: Animals; Bupropion; Female; Heart; Myocytes, Cardiac; Pregnancy; Prenatal Exposure Delayed Effects;

2017
Prescribing during pregnancy. Prenatal drug exposure and an untreated psychiatric disorder both present risks.
    The Harvard mental health letter, 2008, Volume: 25, Issue:6

    Topics: Antidepressive Agents, Tricyclic; Antimanic Agents; Bupropion; Depressive Disorder; Dopamine Uptake

2008
Use of antidepressants during pregnancy and risk of attention-deficit/hyperactivity disorder in the offspring.
    Journal of developmental and behavioral pediatrics : JDBP, 2010, Volume: 31, Issue:8

    Topics: Adult; Antidepressive Agents, Second-Generation; Attention Deficit Disorder with Hyperactivity; Bipo

2010
Hyperinsulinism associated with gestational exposure to bupropion in a newborn infant.
    Journal of pediatric endocrinology & metabolism : JPEM, 2011, Volume: 24, Issue:9-10

    Topics: Antidepressive Agents, Second-Generation; Bupropion; Female; Humans; Hyperinsulinism; Hypoglycemia;

2011
DNA methylation in neonates born to women receiving psychiatric care.
    Epigenetics, 2012, Volume: 7, Issue:4

    Topics: Antidepressive Agents; Antiemetics; Bupropion; CpG Islands; Depressive Disorder, Major; DNA Methylat

2012
Bupropion therapy in pregnancy and the occurrence of cardiovascular malformations in infants.
    Pharmacoepidemiology and drug safety, 2012, Volume: 21, Issue:11

    Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Bupropion; Cardiovascular Abnormalities

2012
Prenatal bupropion exposure enhances the cocaine reward and stress susceptibility in adult mice.
    The Chinese journal of physiology, 2005, Dec-31, Volume: 48, Issue:4

    Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Bupropion; Citalopram; Cocaine; Conditio

2005
Prenatal exposure of bupropion may enhance agitation, anxiety responses, and sensitivity to cocaine effects in adult mice.
    The Chinese journal of physiology, 2007, Feb-28, Volume: 50, Issue:1

    Topics: Aging; Animals; Antidepressive Agents, Second-Generation; Anxiety; Bupropion; Cocaine; Dose-Response

2007