bupropion has been researched along with Crohn Disease in 9 studies
Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Smoking cessation is associated with a 65% reduction in the risk of a relapse as compared with continued smokers, a similar magnitude to that obtained with immunosuppressive therapy." | 2.43 | Review article: smoking cessation as primary therapy to modify the course of Crohn's disease. ( Cosnes, J; Johnson, GJ; Mansfield, JC, 2005) |
| "Smoking is not only a risk factor for Crohn's disease, but ongoing smoking is associated with a poorer disease course." | 2.41 | Helping patients with Crohn's disease quit smoking. ( Hilsden, RJ; Hodgins, DC; Sutherland, LR; Timmer, A, 2000) |
| "Bupropion has been widely utilized as an anti-depressant." | 1.91 | Anti-inflammatory activity of bupropion through immunomodulation of the macrophages. ( Ayaz, F; Yetkin, D; Yılmaz, İA, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Yetkin, D | 1 |
| Yılmaz, İA | 1 |
| Ayaz, F | 1 |
| Scoville, EA | 1 |
| Tindle, HA | 1 |
| Wells, QS | 1 |
| Peyton, SC | 1 |
| Gurwara, S | 1 |
| Pointer, SO | 1 |
| Horst, SN | 1 |
| Schwartz, DA | 1 |
| Adams, DW | 1 |
| Freiberg, MS | 1 |
| Gatskie, V | 1 |
| King, S | 1 |
| Abney, LR | 1 |
| Beaulieu, DB | 1 |
| Hashash, JG | 1 |
| Knisely, MR | 1 |
| Germain, A | 1 |
| McAuliff, K | 1 |
| Strassburger, M | 1 |
| Vachon, A | 1 |
| Binion, DG | 1 |
| Regueiro, M | 1 |
| Wallace, M | 1 |
| Szigethy, E | 1 |
| Kane, S | 1 |
| Altschuler, EL | 4 |
| Kast, RE | 4 |
| Johnson, GJ | 1 |
| Cosnes, J | 1 |
| Mansfield, JC | 1 |
| Hilsden, RJ | 1 |
| Hodgins, DC | 1 |
| Timmer, A | 1 |
| Sutherland, LR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Controlled, Open-label Study to Investigate the Impact of Disease Activity and Nutrition Treat on Postoperative Recurrence and Complications After Bowel Resection for Crohn's Disease[NCT01540942] | 91 participants (Actual) | Interventional | 2011-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for bupropion and Crohn Disease
| Article | Year |
|---|---|
Review article: smoking cessation as primary therapy to modify the course of Crohn's disease.
Topics: Behavior Therapy; Bupropion; Cohort Studies; Colitis, Ulcerative; Counseling; Crohn Disease; Dopamin | 2005 |
Helping patients with Crohn's disease quit smoking.
Topics: Administration, Cutaneous; Behavior, Addictive; Bupropion; Counseling; Crohn Disease; Dopamine Uptak | 2000 |
1 trial available for bupropion and Crohn Disease
| Article | Year |
|---|---|
Brief Behavioral Therapy and Bupropion for Sleep and Fatigue in Young Adults With Crohn's Disease: An Exploratory Open Trial Study.
Topics: Adolescent; Adult; Behavior Therapy; Bupropion; Crohn Disease; Fatigue; Female; Humans; Quality of L | 2022 |
6 other studies available for bupropion and Crohn Disease
| Article | Year |
|---|---|
Anti-inflammatory activity of bupropion through immunomodulation of the macrophages.
Topics: Anti-Inflammatory Agents; Bupropion; Crohn Disease; Cytokines; Humans; Immunomodulation; Inflammatio | 2023 |
Precision nicotine metabolism-informed care for smoking cessation in Crohn's disease: A pilot study.
Topics: Adult; Bupropion; Crohn Disease; Female; Humans; Male; Middle Aged; Nicotine; Patient Compliance; Pi | 2020 |
Crohn's disease remission on bupropion.
Topics: Antidepressive Agents, Second-Generation; Bupropion; Crohn Disease; Humans; Remission Induction | 2003 |
Bupropion for Blau syndrome.
Topics: Arthritis; Bupropion; Carrier Proteins; Chromosome Disorders; Crohn Disease; Dopamine Uptake Inhibit | 2004 |
Bone density loss in Crohn's disease: role of TNF and potential for prevention by bupropion.
Topics: Antidepressive Agents, Second-Generation; Bone Density; Bupropion; Crohn Disease; Humans; Osteoporos | 2004 |
Remission of Crohn's disease on bupropion.
Topics: Adult; Bupropion; Crohn Disease; Cyclic AMP; Female; Humans; Tumor Necrosis Factor-alpha | 2001 |